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Buch ; Online ; Dissertation / Habilitation: Nidogen-1 and Nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilage

Krügel, Jenny [Verfasser]

2009

Verfasserangabe	vorgelegt von Jenny Krügel
Schlagwörter	Medizin, Gesundheit ; Medicine, Health
Thema/Rubrik (Code)	sg610
Sprache	Deutsch
Dokumenttyp	Buch ; Online ; Dissertation / Habilitation
Datenquelle	Digitale Dissertationen im Internet

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Artikel ; Online: Basement membrane components are key players in specialized extracellular matrices.

Kruegel, Jenny / Miosge, Nicolai

Cellular and molecular life sciences : CMLS

2010 Band 67, Heft 17, Seite(n) 2879–2895

Abstract: More than three decades ago, basement membranes (BMs) were described as membrane-like structures capable of isolating a cell from and connecting a cell to its environment. Since this time, it has been revealed that BMs are specialized extracellular ... ...

Abstract	More than three decades ago, basement membranes (BMs) were described as membrane-like structures capable of isolating a cell from and connecting a cell to its environment. Since this time, it has been revealed that BMs are specialized extracellular matrices (sECMs) with unique components that support important functions including differentiation, proliferation, migration, and chemotaxis of cells during development. The composition of these sECM is as unique as the tissues to which they are localized, opening the possibility that such matrices can fulfill distinct functions. Changes in BM composition play significant roles in facilitating the development of various diseases. Furthermore, tissues have to provide sECM for their stem cells during development and for their adult life. Here, we briefly review the latest research on these unique sECM and their components with a special emphasis on embryonic and adult stem cells and their niches.
Mesh-Begriff(e)	Animals ; Basement Membrane/chemistry ; Basement Membrane/physiology ; Cell Culture Techniques ; Collagen Type IV/analysis ; Collagen Type IV/metabolism ; Extracellular Matrix/chemistry ; Heparan Sulfate Proteoglycans/analysis ; Heparan Sulfate Proteoglycans/metabolism ; Humans ; Laminin/analysis ; Laminin/metabolism ; Membrane Glycoproteins/analysis ; Membrane Glycoproteins/metabolism ; Mice ; Stem Cells/chemistry ; Tissue Engineering/methods
Chemische Substanzen	Collagen Type IV ; Heparan Sulfate Proteoglycans ; Laminin ; Membrane Glycoproteins ; nidogen ; perlecan (143972-95-6)
Sprache	Englisch
Erscheinungsdatum	2010-04-29
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-010-0367-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Correction: Renal Cells Express Different Forms of Vimentin: The Independent Expression Alteration of these Forms is Important in Cell Resistance to Osmotic Stress and Apoptosis.

Buchmaier, Bettina S / Bibi, Asima / Müller, Gerhard A / Dihazi, Gry H / Eltoweissy, Marwa / Kruegel, Jenny / Dihazi, Hassan

PloS one

2018 Band 13, Heft 5, Seite(n) e0196935

Abstract: This corrects the article DOI: 10.1371/journal.pone.0068301.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0068301.].
Sprache	Englisch
Erscheinungsdatum	2018
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0196935
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Basement membrane components are key players in specialized extracellular matrices

Kruegel, Jenny / Miosge, Nicolai

Cellular and molecular life sciences CMLS. 2010 Sept., v. 67, no. 17

2010

Abstract	More than three decades ago, basement membranes (BMs) were described as membrane-like structures capable of isolating a cell from and connecting a cell to its environment. Since this time, it has been revealed that BMs are specialized extracellular matrices (sECMs) with unique components that support important functions including differentiation, proliferation, migration, and chemotaxis of cells during development. The composition of these sECM is as unique as the tissues to which they are localized, opening the possibility that such matrices can fulfill distinct functions. Changes in BM composition play significant roles in facilitating the development of various diseases. Furthermore, tissues have to provide sECM for their stem cells during development and for their adult life. Here, we briefly review the latest research on these unique sECM and their components with a special emphasis on embryonic and adult stem cells and their niches.
Schlagwörter	neoplasms ; basement membrane
Sprache	Englisch
Erscheinungsverlauf	2010-09
Umfang	p. 2879-2895.
Verlag	SP Birkhäuser Verlag Basel
Erscheinungsort	Basel
Dokumenttyp	Artikel
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-010-0367-x
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Alport syndrome--insights from basic and clinical research.

