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Artikel ; Online: Management of hepatic hydropericardium with open drainage, maximal medical therapy and terlipressin.

Ermongkonchai, Tai / Ha, Phil / French, Janine

BMJ case reports

2024 Band 17, Heft 1

Abstract: ... on view. The serum ascites albumin gradient was 14 g/L. Maximal medical therapy was commenced including ...

Abstract	We present the case of a woman in her 60s with Child-Pugh C cirrhosis who developed pericardial tamponade during an admission for a haemothorax secondary to a mechanical fall. The patient developed haemodynamic compromise with a rapid decline in renal function. During an open subxiphoid drain tube insertion, a pre-existing peritoneopericardial communication was noted, with ascites in the peritoneal cavity on view. The serum ascites albumin gradient was 14 g/L. Maximal medical therapy was commenced including diuresis and albumin, with adjunctive terlipressin infusion which restored her baseline renal function and resolved the effusion. We believe this is the first case report of using open drainage, maximal medical therapy and terlipressin to successfully treat hepatic hydropericardium and its subsequent renal compromise.
Mesh-Begriff(e)	Female ; Humans ; Terlipressin/therapeutic use ; Ascites/drug therapy ; Ascites/etiology ; Kidney ; Liver Cirrhosis/complications ; Pericardial Effusion/complications ; Edema/complications ; Albumins ; Drainage/adverse effects ; Lypressin/therapeutic use
Chemische Substanzen	Terlipressin (7Z5X49W53P) ; Albumins ; Lypressin (50-57-7)
Sprache	Englisch
Erscheinungsdatum	2024-01-12
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-256908
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Checkpoint inhibitor-induced bullous pemphigoid differs from spontaneous bullous pemphigoid.

Kramer, N / Müller, G / Zierold, S / Röckel, M / Fröhlich, W / Schefzyk, M / Kumbrink, J / Hassel, J C / Berking, C / Ziemer, M / Nashan, D / French, L E / Vera, J / Kerl-French, K E / Gutzmer, R / Heinzerling, L

Journal of the European Academy of Dermatology and Venereology : JEADV

2024

Sprache	Englisch
Erscheinungsdatum	2024-02-24
Erscheinungsland	England
Dokumenttyp	Letter
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.19860
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Both sides now: Changing a long-standing pedigree tradition of men on the left and women on the right.

Resta, Robert G / French, Kathryn Steinhaus / Bennett, Robin L / Austin, Jehannine

Journal of genetic counseling

2022 Band 32, Heft 3, Seite(n) 530–531

Mesh-Begriff(e)	Male ; Humans ; Female ; Pedigree
Sprache	Englisch
Erscheinungsdatum	2022-12-14
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1117799-8
ISSN	1573-3599 ; 1059-7700
ISSN (online)	1573-3599
ISSN	1059-7700
DOI	10.1002/jgc4.1662
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Genome Engineering Human ESCs or iPSCs with Cytosine and Adenine Base Editors.

Pavani, Giulia / Klein, Joshua G / French, Deborah L / Gadue, Paul

Methods in molecular biology (Clifton, N.J.)

2022 Band 2520, Seite(n) 321–333

Abstract: The ability to engineer specific mutations in human embryonic stem cells (ECSs) or induced pluripotent stem cells (iPSCs) is extremely important in the modeling of human diseases and the study of biological processes. While CRISPR/Cas9 can robustly ... ...

Abstract	The ability to engineer specific mutations in human embryonic stem cells (ECSs) or induced pluripotent stem cells (iPSCs) is extremely important in the modeling of human diseases and the study of biological processes. While CRISPR/Cas9 can robustly generate gene knockouts (KOs) and gene loci modifications in coding sequences of iPSCs, it remains difficult to produce monoallelic mutations or modify specific nucleotides in noncoding sequences due to technical constraints.Here, we describe how to leverage cytosine (BE4max) and adenine (ABEmax) base editors to introduce precise mutations in iPSCs without inducing DNA double-stranded breaks. This chapter illustrates how to design and clone gRNAs, evaluate editing efficiency, and detect genomic edits at specific sites in iPSCs through the utilization of base editing technology.
Mesh-Begriff(e)	Adenine ; CRISPR-Cas Systems/genetics ; Cytosine ; Genome, Human ; Humans ; Induced Pluripotent Stem Cells
Chemische Substanzen	Cytosine (8J337D1HZY) ; Adenine (JAC85A2161)
Sprache	Englisch
Erscheinungsdatum	2022-04-20
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/7651_2022_461
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Access to healthcare among sexual and gender minority youth at risk for HIV: barriers and experiences of discrimination.

