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Buch ; Online: Epigenetic Biomarker and Personalized Precision Medicine

Wang, Jiucun / He, Dongyi / Xiong, Momiao / Liu, Yun

2020

Schlagwörter	Science: general issues ; Medical genetics ; DNA methylation ; Epigenetic ; Biomarker ; Personalized and Precision Medicine
Umfang	1 electronic resource (485 pages)
Verlag	Frontiers Media SA
Dokumenttyp	Buch ; Online
Anmerkung	English ; Open Access
HBZ-ID	HT021231605
ISBN	9782889661848 ; 2889661849
Datenquelle	ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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Artikel: 脑功能性近红外光谱技术在新生儿领域中的研究进展.

Yang, Qian / Liu, Yun-Feng

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2024 Band 26, Heft 1, Seite(n) 86–91

Abstract: Functional near infrared spectroscopy (fNIRS) is an emerging neuroimaging tool that reflects the activity and function of brain neurons by monitoring changes in brain oxygen metabolism based on the neurovascular coupling mechanism. It is non-invasive and ...

Titelübersetzung	Research progress on brain functional near-infrared spectroscopy technology in the field of neonates.
Abstract	Functional near infrared spectroscopy (fNIRS) is an emerging neuroimaging tool that reflects the activity and function of brain neurons by monitoring changes in brain oxygen metabolism based on the neurovascular coupling mechanism. It is non-invasive and convenient, especially suitable for monitoring neonatal brain function. This article provides a comprehensive review of research related to the developmental patterns of brain networks concerning language, music, and emotions in neonates using fNIRS. It also covers brain network imaging in neonatal care, resting-state brain network connectivity patterns, and characteristics of brain functional imaging in disease states of neonates using fNIRS.
Mesh-Begriff(e)	Infant, Newborn ; Humans ; Spectroscopy, Near-Infrared ; Brain/diagnostic imaging ; Emotions ; Language ; Technology
Sprache	Chinesisch
Erscheinungsdatum	2024-01-08
Erscheinungsland	China
Dokumenttyp	Review ; English Abstract ; Journal Article
ISSN	1008-8830
ISSN	1008-8830
DOI	10.7499/j.issn.1008-8830.2309002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Morphological and functional alterations of neuromuscular synapses in a mouse model of ACTA1 congenital myopathy.

Liu, Yun / Lin, Weichun

Human molecular genetics

2023 Band 33, Heft 3, Seite(n) 233–244

Abstract: Mutations in skeletal muscle α-actin (Acta1) cause myopathies. In a mouse model of congenital myopathy, heterozygous Acta1 (H40Y) knock-in (Acta1+/Ki) mice exhibit features of human nemaline myopathy, including premature lethality, severe muscle weakness, ...

Abstract	Mutations in skeletal muscle α-actin (Acta1) cause myopathies. In a mouse model of congenital myopathy, heterozygous Acta1 (H40Y) knock-in (Acta1+/Ki) mice exhibit features of human nemaline myopathy, including premature lethality, severe muscle weakness, reduced mobility, and the presence of nemaline rods in muscle fibers. In this study, we investigated the impact of Acta1 (H40Y) mutation on the neuromuscular junction (NMJ). We found that the NMJs were markedly fragmented in Acta1+/Ki mice. Electrophysiological analysis revealed a decrease in amplitude but increase in frequency of miniature end-plate potential (mEPP) at the NMJs in Acta1+/Ki mice, compared with those in wild type (Acta1+/+) mice. Evoked end-plate potential (EPP) remained similar at the NMJs in Acta1+/Ki and Acta1+/+ mice, but quantal content was increased at the NMJs in Acta1+/Ki, compared with Acta1+/+ mice, suggesting a homeostatic compensation at the NMJs in Acta1+/Ki mice to maintain normal levels of neurotransmitter release. Furthermore, short-term synaptic plasticity of the NMJs was compromised in Acta1+/Ki mice. Together, these results demonstrate that skeletal Acta1 H40Y mutation, albeit muscle-origin, leads to both morphological and functional defects at the NMJ.
Mesh-Begriff(e)	Humans ; Mice ; Animals ; Actins/genetics ; Muscular Diseases ; Muscle, Skeletal/physiology ; Myopathies, Nemaline/genetics ; Neuromuscular Junction/genetics ; Disease Models, Animal ; Mutation ; Myotonia Congenita
Chemische Substanzen	Actins
Sprache	Englisch
Erscheinungsdatum	2023-10-26
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddad183
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Identification of key biomarkers in RF-negative polyarticular and oligoarticular juvenile idiopathic arthritis by bioinformatic analysis.

Liu, Yun / Tang, Xuemei

Pediatric rheumatology online journal

2023 Band 21, Heft 1, Seite(n) 143

Abstract: Objective: Juvenile idiopathic arthritis (JIA) is a broad term used to describe arthritis of unknown origin. JIA commonly persists into adulthood, often causing substantial morbidity such as restricted joint function, which can lead to challenges in ... ...

Abstract	Objective: Juvenile idiopathic arthritis (JIA) is a broad term used to describe arthritis of unknown origin. JIA commonly persists into adulthood, often causing substantial morbidity such as restricted joint function, which can lead to challenges in employment and independence. This study aims to identify diagnostic biomarkers and investigate the role of immune cells in the pathogenesis of rheumatoid factor-negative polyarticular juvenile idiopathic arthritis (RF-negative pJIA) and oligoarticular juvenile idiopathic arthritis (oJIA). Methods: We retrieved a JIA dataset from the GEO database and conducted an analysis of differentially expressed genes (DEGs). Subsequently, functional enrichment analysis was performed on the DEGs. Weighted gene co-expression network analysis (WGCNA) was utilized to identify key modules. Additionally, we constructed a protein‒protein interaction network to identify hub genes that serve as signature genes. Furthermore, we employed CIBERSORT to classify immune cell infiltration. Results: From the GSE20307 dataset, we identified a total of 1438 DEGs in RF-negative pJIA and 688 DEGs in oJIA. WGCNA clustered the data into 6 modules in pJIA and 4 modules in oJIA. Notably, the ME5 and ME2 modules exhibited significant associations with pJIA and oJIA, respectively. In both pJIA and oJIA, we identified six hub genes, four of which demonstrated high diagnostic sensitivity and specificity in pJIA, while five showed high diagnostic sensitivity and specificity in oJIA. CIBERSORT analysis suggested the potential involvement of these signature genes in immune cell infiltration. Conclusion: In this study, we identified JUN, CXCL8, SOCS3, and KRAS as biomarkers for RF-negative pJIA and JUN, CXCL8, SOCS3, PTGS2, and NFKBIA as biomarkers for oJIA. Furthermore, our findings suggest that Tfh cells may play a role in the early onset of both RF-negative pJIA and oJIA.
Mesh-Begriff(e)	Humans ; Arthritis, Juvenile/diagnosis ; Arthritis, Juvenile/genetics ; Biomarkers ; Gene Expression Profiling ; Sensitivity and Specificity
Chemische Substanzen	Biomarkers
Sprache	Englisch
Erscheinungsdatum	2023-11-24
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2279468-2
ISSN	1546-0096 ; 1546-0096
ISSN (online)	1546-0096
ISSN	1546-0096
DOI	10.1186/s12969-023-00926-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Comparative study of senile osteoporotic intertrochanteric fractures using Asian proximal femoral nail with and without proximal reaming.

Wang, Yan / Liu, Yun

Minerva gastroenterology

2023 Band 70, Heft 1, Seite(n) 114–116

Mesh-Begriff(e)	Humans ; Femur ; Femoral Fractures ; Hip Fractures/surgery
Sprache	Englisch
Erscheinungsdatum	2023-05-10
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	3062713-8
ISSN	2724-5365
ISSN (online)	2724-5365
DOI	10.23736/S2724-5985.23.03428-9
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effect of electron beam irradiation treatment on the in vitro digestibility and structure of egg white protein powder

HUANG Mengling / LIU Yun

Fushe yanjiu yu fushe gongyi xuebao, Vol 40, Iss 5, Pp 56-

2022 Band 62

Abstract: This article reports the digestibility, antioxidant activity, and protein structure of treated egg white protein powder (EWP) after pretreatment with electron beam irradiation (EBI) at doses of 5‒100 kGy. The results revealed that EWP exhibited excellent ...