Kruegel, Jenny / Rubel, Diana / Gross, Oliver

Nature reviews. Nephrology

2012 Band 9, Heft 3, Seite(n) 170–178

Abstract: In 1927, Arthur C. Alport first published his description of a triad of symptoms in a family with hereditary congenital haemorrhagic nephritis, deafness and ocular changes. A few years after his death, this group of symptoms was renamed Alport syndrome. ... ...

Abstract	In 1927, Arthur C. Alport first published his description of a triad of symptoms in a family with hereditary congenital haemorrhagic nephritis, deafness and ocular changes. A few years after his death, this group of symptoms was renamed Alport syndrome. To this day, Alport syndrome still inevitably leads to end-stage renal disease and the need for renal replacement therapy, starting in young adulthood. During the past two decades, research into this rare disease has focused on the effects of mutations in collagen type IV and the role of changes in podocytes and the glomerular basement membrane that lead to early kidney fibrosis. Animal models of Alport syndrome also demonstrate the pathogenetic importance of interactions between podocytes and the extracellular matrix. Such models might also help researchers to answer basic questions about podocyte function and the development of fibrosis, and to develop new therapeutic approaches that might be of use in other kidney diseases. In this Review, we discuss the latest basic and clinical research on Alport syndrome, focusing on the roles of podocyte pathology and the extracellular matrix. We also highlight early diagnosis and treatment options for young patients with this disorder.
Mesh-Begriff(e)	Animals ; Diagnosis, Differential ; Disease Progression ; Hearing Loss/etiology ; Humans ; Kidney/pathology ; Kidney/physiopathology ; Nephritis, Hereditary/complications ; Nephritis, Hereditary/diagnosis ; Nephritis, Hereditary/genetics ; Nephritis, Hereditary/pathology ; Nephritis, Hereditary/physiopathology ; Nephritis, Hereditary/therapy
Sprache	Englisch
Erscheinungsdatum	2012-11-20
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2490366-8
ISSN	1759-507X ; 1759-5061
ISSN (online)	1759-507X
ISSN	1759-5061
DOI	10.1038/nrneph.2012.259
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: New insights into cartilage repair - the role of migratory progenitor cells in osteoarthritis.

Gerter, Regina / Kruegel, Jenny / Miosge, Nicolai

Matrix biology : journal of the International Society for Matrix Biology

2012 Band 31, Heft 3, Seite(n) 206–213

Abstract: Osteoarthritis is one of the most common musculo-skeletal diseases with a complex patholoy and a strong impact on cell biology, differentiation and migration behavior of mesenchymal stem cell-derived progenitor cells. In this review, we elucidate the ... ...

Abstract	Osteoarthritis is one of the most common musculo-skeletal diseases with a complex patholoy and a strong impact on cell biology, differentiation and migration behavior of mesenchymal stem cell-derived progenitor cells. In this review, we elucidate the influence of the pathologically altered extracellular matrix on progenitor cell behavior. Moreover, we discuss the modulation of progenitor cells especially of previously characterized chondrogenic progenitor cells (Koelling et al., 2009) in situ to enhance their regeneration potential. These options comprise the application of growth factors like fibroblast growth factor-2, a Runx-2 knock down and a contemporary anti-inflammatory therapy. This supports endogenous regeneration on behalf of the diseased osteoarthritic cartilage, which otherwise results mainly in an insufficient fibro-cartilaginous repair tissue. Furthermore, new results indicate a role of pericytes in osteoarthritis for these repair attempts. We discuss the biological mechanisms potentially leading to new therapeutic options in osteoarthritis to enhance regeneration in situ.
Mesh-Begriff(e)	Cartilage Diseases/metabolism ; Cartilage Diseases/physiopathology ; Cartilage, Articular/metabolism ; Cartilage, Articular/physiology ; Cell Differentiation ; Cell Movement ; Chondrocytes/physiology ; Chondrocytes/transplantation ; Chondrogenesis ; Extracellular Matrix/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins ; Mesenchymal Stromal Cells/metabolism ; Mesenchymal Stromal Cells/physiology ; Osteoarthritis/physiopathology ; Pericytes/metabolism ; Pericytes/physiology ; Regeneration
Chemische Substanzen	Intercellular Signaling Peptides and Proteins
Sprache	Englisch
Erscheinungsdatum	2012-04
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Review
ZDB-ID	1183793-7
ISSN	1569-1802 ; 0945-053X
ISSN (online)	1569-1802
ISSN	0945-053X
DOI	10.1016/j.matbio.2012.01.007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Correction

