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Artikel: Editorial: Advances in natural product chemistry: Yunnan University 100th anniversary.

Chen, Wen / Dong, Jianwei / Panda, Siva S

2023 Band 11, Seite(n) 1234211

Sprache	Englisch
Erscheinungsdatum	2023-06-13
Erscheinungsland	Switzerland
Dokumenttyp	Editorial
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2023.1234211
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Microtrap-assisted microfluidic magnetic separation and concentration for ultrasensitive immunoassays of biomarkers.

Dong, Jianwei / Li, Gongke / Xia, Ling / Li, He

Journal of chromatography. A

2023 Band 1699, Seite(n) 464021

Abstract: Precise and accurate quantitation of important biomarkers is significant, especially in early-stage diseases diagnosis. To realized effective biosample preparation and trace-level biomarker detection, a microtrap-assisted microfluidic magnetic ... ...

Abstract	Precise and accurate quantitation of important biomarkers is significant, especially in early-stage diseases diagnosis. To realized effective biosample preparation and trace-level biomarker detection, a microtrap-assisted microfluidic magnetic immunoassays (μMI) method was developed in this work. A microtrap was fabricated inside the straight microchannel of μMI device to help magnetic separation and concentration of immunocomplexes. These immunocomplexes were enriched in microtrap of μMI device to accomplish selective and sensitive biomarker detection. Horseradish peroxidase-labeled magnetic beads were employed to evaluate assay feasibility and microtrap effect on assay sensitivity. The microtrap-assisted μMI was then applied for model biomarkers detection. The limits of detection of μMI were 0.025 pg/mL for monocyte chemoattractant protein-1 (MCP-1) and 0.021 pg/mL for matrix metalloproteinase-9 (MMP-9), which corresponded up to 2014-fold sensitivity improvement compared to their standard microwell enzyme-linked immunosorbent assay (ELISA) results. In addition, the selectivity and reproducibility of microtrap-assisted μMI were confirmed. In clinical serum sample analysis, recoveries of 91.3%-106.7% with relative standard deviations less than 6.1% were obtained for MCP-1 and MMP-9, and method accuracy was verified by commercial ELISA kit. The developed μMI can accomplish ultratrace biomarker detection offering practical tool for laboratorial and clinical research.
Mesh-Begriff(e)	Microfluidics ; Matrix Metalloproteinase 9 ; Reproducibility of Results ; Immunoassay/methods ; Biomarkers ; Enzyme-Linked Immunosorbent Assay/methods ; Magnetic Phenomena
Chemische Substanzen	Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Biomarkers
Sprache	Englisch
Erscheinungsdatum	2023-04-25
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2023.464021
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The impact of venture capital funds with foreign limited partners investment on enterprise internationalization: evidence from China

Feng, Ding / Guo, Lihong / Dong, Jianwei / Wang, Han

Heliyon. 2022 Dec., v. 8, no. 12 p.e12281-

2022

Abstract: This paper examines the relationship between local venture capital (VC) funds and portfolio enterprise internationalization from the perspective of limited partners (LPs). Based on a sample consist of 581 listed enterprises invested by local VC funds in ... ...

Abstract	This paper examines the relationship between local venture capital (VC) funds and portfolio enterprise internationalization from the perspective of limited partners (LPs). Based on a sample consist of 581 listed enterprises invested by local VC funds in China during 2009–2021, it’s found that, compared to the VC funds invested by local LPs completely (LLP_VC), the VC funds with foreign LP investment (FLP_VC) are more likely to help portfolio enterprises list overseas. If FLP_VC syndicates or act as a major investor, it will have a greater role in promoting the internationalization of enterprises.
Schlagwörter	business enterprises ; capital ; China ; Venture capital ; Enterprise internationalization ; Foreign limited partner ; Emerging markets
Sprache	Englisch
Erscheinungsverlauf	2022-12
Erscheinungsort	Elsevier Ltd
Dokumenttyp	Artikel ; Online
Anmerkung	Pre-press version ; Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e12281
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Source, transport, and fate of perfluoroalkyl acids (PFAAs) in turbid bay environments: Significant roles of suspended sediment and water column stratification.

Shang, Meiqi / Dong, Jianwei / Xie, Hui / Wang, Yang / Du, Yongfen

Water research

2023 Band 243, Seite(n) 120384

Abstract: The coastal area was the major region receiving pollution from land-based sources into the sea. Perfluoroalkyl acids (PFAAs) in famous bays had aroused wide concern, but the importance of underdeveloped or small bays with notable levels of PFAAs were ... ...

Abstract	The coastal area was the major region receiving pollution from land-based sources into the sea. Perfluoroalkyl acids (PFAAs) in famous bays had aroused wide concern, but the importance of underdeveloped or small bays with notable levels of PFAAs were often neglected. Moreover, the roles of suspended sediment (SPS) and water column stratification on PFAA behaviors were unclear. In this study, PFAAs distribution in multiphase-multilayer in four underdeveloped bays (two urban bays and two island bays) were investigated. The urban bays not only had higher PFAA contamination but also posed a greater threat of short-chain PFAAs in water-SPS-sediment system than the island bays. The major source of PFAAs in water and SPS was domestic sewage in urban bays and was rainfall-runoff in island bays. Water column stratification with higher PFAA partition in water-SPS system in the surface layer than in the bottom layer was only found in the urban bays due to the higher human activity intensity. These provided new perspectives for managing emerging contaminants and establishing water quality criteria in the turbid coastal environment. The key role of SPS as a carrier offered possibilities to accurately differentiate the effects of dissolved and particulate PFAAs on bioavailability.
Mesh-Begriff(e)	Humans ; Bays ; Environmental Monitoring ; Water Pollutants, Chemical/analysis ; Fluorocarbons/analysis ; Rivers ; Geologic Sediments
Chemische Substanzen	Water Pollutants, Chemical ; Fluorocarbons
Sprache	Englisch
Erscheinungsdatum	2023-07-18
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2023.120384
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Microfluidic Magnetic Spatial Confinement Strategy for the Enrichment and Ultrasensitive Detection of MCF-7 and

Dong, Jianwei / Li, Gongke / Xia, Ling

Analytical chemistry

2022 Band 94, Heft 48, Seite(n) 16901–16909

Abstract: A microfluidic magnetic spatial confinement strategy was developed and employed to realize an ultrasensitive cell immunoassay. The straight confined channels in poly(dimethylsiloxane)-glass hybrid microchips were used as the enrichment and detection ... ...

Abstract	A microfluidic magnetic spatial confinement strategy was developed and employed to realize an ultrasensitive cell immunoassay. The straight confined channels in poly(dimethylsiloxane)-glass hybrid microchips were used as the enrichment and detection chambers for the proposed microfluidic magnetic cell immunoassays (μMCI). To accomplish the μMCI, prepared magnetic cell immunocomplexes were introduced into microchannels and preconcentrated in the detection zone under a permanent magnet. The magnetic cell immunocomplexes were constructed from aptamer-/antibody-coated magnetic beads and antibody-linked horseradish peroxidase-labeled target cells to guarantee the specificity and enhance the detection signal generated from the enzyme reaction. The sensitivity enhancement of μMCI was confirmed in a one-dimensional space confined microchamber, especially in the analysis of cells having more enzyme conjugating sites on their surface. This spatial confinement strategy based μMCI was then applied for model cell detection in the microchannel, the limits of detection (LODs) were 2 cells/mL for MCF-7 and 34 colony-forming unit/mL for
Sprache	Englisch
Erscheinungsdatum	2022-11-18
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c04314
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: How does venture capital cross-border syndication spur corporate innovation? Evidence from China.

Hao, Haixia / Guo, Lihong / Dong, Jianwei

Frontiers in psychology

2022 Band 13, Seite(n) 921168

Abstract: In recent years, venture capital (VC) cross-border syndication has shown an obvious growth trend. Based on the existing studies, this paper explores the impact of VC cross-border syndication on corporate innovation. We also examine the mediating roles of ...

Abstract	In recent years, venture capital (VC) cross-border syndication has shown an obvious growth trend. Based on the existing studies, this paper explores the impact of VC cross-border syndication on corporate innovation. We also examine the mediating roles of cross-border quadratic relationship closure (CBQRC) formed by the strategic cooperation relationship between the respective portfolio companies of domestic and foreign VCs. This paper conducted an empirical analysis to test our hypotheses using a sample of first-round investments in domestic firms by domestic VC firms from 2014 to 2016. Results show that the more investment events of VC cross-border syndication or the more partners of VC cross-border syndication, the more likely it is to have a significant positive impact on the innovation of domestic portfolio companies. CBQRC plays a mediating role between VC cross-border syndication on corporate innovation. Results remain robust after removing endogeneity using the instrumental variables approach and removing sample selection bias using Heckman two-stage regression. Results deepen the understanding of the relationship between VC cross-border syndication and corporate innovation and provide essential guidance to domestic VC firms promoting corporate innovation in open partnerships.
Sprache	Englisch
Erscheinungsdatum	2022-07-22
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.921168
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Source, transport, and fate of perfluoroalkyl acids (PFAAs) in turbid bay environments: Significant roles of suspended sediment and water column stratification

