LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU=Kojima Shihoko
  2. AU="Alcahut-Rodríguez, Cristian"
  3. AU="Whiteside, Theresa L"
  4. AU="Pappalettere, Carmine"
  5. AU="Bolla, Eleana"
  6. AU="Bajkowski, Jared"
  7. AU="Calleros Basilio, Laura"
  8. AU="Mohamad, Okbah"
  9. AU="Holy, Jon"
  10. AU="Farber, Mark O"
  11. AU="Gal, Adiv"
  12. AU="Badenhorst, Marelise"
  13. AU="Pachner, Andrew R"
  14. AU="Colón-Ramos, Daniel A" AU="Colón-Ramos, Daniel A"
  15. AU="Modzelewska, Dominika"
  16. AU="Boethig, Dietmar"
  17. AU="Jurinović, Luka"
  18. AU="Yashila Patel"
  19. AU="Zheng, Lei" AU="Zheng, Lei"
  20. AU="Seah, Penelope M Y"
  21. AU="Marianna Milano"
  22. AU="London, Kevin"
  23. AU=Pain Debkumar
  24. AU="Snider, Elizabeth"
  25. AU="Klein, J R"
  26. AU="Deslandes, K."
  27. AU="Xie, Dandan"
  28. AU=Ward Helen
  29. AU="Grace Deukmedjian"
  30. AU="Lindeman, Neal"
  31. AU="Okoli, Mary"
  32. AU="Mathew, Philip"
  33. AU=Staros Eric B

Suchergebnis

Treffer 1 - 10 von insgesamt 50

Suchoptionen

  1. Artikel: Impacts of the feedback loop between sense-antisense RNAs in regulating circadian rhythms.

    Uriu, Koichiro / Hernandez-Sanchez, Juan P / Kojima, Shihoko

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Antisense transcripts are a unique group of non-coding RNAs that are transcribed from the opposite strand of a sense coding gene in an antisense orientation. Even though they do not encode a protein, these transcripts play a regulatory role in a variety ... ...

    Abstract Antisense transcripts are a unique group of non-coding RNAs that are transcribed from the opposite strand of a sense coding gene in an antisense orientation. Even though they do not encode a protein, these transcripts play a regulatory role in a variety of biological processes, including circadian rhythms. We and others found an antisense transcript,
    Sprache Englisch
    Erscheinungsdatum 2024-04-30
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.04.28.591560
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel: Editorial: Circadian desynchrony: Consequences, mechanisms, and Open Issues.

    Gutman, Roee / Pendergast, Julie S / Nakamura, Wataru / Kojima, Shihoko

    Frontiers in physiology

    2023  Band 14, Seite(n) 1177643

    Sprache Englisch
    Erscheinungsdatum 2023-03-17
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1177643
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Coordination of rhythmic RNA synthesis and degradation orchestrates 24- and 12-h RNA expression patterns in mouse fibroblasts.

    Unruh, Benjamin A / Weidemann, Douglas E / Miao, Lin / Kojima, Shihoko

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Band 121, Heft 7, Seite(n) e2314690121

    Abstract: Circadian RNA expression is essential to ultimately regulate a plethora of downstream rhythmic biochemical, physiological, and behavioral processes. Both transcriptional and posttranscriptional mechanisms are considered important to drive rhythmic RNA ... ...

    Abstract Circadian RNA expression is essential to ultimately regulate a plethora of downstream rhythmic biochemical, physiological, and behavioral processes. Both transcriptional and posttranscriptional mechanisms are considered important to drive rhythmic RNA expression; however, the extent to which each regulatory process contributes to the rhythmic RNA expression remains controversial. To systematically address this, we monitored RNA dynamics using metabolic RNA labeling technology during a circadian cycle in mouse fibroblasts. We find that rhythmic RNA synthesis is the primary contributor of 24-h RNA rhythms, while rhythmic degradation is more important for 12-h RNA rhythms. These rhythms were predominantly regulated by
    Mesh-Begriff(e) Mice ; Animals ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Circadian Rhythm/genetics ; Fibroblasts/metabolism ; Circadian Clocks/genetics
    Chemische Substanzen RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2024-02-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2314690121
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1148: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel: Coordination of rhythmic RNA synthesis and degradation orchestrates 24-hour and 12-hour RNA expression patterns in mouse fibroblasts.

