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Artikel ; Online: More than a "monstrous obesity"! Time to overcome the "anti-fat" bias.

Palmese, Francesco / Reggidori, Nicola / Pappas, Georgios / Gramenzi, Annagiulia

2020 Band 11, Heft 1, Seite(n) e12413

Abstract: A 54-years-old woman complained of unintentional important body weight gain associated with abdominal bloating. For this reason, she had consulted many different diet and nutritional professionals, general practitioners and a gastroenterology specialist, ...

Abstract	A 54-years-old woman complained of unintentional important body weight gain associated with abdominal bloating. For this reason, she had consulted many different diet and nutritional professionals, general practitioners and a gastroenterology specialist, but no one went beyond a simple diagnosis of "monstrous obesity". At our hospital division, based on physical examination, a computed tomography (CT) of the abdomen and pelvis was performed. It showed a voluminous intraperitoneal mass occupying the most part of the abdomen. The patient underwent laparotomy with resection of the abdomino-pelvic mass, originating from the left ovary, measuring 60 x 45 cm and weighing 46 kg. Histopathology examination revealed a tumor composed of three different areas, including a well-differentiated adenocarcinoma of intestinal-type. It is emblematic of a grotesque misdiagnosis generated by a non-comprehensive patient assessment and consequently by a too quick judgement related to the "anti-fat bias".
Mesh-Begriff(e)	Abdomen ; Female ; Humans ; Middle Aged ; Obesity/diagnosis ; Pelvis ; Tomography, X-Ray Computed
Sprache	Englisch
Erscheinungsdatum	2020-09-28
Erscheinungsland	England
Dokumenttyp	Case Reports
ZDB-ID	2625816-X
ISSN	1758-8111 ; 1758-8103
ISSN (online)	1758-8111
ISSN	1758-8103
DOI	10.1111/cob.12413
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Reply to "Re: Survival and Tolerability of Transarterial Chemoembolization in Greater Versus less than 70 Years of Age Patients with Unresectable Hepatocellular Carcinoma-A Propensity Analysis".

Mosconi, Cristina / Gramenzi, Annagiulia / Cappelli, Alberta / Biselli, Maurizio / Golfieri, Rita

Cardiovascular and interventional radiology

2021 Band 44, Heft 7, Seite(n) 1135–1136

Mesh-Begriff(e)	Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic ; Humans ; Liver Neoplasms/mortality ; Liver Neoplasms/therapy ; Propensity Score
Sprache	Englisch
Erscheinungsdatum	2021-03-09
Erscheinungsland	United States
Dokumenttyp	Letter ; Comment
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-021-02799-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Impact of Sarcopenia on the Survival of Patients with Hepatocellular Carcinoma Treated with Sorafenib.

Biselli, Maurizio / Reggidori, Nicola / Iavarone, Massimo / Renzulli, Matteo / Lani, Lorenzo / Granito, Alessandro / Piscaglia, Fabio / Lorenzini, Stefania / Alimenti, Eleonora / Vara, Giulio / Caraceni, Paolo / Sangiovanni, Angelo / Marignani, Massimo / Gigante, Elia / Brandi, Nicolò / Gramenzi, Annagiulia / Trevisani, Franco

Cancers

2024 Band 16, Heft 6

Abstract: Background and aims: Sarcopenia has been associated with poor outcomes in patients with cirrhosis and hepatocellular carcinoma. We investigated the impact of sarcopenia on survival in patients with advanced hepatocellular carcinoma treated with ... ...

Abstract	Background and aims: Sarcopenia has been associated with poor outcomes in patients with cirrhosis and hepatocellular carcinoma. We investigated the impact of sarcopenia on survival in patients with advanced hepatocellular carcinoma treated with Sorafenib. Methods: A total of 328 patients were retrospectively analyzed. All patients had an abdominal CT scan within 8 weeks prior to the start of treatment. Two cohorts of patients were analyzed: the "Training Group" (215 patients) and the "Validation Group" (113 patients). Sarcopenia was defined by reduced skeletal muscle index, calculated from an L3 section CT image. Results: Sarcopenia was present in 48% of the training group and 50% of the validation group. At multivariate analysis, sarcopenia (HR: 1.47,
Sprache	Englisch
Erscheinungsdatum	2024-03-07
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16061080
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Probiotics History.