Gleason, Neil / Serrano, Pedro A / Muñoz, Alejandro / Hosek, Sybil G / French, Audrey L

AIDS care

2023 Band 35, Heft 10, Seite(n) 1480–1491

Abstract: This study examined experiences of healthcare inaccessibility and lesbian, gay, bisexual, transgender, queer, plus (LGBTQ+) discrimination among sexual and gender minority youth at elevated risk for HIV in the United States. Participants for this cross- ... ...

Abstract	This study examined experiences of healthcare inaccessibility and lesbian, gay, bisexual, transgender, queer, plus (LGBTQ+) discrimination among sexual and gender minority youth at elevated risk for HIV in the United States. Participants for this cross-sectional survey study (
Mesh-Begriff(e)	Humans ; Female ; Male ; Adolescent ; United States/epidemiology ; Cross-Sectional Studies ; Gender Identity ; HIV Infections/epidemiology ; Sexual and Gender Minorities ; Transgender Persons ; Health Services Accessibility
Sprache	Englisch
Erscheinungsdatum	2023-05-28
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1012651-x
ISSN	1360-0451 ; 0954-0121
ISSN (online)	1360-0451
ISSN	0954-0121
DOI	10.1080/09540121.2023.2209303
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Practice resource-focused revision: Standardized pedigree nomenclature update centered on sex and gender inclusivity: A practice resource of the National Society of Genetic Counselors.

Bennett, Robin L / French, Kathryn Steinhaus / Resta, Robert G / Austin, Jehannine

Journal of genetic counseling

2022 Band 31, Heft 6, Seite(n) 1238–1248

Abstract: This focused revision builds on the expert opinions from the original publications of 'Recommendations for human standardized pedigree nomenclature' published in 1995 and updated in 2008. Our review of medical publications since 2008 did not identify any ...

Abstract	This focused revision builds on the expert opinions from the original publications of 'Recommendations for human standardized pedigree nomenclature' published in 1995 and updated in 2008. Our review of medical publications since 2008 did not identify any fundamental systematic alternative pedigree nomenclature. These findings attest to the relevance of most of the nomenclature with the critical exception of the nomenclature used to denote sex assigned at birth and gender. While we are not recommending the creation of any new pedigree symbols, a major focus of this publication is clarification of the use of symbols and language in the description of the distinction between sex and gender, with a view to ensuring safe and inclusive practice for people who are gender-diverse or transgender. In addition, we recommend modifications to the way that carrier status is depicted. Our goal is to respect individual differences and identities while maintaining biologically, clinically, and genetically meaningful information.
Mesh-Begriff(e)	Male ; Female ; Infant, Newborn ; Humans ; Counselors ; Pedigree ; Gender Identity ; Transgender Persons ; Societies
Sprache	Englisch
Erscheinungsdatum	2022-09-15
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	1117799-8
ISSN	1573-3599 ; 1059-7700
ISSN (online)	1573-3599
ISSN	1059-7700
DOI	10.1002/jgc4.1621
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Severe weather events and cryptosporidiosis in Aotearoa New Zealand: A case series of space-time clusters.

Grout, Leah / Hales, Simon / Baker, Michael G / French, Nigel / Wilson, Nick

Epidemiology and infection

2024 Band 152, Seite(n) e64

Abstract: Occurrence of cryptosporidiosis has been associated with weather conditions in many settings internationally. We explored statistical clusters of human cryptosporidiosis and their relationship with severe weather events in New Zealand (NZ). Notified ... ...