    Unruh, Benjamin A / Weidemann, Douglas E / Kojima, Shihoko

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Circadian RNA expression is essential to ultimately regulate a plethora of downstream rhythmic biochemical, physiological, and behavioral processes. Both transcriptional and post-transcriptional mechanisms are considered important to drive rhythmic RNA ... ...

    Abstract Circadian RNA expression is essential to ultimately regulate a plethora of downstream rhythmic biochemical, physiological, and behavioral processes. Both transcriptional and post-transcriptional mechanisms are considered important to drive rhythmic RNA expression, however, the extent to which each regulatory process contributes to the rhythmic RNA expression remains controversial. To systematically address this, we monitored RNA dynamics using metabolic RNA labeling technology during a circadian cycle in mouse fibroblasts. We find that rhythmic RNA synthesis is the primary contributor of 24 hr RNA rhythms, while rhythmic degradation is more important for 12 hr RNA rhythms. These rhythms were predominantly regulated by
    Sprache Englisch
    Erscheinungsdatum 2023-07-26
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.07.26.550672
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  5. Artikel ; Online: Timing without coding: How do long non-coding RNAs regulate circadian rhythms?

    Mosig, Rebecca A / Kojima, Shihoko

    Seminars in cell & developmental biology

    2021  Band 126, Seite(n) 79–86

    Abstract: Long non-coding RNAs (lncRNAs) are a new class of regulatory RNAs that play important roles in disease development and a variety of biological processes. Recent studies have underscored the importance of lncRNAs in the circadian clock system and ... ...

    Abstract Long non-coding RNAs (lncRNAs) are a new class of regulatory RNAs that play important roles in disease development and a variety of biological processes. Recent studies have underscored the importance of lncRNAs in the circadian clock system and demonstrated that lncRNAs regulate core clock genes and the core clock machinery in mammals. In this review, we provide an overview of our current understanding of how lncRNAs regulate the circadian clock without coding a protein. We also offer additional insights into the challenges in understanding the functions of lncRNAs and other unresolved questions in the field. We do not cover other regulatory ncRNAs even though they also play important roles; readers are highly encouraged to refer to other excellent reviews on this topic.
    Mesh-Begriff(e) Animals ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Mammals/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Untranslated
    Chemische Substanzen RNA, Long Noncoding ; RNA, Untranslated
    Sprache Englisch
    Erscheinungsdatum 2021-06-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2021.04.020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2918: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel ; Online: Correction: Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression.

    Yao, Xiangyu / Kojima, Shihoko / Chen, Jing

    PLoS computational biology

    2021  Band 17, Heft 5, Seite(n) e1009065

    Abstract: This corrects the article DOI: 10.1371/journal.pcbi.1007842.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pcbi.1007842.].
    Sprache Englisch
    Erscheinungsdatum 2021-05-26
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1009065
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel ; Online: Correction

    Xiangyu Yao / Shihoko Kojima / Jing Chen

    PLoS Computational Biology, Vol 17, Iss 5, p e

    Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression.

    2021  Band 1009065

    Abstract: This corrects the article DOI:10.1371/journal.pcbi.1007842.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pcbi.1007842.].
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel ; Online: The Making and Breaking of RNAs: Dynamics of Rhythmic RNA Expression in Mammals.

    Unruh, Benjamin A / Kojima, Shihoko

    Journal of biological rhythms

    2020  Band 35, Heft 6, Seite(n) 519–529

    Abstract: The identification and characterization of rhythmically expressed mRNAs have been an active area of research over the past 20 years, as these mRNAs are believed to produce the daily rhythms in a wide range of biological processes. Circadian transcriptome ...