Shang, Meiqi / Dong, Jianwei / Xie, Hui / Wang, Yang / Du, Yongfen

Water Research. 2023 July 18, p.120384-

2023 , Seite(n) 120384–

Abstract	The coastal area was the major region receiving pollution from land-based sources into the sea. Perfluoroalkyl acids (PFAAs) in famous bays had aroused wide concern, but the importance of underdeveloped or small bays with notable levels of PFAAs were often neglected. Moreover, the roles of suspended sediment (SPS) and water column stratification on PFAA behaviors were unclear. In this study, PFAAs distribution in multiphase-multilayer in four underdeveloped bays (two urban bays and two island bays) were investigated. The urban bays not only had higher PFAA contamination but also posed a greater threat of short-chain PFAAs in water-SPS-sediment system than the island bays. The major source of PFAAs in water and SPS was domestic sewage in urban bays and was rainfall-runoff in island bays. Water column stratification with higher PFAA partition in water-SPS system in the surface layer than in the bottom layer was only found in the urban bays due to the higher human activity intensity. These provided new perspectives for managing emerging contaminants and establishing water quality criteria in the turbid coastal environment. The key role of SPS as a carrier offered possibilities to accurately differentiate the effects of dissolved and particulate PFAAs on bioavailability.
Schlagwörter	bioavailability ; coasts ; humans ; perfluorocarbons ; pollution ; research ; runoff ; sewage ; suspended sediment ; water quality ; Emerging contaminants ; Perfluoroalkyl acids ; Turbid coastal waters ; stratification
Sprache	Englisch
Erscheinungsverlauf	2023-0718
Erscheinungsort	Elsevier Ltd
Dokumenttyp	Artikel ; Online
Anmerkung	Pre-press version
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2023.120384
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Analysis of the multi-media environmental behavior of polycyclic aromatic hydrocarbons (PAHs) within Haizhou Bay using a fugacity model

Shi, Wenting / Liu, Qing / Cao, Jicheng / Dong, Jianwei / Wang, Zaifeng / Xu, Min

Marine Pollution Bulletin. 2023 Feb., v. 187 p.114603-

2023

Abstract: In this study, we aimed to quantify the transport and fate of PAHs in different environmental phases (air, seawater, soil, sediment and fish), verify application of the Level III fugacity model in a bay simulation, and understand the transport and fate ... ...

Abstract	In this study, we aimed to quantify the transport and fate of PAHs in different environmental phases (air, seawater, soil, sediment and fish), verify application of the Level III fugacity model in a bay simulation, and understand the transport and fate of PAHs in the bay environment on a macroscopic scale. The simulated average concentrations of ∑₁₆PAH in the air and soil (23.8 ng/m³ and 1080.91 ng/g, respectively), which is as a background reference data for the Haizhou Bay. In addition, the soil (307 t), fish (29.4 t), and sediment (9.72 t) phases were found to be important reservoirs in the Haizhou Bay. Emissions from road vehicles (658 t) accounted for the largest share of PAH emissions in the area, and atmospheric deposition contributed most to the input of PAHs to the polluted area in the region. Whereas the contribution of river runoff input was small, and degradation loss was the main output pathway.
Schlagwörter	air ; atmospheric deposition ; fish ; marine pollution ; models ; rivers ; runoff ; seawater ; sediments ; soil ; PAHs ; Water column–sediment-marine organisms ; Fugacity model ; Haizhou Bay
Sprache	Englisch
Erscheinungsverlauf	2023-02
Erscheinungsort	Elsevier Ltd
Dokumenttyp	Artikel ; Online
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.114603
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Size‐resolved counting of circulating tumor cells on pinched flow‐based microfluidic cytometry

Xia, Ling / Zhou, Wanjun / Huang, Jianying / Dong, Jianwei / Xiao, Xiaohua / Li, Gongke

ELECTROPHORESIS. 2023 Jan., v. 44, no. 1-2 p.82-88

2023

Abstract: Precise cell detecting and counting is meaningful in circulating tumor cells (CTCs) analysis. In this work, a simple cyclic olefin copolymer (COC) microflow cytometer device was developed for size‐resolved CTCs counting. The proposed device is ... ...