Gasbarrini, Giovanni / Bonvicini, Fiorenza / Gramenzi, Annagiulia

Journal of clinical gastroenterology

2016 Band 50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015, Seite(n) S116–S119

Abstract: Gut microbiota promotes healthy effects on the host and prevents diseases. Probiotic (probios, for life) are defined as "live microorganisms which when administered in adequate amounts confer a health benefit on the host." At the beginning of 1900s Louis ...

Abstract	Gut microbiota promotes healthy effects on the host and prevents diseases. Probiotic (probios, for life) are defined as "live microorganisms which when administered in adequate amounts confer a health benefit on the host." At the beginning of 1900s Louis Pasteur identified the microorganisms responsible for the process of fermentation, whereas E. Metchnikoff associated the enhanced longevity of Bulgarian rural people to the regular consumption of fermented dairy products such as yogurt. He suggested that lactobacilli might counteract the putrefactive effects of gastrointestinal metabolism that contributed to illness and aging. Hippocrates declared, 2000 years earlier, that "death sits in the bowels." Metchnikoff considered the lactobacilli as probiotics ("probios," conducive to life of the host as opposed to antibiotics); probiotics could have a positive influence on health and prevent aging. During the neolitic period of the age of the stone, the domestication of animals occurred and man began to get fermented food. Probably serendipitous contaminations in favorable environments played a major role. Fecal microbiota transplantation dates to a fourth-century Chinese handbook for food poisoning or severe diarrhea. To date fecal transplant cures Clostridium difficile infections with more efficacy than vancomycin, and prevents recurrence.
Mesh-Begriff(e)	Fecal Microbiota Transplantation/history ; Gastrointestinal Microbiome ; Gastrointestinal Tract/microbiology ; History, 20th Century ; History, Ancient ; Humans ; Probiotics/history
Sprache	Englisch
Erscheinungsdatum	2016-10-12
Erscheinungsland	United States
Dokumenttyp	Historical Article ; Journal Article
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000000697
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Computed Tomography-Colonography With Intravenous Contrast Medium and Urographic Phase for the Evaluation of Pelvic Deep Infiltrating Endometriosis of Intestinal and Urinary Tract.

Coppola, Francesca / Paradisi, Roberto / Zanardi, Sara / Papadopoulos, Dimitris / Gramenzi, Annagiulia / Valerio, Domenico / Pierotti, Luisa / Zannoni, Letizia / Seracchioli, Renato / Golfieri, Rita

Journal of computer assisted tomography

2019 Band 43, Heft 3, Seite(n) 513–518

Abstract: Objectives: The aim of this study was to evaluate the diagnostic accuracy of a specific protocol of computed tomography-colonography with intravenous contrast medium and urographic phase, which combined simultaneously the study of the intestinal and ... ...

Abstract	Objectives: The aim of this study was to evaluate the diagnostic accuracy of a specific protocol of computed tomography-colonography with intravenous contrast medium and urographic phase, which combined simultaneously the study of the intestinal and urinary tract, in the preoperative evaluation of women with deep infiltrating endometriosis (DIE) of anterior and posterior pelvic compartments. Methods: We retrospectively analyzed 73 women who underwent 74 computed tomography-colonography with intravenous contrast medium and urographic phase examinations for strong clinical suspicion of DIE. All the women had surgical confirmation. Results: Computed tomography-colonography with intravenous contrast medium and urographic phase in detecting DIE rectosigmoid involvement had a sensitivity of 82.3% and a specificity of 66.7%, while in detecting DIE urinary tract involvement had a sensitivity of 45.9% and a specificity of 78.4%. Conclusions: Computed tomography-colonography with intravenous contrast medium and urographic phase is a useful technique for the preoperative planning of selected women with DIE, in particular, for the detection of sigmoid colon and bladder lesions especially when performed with a dose reduction protocol.
Mesh-Begriff(e)	Administration, Intravenous ; Adult ; Colonography, Computed Tomographic ; Contrast Media/administration & dosage ; Endometriosis/diagnostic imaging ; Female ; Humans ; Intestines/diagnostic imaging ; Middle Aged ; Multimodal Imaging ; Pelvis/diagnostic imaging ; Retrospective Studies ; Sensitivity and Specificity ; Urinary Tract/diagnostic imaging ; Urography
Chemische Substanzen	Contrast Media
Sprache	Englisch
Erscheinungsdatum	2019-05-13
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Observational Study
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000000867
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Biomarkers for the early diagnosis of bacterial infection and the surveillance of hepatocellular carcinoma in cirrhosis.

Conti, Fabio / Dall'Agata, Marco / Gramenzi, Annagiulia / Biselli, Maurizio

Biomarkers in medicine

2015 Band 9, Heft 12, Seite(n) 1343–1351

Abstract: The early detection of bacterial infections and hepatocellular carcinoma (HCC) could ameliorate the prognosis of cirrhosis. C-reactive protein and procalcitonin are under investigation in the setting of cirrhosis as markers of sepsis. In the attempt to ... ...

Abstract	The early detection of bacterial infections and hepatocellular carcinoma (HCC) could ameliorate the prognosis of cirrhosis. C-reactive protein and procalcitonin are under investigation in the setting of cirrhosis as markers of sepsis. In the attempt to discriminate bacterial infection from systemic inflammation, the role of novel biomarkers such as lypopolysaccharide binding-protein, mid-regional fragment of pro-adrenomedullin and delta neutrophil index are currently in development. Concerning HCC, many studies attempted to evaluate biomarkers in the hope of ameliorating the accuracy of the surveillance based on ultrasound. The use of α-fetoprotein (AFP) has been extensively investigated, as well as other biomarkers expressed in the serum of HCC patients like lens culinaris agglutinin-reactive fraction of AFP, des-γ-carboxy prothrombin, glypican-3, α-l-fucosidase and their combined use.
Mesh-Begriff(e)	Bacterial Infections/complications ; Bacterial Infections/diagnosis ; Biomarkers/metabolism ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/diagnosis ; Early Diagnosis ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Neoplasms/complications ; Liver Neoplasms/diagnosis
Chemische Substanzen	Biomarkers
Sprache	Englisch
Erscheinungsdatum	2015
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm.15.100
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Authors' reply: comment to "liver transplantation for patients with alcoholic liver disease: an open question".

Gramenzi, Annagiulia / Biselli, Maurizio / Andreone, Pietro

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2013 Band 45, Heft 1, Seite(n) 81

Mesh-Begriff(e)	Alcoholism/diagnosis ; Humans ; Liver Diseases, Alcoholic/diagnosis ; Liver Diseases, Alcoholic/surgery ; Liver Transplantation
Sprache	Englisch
Erscheinungsdatum	2013-01
Erscheinungsland	Netherlands
Dokumenttyp	Comment ; Letter
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2012.07.006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The HEART score with high-sensitive troponin T at presentation: ruling out patients with chest pain in the emergency room.

Santi, Luca / Farina, Gabriele / Gramenzi, Annagiulia / Trevisani, Franco / Baccini, Margherita / Bernardi, Mauro / Cavazza, Mario

Internal and emergency medicine

2017 Band 12, Heft 3, Seite(n) 357–364

Abstract: The HEART score is a simple scoring system, ranging from 0 to 10, specifically developed for risk stratification of patients with undifferentiated chest pain. It has been validated for the conventional troponin, but not for high-sensitive troponin. We ... ...

Abstract	The HEART score is a simple scoring system, ranging from 0 to 10, specifically developed for risk stratification of patients with undifferentiated chest pain. It has been validated for the conventional troponin, but not for high-sensitive troponin. We assess a modified version of the HEART score using a single high-sensitivity troponin T dosage at presentation, regardless of symptom duration, and with different ECG criteria to evaluate if the patients with a low HEART score could be safely discharged early. The secondary aim was to confirm a statistically significant difference in each HEART score group (low 0-3, intermediate 4-6, high 7-10) in the occurrence of major adverse cardiac events at 30 and 180 days. We retrospectively analyzed the HEART score of 1597 consecutive patients admitted to the Emergency Department of our Hospital for chest pain between January 1 and June 30, 2014. Of these, 190 did not meet the inclusion criteria and 29 were lost to follow-up. None of the 512 (37.2 %) patients with a low HEART score had an event within 180 days. The difference between the cumulative incidences of events in the three HEART score groups was statistically significant (P < 0.0001). We demonstrate that it might be possible to safely discharge Emergency Department chest pain patients with a low modified HEART score after an initial determination of high-sensitive troponin T, without a prolonged observation period or an additional cardiac testing.
Mesh-Begriff(e)	Adult ; Aged ; Electrocardiography/classification ; Emergency Service, Hospital/organization & administration ; Female ; Humans ; Italy ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Prospective Studies ; Retrospective Studies ; Risk Assessment/methods ; Risk Assessment/standards ; Risk Factors ; Severity of Illness Index ; Troponin T/analysis
Chemische Substanzen	Troponin T
Sprache	Englisch
Erscheinungsdatum	2017-04
Erscheinungsland	Italy
Dokumenttyp	Journal Article ; Observational Study
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-016-1461-3
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Hepatitis C virus reinfection after liver transplantation: is there a role for direct antiviral agents?

Dall'Agata, Marco / Gramenzi, Annagiulia / Biselli, Maurizio / Bernardi, Mauro

World journal of gastroenterology

2014 Band 20, Heft 28, Seite(n) 9253–9260

Abstract: Recurrence of hepatitis C virus (HCV) infection following liver transplantation (LT) is almost universal and can accelerate graft cirrhosis in up to 30% of patients. The development of effective strategies to treat or prevent HCV recurrence after LT ... ...

Abstract	Recurrence of hepatitis C virus (HCV) infection following liver transplantation (LT) is almost universal and can accelerate graft cirrhosis in up to 30% of patients. The development of effective strategies to treat or prevent HCV recurrence after LT remains a major challenge, considering the shortage of donor organs and the accelerated progression of HCV in LT recipients. Standard antiviral therapy with pegylated-interferon plus ribavirin is the current treatment of choice for HCV LT recipients, even though the combination is not as effective as it is in immunocompetent patients. A sustained virological response in the setting of LT improves patient and graft survival, but this is only achieved in 30%-45% of patients and the treatment is poorly tolerated. To improve the efficacy of pre- and post-transplant antiviral therapy, a new class of potent direct-acting antiviral agents (DAAs) has been developed. The aim of this review is to summarize the use of DAAs in LT HCV patients. PubMed, Cochrane Library, MEDLINE, EMBASE, Web of Science and clinical trial databases were searched for this purpose. To date, only three clinical studies on the topic have been published and most of the available data are in abstract form. Although a moderately successful early virological response has been reported, DAA treatment regimens were associated with severe toxicity mitigating their potential usefulness. Moreover, the ongoing nature of data, the lack of randomized studies, the small number of enrolled patients and the heterogeneity of these studies make the results largely anecdotal and questionable. In conclusion, large well-designed clinical studies on DAAs in HCV LT patients are required before these drugs can be recommended after transplantation.
Mesh-Begriff(e)	Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Hepacivirus/drug effects ; Hepacivirus/pathogenicity ; Hepatitis C/complications ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Humans ; Immunosuppressive Agents/adverse effects ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/surgery ; Liver Cirrhosis/virology ; Liver Transplantation/adverse effects ; Recurrence ; Risk Factors ; Treatment Outcome ; Virus Activation/drug effects
Chemische Substanzen	Antiviral Agents ; Immunosuppressive Agents
Sprache	Englisch
Erscheinungsdatum	2014-05-17
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v20.i28.9253
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Radiomics of cholangiocarcinoma on pretreatment CT can identify patients who would best respond to radioembolisation.

Mosconi, Cristina / Cucchetti, Alessandro / Bruno, Antonio / Cappelli, Alberta / Bargellini, Irene / De Benedittis, Caterina / Lorenzoni, Giulia / Gramenzi, Annagiulia / Tarantino, Francesco Paolo / Parini, Lorenza / Pettinato, Vincenzina / Modestino, Francesco / Peta, Giuliano / Cioni, Roberto / Golfieri, Rita

European radiology

2020 Band 30, Heft 8, Seite(n) 4534–4544

Abstract: Objectives: Results after trans-arterial radioembolisation (TARE) for intrahepatic cholangiocarcinoma (iCC) depend on the architecture of the tumour. This latter can be quantified through computed tomography (CT) texture analysis. The aims of the ... ...

Abstract	Objectives: Results after trans-arterial radioembolisation (TARE) for intrahepatic cholangiocarcinoma (iCC) depend on the architecture of the tumour. This latter can be quantified through computed tomography (CT) texture analysis. The aims of the present study were to analyse relationships between CT textural features prior to TARE and objective response (OR), progression-free survival (PFS), and overall survival (OS). Methods: Texture analysis was retrospectively applied to 55 pre-TARE CT scans of iCCs, focusing attention on the histogram-based features and the grey-level co-occurrence matrix (GLCM). Texture features were harmonised using the ComBat procedure. Objective response was assessed using the Response Evaluation Criteria In Solid Tumours 1.1. The least absolute shrinkage and selection operator (LASSO) method was applied to select the most useful textural features related to OR. Results: Of the 55 patients, 53 had post-TARE imaging available, showing OR in 56.6% of cases. Texture analysis showed that iCCs showing OR after TARE had a higher uptake of iodine contrast in the arterial phase (higher mean histogram values, p < 0.001) and more homogeneous distribution (lower kurtosis, p = 0.043; GLCM contrast, p = 0.004; GLCM dissimilarity, p = 0.005, and higher GLCM homogeneity, p = 0.005; and GLCM correlation p = 0.030) at the pre-TARE CT scan. A favourable radiomic signature was calculated and observed in 15 of the 55 patients. The median PFS of these 15 patients was 12.1 months and that of the remaining 40 patients was 5.1 months (p = 0.008). Conclusions: Texture analysis of pre-TARE CT scans can quantify vascularisation and homogeneity of iCC architecture, providing clinical information useful in identifying ideal TARE candidates. Key points: • Hypervascular tumours with a more homogeneous uptake of iodine contrast in the arterial phase were those most likely to be effectively treated by TARE. • The arterial phase was observed to be the best acquisition phase for providing information regarding the "sensitivity" of the tumour to TARE. • Patients with favourable radiomic signature showed a median progression-free survival of 12.1 months versus 5.1 months of patients with an unfavourable signature (p = 0.008).
Mesh-Begriff(e)	Aged ; Bile Duct Neoplasms/diagnostic imaging ; Bile Duct Neoplasms/radiotherapy ; Bile Ducts, Intrahepatic/diagnostic imaging ; Brachytherapy ; Cholangiocarcinoma/diagnostic imaging ; Cholangiocarcinoma/radiotherapy ; Contrast Media ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Response Evaluation Criteria in Solid Tumors ; Retrospective Studies ; Tomography, X-Ray Computed/methods
Chemische Substanzen	Contrast Media
Sprache	Englisch
Erscheinungsdatum	2020-03-29
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Multicenter Study
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-020-06795-9
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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