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  1. Artikel ; Online: Correction: Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.

    Zhang, Zhongwei / Tanaka, Izumi / Nakahashi-Ouchida, Rika / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    Seminars in immunopathology

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-04-22
    Erscheinungsland Germany
    Dokumenttyp Published Erratum
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-024-01002-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.

    Zhang, Zhongwei / Tanaka, Izumi / Nakahashi-Ouchida, Rika / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    Seminars in immunopathology

    2024  

    Abstract: Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. ... ...

    Abstract Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. This review sheds light on the extensive distribution of GP2 within the gastrointestinal tract and its intricate interplay with the immune system. Furthermore, the significance of GP2 autoantibodies in diagnosing and categorizing IBD is underscored, alongside the promising therapeutic avenues for modulating GP2 to regulate immunity and maintain mucosal balance.
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-023-00999-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Mucosal vaccines: wisdom from now and then.

    Kiyono, Hiroshi / Yuki, Yoshikazu / Nakahashi-Ouchida, Rika / Fujihashi, Kohtaro

    International immunology

    2021  Band 33, Heft 12, Seite(n) 767–774

    Abstract: The oral and nasal cavities are covered by the mucosal epithelium that starts at the beginning of the aero-digestive tract. These mucosal surfaces are continuously exposed to environmental antigens including pathogens and allergens and are thus equipped ... ...

    Abstract The oral and nasal cavities are covered by the mucosal epithelium that starts at the beginning of the aero-digestive tract. These mucosal surfaces are continuously exposed to environmental antigens including pathogens and allergens and are thus equipped with a mucosal immune system that mediates initial recognition of pathogenicity and initiates pathogen-specific immune responses. At the dawn of our scientific effort to explore the mucosal immune system, dental science was one of the major driving forces as it provided insights into the importance of mucosal immunity and its application for the control of oral infectious diseases. The development of mucosal vaccines for the prevention of dental caries was thus part of a novel approach that contributed to building the scientific foundations of the mucosal immune system. Since then, mucosal immunology and vaccines have gone on a scientific journey to become one of the major entities within the discipline of immunology. Here, we introduce our past and current efforts and future directions for the development of mucosal vaccines, specifically a rice-based oral vaccine (MucoRice) and a nanogel-based nasal vaccine, with the aim of preventing and controlling gastrointestinal and respiratory infectious diseases using the interdisciplinary fusion of mucosal immunology with agricultural science and biomaterial engineering, respectively.
    Mesh-Begriff(e) Communicable Diseases/immunology ; Immunity, Mucosal/immunology ; Vaccines/immunology
    Chemische Substanzen Vaccines
    Sprache Englisch
    Erscheinungsdatum 2021-08-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxab056
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Nasal vaccines: solutions for respiratory infectious diseases.

    Nakahashi-Ouchida, Rika / Fujihashi, Kohtaro / Kurashima, Yosuke / Yuki, Yoshikazu / Kiyono, Hiroshi

    Trends in molecular medicine

    2022  Band 29, Heft 2, Seite(n) 124–140

    Abstract: Nasal vaccines induce pathogen-specific dual protective immunity at mucosal surfaces and systemically throughout the body. Consequently, nasal vaccines both prevent pathogen invasion and reduce disease severity. Because of these features, nasal vaccines ... ...

    Abstract Nasal vaccines induce pathogen-specific dual protective immunity at mucosal surfaces and systemically throughout the body. Consequently, nasal vaccines both prevent pathogen invasion and reduce disease severity. Because of these features, nasal vaccines are considered to be a next-generation tool for preventing respiratory infectious diseases, including COVID-19. However, nasal vaccines must overcome key safety concerns given the anatomic proximity of the central nervous system (CNS) via the olfactory bulbs which lie next to the nasal cavity. This review summarizes current efforts to develop safe and effective nasal vaccines and delivery systems, as well as their clinical applications for the prevention of respiratory infections. We also discuss various concerns regarding the safety of nasal vaccines and introduce a system for evaluating them.
    Mesh-Begriff(e) Humans ; Administration, Intranasal ; COVID-19/prevention & control ; Vaccines ; Communicable Diseases ; Respiratory Tract Infections/prevention & control ; Immunity, Mucosal
    Chemische Substanzen Vaccines
    Sprache Englisch
    Erscheinungsdatum 2022-11-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2022.10.009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Cationic pullulan nanogel as a safe and effective nasal vaccine delivery system for respiratory infectious diseases.

    Nakahashi-Ouchida, Rika / Yuki, Yoshikazu / Kiyono, Hiroshi

    Human vaccines & immunotherapeutics

    2018  Band 14, Heft 9, Seite(n) 2189–2193

    Abstract: The mucosal surfaces of the respiratory and gastrointestinal tracts are continuously exposed to countless beneficial and pathologic antigens. These mucosal surfaces are thus equipped with an immune system that is unique from those elsewhere in the body; ... ...

    Abstract The mucosal surfaces of the respiratory and gastrointestinal tracts are continuously exposed to countless beneficial and pathologic antigens. These mucosal surfaces are thus equipped with an immune system that is unique from those elsewhere in the body; this unique system provides the first line of immune surveillance and defense against pathogen invasion. The sophisticated immune induction machinery in the aero-digestive tract involves mucosa-associated lymphoid tissues, including nasopharyngeal- and gut-associated lymphoid tissues, for the generation of antigen-specific humoral and cellular immune responses. Consequently, nasal or oral immunization with an appropriate vaccine delivery vehicle prompts the induction of protective immunity in both the mucosal and systemic compartments, leading to a double layer of protection against pathogens. To harness the benefits of mucosal vaccines, various mucosal antigen delivery vehicles are under development, and a cationic cholesteryl-group-bearing pullulan nanogel (cCHP nanogel) has emerged as a potent nasal vaccine delivery system for the induction of protective immunity against respiratory infections.
    Mesh-Begriff(e) Administration, Intranasal ; Drug Carriers/administration & dosage ; Drug Carriers/adverse effects ; Glucans/administration & dosage ; Glucans/adverse effects ; Humans ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/adverse effects ; Polyethyleneimine/administration & dosage ; Polyethyleneimine/adverse effects ; Respiratory Tract Infections/prevention & control ; Vaccines/administration & dosage ; Vaccines/adverse effects
    Chemische Substanzen Drug Carriers ; Glucans ; NanoGel ; Vaccines ; Polyethylene Glycols (3WJQ0SDW1A) ; pullulan (8ZQ0AYU1TT) ; Polyethyleneimine (9002-98-6)
    Sprache Englisch
    Erscheinungsdatum 2018-07-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2018.1461298
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: MucoRice-CTB line 19A, a new marker-free transgenic rice-based cholera vaccine produced in an LED-based hydroponic system.

    Yuki, Yoshikazu / Kurokawa, Shiho / Sugiura, Kotomi / Kashima, Koji / Maruyama, Shinichi / Yamanoue, Tomoyuki / Honma, Ayaka / Mejima, Mio / Takeyama, Natsumi / Kuroda, Masaharu / Kozuka-Hata, Hiroko / Oyama, Masaaki / Masumura, Takehiro / Nakahashi-Ouchida, Rika / Fujihashi, Kohtaro / Hiraizumi, Takashi / Goto, Eiji / Kiyono, Hiroshi

    Frontiers in plant science

    2024  Band 15, Seite(n) 1342662

    Abstract: We previously established the selection-marker-free rice-based oral cholera vaccine (MucoRice-CTB) line 51A for human use ... ...

    Abstract We previously established the selection-marker-free rice-based oral cholera vaccine (MucoRice-CTB) line 51A for human use by
    Sprache Englisch
    Erscheinungsdatum 2024-03-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2024.1342662
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Biodistribution assessment of cationic pullulan nanogel, a nasal vaccine delivery system, in mice and non-human primates

    Yuki, Yoshikazu / Harada, Norihiro / Sawada, Shin-ichi / Uchida, Yohei / Nakahashi-Ouchida, Rika / Mori, Hiromi / Yamanoue, Tomoyuki / Machita, Tomonori / Kanazawa, Masakatsu / Fukumoto, Dai / Ohba, Hiroyuki / Miyazaki, Takashi / Akiyoshi, Kazunari / Fujihashi, Kohtaro / Kiyono, H.

    Vaccine. 2023 June 27,

    2023  

    Abstract: Cationic cholesteryl-group–bearing pullulan nanogel (cCHP-nanogel) is an effective drug-delivery system for nasal vaccines. However, cCHP-nanogel-based nasal vaccines might access the central nervous system due to its close proximity via the olfactory ... ...

    Abstract Cationic cholesteryl-group–bearing pullulan nanogel (cCHP-nanogel) is an effective drug-delivery system for nasal vaccines. However, cCHP-nanogel-based nasal vaccines might access the central nervous system due to its close proximity via the olfactory bulb in the nasal cavity. Using real-time quantitative tracking of the nanogel-based nasal botulinum neurotoxin and pneumococcal vaccines, we previously confirmed the lack of deposition of vaccine antigen in the cerebrum or olfactory bulbs of mice and non-human primates (NHPs), rhesus macaques. Here, we used positron emission tomography to investigate the biodistribution of the drug-delivery system itself, cCHP-nanogel after mice and NHPs were nasally administered with ¹⁸F-labeled cCHP nanogel. The results generated by the PET analysis of rhesus macaques were consistent with the direct counting of radioactivity due to ¹⁸F or ¹¹¹In in dissected mouse tissues. Thus, no depositions of cCHP-nanogel were noted in the cerebrum, olfactory bulbs, or eyes of both species after nasal administration of the radiolabeled cCHP-nanogel compound. Our findings confirm the safe biodistribution of the cCHP-nanogel-based nasal vaccine delivery system in mice and NHPs.
    Schlagwörter Streptococcus pneumoniae ; antigens ; botulinum toxin ; cerebrum ; intranasal administration ; mice ; nanogels ; nasal cavity ; olfactory bulb ; positron-emission tomography ; pullulan ; radioactivity ; radiolabeling ; vaccines ; Nasal vaccine ; Drug delivery system ; Positron emission tomography (PET) ; Biodistribution ; Mouse ; Non-human primate ; cCHP nanogel ; CDI ; CHI ; CNS ; CHP ; DDS ; DOTA-NHS-ester ; HPLC ; K[2,2,2] ; LNP ; MRI ; NALT ; NHP ; OB ; PBS ; percent ID (%ID) ; PET ; PspA ; SFB ; SUV ; TSTU
    Sprache Englisch
    Erscheinungsverlauf 2023-0627
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.06.065
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Development of a nanogel-based nasal vaccine as a novel antigen delivery system.

    Nakahashi-Ouchida, Rika / Yuki, Yoshikazu / Kiyono, Hiroshi

    Expert review of vaccines

    2017  Band 16, Heft 12, Seite(n) 1231–1240

    Abstract: Introduction: Nasal vaccination is one of the most effective immunization methods because it can induce effective antigen-specific immune responses not only at the mucosal site of administration but also at distant mucosal surfaces, as well as in the ... ...

    Abstract Introduction: Nasal vaccination is one of the most effective immunization methods because it can induce effective antigen-specific immune responses not only at the mucosal site of administration but also at distant mucosal surfaces, as well as in the systemic compartment. Based on this advantage, many nasal vaccines are being developed and some have been licensed and marketed for clinical use. However, some have been withdrawn because of unacceptable adverse events such as inactivated influenza vaccine administrated with a heat-labile enterotoxin of Escherichia coli as an adjuvant. Thus, it is important to consider both the efficacy and safety of nasal vaccines. Areas covered: This review describes the benefits of cholesteryl group-bearing pullulan (CHP) nanogels for nasal vaccine delivery and vaccine development identified on Pubmed database with the term 'Nanogel-based nasal vaccine'. Expert commentary: CHP nanogels have been developed as novel drug delivery system, and a cationic CHP nanogels have been demonstrated to induce effective immunity as a nasal vaccine antigen carrier. Since vaccine antigens incorporated into CHP nanogels have exhibited no brain deposition after nasal administration in mice and nonhuman primates, the vaccine seems safe, and could be a promising new delivery system.
    Mesh-Begriff(e) Administration, Intranasal ; Animals ; Drug Delivery Systems ; Drug Evaluation, Preclinical ; Mice ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/adverse effects ; Polyethyleneimine/administration & dosage ; Polyethyleneimine/adverse effects ; Primates ; Vaccines/administration & dosage ; Vaccines/adverse effects ; Vaccines/immunology
    Chemische Substanzen NanoGel ; Vaccines ; Polyethylene Glycols (30IQX730WE) ; Polyethyleneimine (9002-98-6)
    Sprache Englisch
    Erscheinungsdatum 2017
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2017.1395702
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Biodistribution assessment of cationic pullulan nanogel, a nasal vaccine delivery system, in mice and non-human primates.

    Yuki, Yoshikazu / Harada, Norihiro / Sawada, Shin-Ichi / Uchida, Yohei / Nakahashi-Ouchida, Rika / Mori, Hiromi / Yamanoue, Tomoyuki / Machita, Tomonori / Kanazawa, Masakatsu / Fukumoto, Dai / Ohba, Hiroyuki / Miyazaki, Takashi / Akiyoshi, Kazunari / Fujihashi, Kohtaro / Kiyono, Hiroshi

    Vaccine

    2023  Band 41, Heft 34, Seite(n) 4941–4949

    Abstract: Cationic cholesteryl-group-bearing pullulan nanogel (cCHP-nanogel) is an effective drug-delivery system for nasal vaccines. However, cCHP-nanogel-based nasal vaccines might access the central nervous system due to its close proximity via the olfactory ... ...

    Abstract Cationic cholesteryl-group-bearing pullulan nanogel (cCHP-nanogel) is an effective drug-delivery system for nasal vaccines. However, cCHP-nanogel-based nasal vaccines might access the central nervous system due to its close proximity via the olfactory bulb in the nasal cavity. Using real-time quantitative tracking of the nanogel-based nasal botulinum neurotoxin and pneumococcal vaccines, we previously confirmed the lack of deposition of vaccine antigen in the cerebrum or olfactory bulbs of mice and non-human primates (NHPs), rhesus macaques. Here, we used positron emission tomography to investigate the biodistribution of the drug-delivery system itself, cCHP-nanogel after mice and NHPs were nasally administered with
    Mesh-Begriff(e) Animals ; Nanogels ; Macaca mulatta ; Tissue Distribution ; Drug Delivery Systems ; Administration, Intranasal ; Pneumococcal Vaccines
    Chemische Substanzen polyethylene glycol polyethyleneimine nanogel ; Nanogels ; pullulan (8ZQ0AYU1TT) ; Pneumococcal Vaccines
    Sprache Englisch
    Erscheinungsdatum 2023-06-27
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.06.065
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Oral MucoRice-CTB vaccine is safe and immunogenic in healthy US adults

    Yuki, Yoshikazu / Nojima, Masanori / Kashima, Koji / Sugiura, Kotomi / Maruyama, Shinichi / Kurokawa, Shiho / Yamanoue, Tomoyuki / Nakahashi-Ouchida, Rika / Nakajima, Hiroyuki / Hiraizumi, Takashi / Kohno, Hitoshi / Goto, Eiji / Fujihashi, Kohtaro / Kiyono, Hiroshi

    Vaccine. 2022 Apr. 14,

    2022  

    Abstract: MucoRice-CTB is a promising cold-chain-free oral cholera vaccine candidate. Here, we report a double-blind, randomized, placebo-controlled, phase I study conducted in the USA in which vaccination with the 6-g dose of MucoRice-CTB induced cross-reactive ... ...

    Abstract MucoRice-CTB is a promising cold-chain-free oral cholera vaccine candidate. Here, we report a double-blind, randomized, placebo-controlled, phase I study conducted in the USA in which vaccination with the 6-g dose of MucoRice-CTB induced cross-reactive antigen-specific antibodies against the B subunit of cholera toxin (CTB) and enterotoxigenic Escherichia coli heat-labile enterotoxin without inducing serious adverse events. This dosage was acceptably safe and tolerable in healthy men and women. In addition, it induced a CTB-specific IgA response in the saliva of two of the nine treated subjects; in one subject, the immunological kinetics of the salivary IgA were similar to those of the serum CTB-specific IgA. Antibodies from three of the five responders to the vaccine prevented CTB from binding its GM1 ganglioside receptor. These results are consistent with those of the phase I study in Japan, suggesting that oral MucoRice-CTB induces neutralizing antibodies against diarrheal toxins regardless of ethnicity.
    Schlagwörter Japan ; blood serum ; cholera ; cholera toxin ; diarrhea ; enterotoxigenic Escherichia coli ; enterotoxins ; gangliosides ; nationalities and ethnic groups ; saliva ; vaccination ; vaccines
    Sprache Englisch
    Erscheinungsverlauf 2022-0414
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.04.051
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