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Artikel: The protective effects of nerol to prevent the toxicity of carbon tetrachloride to the liver in Sprague-Dawley rats.

Mondal, Milon / Bala, Jibanananda / Mondal, Kakoli Rani / Afrin, Sadia / Saha, Protyaee / Saha, Moumita / Jamaddar, Sarmin / Roy, Uttam Kumar / Sarkar, Chandan

Heliyon

2023  Band 9, Heft 12, Seite(n) e23065

Abstract: Introduction: Carbon-tetrachloride (CCl: Materials and methods: For the aim of this experiment, 35 male Sprague-Dawley rats ranging in body weight (BW) from 140 to 180 g were split into five separate groups. With the exception of vehicle control ... ...

Abstract Introduction: Carbon-tetrachloride (CCl
Materials and methods: For the aim of this experiment, 35 male Sprague-Dawley rats ranging in body weight (BW) from 140 to 180 g were split into five separate groups. With the exception of vehicle control group 1, all experimental rats were subjected to carbon tetrachloride exposure through intra-peritoneal injection at a 0.7 mL/kg body weight dose once a week for 4 weeks (28 days). The treatment groups 3 and 4 received oral administration of nerol at 50 and 100 mg/kg BW for 28 days. In the same time period, the standard control group received 100 mg/kg BW silymarin.
Results: Serum hepatic markers, lipid profiles, albumin, globulin, bilirubin, and total protein were all substantially improved in nerol-treated rats in a dose-dependent manner that had been exposed to CCl
Conclusion: According to the findings of our investigation, nerol has potential as a functional element to shield the liver from harm brought on by ROS that are caused by CCL
Sprache Englisch
Erscheinungsdatum 2023-11-30
Erscheinungsland England
Dokumenttyp Journal Article
ZDB-ID 2835763-2
ISSN 2405-8440
ISSN 2405-8440
DOI 10.1016/j.heliyon.2023.e23065
Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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