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  1. AU="Athira S. Raj"
  2. AU="Corbacho, Belen"
  3. AU="Andrei, Adin Cristian" AU="Andrei, Adin Cristian"
  4. AU="Erminia Donnarumma"
  5. AU="Albores-Figueroa, Rosenberg"
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  7. AU="Laufs, Sebastian"
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  1. Artikel ; Online: Identification of gene classifier and modules associated with SARS-CoV-2 ARI in nasal swab

    Pandikannan Krishnamoorthy / Athira S. Raj / Himanshu Kumar

    Genes and Diseases, Vol 11, Iss 1, Pp 38-

    2024  Band 41

    Schlagwörter Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag KeAi Communications Co., Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Innate immune sensing of influenza A viral RNA through IFI16 promotes pyroptotic cell death

    Shalabh Mishra / Athira S. Raj / Akhilesh Kumar / Ashwathi Rajeevan / Puja Kumari / Himanshu Kumar

    iScience, Vol 25, Iss 1, Pp 103714- (2022)

    2022  

    Abstract: Summary: Programmed cell death pathways are triggered by various stresses or stimuli, including viral infections. The mechanism underlying the regulation of these pathways upon Influenza A virus (IAV) infection is not well characterized. We report that a ...

    Abstract Summary: Programmed cell death pathways are triggered by various stresses or stimuli, including viral infections. The mechanism underlying the regulation of these pathways upon Influenza A virus (IAV) infection is not well characterized. We report that a cytosolic DNA sensor IFI16 is essential for the activation of programmed cell death pathways in IAV infected cells. We have identified that IFI16 functions as an RNA sensor for the influenza A virus by interacting with genomic RNA. The activation of IFI16 triggers the production of type I, III interferons, and also pro-inflammatory cytokines via the STING-TBK1 and Pro-caspase-1 signaling axis, thereby promoting cell death (apoptosis and pyroptosis in IAV infected cells). On the contrary, IFI16 knockdown cells showed reduced inflammatory responses and also prevented cell mortality during IAV infection. Collectively, these results demonstrate the pivotal role of IFI16-mediated IAV sensing and its essential role in activating programmed cell death pathways.
    Schlagwörter Virology ; Biological sciences ; Immunology ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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