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Artikel ; Online: Fluoride Ion Binding and Translocation in the CLC

Chon, Nara L / Lin, Hai

The journal of physical chemistry. B

2024 Band 128, Heft 11, Seite(n) 2697–2706

Abstract: ... ...

Abstract	CLC
Mesh-Begriff(e)	Antiporters/chemistry ; Antiporters/metabolism ; Protons ; Fluorides/chemistry ; Models, Molecular ; Membrane Transport Proteins/metabolism ; Chlorides/chemistry ; Chloride Channels/chemistry ; Chloride Channels/metabolism ; Ion Transport
Chemische Substanzen	Antiporters ; Protons ; Fluorides (Q80VPU408O) ; Membrane Transport Proteins ; Chlorides ; Chloride Channels
Sprache	Englisch
Erscheinungsdatum	2024-03-06
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.4c00079
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: CTRP3 regulates NF-κB and TGFβ1/Smad3 pathways to alleviate airway inflammation and remodeling in asthmatic mice induced by OVA.

Lin, Hai / Yi, Jinrong

Allergologia et immunopathologia

2023 Band 51, Heft 4, Seite(n) 31–39

Abstract: Background: Asthma is a common illness with chronic airway inflammation. C1q/tumor necrosis factor (TNF)-related protein 3 (CTRP3) plays a vital role ininflammatory response, but its effect on asthma is imprecise. Herein, we analyzed the functions of ... ...

Abstract	Background: Asthma is a common illness with chronic airway inflammation. C1q/tumor necrosis factor (TNF)-related protein 3 (CTRP3) plays a vital role ininflammatory response, but its effect on asthma is imprecise. Herein, we analyzed the functions of CTRP3 in asthma. Methods: The BALB/c mice were randomized into four groups: control, ovalbumin (OVA), OVA+vector, and OVA+CTRP3. The asthmatic mice model was established by OVA stimulation. Overexpression of CTRP3 was implemented by the transfection of corresponding adeno-associated virus 6 (AAV6). The contents of CTRP3, E-cadherin, N-cadherin, smooth muscle alpha-actin (α-SMA), phosphorylated (p)-p65/p65, transforming growth factor-beta 1 (TGFβ1), and p-Smad3/Smad3 were determined by Western blot analysis. The quantity of total cells, eosinophils, neutrophils, and lymphocytes in bronchoalveolar lavage fluid (BALF) was assessed by using a hemocytometer. The contents of tumor necrosis factor-α and interleukin-1β in BALF were examined by enzyme-linked immunesorbent serologic assay. The lung function indicators and airway resistance (AWR) were measured. The bronchial and alveolar structures were evaluated by hematoxylin and eosin staining and sirius red staining. Results: The CTRP3 was downregulated in mice of OVA groups; however, AAV6-CTRP3 treatment markedly upregulated the expression of CTRP3. Upregulation of CTRP3 diminished asthmatic airway inflammation by decreasing the number of inflammatory cells and the contents of proinflammatory factors. CTRP3 markedly lessened AWR and improved lung function in OVA-stimulated mice. Histological analysis found that CTRP3 alleviated OVA-induced airway remodeling in mice. Moreover, CTRP3 modulated NF-κB and TGFβ1/Smad3 pathways in OVA-stimulated mice. Conclusion: CTRP3 alleviated airway inflammation and remodeling in OVA-induced asthmatic mice via regulating NF-κB and TGFβ1/Smad3 pathways.
Mesh-Begriff(e)	Mice ; Animals ; Ovalbumin ; NF-kappa B/metabolism ; Asthma ; Lung/pathology ; Bronchoalveolar Lavage Fluid ; Inflammation/pathology ; Mice, Inbred BALB C ; Disease Models, Animal ; Airway Remodeling
Chemische Substanzen	Ovalbumin (9006-59-1) ; NF-kappa B
Sprache	Englisch
Erscheinungsdatum	2023-07-01
Erscheinungsland	Singapore
Dokumenttyp	Journal Article
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.15586/aei.v51i4.867
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Reshaping the QM Region On-the-Fly: Adaptive-Shape QM/MM Dynamic Simulations of a Hydrated Proton in Bulk Water.