Abstract	This article reports the digestibility, antioxidant activity, and protein structure of treated egg white protein powder (EWP) after pretreatment with electron beam irradiation (EBI) at doses of 5‒100 kGy. The results revealed that EWP exhibited excellent in vitro digestibility under the tested EBI dose conditions. After EBI pretreatment, the treated EWP digestibility of the treated sample was slightly higher than that of the untreated sample. When EWP wais treated at 100 kGy EBI, the EWP in vitro digestibility was high, reaching up to (99.30 ± 0.53)%. The EWP digestion solution exhibited high antioxidation capacities of ABTS•+ radical scavenging activity (˃80%), Fe2+ chelation ability (˃70%), and •OH radical scavenging activity (~40%). Circular dichroism and fluorescence spectrum analyses indicated differences in the surface hydrophobicity and secondary structure of the EWP protein at the tested EBI doses. The protein peptides of the EWP digestion solution observed via sodium dodecyl-sulfate polyacrylamide gel electrophoresis were close to 25 kDa and 10 kDa. We believe that this study provides technical support for future practical applications of EBI in protein food-processing fields.
Schlagwörter	egg white protein powder ; electron beam irradiation pretreatment ; in vitro digestion ; protein structure ; antioxidant activity ; Nuclear and particle physics. Atomic energy. Radioactivity ; QC770-798 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Thema/Rubrik (Code)	500
Sprache	Chinesisch
Erscheinungsdatum	2022-10-01T00:00:00Z
Verlag	Science Press
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Experimental study on the damage performance and forced response of concrete lining in fault-crossing tunnel.

Hu, Hui / Lan, Youdi / Liu, Yun / Qiu, Wenge

Scientific reports

2024 Band 14, Heft 1, Seite(n) 2120

Abstract: Understanding the adverse effects of tunnel crossing active faults on tunnel structures is crucial for ensuring their safe operation and construction. This paper presents the results of a series of model tests conducted at a scale of 1:40 using a fault ... ...

Abstract	Understanding the adverse effects of tunnel crossing active faults on tunnel structures is crucial for ensuring their safe operation and construction. This paper presents the results of a series of model tests conducted at a scale of 1:40 using a fault sliding test box. Three sets of fault comparison tests were carried out, namely: (1) the tunnel does not cross the fault, (2) the spring stiffness is reduced, and (3) the model is not reinforced. The objective was to study the failure characteristics of tunnels crossing active faults. The findings reveal that when the hanging wall moves downwards, cracks appear on the surrounding rock surface of the hanging wall, specifically above the tunnel lining crossing the fault. The lining is significantly damaged within the range of - 30-+ 30 cm. All points of axial force exhibit an increasing compression trend. The section of axial force and bending moment near the fault fracture surface is notably larger than that far from the fault fracture surface. The safety factor of the entire structure decreases sharply after dislocation, making the tunnel more susceptible to cracking at various locations such as the vault, arch waist, left and right arch feet, and inverted arch. It has been proven that the shear compression of the fracture surface during fault dislocation is the main cause of longitudinal through cracks in the lining. The use of springs with higher stiffness effectively ensures the reciprocating dislocation of the upper and foot walls, with long duration and large displacement, providing a better simulation of the dislocation of active faults.
Sprache	Englisch
Erscheinungsdatum	2024-01-24
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52318-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Development and validation of comprehensive nomograms from the SEER database for predicting early mortality in metastatic rectal cancer patients.

Li, Yanli / Tao, Ting / Liu, Yun

BMC gastroenterology

2024 Band 24, Heft 1, Seite(n) 89

Abstract: Background: Metastatic rectal cancer is an incurable malignancy, which is prone to early mortality. We aimed to establish nomograms for predicting the risk of early mortality in patients with metastatic rectal cancer.: Methods: In this study, ... ...

Abstract	Background: Metastatic rectal cancer is an incurable malignancy, which is prone to early mortality. We aimed to establish nomograms for predicting the risk of early mortality in patients with metastatic rectal cancer. Methods: In this study, clinical data were obtained from the Surveillance, Epidemiology, and End Results (SEER) database.We utilized X-tile software to determine the optimal cut-off points of age and tumor size in diagnosis. Significant independent risk factors for all-cause and cancer-specific early mortality were determined by the univariate and multivariate logistic regression analyses, then we construct two practical nomograms. In order to assess the predictive performance of nomograms, we performed calibration plots, time-dependent receiver-operating characteristic curve (ROC), decision curve analysis (DCA) and clinical impact curve (CIC). Results: A total of 2570 metastatic rectal cancer patients were included in the study. Multivariate logistic regression analyses revealed that age at diagnosis, CEA level, tumor size, surgical intervention, chemotherapy, radiotherapy, and metastases to bone, brain, liver, and lung were independently associated with early mortality of metastatic rectal cancer patients in the training cohort. The area under the curve (AUC) values of nomograms for all-cause and cancer-specific early mortality were all higher than 0.700. Calibration curves indicated that the nomograms accurately predicted early mortality and exhibited excellent discrimination. DCA and CIC showed moderately positive net benefits. Conclusions: This study successfully generated applicable nomograms that predicted the high-risk early mortality of metastatic rectal cancer patients, which can assist clinicians in tailoring more effective treatment regimens.
Mesh-Begriff(e)	Humans ; Nomograms ; Rectal Neoplasms ; Area Under Curve ; Brain ; Databases, Factual ; Prognosis
Sprache	Englisch
Erscheinungsdatum	2024-02-26
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-024-03178-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Neurotrophin-associated mechanisms of delayed-onset muscle soreness: research progress and perspective].

Liu, Yun-Xiao / Lei, Jing / You, Hao-Jun

Sheng li xue bao : [Acta physiologica Sinica

2024 Band 76, Heft 2, Seite(n) 301–308

Abstract: Delayed-onset muscle soreness (DOMS) is a common phenomenon that occurs following a sudden increase in exercise intensity or unfamiliar exercise, significantly affecting athletic performance and efficacy in athletes and fitness individuals. DOMS is ... ...

Abstract	Delayed-onset muscle soreness (DOMS) is a common phenomenon that occurs following a sudden increase in exercise intensity or unfamiliar exercise, significantly affecting athletic performance and efficacy in athletes and fitness individuals. DOMS is characterized by allodynia and hyperalgesia, and their mechanisms remain unclear. Recent studies have reported that neurotrophic factors, such as nerve growth factor (NGF) and glial cell derived neurotrophic factor (GDNF), are involved in the development and maintenance of DOMS. This article provides a review of the research progress on the signaling pathways related to the involvement of NGF and GDNF in DOMS, hoping to provide novel insights into the mechanisms underlying allodynia and hyperalgesia in DOMS, as well as potential targeted treatment.
Mesh-Begriff(e)	Humans ; Myalgia/physiopathology ; Nerve Growth Factor/metabolism ; Nerve Growth Factor/physiology ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Glial Cell Line-Derived Neurotrophic Factor/physiology ; Signal Transduction ; Animals ; Hyperalgesia/physiopathology ; Muscle, Skeletal/physiopathology ; Muscle, Skeletal/physiology ; Exercise/physiology
Chemische Substanzen	Nerve Growth Factor (9061-61-4) ; Glial Cell Line-Derived Neurotrophic Factor
Sprache	Chinesisch
Erscheinungsdatum	2024-04-23
Erscheinungsland	China
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; English Abstract
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Autologous blood patch intraparenchymal injection reduces the incidence of pneumothorax and the need for chest tube placement following CT-guided lung biopsy: a systematic review and meta-analysis.

Li, Teng / Zhang, Qiang / Li, Wenjun / Liu, Yun

European journal of medical research

2024 Band 29, Heft 1, Seite(n) 108

Abstract: Purpose: To assess the effectiveness of autologous blood patch intraparenchymal injection during CT-guided lung biopsies with a focus on the incidence of pneumothorax and the subsequent requirement for chest tube placement.: Methods: A comprehensive ... ...

Abstract	Purpose: To assess the effectiveness of autologous blood patch intraparenchymal injection during CT-guided lung biopsies with a focus on the incidence of pneumothorax and the subsequent requirement for chest tube placement. Methods: A comprehensive search of major databases was conducted to identify studies that utilized autologous blood patches to mitigate the risk of pneumothorax following lung biopsies. Efficacy was next assessed through a meta-analysis using a random-effects model. Results: Of the 122 carefully analyzed studies, nine, representing a patient population of 4116, were incorporated into the final analysis. Conclusion deduced showed a noteworthy reduction in the overall incidence of pneumothorax (RR = 0.65; 95% CI 0.53-0.80; P = 0.00) and a significantly decline in the occasion for chest tube placement due to pneumothorax (RR = 0.45; 95% CI 0.32-0.64; P = 0.00). Conclusions: Utilizing autologous blood patch intraparenchymal injection during the coaxial needle retraction process post-lung biopsy is highly effective in diminishing both the incidence of pneumothorax and consequent chest tube placement requirement.
Mesh-Begriff(e)	Humans ; Pneumothorax/epidemiology ; Pneumothorax/etiology ; Pneumothorax/prevention & control ; Chest Tubes/adverse effects ; Incidence ; Biopsy, Needle/adverse effects ; Retrospective Studies ; Lung/diagnostic imaging ; Lung/pathology ; Image-Guided Biopsy ; Tomography, X-Ray Computed ; Risk Factors
Sprache	Englisch
Erscheinungsdatum	2024-02-09
Erscheinungsland	England
Dokumenttyp	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-024-01707-9
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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