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  1. AU="Chen, T T"
  2. AU="Alves, Luiz Felipe M F"
  3. AU="Liao, Jing" AU="Liao, Jing"

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  1. Artikel: [Research and discovery of "inner GPS" of brain].

    Chen, T T / Li, Z P

    Zhonghua yi shi za zhi (Beijing, China : 1980)

    2023  Band 53, Heft 4, Seite(n) 251–256

    Abstract: Since the 20th century, with the progress of brain science research, scientists have discovered the brain GPS, revealing the mechanism of brain spatial cognition. The discovery process of brain GPS has gone through three stages. In 1971, John O'Keefe ... ...

    Abstract Since the 20th century, with the progress of brain science research, scientists have discovered the brain GPS, revealing the mechanism of brain spatial cognition. The discovery process of brain GPS has gone through three stages. In 1971, John O'Keefe discovered the position cells in the hippocampus of the brain, which was the beginning of the research on the GPS in the brain; In 1900, James Rank discovered the head direction cells in the medial entorhinal cortex of the brain, and the research on the GPS in the brain made a breakthrough; In 2005, Edvard I. Moser and his wife discovered grid cells, marking the maturity of the research on GPS in the brain. The discovery of intracerebral GPS not only reveals the spatial cognitive function of the brain at the cellular level, but also provides a theoretical basis for the study of diseases related to the nervous system.
    Mesh-Begriff(e) Humans ; Brain ; Physicians
    Sprache Chinesisch
    Erscheinungsdatum 2023-09-19
    Erscheinungsland China
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 1052411-3
    ISSN 0255-7053
    ISSN 0255-7053
    DOI 10.3760/cma.j.cn112155-20221214-00177
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Re: Automatic identification and segmentation of slice of minimal hiatal dimensions in transperineal ultrasound volumes.

    Chen, T-T / Fang, J-H / Long, C-Y

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

    2023  Band 60, Heft 4, Seite(n) 588–589

    Mesh-Begriff(e) Humans ; Imaging, Three-Dimensional/methods ; Pelvic Floor/diagnostic imaging ; Ultrasonography/methods
    Sprache Englisch
    Erscheinungsdatum 2023-02-10
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 1073183-0
    ISSN 1469-0705 ; 0960-7692
    ISSN (online) 1469-0705
    ISSN 0960-7692
    DOI 10.1002/uog.26055
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The expression of UNC5D is abnormal in the early stage of colorectal tumors associated with its proliferation and migration.

    Shi, L-P / Zou, C / Mao, L-J / Chen, T-T / Xie, T

    European review for medical and pharmacological sciences

    2024  Band 28, Heft 1, Seite(n) 199–213

    Abstract: Objective: Colorectal adenomas are an important precancerous lesion of colorectal adenoma with a high incidence. This study aims to explore new prognostic targets for colorectal adenomas through bioinformatics techniques.: Materials and methods: In ... ...

    Abstract Objective: Colorectal adenomas are an important precancerous lesion of colorectal adenoma with a high incidence. This study aims to explore new prognostic targets for colorectal adenomas through bioinformatics techniques.
    Materials and methods: In this study, data from 29 colonic adenomas and 38 normal colonic mucosa in GSE37364 were analyzed to screen for differentially expressed genes (DEGs). Then, batch survival analysis, construction of risk model, mutation analysis, Cox regression analysis and expression analysis were performed on DEGs to determine the hub genes of this study. Finally, immune correlation analysis and cell experiments were carried out on the hub gene to explore its potential mechanism.
    Results: In our study, a total of 431 up-regulated and 809 down-regulated differentially expressed genes (DEGs) were identified. Among these, Unc-5 Netrin Receptor D (UNC5D) emerged as a pivotal gene associated with colorectal adenoma. Notably, UNC5D expression levels were found to be significantly higher in normal tissues compared to colorectal adenoma tissues. Furthermore, our analysis demonstrated that UNC5D showed promising diagnostic potential for patients with colon adenocarcinoma. In vitro experiments revealed that the overexpression of UNC5D had a profound impact on the behavior of colorectal tumor cells. Specifically, it led to a substantial reduction in the proliferation, motility, and invasion of these tumor cells. Additionally, UNC5D was shown to exert control over STAT1/STAT3 phosphorylation, which in turn regulated the expression of PD-L1 in response to interferon (IFN) stimulation. These findings highlight the significant role of UNC5D in modulating immune responses and the development of colorectal adenoma. UNC5D emerges as a potential diagnostic biomarker and an attractive immunotherapeutic target in the context of colorectal malignancies. These results call for further exploration of UNC5D-based strategies for the diagnosis and treatment of colorectal adenoma and adenocarcinoma.
    Conclusions: In addition to having the potential to be used as a diagnostic biomarker and an immunotherapeutic target in colorectal malignancies, UNC5D is necessary for the growth of colorectal adenomas. Additionally, UNC5D controlled STAT1/STAT3 phosphorylation to suppress the growth of colorectal cancers by regulating IFN-induced PD-L1 expression.
    Mesh-Begriff(e) Humans ; Adenocarcinoma/genetics ; Adenoma/genetics ; B7-H1 Antigen/genetics ; Biomarkers ; Cell Proliferation ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Receptors, Cell Surface/genetics
    Chemische Substanzen B7-H1 Antigen ; Biomarkers ; UNC5D protein, human ; Receptors, Cell Surface
    Sprache Englisch
    Erscheinungsdatum 2024-02-07
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202401_34905
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: [Comparative study of next generation sequencing and immunohistochemistry on molecular classification of endometrial carcinoma].