Yan, Shengheng / Wang, Binju / Lin, Hai

Journal of chemical theory and computation

2024 Band 20, Heft 9, Seite(n) 3462–3472

Abstract: Adaptive quantum mechanics/molecular mechanics (QM/MM) reclassifies on-the-fly a molecule or molecular fragment as QM or MM during dynamics simulations without abrupt changes in the energy or forces. Notably, the permuted adaptive-partitioning (PAP) ... ...

Abstract	Adaptive quantum mechanics/molecular mechanics (QM/MM) reclassifies on-the-fly a molecule or molecular fragment as QM or MM during dynamics simulations without abrupt changes in the energy or forces. Notably, the permuted adaptive-partitioning (PAP) algorithms have been applied to simulate a hydrated proton, with a mobile QM zone anchored at a pseudoatom called a proton indicator. The position of the proton indicator approximates the location of the delocalized excess proton, yielding a smooth trajectory of the proton diffusing via the Grotthuss mechanism in aqueous solutions. The mobile QM zone, which has been taken to be a sphere with a preset radius, follows the proton wherever it goes. Although the simulations are successful, the use of a spherical QM zone has one disadvantage: A large preset radius must be utilized to minimize the chance of missing water molecules that are important to proton translocation. A large radius leads to a large QM zone, which is computationally expensive. In this work, we report a new way to set up the QM zone, where one includes only the water molecules important to proton transfer. The importance of a given water molecule is quantified by its "weight" that depends on its relation to the reaction path of proton transfer. The weight varies smoothly, ensuring that a water molecule gradually appears in or disappears from the QM zone without abrupt changes, as required by the PAP method. Consequently, the shape of the QM zone evolves on-the-fly, keeping the QM zone as small as possible and as large as necessary. Test simulations demonstrate that the new algorithm significantly improves the computation efficiency while maintaining the proper descriptions of proton transfer in bulk water.
Sprache	Englisch
Erscheinungsdatum	2024-04-26
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1549-9626
ISSN (online)	1549-9626
DOI	10.1021/acs.jctc.4c00164
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effects of microcystin-LR on purification efficiency of simulating drinking water source by Hydrocharis dubia (Bl.) backer.

Liu, Junfei / Dong, Yingbo / Lin, Hai

Toxicon : official journal of the International Society on Toxinology

2024 Band 241, Seite(n) 107654

Abstract: The safety of drinking water source directly affects human health. Microcystin-LR (MC-LR), a toxic and common pollutant in drinking water source, is released by algae and can impede the in-situ remediation effect of aquatic plant. Finding out the effect ... ...

Abstract	The safety of drinking water source directly affects human health. Microcystin-LR (MC-LR), a toxic and common pollutant in drinking water source, is released by algae and can impede the in-situ remediation effect of aquatic plant. Finding out the effect mechanism of MC-LR on the purification of drinking water by aquatic plant is the key to its application. This study aims to explore the performance and mechanism of MC-LR on drinking water source purification by Hydrocharis dubia (Bl.) backer. The optimum removal efficiency of NH
Mesh-Begriff(e)	Humans ; Drinking Water/analysis ; Antioxidants/pharmacology ; Microcystins/toxicity ; Microcystins/analysis ; Marine Toxins ; Hydrocharitaceae ; Water Purification ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/analysis
Chemische Substanzen	cyanoginosin LR (EQ8332842Y) ; Drinking Water ; Antioxidants ; Microcystins ; Marine Toxins ; Water Pollutants, Chemical
Sprache	Englisch
Erscheinungsdatum	2024-02-17
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2024.107654
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Silkworm Self-spun Fluorescent Silk Fiber with Enhanced Mechanical Properties

Jiang, Lin-Hai / Shen, Qing

Journal of natural fibers. 2022 Mar. 04, v. 19, no. 3

2022

Abstract: Silk fiber (SF) is a well-known natural material broadly applied for the common textile industry and modern medical field cases. This work introduces a simple process for silkworm self-spun producing fluorescent silk fiber (FSF) with enhanced strength. ... ...