Abstract	Occurrence of cryptosporidiosis has been associated with weather conditions in many settings internationally. We explored statistical clusters of human cryptosporidiosis and their relationship with severe weather events in New Zealand (NZ). Notified cases of cryptosporidiosis from 1997 to 2015 were obtained from the national surveillance system. Retrospective space-time permutation was used to identify statistical clusters. Cluster data were compared to severe weather events in a national database. SaTScan analysis detected 38 statistically significant cryptosporidiosis clusters. Around a third (34.2%, 13/38) of these clusters showed temporal and spatial alignment with severe weather events. Of these, nearly half (46.2%, 6/13) occurred in the spring. Only five (38%, 5/13) of these clusters corresponded to a previously reported cryptosporidiosis outbreak. This study provides additional evidence that severe weather events may contribute to the development of some cryptosporidiosis clusters. Further research on this association is needed as rainfall intensity is projected to rise in NZ due to climate change. The findings also provide further arguments for upgrading the quality of drinking water sources to minimize contamination with pathogens from runoff from livestock agriculture.
Mesh-Begriff(e)	Cryptosporidiosis/epidemiology ; New Zealand/epidemiology ; Humans ; Weather ; Retrospective Studies ; Adult ; Child, Preschool ; Male ; Middle Aged ; Child ; Female ; Aged ; Adolescent ; Young Adult ; Space-Time Clustering ; Infant ; Disease Outbreaks ; Aged, 80 and over ; Seasons ; Infant, Newborn
Sprache	Englisch
Erscheinungsdatum	2024-04-15
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S095026882400058X
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Shedding Light on the Vibrational Signatures in Halogen-Bonded Graphitic Carbon Nitride Building Blocks.

Ellington, Thomas L / Devore, Daniel P / Uvin G De Alwis, W M / French, Kirk A / Shuford, Kevin L

Chemphyschem : a European journal of chemical physics and physical chemistry

2023 Band 24, Heft 7, Seite(n) e202200812

Abstract: The relative contributions of halogen and hydrogen bonding to the interaction between graphitic carbon nitride monomers and halogen bond (XB) donors containing C-X and C≡C bonds were evaluated using computational vibrational spectroscopy. Conventional ... ...

Abstract	The relative contributions of halogen and hydrogen bonding to the interaction between graphitic carbon nitride monomers and halogen bond (XB) donors containing C-X and C≡C bonds were evaluated using computational vibrational spectroscopy. Conventional probes into select vibrational stretching frequencies can often lead to disconnected results. To elucidate this behavior, local mode analyses were performed on the XB donors and complexes identified previously at the M06-2X/aVDZ-PP level of theory. Due to coupling between low and high energy C-X vibrations, the C≡C stretch is deemed a better candidate when analyzing XB complex properties or detecting XB formation. The local force constants support this conclusion, as the C≡C values correlate much better with the σ-hole magnitude than their C-X counterparts. The intermolecular local stretching force constants were also assessed, and it was found that attractive forces other than halogen bonding play a supporting role in complex formation.
Sprache	Englisch
Erscheinungsdatum	2023-01-20
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2025223-7
ISSN	1439-7641 ; 1439-4235
ISSN (online)	1439-7641
ISSN	1439-4235
DOI	10.1002/cphc.202200812
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Monkeypox-Induced Secondary Traumatic Stress: An Exploratory Analysis of Young Sexual and Gender Minority Adults Living in Illinois.

Curtis, Michael G / Davoudpour, Shahin / Felt, Dylan / French, Audrey L / Hosek, Sybil G / Phillips, Gregory / Serrano, Pedro A

European journal of trauma & dissociation = Revue europeenne du trauma et de la dissociation

2023 Band 7, Heft 4

Abstract: Objective: Prior epidemic literature suggests that the rapid proliferation of Monkeypox (Mpox) within the United States may trigger severe stress reactions that increase the risk of developing secondary traumatic stress among young adults most at risk ... ...