    Chen, T T / Tao, X / Liu, T Q / Zhou, X R

    Zhonghua bing li xue za zhi = Chinese journal of pathology

    2023  Band 52, Heft 6, Seite(n) 580–585

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Female ; Humans ; Middle Aged ; China ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/pathology ; Exons ; High-Throughput Nucleotide Sequencing ; Immunohistochemistry ; Microsatellite Instability ; Mutation ; Young Adult ; Adult ; Aged ; Aged, 80 and over
    Sprache Chinesisch
    Erscheinungsdatum 2023-06-01
    Erscheinungsland China
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 784533-9
    ISSN 0529-5807
    ISSN 0529-5807
    DOI 10.3760/cma.j.cn112151-20230303-00166
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Conjugation in Paramecium bursaria. III. Nuclear changes in conjugation between double monsters and single animals.

    CHEN, T T

    Journal of morphology

    2014  Band 88, Heft 2, Seite(n) 245–291

    Mesh-Begriff(e) Animals ; Cell Division ; Paramecium
    Sprache Englisch
    Erscheinungsdatum 2014-02-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3084-3
    ISSN 1097-4687 ; 0362-2525 ; 0022-2887
    ISSN (online) 1097-4687
    ISSN 0362-2525 ; 0022-2887
    DOI 10.1002/jmor.1050880204
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Conjugation in Paramecium bursaria. IV. Nuclear behavior in conjugation between old and young clones.

    CHEN, T T

    Journal of morphology

    2014  Band 88, Heft 2, Seite(n) 293–359

    Mesh-Begriff(e) Animals ; Cell Division ; Paramecium
    Sprache Englisch
    Erscheinungsdatum 2014-02-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3084-3
    ISSN 1097-4687 ; 0362-2525 ; 0022-2887
    ISSN (online) 1097-4687
    ISSN 0362-2525 ; 0022-2887
    DOI 10.1002/jmor.1050880205
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: [Value of high-risk HPV E6/E7 mRNA in situ hybridization in grading of cervical intraepithelial neoplasia].

    Chen, T T / Zhang, Y / Cheng, H X / Chen, M Y / Wang, W

    Zhonghua bing li xue za zhi = Chinese journal of pathology

    2022  Band 51, Heft 7, Seite(n) 608–614

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Cervical Intraepithelial Neoplasia/pathology ; Female ; Humans ; In Situ Hybridization ; Oncogene Proteins, Viral/genetics ; Papillomavirus Infections/diagnosis ; RNA, Messenger
    Chemische Substanzen Oncogene Proteins, Viral ; RNA, Messenger
    Sprache Chinesisch
    Erscheinungsdatum 2022-07-04
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 784533-9
    ISSN 0529-5807
    ISSN 0529-5807
    DOI 10.3760/cma.j.cn112151-20211027-00780
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: [Interim follow-up of fetal cardiac intervention in five fetuses with pulmonary atresia with intact ventricular septum].

    Luo, G / Pan, S L / Wan, H / Chen, T T / Xu, Q / Sun, Y

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2021  Band 59, Heft 9, Seite(n) 782–786

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Child, Preschool ; Female ; Fetus ; Follow-Up Studies ; Heart Defects, Congenital ; Heart Ventricles/diagnostic imaging ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Pulmonary Atresia/surgery ; Retrospective Studies ; Treatment Outcome ; Ultrasonography, Prenatal
    Sprache Chinesisch
    Erscheinungsdatum 2021-10-14
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20210219-00141
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: A technique for counting numerous chromosomes.

    CHEN, T T

    Journal of morphology

    2010  Band 78, Seite(n) 221–230

    Mesh-Begriff(e) Animals ; Chromosomes
    Sprache Englisch
    Erscheinungsdatum 2010-09-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3084-3
    ISSN 1097-4687 ; 0362-2525 ; 0022-2887
    ISSN (online) 1097-4687
    ISSN 0362-2525 ; 0022-2887
    DOI 10.1002/jmor.1050780204
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Conjugation in Paramecium bursaria; conjugation of three animals.

    CHEN, T T

    Journal of morphology

    2010  Band 78, Seite(n) 353–395

    Mesh-Begriff(e) Animals ; Eukaryota ; Invertebrates ; Paramecium
    Sprache Englisch
    Erscheinungsdatum 2010-09-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3084-3
    ISSN 1097-4687 ; 0362-2525 ; 0022-2887
    ISSN (online) 1097-4687
    ISSN 0362-2525 ; 0022-2887
    DOI 10.1002/jmor.1050780303
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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