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  1. Buch ; Online: Frailty and Herbal Medicines- From Molecular Mechanisms to Clinical Efficacy

    Inui, Akio / Bo Li, Jiang / Ataka, Koji / Takahashi, Ryuji / Iizuka, Noiro

    2020  

    Schlagwörter Medicine ; Dietetics & nutrition ; herbal medicine ; Kampo medicine ; Ninjin'yoeito ; frailty ; aging
    Umfang 1 electronic resource (325 pages)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT021230849
    ISBN 9782889637614 ; 2889637611
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch ; Dissertation / Habilitation: Early risk of type 2 diabetes mellitus and insulin restistance

    Li, Jiang

    estimation and identification

    2008  

    Verfasserangabe by Jiang Li
    Thema/Rubrik (Code) 616.4
    Sprache Englisch
    Umfang 79, [48] S., graph. Darst., 30 cm
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dresden, Techn. Univ., Diss., 2009
    Anmerkung Enth. 8 Beitr. aus verschiedenen Zeitschr.
    HBZ-ID HT016474563
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    2010 E 2747 bestellbar zur Ausleihe Magazin

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  3. Artikel ; Online: Eyelid Metastatic Renal Clear Cell Carcinoma Mimics Sebaceous Carcinoma.

    Xu, Mingpeng / Zhou, Chuandi / Li, Jiang

    Ophthalmology

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-03-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2024.02.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Digital Circulating Tumor Cells Quantification.

    Wang, Jidong / Liu, Xiaolei / Li, Jiang / Chen, Wenwen

    Analytical chemistry

    2024  Band 96, Heft 18, Seite(n) 6881–6888

    Abstract: Circulating tumor cells (CTCs) are an emerging but vital biomarker for cancer management. An efficient methodology for accurately quantifying CTCs remains challenging due to their rareness. Here, we develop a digital CTC detection strategy using ... ...

    Abstract Circulating tumor cells (CTCs) are an emerging but vital biomarker for cancer management. An efficient methodology for accurately quantifying CTCs remains challenging due to their rareness. Here, we develop a digital CTC detection strategy using partitioning instead of enrichment to quantify CTCs. By utilizing the characteristics of droplet microfluidics that can rapidly generate a large number of parallel independent reactors, combined with Poisson distribution, we realize the quantification of CTCs in the blood directly. The limit of detection of our digital CTCs quantification assay is five cells per 5 mL of whole blood. By simultaneously detecting multiple genetic mutations, our approach achieves highly sensitive and specific detection of CTCs in peripheral blood from NSCLC patients (AUC = 1). Our digital platform offers a potential approach and strategy for the quantification of CTCs, which could contribute to the advancement of cancer medical management.
    Mesh-Begriff(e) Neoplastic Cells, Circulating/pathology ; Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Lung Neoplasms/pathology ; Lung Neoplasms/blood ; Microfluidic Analytical Techniques ; Cell Line, Tumor
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c02769
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Efficient Massive MIMO Detection for M-QAM Symbols

    Zhi Quan / Jiyu Luo / Hailong Zhang / Li Jiang

    Entropy, Vol 25, Iss 391, p

    2023  Band 391

    Abstract: Massive multiple-input multiple-output (MIMO) systems significantly outperform small-scale MIMO systems in terms of data rate, making them an enabling technology for next-generation wireless systems. However, the increased number of antennas increases ... ...

    Abstract Massive multiple-input multiple-output (MIMO) systems significantly outperform small-scale MIMO systems in terms of data rate, making them an enabling technology for next-generation wireless systems. However, the increased number of antennas increases the computational difficulty of data detection, necessitating more efficient detection techniques. This paper presents a detector based on joint deregularized and box-constrained dichotomous coordinate descent (BOXDCD) with iterations for rectangular m-ary quadrature amplitude modulation (M-QAM) symbols. Deregularization maximized the energy of the solution. With the box-constraint, the deregularization forces the solution to be close to the rectangular boundary set. The numerical results demonstrate that the proposed detector achieves a considerable performance gain compared to existing detection algorithms. The performance advantage increases with the system size and signal-to-noise ratio.
    Schlagwörter box-constrained dichotomous coordinate descent ; massive MIMO ; negative diagonal loading regularization ; signal detection ; quadrature amplitude modulation ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
    Thema/Rubrik (Code) 003
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  6. Artikel ; Online: Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins

    Li Jiang / Hualan Chen / Chengjun Li

    Cell Insight, Vol 2, Iss 2, Pp 100079- (2023)

    2023  

    Abstract: Influenza A virus (IAV) poses a severe threat to the health of animals and humans. The genome of IAV consists of eight single-stranded negative-sense RNA segments, encoding ten essential proteins as well as certain accessory proteins. In the process of ... ...