Abstract	Silk fiber (SF) is a well-known natural material broadly applied for the common textile industry and modern medical field cases. This work introduces a simple process for silkworm self-spun producing fluorescent silk fiber (FSF) with enhanced strength. Experimental, by applying the nontoxic fluorescein sodium (FS), water solution was employed to pretreat the mulberry leaves (ML), and then applied to feeding the silkworm. Our results have shown that the obtained FSF has kept similar tortuosity as with the common SF while the mechanical properties were obviously enhanced due to these special feeding process caused by the reconstruction of β-folding structure of protein reconstruction. Compared to the normal SF, the FSF has shown the expected fluorescent property while keeping similar thermal stability.
Schlagwörter	fluorescein ; fluorescence ; mulberries ; silk ; silkworms ; textile industry ; thermal stability
Sprache	Englisch
Erscheinungsverlauf	2022-0304
Umfang	p. 1137-1145.
Erscheinungsort	Taylor & Francis
Dokumenttyp	Artikel
ZDB-ID	2182715-1
ISSN	1544-046X ; 1544-0478
ISSN (online)	1544-046X
ISSN	1544-0478
DOI	10.1080/15440478.2020.1807435
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Predictive values of ultrasonic diaphragm thickening fraction combined with integrative weaning index in weaning patients with mechanical ventilation: a retrospective study.

Lin, Hai / Yao, Mingming / Qin, Ziwen / Fu, Shilin / Wang, Hongyou

Journal of cardiothoracic surgery

2024 Band 19, Heft 1, Seite(n) 66

Abstract: Objective: We aimed to explore the predictive values of ultrasonic diaphragm thickening fraction (DTF) combined with integrative weaning index (IWI) in weaning patients with mechanical ventilation.: Methods: Patients with mechanical ventilation who ... ...

Abstract	Objective: We aimed to explore the predictive values of ultrasonic diaphragm thickening fraction (DTF) combined with integrative weaning index (IWI) in weaning patients with mechanical ventilation. Methods: Patients with mechanical ventilation who received oral endotracheal intubation from September 2020 to September 2021 were included in this retrospective study. Before the start of the spontaneous breathing test (SBT), IWI was calculated according to the blood gas analysis parameters and parameters read in volume control mode. After the start of SBT, DTF was calculated according to the end-expiratory thickness and end-inspiratory thickness of the right diaphragm. The receiver operating curve (ROC) was used to evaluate the predictive value of DTF and IWI for successful weaning, and the sensitivity and specificity were calculated according to the best critical value. Results: The sensitivity, specificity, and best cutoff value of DTF to predict successful weaning was 0.772, 0.727, and 0.293, respectively, and the area under the curve (AUC) was 0.72 (95%CI 0.59-0.86, p = 0.003). The sensitivity, specificity, and best cutoff value of IWI to predict successful weaning was 0.614, 0.909, 53.00, respectively, and AUC was 0.82 (95%CI 0.72-0.91, p < 0.001). The sensitivity, specificity, and best cutoff value of the combination of DTF and IWI to predict successful weaning was 0.614, 0.909, 17.848, respectively, and AUC was 0.84 (95%CI 0.75-0.93, p < 0.001). Conclusion: DTF and IWI can guide the selection of weaning, while DTF combined with IWI can improve the effect of weaning prediction and provide support for patients' weaning safety.
Mesh-Begriff(e)	Humans ; Respiration, Artificial ; Diaphragm ; Ventilator Weaning ; Retrospective Studies ; Ultrasonics ; Predictive Value of Tests ; Prospective Studies
Sprache	Englisch
Erscheinungsdatum	2024-02-06
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-024-02544-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effects of

Huang, Jiaqi / Cui, Lulu / Lin, Hai / Song, Mengze / Sun, Shuhong

Veterinary sciences

2024 Band 11, Heft 4

Abstract: Probiotics are safe, inexpensive, and effective feed additives, ... ...

