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  1. Buch ; Online: Recent Advances in Asthma Research and Treatments

    Chapoval, Svetlana P.

    2022  

    Schlagwörter Respiratory medicine
    Sprache 0|e
    Umfang 1 electronic resource (108 pages)
    Verlag IntechOpen
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT021612950
    ISBN 9781839692079 ; 1839692073
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch ; Online: Dendritic Cells

    Chapoval, Svetlana P

    2018  

    Schlagwörter Immunology ; cancer, immunotherapy, biocompatibility, magnesium, cell therapy, titanium
    Sprache Englisch
    Umfang 1 electronic resource (138 pages)
    Verlag IntechOpen
    Dokumenttyp Buch ; Online
    Anmerkung English
    HBZ-ID HT030646458
    ISBN 9781838817879 ; 1838817875
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Artikel ; Online: Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins.

    Chapoval, Svetlana P / Gao, Hongjuan / Fanaroff, Rachel / Keegan, Achsah D

    Frontiers in immunology

    2024  Band 14, Seite(n) 1297354

    Abstract: We investigated the effect of global Plexin B1 deficiency on allergic airway responses to house dust mite (HDM) or ovalbumin (OVA). In the HDM model, there were higher Th2 cytokine levels in the BALF of Plexin B1 knock-out (KO) mice compared to wild type ...

    Abstract We investigated the effect of global Plexin B1 deficiency on allergic airway responses to house dust mite (HDM) or ovalbumin (OVA). In the HDM model, there were higher Th2 cytokine levels in the BALF of Plexin B1 knock-out (KO) mice compared to wild type (WT), and tissue inflammation and mucus production were modestly enhanced. In the OVA model, Plexin B1 deficiency led to increases in lung inflammation, mucus production, and lung Th2 cytokines accompanied by dysregulated mucin gene expression without affecting anti-OVA IgE/IgG1 levels. Spleen cells from Plexin B1 KO mice proliferated more robustly than WT cells
    Mesh-Begriff(e) Animals ; Mice ; Cytokines ; Dermatophagoides pteronyssinus ; Hypersensitivity ; Inflammation ; Interleukin-4 ; Mucins ; Nerve Tissue Proteins/metabolism ; Ovalbumin ; Pneumonia ; T-Lymphocytes, Regulatory ; Receptors, Cell Surface/metabolism
    Chemische Substanzen Cytokines ; Interleukin-4 (207137-56-2) ; Mucins ; Nerve Tissue Proteins ; Ovalbumin (9006-59-1) ; Plxnb1 protein, mouse ; Receptors, Cell Surface
    Sprache Englisch
    Erscheinungsdatum 2024-01-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1297354
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Neuroimmune semaphorins as costimulatory molecules and beyond.

    Chapoval, Svetlana P

    Molecular medicine (Cambridge, Mass.)

    2018  Band 24, Heft 1, Seite(n) 13

    Abstract: Several neuronal guidance proteins, known as semaphorin molecules, function in the immune system. This dual tissue performance has led to them being defined as "neuroimmune semaphorins". They have been shown to regulate T cell activation by serving as ... ...

    Abstract Several neuronal guidance proteins, known as semaphorin molecules, function in the immune system. This dual tissue performance has led to them being defined as "neuroimmune semaphorins". They have been shown to regulate T cell activation by serving as costimulatory molecules. Similar to classical costimulatory molecules, neuroimmune semaphorins are either constitutively or inducibly expressed on immune cells. In contrast to the classical costimulatory molecule function, the action of neuroimmune semaphorins requires the presence of two signals, the first one provided by TCR/MHC engagement, and the second one provided by B7/CD28 interaction. Thus, neuroimmune semaphorins serve as a "signal three" for immune cell activation and regulate the overall intensity of immune response. The current knowledge on their structures, multiple receptors, specific cell/tissue/organ expression, and distinct functions in different diseases are summarized and discussed in this review.
    Mesh-Begriff(e) Animals ; Humans ; Nervous System/immunology ; Semaphorins/chemistry ; Semaphorins/immunology ; Semaphorins/metabolism
    Chemische Substanzen Semaphorins
    Sprache Englisch
    Erscheinungsdatum 2018-04-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1283676-x
    ISSN 1528-3658 ; 1076-1551
    ISSN (online) 1528-3658
    ISSN 1076-1551
    DOI 10.1186/s10020-018-0014-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection.

    Chapoval, Svetlana P / Keegan, Achsah D

    Molecular medicine (Cambridge, Mass.)

    2021  Band 27, Heft 1, Seite(n) 162

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly manifestation. This perspective focuses on the contribution of the recently discovered interaction of SARS-CoV-2 Spike protein with neuropilin 1 (NRP1) receptor, NRP1 as a virus entry receptor for SARS-CoV-2, its role in different physiologic and pathologic conditions, and the potential to target the Spike-NRP1 interaction to combat virus infectivity and severe disease manifestations.
    Mesh-Begriff(e) Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/pharmacology ; COVID-19/epidemiology ; COVID-19/etiology ; Comorbidity ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/virology ; Female ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/immunology ; Humans ; Infant ; Molecular Targeted Therapy/methods ; Neuropilin-1/chemistry ; Neuropilin-1/immunology ; Neuropilin-1/metabolism ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Pregnancy Complications, Infectious/virology ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/metabolism ; COVID-19 Drug Treatment
    Chemische Substanzen Antiviral Agents ; NRP1 protein, human ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Neuropilin-1 (144713-63-3) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Sprache Englisch
    Erscheinungsdatum 2021-12-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 1283676-x
    ISSN 1528-3658 ; 1076-1551
    ISSN (online) 1528-3658
    ISSN 1076-1551
    DOI 10.1186/s10020-021-00423-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis.

    Chapoval, Svetlana P

    Arthritis research & therapy

    2015  Band 17, Seite(n) 313

    Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease manifesting in joint destruction. The recognized hallmark of RA pathogenesis is the involvement of immune cells which produce many mediators potentiating an inflammatory environment. RA synovial ... ...

    Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease manifesting in joint destruction. The recognized hallmark of RA pathogenesis is the involvement of immune cells which produce many mediators potentiating an inflammatory environment. RA synovial fibroblasts (RASFs) contribute significantly to disease progression by initiating and regulating many pathways of joint destruction. Detailed molecular insights into RASF biology may lead to identification of important therapeutic targets. The discovery of common molecular targets for joint resident and inflammatory cells may help to develop the most effective therapeutic strategy. One such pathway includes semaphorin 4A as reported in a recent article in Arthritis Research & Therapy.
    Mesh-Begriff(e) Arthritis, Rheumatoid/genetics ; Female ; Fibroblasts/metabolism ; Gene Expression/genetics ; Humans ; Male ; Semaphorins/genetics ; Synovial Membrane/metabolism
    Chemische Substanzen Semaphorins
    Sprache Englisch
    Erscheinungsdatum 2015-11-06
    Erscheinungsland England
    Dokumenttyp Comment ; Editorial
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-015-0846-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Buch ; Online: Dendritic Cells

    Svetlana P. Chapoval

    2018  

    Abstract: Since their discovery in 1973 by Zanvil Cohn and Ralph Steinman (Nobel Prize in Physiology and Medicine, 2011), dendritic cells (DCs) continue to intrigue research scientists as their new markers, subpopulations and properties are being detected and the ... ...

    Abstract Since their discovery in 1973 by Zanvil Cohn and Ralph Steinman (Nobel Prize in Physiology and Medicine, 2011), dendritic cells (DCs) continue to intrigue research scientists as their new markers, subpopulations and properties are being detected and the relevant literature is being doubled each year. This book combines the most comprehensive reviews of several critical aspects of DC biology and function written by a group of international experts in the field. The first section briefly discusses recent advances in DC subtypes, phenotypes, and functions in different diseases. The following sections look closely at DC phenotyping, DC-NK cell interplay, and roles of DC in bone loss and repair and parasitic infections. The final section on DC and cancer includes perspectives on DC vaccination based on modifications and therapeutic applications.
    Schlagwörter Life Sciences ; Biochemistry ; Genetics and Molecular Biology ; Immunology
    Sprache Englisch
    Verlag IntechOpen
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation: A Promoter or a Suppressor?

    Iyer, Apoorva S / Chapoval, Svetlana P

    International journal of molecular sciences

    2018  Band 20, Heft 1

    Abstract: Neuroimmune semaphorin 4A (Sema4A), a member of semaphorin family of transmembrane and secreted proteins, is an important regulator of neuronal and immune functions. In the nervous system, Sema4A primarily regulates the functional activity of neurons ... ...

    Abstract Neuroimmune semaphorin 4A (Sema4A), a member of semaphorin family of transmembrane and secreted proteins, is an important regulator of neuronal and immune functions. In the nervous system, Sema4A primarily regulates the functional activity of neurons serving as an axon guidance molecule. In the immune system, Sema4A regulates immune cell activation and function, instructing a fine tuning of the immune response. Recent studies have shown a dysregulation of Sema4A expression in several types of cancer such as hepatocellular carcinoma, colorectal, and breast cancers. Cancers have been associated with abnormal angiogenesis. The function of Sema4A in angiogenesis and cancer is not defined. Recent studies have demonstrated Sema4A expression and function in endothelial cells. However, the results of these studies are controversial as they report either pro- or anti-angiogenic Sema4A effects depending on the experimental settings. In this mini-review, we discuss these findings as well as our data on Sema4A regulation of inflammation and angiogenesis, which both are important pathologic processes underlining tumorigenesis and tumor metastasis. Understanding the role of Sema4A in those processes may guide the development of improved therapeutic treatments for cancer.
    Mesh-Begriff(e) Animals ; Anti-Inflammatory Agents/therapeutic use ; Antineoplastic Agents/therapeutic use ; Carcinogenesis/metabolism ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/metabolism ; Semaphorins/genetics ; Semaphorins/metabolism ; Vascular Endothelial Growth Factor A/metabolism
    Chemische Substanzen Anti-Inflammatory Agents ; Antineoplastic Agents ; SEMA4A protein, human ; Semaphorins ; Vascular Endothelial Growth Factor A
    Sprache Englisch
    Erscheinungsdatum 2018-12-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20010124
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Mice Expressing Cosegregating Single Nucleotide Polymorphisms (D298G and N397I) in TLR4 Have Enhanced Responses to House Dust Mite Allergen.

    Fink, Marc Y / Qi, Xiulan / Shirey, Kari Ann / Fanaroff, Rachel / Chapoval, Svetlana / Viscardi, Rose M / Vogel, Stefanie N / Keegan, Achsah D

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Band 208, Heft 9, Seite(n) 2085–2097

    Abstract: Asthma is a common and ubiquitous chronic respiratory disease that is associated with airway inflammation and hyperreactivity resulting in airway obstruction. It is now accepted that asthma is controlled by a combination of host genetics and environment ... ...

    Abstract Asthma is a common and ubiquitous chronic respiratory disease that is associated with airway inflammation and hyperreactivity resulting in airway obstruction. It is now accepted that asthma is controlled by a combination of host genetics and environment in a rather complex fashion; however, the link between sensing of the environment and development and exacerbation of allergic lung inflammation is unclear. Human populations expressing cosegregating D299G and T399I polymorphisms in the
    Mesh-Begriff(e) Allergens ; Animals ; Antigens, Dermatophagoides/immunology ; Asthma/genetics ; Asthma/pathology ; Inflammation ; Lipopolysaccharides ; Mice ; Polymorphism, Single Nucleotide ; Pulmonary Eosinophilia ; Pyroglyphidae ; Toll-Like Receptor 4/genetics
    Chemische Substanzen Allergens ; Antigens, Dermatophagoides ; Lipopolysaccharides ; Tlr4 protein, mouse ; Toll-Like Receptor 4
    Sprache Englisch
    Erscheinungsdatum 2022-04-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2100926
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Semaphorins 4A and 4D in chronic inflammatory diseases.

    Chapoval, Svetlana P / Vadasz, Zahava / Chapoval, Andrei I / Toubi, Elias

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2017  Band 66, Heft 2, Seite(n) 111–117

    Abstract: Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, ...

    Abstract Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer. Recent discoveries of neuroimmune semaphorins 4A and 4D (Sema4A and Sema4D, respectively) expression and function in the immune system and their key regulatory roles in fine tuning of inflammatory processes made them the molecules of interest for a potential immunotherapy. In this short review, we discuss the current knowledge in the Sema4A and Sema4D actions in chronic inflammation underlying the outlined above diseases.
    Mesh-Begriff(e) Animals ; Antigens, CD/immunology ; Arthritis, Rheumatoid/immunology ; Asthma/immunology ; Atherosclerosis/immunology ; Humans ; Inflammatory Bowel Diseases/immunology ; Lupus Erythematosus, Systemic/immunology ; Multiple Sclerosis/immunology ; Myocarditis/immunology ; Neoplasms/immunology ; Nerve Tissue Proteins/immunology ; Receptors, Cell Surface/immunology ; Semaphorins/immunology
    Chemische Substanzen Antigens, CD ; CD100 antigen ; Nerve Tissue Proteins ; PLXNB1 protein, human ; Receptors, Cell Surface ; SEMA4A protein, human ; Semaphorins
    Sprache Englisch
    Erscheinungsdatum 2017-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-016-0983-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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