    Abstract Influenza A virus (IAV) poses a severe threat to the health of animals and humans. The genome of IAV consists of eight single-stranded negative-sense RNA segments, encoding ten essential proteins as well as certain accessory proteins. In the process of virus replication, amino acid substitutions continuously accumulate, and genetic reassortment between virus strains readily occurs. Due to this high genetic variability, new viruses that threaten animal and human health can emerge at any time. Therefore, the study on IAV has always been a focus of veterinary medicine and public health. The replication, pathogenesis, and transmission of IAV involve intricate interplay between the virus and host. On one hand, the entire replication cycle of IAV relies on numerous proviral host proteins that effectively allow the virus to adapt to its host and support its replication. On the other hand, some host proteins play restricting roles at different stages of the viral replication cycle. The mechanisms of interaction between viral proteins and host cellular proteins are currently receiving particular interest in IAV research. In this review, we briefly summarize the current advances in our understanding of the mechanisms by which host proteins affect virus replication, pathogenesis, or transmission by interacting with viral proteins. Such information about the interplay between IAV and host proteins could provide insights into how IAV causes disease and spreads, and might help support the development of antiviral drugs or therapeutic approaches.
    Schlagwörter Biology (General) ; QH301-705.5 ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Ginkgolide B can alleviate spinal cord glymphatic system dysfunction and provide neuroprotection in painful diabetic neuropathy rats by inhibiting matrix metalloproteinase-9.

    Li, Jiang / Jia, Shuaiying / Song, Yuehan / Xu, Wenmei / Lin, Jingyan

    Neuropharmacology

    2024  Band 250, Seite(n) 109907

    Abstract: The glymphatic system plays a crucial role in maintaining optimal central nervous system (CNS) function by facilitating the removal of metabolic wastes. Aquaporin-4 (AQP4) protein, predominantly located on astrocyte end-feet, is a key pathway for ... ...

    Abstract The glymphatic system plays a crucial role in maintaining optimal central nervous system (CNS) function by facilitating the removal of metabolic wastes. Aquaporin-4 (AQP4) protein, predominantly located on astrocyte end-feet, is a key pathway for metabolic waste excretion. β-Dystroglycan (β-DG) can anchor AQP4 protein to the end-feet membrane of astrocytes and can be cleaved by matrix metalloproteinase (MMP)-9 protein. Studies have demonstrated that hyperglycemia upregulates MMP-9 expression in the nervous system, leading to neuropathic pain. Ginkgolide B (GB) exerts an inhibitory effect on the MMP-9 protein. In this study, we investigated whether inhibition of MMP-9-mediated β-DG cleavage by GB is involved in the regulation of AQP4 polarity within the glymphatic system in painful diabetic neuropathy (PDN) and exerts neuroprotective effects. The PDN model was established by injecting streptozotocin (STZ). Functional changes in the glymphatic system were observed using magnetic resonance imaging (MRI). The paw withdrawal threshold (PWT) was measured to assess mechanical allodynia. The protein expressions of MMP-9, β-DG, and AQP4 were detected by Western blotting and immunofluorescence. Our findings revealed significant decreases in the efficiency of contrast agent clearance within the spinal glymphatic system of the rats, accompanied by decreased PWT, increased MMP-9 protein expression, decreased β-DG protein expression, and loss of AQP4 polarity. Notably, GB treatment demonstrated the capacity to ameliorate spinal cord glymphatic function by modulating AQP4 polarity through MMP-9 inhibition, offering a promising therapeutic avenue for PDN.
    Mesh-Begriff(e) Rats ; Animals ; Glymphatic System/metabolism ; Matrix Metalloproteinase 9 ; Neuroprotection ; Diabetic Neuropathies/drug therapy ; Diabetic Neuropathies/metabolism ; Spinal Cord/metabolism ; Aquaporin 4/metabolism ; Diabetes Mellitus ; Lactones ; Ginkgolides
    Chemische Substanzen Matrix Metalloproteinase 9 (EC 3.4.24.35) ; ginkgolide B (DF149B9460) ; Aquaporin 4 ; Lactones ; Ginkgolides
    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2024.109907
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Effect of Maternal DEHP Exposure on Lipid Metabolism in Adult Male Rats and the Antagonistic Effect of Genistein.