Bettina S Buchmaier / Asima Bibi / Gerhard A Müller / Gry H Dihazi / Marwa Eltoweissy / Jenny Kruegel / Hassan Dihazi

PLoS ONE, Vol 13, Iss 5, p e

Renal Cells Express Different Forms of Vimentin: The Independent Expression Alteration of these Forms is Important in Cell Resistance to Osmotic Stress and Apoptosis.

2018 Band 0196935

Abstract: This corrects the article DOI:10.1371/journal.pone.0068301.]. ...

Abstract	[This corrects the article DOI:10.1371/journal.pone.0068301.].
Schlagwörter	Medicine ; R ; Science ; Q
Sprache	Englisch
Erscheinungsdatum	2018-01-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Tissue distribution of perlecan domains III and V during embryonic and fetal human development.

Roediger, Matthias / Kruegel, Jenny / Miosge, Nicolai / Gersdorff, Nikolaus

Histology and histopathology

2009 Band 24, Heft 7, Seite(n) 859–868

Abstract: A major component of basement membranes (BMs) is perlecan, a five-domain heparan sulphate proteoglycan. During murine embryogenesis, nearly all BMs of mesenchymal origin express perlecan, and it is believed to participate in the supramolecular assembly ... ...

Abstract	A major component of basement membranes (BMs) is perlecan, a five-domain heparan sulphate proteoglycan. During murine embryogenesis, nearly all BMs of mesenchymal origin express perlecan, and it is believed to participate in the supramolecular assembly of BMs. However, the distribution of perlecan in human embryonic and fetal tissues is widely unknown, except for cartilage anlagen of developing extremities and the fetal spine. Clinical syndromes, caused by perlecan-associated mutations or gene-defects, suggest its multifunctional involvement during human development. Here we reveal the immunohistochemistry of perlecan domains III and V during human development from gestational weeks (gw) 6 to 12 in basement membrane zones (BMZs) of the developing brain, nervous system, blood vessels, skin, lung, heart, kidney, liver, intestine and skeletal system. Interestingly, a difference in the distribution of the two perlecan domains was found in the endoneurium of ganglia. Domain III is strongly present from gw 6 onwards, while domain V shows attenuated expression at this stage and has been detected abundantly only from gw 8 onwards, possibly indicating vascularization of the endoneurium during this early stage. We found perlecan to be present particularly at those stages of human development where epithelial-mesenchymal interactions occur.
Mesh-Begriff(e)	Basement Membrane/embryology ; Basement Membrane/metabolism ; Fetal Development ; Heparan Sulfate Proteoglycans/chemistry ; Heparan Sulfate Proteoglycans/metabolism ; Humans ; Immunohistochemistry ; Protein Structure, Tertiary ; Tissue Distribution
Chemische Substanzen	Heparan Sulfate Proteoglycans ; perlecan (143972-95-6)
Sprache	Englisch
Erscheinungsdatum	2009
Erscheinungsland	Spain
Dokumenttyp	Journal Article
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-24.859
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilage.

Kruegel, Jenny / Sadowski, Boguslawa / Miosge, Nicolai

Arthritis and rheumatism

2008 Band 58, Heft 5, Seite(n) 1422–1432

Abstract: Objective: To investigate the presence and function of nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis (OA) cartilage.: Methods: The location and quantity of nidogen-1 and nidogen-2 protein and messenger RNA were ... ...

Abstract	Objective: To investigate the presence and function of nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis (OA) cartilage. Methods: The location and quantity of nidogen-1 and nidogen-2 protein and messenger RNA were determined in cartilage tissue obtained from healthy donors and from patients with late-stage knee OA. Samples were analyzed by immunohistochemistry, in situ hybridization, and real-time reverse transcription-polymerase chain reaction. Adhesion and inhibition assays, a pre-embedding method, fluorescence-activated cell sorting, and ultrastructural investigations with integrins were also carried out. Results: Developing tissue from human embryos showed strong staining for both nidogens in condensed mesenchyme and in rib anlagen. Homogeneous staining for nidogen-1 was observed in the extracellular matrix of healthy articular cartilage, whereas nidogen-2 was localized pericellularly. In late-stage OA cartilage, expression of nidogen-1 was decreased pericellularly around diseased chondrocytes, whereas nidogen-2 was increased. However, both nidogens had strongly increased levels around elongated chondrocytes, especially in areas of deep surface fissures. In vitro, both nidogens functioned as adhesion proteins for cells from the OA defect. In vivo, colocalizations with integrins alphav and beta1 as well as internalization of nidogens by chondrocytes in vitro were observed. Conclusion: Nidogens are involved in human limb development. They occur in healthy articular cartilage and show increased expression, primarily around elongated chondrocytes, in OA cartilage. Therefore, the activities of nidogens might be a sign of cartilage regeneration in late-stage OA. Furthermore, the adhesive character of nidogens, specifically as adhesion proteins for chondrocytes from late-stage OA, as well as the enhanced chondrocyte-nidogen interaction in OA indicate that both proteins play a key role in the pathogenesis of OA and either could be applied as a diagnostic marker.
Mesh-Begriff(e)	Cartilage, Articular/metabolism ; Cell Adhesion Molecules/biosynthesis ; Disease Progression ; Extracellular Matrix ; Humans ; Membrane Glycoproteins/biosynthesis ; Osteoarthritis/metabolism
Chemische Substanzen	Cell Adhesion Molecules ; Membrane Glycoproteins ; NID2 protein, human ; nidogen
Sprache	Englisch
Erscheinungsdatum	2008-05
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127294-9
ISSN	1529-0131 ; 0004-3591 ; 2326-5191
ISSN (online)	1529-0131
ISSN	0004-3591 ; 2326-5191
DOI	10.1002/art.23480
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Botulinum toxin: A noninvasive option for the symptomatic treatment of salivary gland stenosis - a case report.

Kruegel, Jenny / Winterhoff, Jan / Koehler, Sabrina / Matthes, Philipp / Laskawi, Rainer

Head & neck

2010 Band 32, Heft 7, Seite(n) 959–963

Abstract: Background: A man diagnosed with Stensen's duct stenosis exhibited recurrent parotid swelling, invariably during meals. Previous parotid duct dilations and percutaneous radiotherapy were ineffective. Botulinum toxin (BTX) injections were injected into ... ...

Abstract	Background: A man diagnosed with Stensen's duct stenosis exhibited recurrent parotid swelling, invariably during meals. Previous parotid duct dilations and percutaneous radiotherapy were ineffective. Botulinum toxin (BTX) injections were injected into the affected gland to regulate salivary flow and reduce parotid swelling. Methods: BTX (22.5 units) was injected into the affected gland. A second treatment with 30 units BTX was carried out 7 weeks later. Two further injections followed after 4 months, respectively. The results were scored by the patient and evaluated in an examination. Results: The patient reported the disappearance of parotid swelling after 2 weeks of injections. This effect was maintained for 5 weeks after the first treatment and for 4 months after the following 2 treatments. There were no side effects. Conclusion: Here we introduce BTX as a therapeutic option for the treatment of salivary duct stenosis when other therapies are ineffective and before opting for gland extirpation.
Mesh-Begriff(e)	Botulinum Toxins, Type A/therapeutic use ; Constriction, Pathologic/etiology ; Constriction, Pathologic/pathology ; Constriction, Pathologic/therapy ; Humans ; Male ; Middle Aged ; Neuromuscular Agents/therapeutic use ; Parotitis/complications ; Parotitis/drug therapy ; Parotitis/pathology ; Salivary Ducts
Chemische Substanzen	Neuromuscular Agents ; Botulinum Toxins, Type A (EC 3.4.24.69)
Sprache	Englisch
Erscheinungsdatum	2010-07
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.21150
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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