Abstract	Probiotics are safe, inexpensive, and effective feed additives, and
Sprache	Englisch
Erscheinungsdatum	2024-04-01
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci11040160
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: MoS

Liu, Junfei / Dong, Yingbo / Liu, Qiaojun / Liu, Wei / Lin, Hai

Chemosphere

2024 Band 354, Seite(n) 141582

Abstract: Photocatalytic technologies based on molybdenum disulfide ( ... ...

Abstract	Photocatalytic technologies based on molybdenum disulfide (MoS
Mesh-Begriff(e)	Anti-Bacterial Agents/chemistry ; Wastewater ; Environmental Pollutants ; Molybdenum/chemistry ; Reactive Oxygen Species ; Nanocomposites/chemistry
Chemische Substanzen	Anti-Bacterial Agents ; Wastewater ; Environmental Pollutants ; Molybdenum (81AH48963U) ; Reactive Oxygen Species
Sprache	Englisch
Erscheinungsdatum	2024-03-08
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141582
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Traded Plastic, Traded Impacts? Designing Counterfactual Scenarios to Assess Environmental Impacts of Global Plastic Waste Trade.

Li, Kai / Ward, Hauke / Lin, Hai Xiang / Tukker, Arnold

Environmental science & technology

2024 Band 58, Heft 20, Seite(n) 8631–8642

Abstract: The global trade of plastic waste has raised environmental concerns, especially regarding pollution in waste-importing countries. However, the overall environmental contribution remains unclear due to uncertain treatment shares between handling plastic ... ...

Abstract	The global trade of plastic waste has raised environmental concerns, especially regarding pollution in waste-importing countries. However, the overall environmental contribution remains unclear due to uncertain treatment shares between handling plastic waste abroad and domestically. Here, we conduct a life cycle assessment of global plastic waste trade in 2022 across 18 countries and six plastic waste types, alongside three "nontrade" counterfactual scenarios. By considering the required cycling rate, which balances importers' costs and recycling revenues, we find that the trade resulted in lower environmental impacts than treating domestically with the average treatment mix. The trade scenario alone reduced climate change impact by 2.85 million tonnes of CO
Mesh-Begriff(e)	Plastics ; Recycling ; Commerce ; Humans ; Climate Change ; Environment
Sprache	Englisch
Erscheinungsdatum	2024-05-10
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.4c02149
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: On Delay-Doppler Plane Orthogonal Pulse

Lin, Hai / Yuan, Jinhong

2023

Abstract: In this paper, we analyze the recently discovered delay-Doppler plane orthogonal pulse (DDOP), which is essential for delay-Doppler plane multi-carrier modulation waveform. In particular, we introduce a local orthogonality property of pulses ... ...

Abstract	In this paper, we analyze the recently discovered delay-Doppler plane orthogonal pulse (DDOP), which is essential for delay-Doppler plane multi-carrier modulation waveform. In particular, we introduce a local orthogonality property of pulses corresponding to Weyl-Heisenberg (WH) subset and justify the DDOP's existence, in contrast to global orthogonality corresponding to WH set governed by the WH frame theory. Then, sufficient conditions for locally-orthogonal pulses are presented and discussed. Based on the analysis, we propose a general DDOP design. We also derive the frequency domain representation of the DDOP, and compare the DDOP-based orthogonal delay-Doppler division multiplexing (ODDM) modulation with other modulation schemes, in terms of TF signal localization. Interestingly, we show perfect local orthogonality property of the DDOP with respect to delay-Doppler resolutions using its ambiguity function. Comment: This paper was presented at the IEEE GLOBECOM 2022
Schlagwörter	Computer Science - Information Theory ; Electrical Engineering and Systems Science - Signal Processing
Thema/Rubrik (Code)	515
Erscheinungsdatum	2023-01-17
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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