    Zhang, Yun Bo / Li, Jiang Li / Tian, Jie / Na, Xiao Lin

    Biomedical and environmental sciences : BES

    2024  Band 37, Heft 3, Seite(n) 315–319

    Mesh-Begriff(e) Humans ; Female ; Rats ; Animals ; Male ; Genistein/pharmacology ; Lipid Metabolism ; Diethylhexyl Phthalate/toxicity ; Maternal Exposure ; Prenatal Exposure Delayed Effects
    Chemische Substanzen Genistein (DH2M523P0H) ; Diethylhexyl Phthalate (C42K0PH13C)
    Sprache Englisch
    Erscheinungsdatum 2024-04-07
    Erscheinungsland China
    Dokumenttyp Letter
    ZDB-ID 645083-0
    ISSN 2214-0190 ; 0895-3988
    ISSN (online) 2214-0190
    ISSN 0895-3988
    DOI 10.3967/bes2024.034
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Bubble Growth on Hydrophobic Rough Surfaces in the Shear Flow.

    Li, Jiang / Li, Xiaohe / Wang, Chenyang / He, Peng / Chen, Haosheng

    Langmuir : the ACS journal of surfaces and colloids

    2024  Band 40, Heft 18, Seite(n) 9630–9635

    Abstract: It is well known that bubbles will form on a hydrophobic rough surface immersed in water, which can create a surface covered with bubbles and leads to drag reduction. However, it is still not clear how bubbles grow on the surface under flow conditions. ... ...

    Abstract It is well known that bubbles will form on a hydrophobic rough surface immersed in water, which can create a surface covered with bubbles and leads to drag reduction. However, it is still not clear how bubbles grow on the surface under flow conditions. In this work, a rotating flow field is created using a parallel-plate setup of a rotational rheometer, and sample surfaces with different roughnesses and wettabilities are examined with different shear rates. The growth of bubbles is exclusively observed on the hydrophobic rough surface, and subsequent drag reduction is also detected simultaneously. The growth of bubbles is attributed to heterogeneous nucleation in the crevices under a local pressure reduction generated by the shear flow. A geometric model is established to describe the profile evolution of the trapped bubble in the crevice based on the contact angle and the pressure balance across the gas-liquid interface, which involves the variations of the Laplace pressure resulting from changes in the local liquid pressure. The growth of bubbles on the hydrophobic rough surface does not need a large decrease of the surrounding pressure or a high moving speed, which will have potential applications in drag reduction under the condition of a moderate shear rate.
    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.4c00445
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Recent advances in the catalytic transfer hydrogenation of furfural to furfuryl alcohol over heterogeneous catalysts

    An, Zhidong / Li, Jiang

    Green chemistry. 2022 Mar. 7, v. 24, no. 5

    2022  

    Abstract: Catalytic transfer hydrogenation (CTH) has recently emerged as a highly attractive approach for achieving biomass-based hydrogenation due to its avoidance of high-pressure fossil-derived H₂ and potentially reduced process costs. As numerous studies ... ...

    Abstract Catalytic transfer hydrogenation (CTH) has recently emerged as a highly attractive approach for achieving biomass-based hydrogenation due to its avoidance of high-pressure fossil-derived H₂ and potentially reduced process costs. As numerous studies relating to the CTH of furfural (FF) have been reported recently, it is quite urgent to systematically review the recent advances, especially those in which excellent catalytic performance is achieved over simple solid acid–base catalysts. In this review, recent advances relating to the CTH of FF over heterogeneous catalysts, including metal catalysts and solid acid–base catalysts, are extensively summarized. Some potential research trends for the design of more effective catalysts and the realization of the practical industrial production of furfuryl alcohol (FFA) via CTH are also proposed. As acidic or basic sites always play an important role during biomass conversion, the great progress made in the area of CTH also provides great potential for other reactions, especially reductive functionalization.
    Schlagwörter biomass ; catalytic activity ; furfural ; furfuryl alcohol ; green chemistry ; hydrogenation
    Sprache Englisch
    Erscheinungsverlauf 2022-0307
    Umfang p. 1780-1808.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ZDB-ID 2006274-6
    ISSN 1463-9270 ; 1463-9262
    ISSN (online) 1463-9270
    ISSN 1463-9262
    DOI 10.1039/d1gc04440k
    Datenquelle NAL Katalog (AGRICOLA)

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