    Abstract The identification and characterization of rhythmically expressed mRNAs have been an active area of research over the past 20 years, as these mRNAs are believed to produce the daily rhythms in a wide range of biological processes. Circadian transcriptome studies have used mature mRNA as a primary readout and focused largely on rhythmic RNA synthesis as a regulatory mechanism underlying rhythmic mRNA expression. However, RNA synthesis, RNA degradation, or a combination of both must be rhythmic to drive rhythmic RNA profiles, and it is still unclear to what extent rhythmic synthesis leads to rhythmic RNA profiles. In addition, circadian RNA expression is also often tissue specific. Although a handful of genes cycle in all or most tissues, others are rhythmic only in certain tissues, even though the same core clock mechanism is believed to control the rhythmic RNA profiles in all tissues. This review focuses on the dynamics of rhythmic RNA synthesis and degradation and discusses how these steps collectively determine the rhythmicity, phase, and amplitude of RNA accumulation. In particular, we highlight a possible role of RNA degradation in driving tissue-specific RNA rhythms. By unifying findings from experimental and theoretical studies, we will provide a comprehensive overview of how rhythmic gene expression can be achieved and how each regulatory step contributes to tissue-specific circadian transcriptome output in mammals.
    Mesh-Begriff(e) Animals ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Humans ; Mammals/metabolism ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; Transcriptome/genetics
    Chemische Substanzen RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2020-09-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 896387-3
    ISSN 1552-4531 ; 0748-7304
    ISSN (online) 1552-4531
    ISSN 0748-7304
    DOI 10.1177/0748730420957498
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2872: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  9. Artikel: A comparative study of algorithms detecting differential rhythmicity in transcriptomic data.

    Miao, Lin / Weidemann, Douglas E / Ngo, Katherine / Unruh, Benjamin A / Kojima, Shihoko

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Rhythmic transcripts play pivotal roles in driving the daily oscillations of various biological processes. Genetic or environmental disruptions can lead to alterations in the rhythmicity of transcripts, ultimately impacting downstream circadian outputs, ... ...

    Abstract Rhythmic transcripts play pivotal roles in driving the daily oscillations of various biological processes. Genetic or environmental disruptions can lead to alterations in the rhythmicity of transcripts, ultimately impacting downstream circadian outputs, including metabolic processes and even behavior. To statistically compare the differences in transcript rhythms between two or more conditions, several algorithms have been developed to analyze circadian transcriptomic data, each with distinct features. In this study, we compared the performance of seven algorithms that were specifically designed to detect differential rhythmicity. We found that even when applying the same statistical threshold, these algorithms yielded varying numbers of differentially rhythmic transcripts. Nevertheless, the set of transcripts commonly identified as differentially rhythmic exhibited substantial overlap among algorithms. Furthermore, the phase and amplitude differences calculated by these algorithms displayed significant correlations. In summary, our study highlights a high degree of similarity in the results produced by these algorithms. Furthermore, when selecting an algorithm for analysis, it is crucial to ensure the compatibility of input data with the specific requirements of the chosen algorithm and to assess whether the algorithm's output fits the needs of the user.
    Sprache Englisch
    Erscheinungsdatum 2023-10-17
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.10.12.562079
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  10. Artikel ; Online: Genetic and environmental perturbations alter the rhythmic expression pattern of a circadian long non-coding RNA,

    Miao, Lin / Batty, Kyle R / Jackson, Ayana N / Pieno, Heather A / Rhoades, Maisy W / Kojima, Shihoko

    F1000Research

    2022  Band 11, Seite(n) 1073

    Abstract: ... ...

    Abstract Background
    Mesh-Begriff(e) Mice ; Animals ; RNA, Long Noncoding/genetics ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Transcription Factors/metabolism ; Liver
    Chemische Substanzen RNA, Long Noncoding ; Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2022-09-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.125628.2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang