Artikel: Influence of AS-7 on the storage lesion in young and old circulating erythrocytes.
2020 Band 59, Heft 6, Seite(n) 102905
Abstract: Blood and its components are stored to meet the demands of blood transfusion. Erythrocytes undergo progressive modifications during storage known as storage lesions. Storage solutions were developed to improve shelf life and extend red cell viability. ... ...
Abstract | Blood and its components are stored to meet the demands of blood transfusion. Erythrocytes undergo progressive modifications during storage known as storage lesions. Storage solutions were developed to improve shelf life and extend red cell viability. Therefore, the objective of this study is to analyze the effects of AS-7 on young and old erythrocytes during storage. Blood was collected from the blood bank at Kempegowda Institute of Medical Sciences (KIMS) hospital, Bengaluru. Erythrocytes were isolated from whole blood and separated based on its age using Percoll density gradient. The young and old erythrocytes were stored in AS-7 for 35 days and every 5th day, oxidative stress markers - Hemoglobin (Hb), Oxidative Hemolysis, Mechanical Fragility, Sialic Acid, Superoxides, Glucose, Lactate Dehydrogenase (LDH), Glutathione, antioxidant capacity (TAC |
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Mesh-Begriff(e) | Blood Preservation/methods ; Erythrocytes/cytology ; Erythrocytes/metabolism ; Humans ; N-Acetylneuraminic Acid/metabolism ; Oxidative Stress/drug effects |
Chemische Substanzen | N-Acetylneuraminic Acid (GZP2782OP0) |
Sprache | Englisch |
Erscheinungsdatum | 2020-08-03 |
Erscheinungsland | England |
Dokumenttyp | Journal Article |
ZDB-ID | 2046795-3 |
ISSN | 1878-1683 ; 1473-0502 |
ISSN (online) | 1878-1683 |
ISSN | 1473-0502 |
DOI | 10.1016/j.transci.2020.102905 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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