LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 143

Suchoptionen

  1. Artikel: Idiopathic Pulmonary Fibrosis and Post-COVID-19 Lung Fibrosis: Links and Risks.

    Patrucco, Filippo / Solidoro, Paolo / Gavelli, Francesco / Apostolo, Daria / Bellan, Mattia

    Microorganisms

    2023  Band 11, Heft 4

    Abstract: Idiopathic pulmonary fibrosis (IPF) is considered the paradigmatic example of chronic progressive fibrosing disease; IPF does not result from a primary immunopathogenic mechanism, but immune cells play a complex role in orchestrating the fibrosing ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) is considered the paradigmatic example of chronic progressive fibrosing disease; IPF does not result from a primary immunopathogenic mechanism, but immune cells play a complex role in orchestrating the fibrosing response. These cells are activated by pathogen-associated or danger-associated molecular patterns generating pro-fibrotic pathways or downregulating anti-fibrotic agents. Post-COVID pulmonary fibrosis (PCPF) is an emerging clinical entity, following SARS-CoV-2 infection; it shares many clinical, pathological, and immune features with IPF. Similarities between IPF and PCPF can be found in intra- and extracellular physiopathological pro-fibrotic processes, genetic signatures, as well as in the response to antifibrotic treatments. Moreover, SARS-CoV-2 infection can be a cause of acute exacerbation of IPF (AE-IPF), which can negatively impact on IPF patients' prognosis. In this narrative review, we explore the pathophysiological aspects of IPF, with particular attention given to the intracellular signaling involved in the generation of fibrosis in IPF and during the SARS-CoV-2 infection, and the similarities between IPF and PCPF. Finally, we focus on COVID-19 and IPF in clinical practice.
    Sprache Englisch
    Erscheinungsdatum 2023-03-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11040895
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: COVID‑19: different waves and different outcomes.

    Patrucco, Filippo / Bellan, Mattia / Solidoro, Paolo

    Polish archives of internal medicine

    2022  Band 132, Heft 10

    Mesh-Begriff(e) Humans ; COVID-19 ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2022-10-21
    Erscheinungsland Poland
    Dokumenttyp Editorial ; Comment
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16352
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: Central venous pressure in critically ill patients: do we still need it?

    Gavelli, Francesco / Patrucco, Filippo / DE Vita, Nello / Solidoro, Paolo / Avanzi, Gian C

    Panminerva medica

    2023  Band 66, Heft 1, Seite(n) 1–3

    Mesh-Begriff(e) Humans ; Central Venous Pressure ; Critical Illness ; Intensive Care Units
    Sprache Englisch
    Erscheinungsdatum 2023-12-12
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 123572-2
    ISSN 1827-1898 ; 0031-0808
    ISSN (online) 1827-1898
    ISSN 0031-0808
    DOI 10.23736/S0031-0808.23.05082-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: The importance of a diagnostic pathway in the diagnosis of haemoptysis.

    Solidoro, Paolo / Guerrera, Francesco

    Advances in respiratory medicine

    2018  

    Abstract: The role of interventional pulmonology in both the diagnostic and therapeutic aspects of haemopthysis is far to be completely defined. Even if we have to differentiate massive from mild and moderate bleeding it seems to be reasonable to asses that a ... ...

    Abstract The role of interventional pulmonology in both the diagnostic and therapeutic aspects of haemopthysis is far to be completely defined. Even if we have to differentiate massive from mild and moderate bleeding it seems to be reasonable to asses that a bronchoscopy (fiberoptic or rigid) can be safely proposed in skilled centers with a wide range of immediate therapeutical interventional options, whether pneumological, either radiological or surgical.
    Sprache Englisch
    Erscheinungsdatum 2018-12-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.5603/ARM.a2018.0053
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel ; Online: Serum biomarkers in idiopathic pulmonary fibrosis.

    Patrucco, Filippo / Bellan, Mattia / Solidoro, Paolo

    Panminerva medica

    2020  Band 63, Heft 2, Seite(n) 199–200

    Mesh-Begriff(e) Biomarkers/blood ; Disease Progression ; Humans ; Idiopathic Pulmonary Fibrosis/blood ; Idiopathic Pulmonary Fibrosis/diagnosis
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2020-08-05
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 123572-2
    ISSN 1827-1898 ; 0031-0808
    ISSN (online) 1827-1898
    ISSN 0031-0808
    DOI 10.23736/S0031-0808.20.04049-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: Severe asthma management during COVID pandemic.

    Spina, Maria F / Banfi, Paolo I / Nicolini, Antonello / Solidoro, Paolo

    Minerva medica

    2021  Band 113, Heft 3, Seite(n) 571–572

    Mesh-Begriff(e) Asthma/complications ; Asthma/epidemiology ; Asthma/therapy ; COVID-19 ; Humans ; Pandemics ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-05-05
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.21.07484-X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  7. Artikel: Triple Therapy in COPD: Can We Welcome the Reduction in Cardiovascular Risk and Mortality?