Abstract	Precise cell detecting and counting is meaningful in circulating tumor cells (CTCs) analysis. In this work, a simple cyclic olefin copolymer (COC) microflow cytometer device was developed for size‐resolved CTCs counting. The proposed device is constructed by a counting channel and a pinched injection unit having three channels. Through injection flow rate control, microspheres/cells can be focused into the centerline of the counting channel. Polystyrene microspheres of 3, 9, 15, and 20 µm were used for the microspheres focusing characterization. After coupling to laser‐induced fluorescence detection technique, the proposed device was used for polystyrene microspheres counting and sizing. A count accuracy up to 97.6% was obtained for microspheres. Moreover, the proposed microflow cytometer was applied to CTCs detecting and counting. To mimic blood sample containing CTCs and CTCs mixture with different subtypes, an MDA‐MB‐231 (human breast cell line) spiked red blood cells sample and a mixture of MDA‐MB‐231 and MCF‐7 (human breast cell line) sample were prepared, respectively, and then analyzed by the developed pinched flow‐based microfluidic cytometry. The simple fabricated and easy operating COC microflow cytometer exhibits the potential in the point‐of‐care clinical application.
Schlagwörter	blood ; blood sampling ; breasts ; cell lines ; composite polymers ; electrophoresis ; flow cytometry ; fluorescence ; humans ; microparticles ; neoplasms ; olefin ; point-of-care systems ; polystyrenes
Sprache	Englisch
Erscheinungsverlauf	2023-01
Umfang	p. 82-88.
Erscheinungsort	John Wiley & Sons, Ltd
Dokumenttyp	Artikel ; Online
Anmerkung	JOURNAL ARTICLE
ZDB-ID	619001-7
ISSN	1522-2683 ; 0173-0835
ISSN (online)	1522-2683
ISSN	0173-0835
DOI	10.1002/elps.202200171
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Efficacy and safety of rituximab for primary membranous nephropathy with different clinical presentations: a retrospective study.

Zhang, Shasha / Huang, Jing / Dong, Jianwei / Li, Zhuo / Sun, Mengyao / Sun, Yujiao / Chen, Bing

Frontiers in immunology

2023 Band 14, Seite(n) 1156470

Abstract: Background: Rituximab (RTX) is gaining increasing clinical acceptance in the treatment of primary membranous nephropathy (PMN), with demonstrated efficacy and safety. However, there are few clinical studies on RTX for PMN in Asian populations, ... ...

Abstract	Background: Rituximab (RTX) is gaining increasing clinical acceptance in the treatment of primary membranous nephropathy (PMN), with demonstrated efficacy and safety. However, there are few clinical studies on RTX for PMN in Asian populations, especially in China. Methods: To observe and analyse the efficacy and safety of RTX treatment, 81 patients with PMN suffering from nephrotic syndrome (NS) were enrolled and divided into an initial therapy group, a conventional immunosuppressive therapy relapse group, and a conventional immunosuppressive therapy ineffective group according to their pre-RTX treatment background. Patients in each group were followed up for 12 months. The primary outcome was clinical remission at 12 months, and the secondary outcomes were safety and the occurrence of adverse events. Results: At 12 months, 65 of 81 (80.2%) patients achieved complete (n=21, 25.9%) or partial (n=44, 54.3%) remission after rituximab treatment. Thirty-two of 36 (88.9%) patients in the initial therapy group, 11 of 12 (91.7%) patients in the relapse group and 22 of 33 (66.7%) patients in the ineffective group achieved clinical remission. All 59 patients with positive anti-PLA2R antibodies showed a decreasing trend in antibody levels after RTX treatment, and 55 (93.2%) of them achieved antibody clearance (<20 U/mL). Logistic regression analysis showed that a high anti-PLA2R antibody titer (OR=0.993, P=0.032) was an independent risk factor for nonremission. Adverse events occurred in 18 (22.2%) patients, of which 5 (6.2%) were serious adverse events, and none were malignant or otherwise fatal. Conclusion: RTX alone can effectively induce remission PMN and maintain stable renal function. It is recommended as the first choice of treatment and is also effective in patients who relapse and have poor responses to conventional immunosuppressive therapy. Anti-PLA2R antibodies can be used as a marker for RTX treatment monitoring, and antibody clearance is necessary to achieve and improve the rates of clinical remission.
Mesh-Begriff(e)	Humans ; Rituximab/adverse effects ; Retrospective Studies ; Glomerulonephritis, Membranous/diagnosis ; Glomerulonephritis, Membranous/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Immunosuppressive Agents/adverse effects ; Antibodies/therapeutic use
Chemische Substanzen	Rituximab (4F4X42SYQ6) ; Immunosuppressive Agents ; Antibodies
Sprache	Englisch
Erscheinungsdatum	2023-04-28
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1156470
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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