Abstract	Objective: Prior epidemic literature suggests that the rapid proliferation of Monkeypox (Mpox) within the United States may trigger severe stress reactions that increase the risk of developing secondary traumatic stress among young adults most at risk of exposure. The present exploratory study aimed to investigate the degree to which proximity to Mpox (i.e. knowing people who acquired Mpox), was associated with symptoms of secondary traumatization. Method: An online survey was administered to 253 participants enrolled in Keeping it LITE, a prospective U.S. cohort study of ethnically diverse, sexually active, sexual and gender minority persons ages 19-39 in September 2022. A multiple linear regression was used to examine the association between proximity to Mpox and secondary traumatic stress (STS) symptoms. Results: Study findings demonstrated that Mpox morbidity was low (1%); however, 37% of participants reported knowing at least one person diagnosed with Mpox. For most individuals, this person was a friend (28%). 16% of participants were found to have at least one indicator of Mpox-related STS. Results of our multiple linear regression demonstrated a positive association between an individual's indirect exposure to Mpox via their interpersonal relationships and STS symptoms. Conclusions: Findings suggest that the more adults' interpersonal relationships are saturated with people who have acquired Mpox, the more likely they are to develop symptoms of secondary traumatization. These findings provide tentative initial evidence that secondary exposure to Mpox via one's social network may undermine adults' mental health even after the conclusion of the outbreak.
Sprache	Englisch
Erscheinungsdatum	2023-09-11
Erscheinungsland	France
Dokumenttyp	Journal Article
ISSN	2468-7499
ISSN (online)	2468-7499
DOI	10.1016/j.ejtd.2023.100349
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Predictors of Mpox vaccine uptake among sexual and gender minority young adults living in Illinois: Unvaccinated vs. double vs. single dose vaccine recipients.

Curtis, Michael G / Davoudpour, Shahin / Rodriguez-Ortiz, Anthony E / Felt, Dylan / French, Audrey L / Hosek, Sybil G / Phillips, Gregory / Serrano, Pedro A

Vaccine

2023 Band 41, Heft 27, Seite(n) 4002–4008

Abstract: Introduction: The 2022 global outbreak of Monkeypox virus (Mpox), which has primarily spread through the sexual networks of sexual and gender minority (SGM) individuals, has introduced new public health challenges. While an efficacious Mpox vaccine is ... ...

Abstract	Introduction: The 2022 global outbreak of Monkeypox virus (Mpox), which has primarily spread through the sexual networks of sexual and gender minority (SGM) individuals, has introduced new public health challenges. While an efficacious Mpox vaccine is in active circulation, few Mpox vaccine studies have examined its uptake among SGM groups. The aims of this study were to investigate (a) the prevalence of Mpox vaccine uptake among SGM and (b) the contextual, Mpox-disease specific, and Mpox-vaccine specific factors associated with Mpox vaccine among SGM. Methods: We conducted a cross-sectional survey in Illinois, USA in September 2022; 320 young SGM completed self-administered questionnaires. Multinomial logistic regression was used to assess the contextual, Mpox-disease specific, and Mpox-vaccine specific factors associated with Mpox vaccine uptake. Adjusted Odds Ratios (aORs) and 95 % Confidence Intervals (CI) are reported. Results: Approximately 50 % of the SGM participants included in this study had received at least their first dose of the Mpox vaccine. Multinomial regression analysis showed that individuals who had recently experienced food insecurity, had higher degrees of fear of social rejection due to Mpox acquisition, and were more Mpox-vaccine hesitant were more likely to be unvaccinated. Conversely, knowing people who have contracted Mpox, having higher formal educational attainment, having higher degrees of Mpox-related internalized heterosexism, and being more concerned about one's safety regarding Mpox morbidity were more likely to be double-dosers. Conclusion: Approximately 50 % of the SGMs included in this study received at least their first dose of the Mpox vaccine; however, only one-quarter of participants completed the recommended 2-dose Mpox regimen. Our findings indicate that socioeconomic stability, fear of social rejection due to disease acquisition, and Mpox-specific vaccine hesitancy may be important structural targets to consider when developing vaccine-uptake prevention and intervention strategies tailored to the needs of sexual and gender minorities.
Mesh-Begriff(e)	Humans ; Young Adult ; Smallpox Vaccine ; Cross-Sectional Studies ; Mpox (monkeypox) ; Illinois ; Sexual and Gender Minorities
Chemische Substanzen	Smallpox Vaccine
Sprache	Englisch
Erscheinungsdatum	2023-05-24
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.05.043
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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