    Solidoro, Paolo / Albera, Carlo / Ribolla, Fulvia / Bellocchia, Michela / Brussino, Luisa / Patrucco, Filippo

    Frontiers in medicine

    2022  Band 9, Seite(n) 816843

    Abstract: Chronic obstructive pulmonary disease (COPD) is a complex disease which consists in the reduction of the airflow and leads to the disruption of the pulmonary tissue due to a chronic inflammation. The progression of the disease is characterized by an ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a complex disease which consists in the reduction of the airflow and leads to the disruption of the pulmonary tissue due to a chronic inflammation. The progression of the disease is characterized by an exacerbation of the symptoms and the presence of life-threatening systemic complications, such as stroke and ischemic heart disease, with a progressive decline in lung function which can deeply impact the quality of life. Mortality represents the most important COPD outcome, with an increased risk in patients with cardiovascular comorbidities. The efficacy and safety of triple inhaled therapy were demonstrated by numerous controlled trials. Above all, many robust data are now available on the effectiveness of the triple therapy to reduce mortality in COPD patients.
    Sprache Englisch
    Erscheinungsdatum 2022-03-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.816843
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Artikel ; Online: Herpes Virus Infection in Lung Transplantation: Diagnosis, Treatment and Prevention Strategies.

    Patrucco, Filippo / Curtoni, Antonio / Sidoti, Francesca / Zanotto, Elisa / Bondi, Alessandro / Albera, Carlo / Boffini, Massimo / Cavallo, Rossana / Costa, Cristina / Solidoro, Paolo

    Viruses

    2023  Band 15, Heft 12

    Abstract: Lung transplantation is an ultimate treatment option for some end-stage lung diseases; due to the intense immunosuppression needed to reduce the risk of developing acute and chronic allograft failure, infectious complications are highly incident. Viral ... ...

    Abstract Lung transplantation is an ultimate treatment option for some end-stage lung diseases; due to the intense immunosuppression needed to reduce the risk of developing acute and chronic allograft failure, infectious complications are highly incident. Viral infections represent nearly 30% of all infectious complications, with herpes viruses playing an important role in the development of acute and chronic diseases. Among them, cytomegalovirus (CMV) is a major cause of morbidity and mortality, being associated with an increased risk of chronic lung allograft failure. Epstein-Barr virus (EBV) is associated with transformation of infected B cells with the development of post-transplantation lymphoproliferative disorders (PTLDs). Similarly, herpes simplex virus (HSV), varicella zoster virus and human herpesviruses 6 and 7 can also be responsible for acute manifestations in lung transplant patients. During these last years, new, highly sensitive and specific diagnostic tests have been developed, and preventive and prophylactic strategies have been studied aiming to reduce and prevent the incidence of these viral infections. In this narrative review, we explore epidemiology, diagnosis and treatment options for more frequent herpes virus infections in lung transplant patients.
    Mesh-Begriff(e) Humans ; Epstein-Barr Virus Infections ; Herpesvirus 4, Human ; Herpesviridae Infections/diagnosis ; Herpesviridae Infections/epidemiology ; Herpesviridae Infections/prevention & control ; Lung Transplantation/adverse effects ; Herpesvirus 3, Human ; Simplexvirus ; Herpes Zoster/complications
    Sprache Englisch
    Erscheinungsdatum 2023-11-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15122326
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  9. Artikel: Antiviral Approach to Cytomegalovirus Infection: An Overview of Conventional and Novel Strategies.

    Bottino, Paolo / Pastrone, Lisa / Curtoni, Antonio / Bondi, Alessandro / Sidoti, Francesca / Zanotto, Elisa / Cavallo, Rossana / Solidoro, Paolo / Costa, Cristina

    Microorganisms

    2023  Band 11, Heft 10

    Abstract: Human cytomegalovirus (HCMV) is a herpesvirus capable of establishing a lifelong persistence in the host through a chronic state of infection and remains an essential global concern due to its distinct life cycle, mutations, and latency. It represents a ... ...

    Abstract Human cytomegalovirus (HCMV) is a herpesvirus capable of establishing a lifelong persistence in the host through a chronic state of infection and remains an essential global concern due to its distinct life cycle, mutations, and latency. It represents a life-threatening pathogen for immunocompromised patients, such as solid organ transplanted patients, HIV-positive individuals, and hematopoietic stem cell recipients. Multiple antiviral approaches are currently available and administered in order to prevent or manage viral infections in the early stages. However, limitations due to side effects and the onset of antidrug resistance are a hurdle to their efficacy, especially for long-term therapies. Novel antiviral molecules, together with innovative approaches (e.g., genetic editing and RNA interference) are currently in study, with promising results performed in vitro and in vivo. Since HCMV is a virus able to establish latent infection, with a consequential risk of reactivation, infection management could benefit from preventive treatment for critical patients, such as immunocompromised individuals and seronegative pregnant women. This review will provide an overview of conventional antiviral clinical approaches and their mechanisms of action. Additionally, an overview of proposed and developing new molecules is provided, including nucleic-acid-based therapies and immune-mediated approaches.
    Sprache Englisch
    Erscheinungsdatum 2023-09-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11102372
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  10. Artikel ; Online: Cytokines Removal During

    Boffini, Massimo / Marro, Matteo / Simonato, Erika / Scalini, Fabrizio / Costamagna, Andrea / Fanelli, Vito / Barbero, Cristina / Solidoro, Paolo / Brazzi, Luca / Rinaldi, Mauro

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Band 36, Seite(n) 10777

    Abstract: ... Ex ... ...

    Abstract Ex Vivo
    Mesh-Begriff(e) Humans ; Cytokines ; Extracorporeal Circulation ; Interleukin-10 ; Perfusion ; Lung Transplantation ; Tissue and Organ Harvesting/methods
    Chemische Substanzen Cytokines ; Interleukin-10 (130068-27-8)
    Sprache Englisch
    Erscheinungsdatum 2023-08-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.10777
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang