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  1. Artikel ; Online: Atmospheric air plasma sustainment by semiconductor microwave for hydroxyl radical production and powder metal element analysis.

    Ikeda, Yuji

    Optics express

    2022  Band 30, Heft 17, Seite(n) 29868–29884

    Abstract: A semiconductor microwave device that generates a series of burst microwaves at a sub-microsecond duration has been successfully used in a breakdown plasma spectrometer in atmospheric conditions. Microwave delivery has been changed to couple the ... ...

    Abstract A semiconductor microwave device that generates a series of burst microwaves at a sub-microsecond duration has been successfully used in a breakdown plasma spectrometer in atmospheric conditions. Microwave delivery has been changed to couple the microwave with laser sparks and electric sparks which are typical plasma ignition sources in laser-induced breakdown spectroscopy (LIBS) and spark-induced breakdown spectroscopy (SIBS). A helical antenna was used for the laser spark, while a coaxial antenna was considered more appropriate for the electric spark. The weak and transient sparks in LIBS and SIBS are enlarged by the microwaves which are stably sustained in the air. The microwave's output power and pulse duration are easily controllable, resulting in tunable plasma intensity and sustained production of hydroxyl radicals (OH radicals). Even in continuous-wave operation by microwave, the low-energy system prevented the formation of high-temperature thermal plasma (>10,000 K) without any mechanical cooling system. The microwave-enhanced LIBS (MW-LIBS) and microwave-enhanced SIBS (MW-SIBS) could be applied to optical emission spectroscopy analyses. In analytical applications, MW-SIBS produces no shockwave in contrast with MW-LIBS which is a great advantage in powdered samples. The MW-SIBS successfully analyzed the direct introduction of copper metal powders.
    Sprache Englisch
    Erscheinungsdatum 2022-10-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.461394
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  2. Artikel: Development of 2.45 GHz Semiconductor Microwave System for Combustion Ignition Enhancement and Failure Analysis.

    Ikeda, Yuji

    Materials (Basel, Switzerland)

    2022  Band 15, Heft 6

    Abstract: We developed a semiconductor microwave system to improve the ignition process in a combustion system. Under atmospheric pressure conditions, large plasma was successfully ignited by a 2.45 GHz microwave, and it is characterized in comparison with ... ...

    Abstract We developed a semiconductor microwave system to improve the ignition process in a combustion system. Under atmospheric pressure conditions, large plasma was successfully ignited by a 2.45 GHz microwave, and it is characterized in comparison with standard spark plug ignition and laser ignition. The size of the microwave power source was also effectively reduced with the minimal size (100 × 60 mm
    Sprache Englisch
    Erscheinungsdatum 2022-03-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15062042
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  3. Artikel ; Online: Ability to Use and Values of Everyday Technology among Older Adults.

    Ikeda, Yuriko

    Gerontology

    2022  Band 69, Heft 1, Seite(n) 83

    Mesh-Begriff(e) Humans ; Aged ; Technology ; Activities of Daily Living
    Sprache Englisch
    Erscheinungsdatum 2022-09-06
    Erscheinungsland Switzerland
    Dokumenttyp Letter ; Comment
    ZDB-ID 193798-4
    ISSN 1423-0003 ; 0304-324X
    ISSN (online) 1423-0003
    ISSN 0304-324X
    DOI 10.1159/000526258
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  4. Artikel ; Online: [[Applications] 9. Development of an AI System for Liver Tumor Detection from Abdominal Ultrasound Images].

    Ikeda, Yusuke / Mekada, Yoshito

    Nihon Hoshasen Gijutsu Gakkai zasshi

    2024  Band 80, Heft 4, Seite(n) 417–420

    Mesh-Begriff(e) Liver Neoplasms/diagnostic imaging ; Humans ; Ultrasonography/methods ; Artificial Intelligence ; Abdomen/diagnostic imaging
    Sprache Japanisch
    Erscheinungsdatum 2024-03-31
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2269092-X
    ISSN 1881-4883 ; 0369-4305
    ISSN (online) 1881-4883
    ISSN 0369-4305
    DOI 10.6009/jjrt.2024-2347
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  5. Artikel ; Online: Improvement plan for professionalism course guidance based on adult learning theory.

    Ikeda, Yukihiro

    MedEdPublish (2016)

    2021  Band 10, Seite(n) 130

    Abstract: This article was migrated. The article was marked as recommended. Professionalism is widely known as extremely important to the practice of medicine. However, a methodology has not been established in Japan, such that teachers-in-charge at medical ... ...

    Abstract This article was migrated. The article was marked as recommended. Professionalism is widely known as extremely important to the practice of medicine. However, a methodology has not been established in Japan, such that teachers-in-charge at medical schools are using personal strategies in conducting classes. Evidently, research on professionalism education in Japan is lacking. Therefore, the study aims to report an improvement plan for professionalism education in a certain medical school in Japan with emphasis on practice. Specifically, the study focuses on problem extraction and targets medical students in the first year. The problems of the program were extracted for learner, grouping, facilitator, and presentation. Program improvements were implemented for each of these parts to overcome the problems. The result shows that students gained a better understanding of their roles until graduation. In addition, the number of students who answered that this program was the most memorable in 2019 has tripled compared with that in 2018. Regarding the program improvement, the effect of the program cannot be concluded based on this result alone. In the future, these students should be followed up to investigate any changes. In addition, feedback from each facilitator should be investigated as a future endeavor.
    Sprache Englisch
    Erscheinungsdatum 2021-05-16
    Erscheinungsland Scotland
    Dokumenttyp Journal Article
    ISSN 2312-7996
    ISSN (online) 2312-7996
    DOI 10.15694/mep.2021.000130.1
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  6. Artikel ; Online: Novel roles of HIF-PHIs in chronic kidney disease: the link between iron metabolism, kidney function, and FGF23.

    Ikeda, Yasumasa

    Kidney international

    2021  Band 100, Heft 1, Seite(n) 14–16

    Abstract: Hanudel et al. investigated the effects of hypoxia-inducible factor-prolyl hydroxylase domain inhibitors (HIF-PHIs) on iron metabolism in a chronic kidney disease (CKD) mouse model and showed that vadadustat, an HIF-PHI, exerted beneficial effects on ... ...

    Abstract Hanudel et al. investigated the effects of hypoxia-inducible factor-prolyl hydroxylase domain inhibitors (HIF-PHIs) on iron metabolism in a chronic kidney disease (CKD) mouse model and showed that vadadustat, an HIF-PHI, exerted beneficial effects on anemia and iron disorders independently of erythroferrone. Vadadustat also inhibited the progression of CKD and the CKD-associated increase of plasma fibroblast growth factor 23 in CKD mice. This study provides new insights into the action of HIF-PIHs in CKD.
    Mesh-Begriff(e) Anemia ; Animals ; Fibroblast Growth Factors ; Glycine/analogs & derivatives ; Hypoxia-Inducible Factor-Proline Dioxygenases ; Iron ; Kidney ; Mice ; Picolinic Acids ; Renal Insufficiency, Chronic/drug therapy
    Chemische Substanzen Picolinic Acids ; vadadustat ; Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE) ; Iron (E1UOL152H7) ; Hypoxia-Inducible Factor-Proline Dioxygenases (EC 1.14.11.29) ; Glycine (TE7660XO1C)
    Sprache Englisch
    Erscheinungsdatum 2021-06-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.04.030
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  7. Artikel ; Online: Measurement of Nutritional Status as Frailty Severity is Indispensable to Treat Patients with Chronic Limb-Threatening Ischemia.

    Ikeda, Yoshiyuki

    Journal of atherosclerosis and thrombosis

    2021  Band 29, Heft 2, Seite(n) 150–151

    Mesh-Begriff(e) Chronic Limb-Threatening Ischemia/diagnosis ; Chronic Limb-Threatening Ischemia/etiology ; Chronic Limb-Threatening Ischemia/therapy ; Frailty/complications ; Frailty/diagnosis ; Humans ; Malnutrition/complications ; Malnutrition/diagnosis ; Malnutrition/prevention & control ; Nutritional Status ; Severity of Illness Index
    Sprache Englisch
    Erscheinungsdatum 2021-05-22
    Erscheinungsland Japan
    Dokumenttyp Editorial
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.ED169
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  8. Artikel ; Online: [Mechanism of Taurohyodeoxycholate-induced Biliary Phospholipid Efflux -Understanding the Function of the ABCB4 Enhancer for Developing Therapeutic Agents against Bile Salt-induced Liver Injury].

    Ikeda, Yoshito

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2020  Band 140, Heft 11, Seite(n) 1329–1334

    Abstract: Biliary lipids primarily consist of bile salts, phospholipids, and cholesterol. Bile salts have potent detergent properties and deleterious effects on the cell membrane and are cytotoxic to hepatocytes. We have previously reported that ... ...

    Abstract Biliary lipids primarily consist of bile salts, phospholipids, and cholesterol. Bile salts have potent detergent properties and deleterious effects on the cell membrane and are cytotoxic to hepatocytes. We have previously reported that phosphatidylcholine (PC), the predominant bile phospholipid, protects hepatocytes from the cytotoxicity of bile salts, whereas cholesterol reverses the cytoprotective effects of PC against bile salts. ABCB4, a member of the ATP-binding cassette transporter family, secretes biliary phospholipids, especially PC, from the hepatocytes into the bile. Using Abcb4 knockout mice and HEK293 cells that stably expressed ABCB4, we examined the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate, and hyodeoxycholate on the ABCB4-mediated efflux of PC. We observed that the biliary secretion of PC in wild-type mice significantly increased following infusion of all the tested bile salts, especially taurohyodeoxycholate. On the other hand, the biliary secretion of PC in Abcb4 knockout mice was not affected by the bile salt infusions. The results also demonstrated that the efflux of PC from ABCB4-expressing HEK293 cells was significantly stimulated by taurohyodeoxycholate, which has a strong potential to form mixed micelles with PC. Furthermore, the results of our study emphasized the possibility that the specific interactions of bile salts with ABCB4 are necessary for the release of PC molecules from the binding pocket of ABCB4 into the aqueous environment. Further understanding of this mechanism will aid in the development of novel therapeutic agents for cholestatic liver diseases.
    Mesh-Begriff(e) ATP Binding Cassette Transporter, Subfamily B/physiology ; Animals ; Bile/metabolism ; Bile Acids and Salts/adverse effects ; Chemical and Drug Induced Liver Injury, Chronic/drug therapy ; Chemical and Drug Induced Liver Injury, Chronic/etiology ; Chemical and Drug Induced Liver Injury, Chronic/genetics ; Cholesterol/pharmacology ; Drug Development ; HEK293 Cells ; Hepatocytes/metabolism ; Humans ; Mice, Knockout ; Phosphatidylcholines/metabolism ; Phosphatidylcholines/pharmacology ; Phospholipids/metabolism ; Taurodeoxycholic Acid/analogs & derivatives ; Taurodeoxycholic Acid/pharmacology
    Chemische Substanzen ATP Binding Cassette Transporter, Subfamily B ; Bile Acids and Salts ; Phosphatidylcholines ; Phospholipids ; taurohyodeoxycholic acid (2958-04-5) ; Taurodeoxycholic Acid (516-50-7) ; Cholesterol (97C5T2UQ7J) ; multidrug resistance protein 3 (9EI49ZU76O)
    Sprache Japanisch
    Erscheinungsdatum 2020-10-22
    Erscheinungsland Japan
    Dokumenttyp Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.20-00156
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  9. Artikel ; Online: Neurophysiological control of urinary bladder storage and voiding-functional changes through development and pathology.

    Ikeda, Youko

    Pediatric nephrology (Berlin, Germany)

    2020  Band 36, Heft 5, Seite(n) 1041–1052

    Abstract: The effective storage of urine and its expulsion relies upon the coordinated activity of parasympathetic, sympathetic, and somatic innervations to the lower urinary tract (LUT). At birth, all mammalian neonates lack the ability to voluntary regulate ... ...

    Abstract The effective storage of urine and its expulsion relies upon the coordinated activity of parasympathetic, sympathetic, and somatic innervations to the lower urinary tract (LUT). At birth, all mammalian neonates lack the ability to voluntary regulate bladder storage or voiding. The ability to control urinary bladder activity is established as connections to the central nervous system (CNS) form through development. The neural regulation of the LUT has been predominantly investigated in adult animal models where comparatively less is known about the neonatal and postnatal neurophysiological development that facilitate urinary continence. Furthermore, congenital neurological or anatomical defects can adversely affect both storage and voiding functions through postnatal development and into adulthood, leading to secondary conditions including vesicoureteral reflux, chronic urinary tract infections, and end-stage renal disease. Therefore, the aim of the review is to provide the current knowledge available on neurophysiological regulation of the LUT through pre- to postnatal development of human and animal models and the consequences of congenital anomalies that can affect LUT neural function.
    Mesh-Begriff(e) Adult ; Animals ; Central Nervous System ; Humans ; Renal Insufficiency ; Urinary Bladder/innervation ; Urinary Incontinence ; Urinary Tract/innervation ; Urinary Tract Infections ; Urination/physiology ; Vesico-Ureteral Reflux
    Sprache Englisch
    Erscheinungsdatum 2020-05-15
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04594-4
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  10. Artikel ; Online: Gut Protective Effect from D-Methionine or Butyric Acid against DSS and Carrageenan-Induced Ulcerative Colitis.

    Ikeda, Yuka / Matsuda, Satoru

    Molecules (Basel, Switzerland)

    2023  Band 28, Heft 11

    Abstract: Microbiome dysbiosis resulting in altered metabolite profiles may be associated with certain diseases, including inflammatory bowel diseases (IBD), which are characterized by active intestinal inflammation. Several studies have indicated the beneficial ... ...

    Abstract Microbiome dysbiosis resulting in altered metabolite profiles may be associated with certain diseases, including inflammatory bowel diseases (IBD), which are characterized by active intestinal inflammation. Several studies have indicated the beneficial anti-inflammatory effect of metabolites from gut microbiota, such as short-chain fatty acids (SCFAs) and/or D-amino acids in IBD therapy, through orally administered dietary supplements. In the present study, the potential gut protective effects of d-methionine (D-Met) and/or butyric acid (BA) have been investigated in an IBD mouse model. We have also built an IBD mouse model, which was cost-effectively induced with low molecular weight DSS and kappa-carrageenan. Our findings revealed that D-Met and/or BA supplementation resulted in the attenuation of the disease condition as well as the suppression of several inflammation-related gene expressions in the IBD mouse model. The data shown here may suggest a promising therapeutic potential for improving symptoms of gut inflammation with an impact on IBD therapy. However, molecular metabolisms need to be further explored.
    Mesh-Begriff(e) Mice ; Animals ; Carrageenan/adverse effects ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Methionine ; Butyric Acid/pharmacology ; Inflammatory Bowel Diseases/metabolism ; Inflammation ; Racemethionine ; Dextran Sulfate/toxicity ; Colitis/chemically induced ; Disease Models, Animal ; Mice, Inbred C57BL
    Chemische Substanzen Carrageenan (9000-07-1) ; Methionine (AE28F7PNPL) ; Butyric Acid (107-92-6) ; Racemethionine (73JWT2K6T3) ; Dextran Sulfate (9042-14-2)
    Sprache Englisch
    Erscheinungsdatum 2023-05-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28114392
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