Artikel ; Online: Hepatitis C virus: life cycle in cells, infection and host response, and analysis of molecular markers influencing the outcome of infection and response to therapy.
2016 Band 22, Heft 10, Seite(n) 826–832
Abstract: Hepatitis C virus (HCV) is a major global health burden accounting for around 170 million chronic infections worldwide. Since its discovery, which dates back to about 30 years ago, many details of the viral genome organization and the astonishing genetic ...
Abstract | Hepatitis C virus (HCV) is a major global health burden accounting for around 170 million chronic infections worldwide. Since its discovery, which dates back to about 30 years ago, many details of the viral genome organization and the astonishing genetic diversity have been unveiled but, owing to the difficulty of culturing HCV in vitro and obtaining fully susceptible yet immunocompetent in vivo models, we are still a long way from the full comprehension of viral life cycle, host cell pathways facilitating or counteracting infection, pathogenetic mechanisms in vivo, and host defences. Here, we illustrate the viral life cycle into cells, describe the interplay between immune and genetic host factors shaping the course of infection, and provide details of the molecular approaches currently used to genotype, monitor replication in vivo, and study the emergence of drug-resistant viral variants. |
---|---|
Mesh-Begriff(e) | Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Drug Resistance, Viral ; Genotype ; Hepacivirus/pathogenicity ; Hepacivirus/physiology ; Hepatitis C/drug therapy ; Hepatitis C/genetics ; Hepatitis C/immunology ; Host-Pathogen Interactions ; Humans ; Virulence Factors/genetics ; Virulence Factors/immunology ; Virus Replication |
Chemische Substanzen | Antiviral Agents ; Virulence Factors |
Sprache | Englisch |
Erscheinungsdatum | 2016-10 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Review |
ZDB-ID | 1328418-6 |
ISSN | 1469-0691 ; 1470-9465 ; 1198-743X |
ISSN (online) | 1469-0691 |
ISSN | 1470-9465 ; 1198-743X |
DOI | 10.1016/j.cmi.2016.08.025 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 4541: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
|||
Zs.MO 284: Hefte anzeigen |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.