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  1. Artikel ; Online: Association Between Parental BMI and Offspring’s Blood Pressure by Mediation Analysis

    Hyowon Choi / Hunju Lee / Yeon-Soon Ahn

    Journal of Preventive Medicine and Public Health, Vol 56, Iss 6, Pp 533-

    A Study Using Data From the Korean National Health and Nutrition Examination Survey

    2023  Band 541

    Abstract: Objectives This study analyzed the relationship between parental body mass index (BMI; BMI_p) and hypertension in their adolescent offspring (HTN_a), focusing on the mediating effect of adolescents’ BMI (BMI_a). Methods Utilizing data from the Korea ... ...

    Abstract Objectives This study analyzed the relationship between parental body mass index (BMI; BMI_p) and hypertension in their adolescent offspring (HTN_a), focusing on the mediating effect of adolescents’ BMI (BMI_a). Methods Utilizing data from the Korea National Health and Nutrition Examination Survey, including participants aged 12-18, we conducted a mediation analysis while controlling for confounding factors such as age, sex, physical activity, dietary habits, household income quartile, and parents’ alcohol and smoking habits. Results The study included a total of 5731 participants, of whom 3381 and 5455 participants had data on fathers’ and mothers’ BMI, respectively. For adolescent systolic blood pressure (SBP_a), the father’s BMI (BMI_f) had a significant total effect (β, 0.23; 95% confidence interval [CI], 0.12 to 0.34) and average controlled mediated effect (ACME) (β, 0.27; 95% CI, 0.23 to 0.32), but the average direct effect (ADE) was not significant. The mother’s BMI (BMI_m) had a significant total effect (β, 0.17; 95% CI, 0.09 to 0.25), ACME (β, 0.25; 95% CI, 0.22 to 0.28) and ADE (β, -0.08; 95% CI, -0.16 to 0.00). For adolescent diastolic blood pressure, both BMI_f and BMI_m had significant ACMEs (β, 0.10; 95% CI, 0.08 to 0.12 and β, 0.09; 95% CI, 0.07 to 0.12, respectively), BMI_m had a significant ADE (β, -0.09; 95% CI, -0.16 to -0.02) but BMI_f had an insignificant ADE and total effect. Conclusions The study found that parental BMI had a significant effect on SBP_a, mediated through BMI_a. Therefore, a high BMI in parents could be a risk factor, mediated through BMI_a, for systolic hypertension in adolescents, necessitating appropriate management.
    Schlagwörter hypertension ; adolescent ; body mass index ; mediation analysis ; Medicine ; R ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag Korean Society for Preventive Medicine
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Non-planar graphene directly synthesized on intracavity optical microresonators for GHz repetition rate mode-locked lasers

    Oleksiy Kovalchuk / Sungjae Lee / Hyowon Moon / Andrea M. Armani / Yong-Won Song

    npj 2D Materials and Applications, Vol 8, Iss 1, Pp 1-

    2024  Band 9

    Abstract: Abstract Generation of high-speed laser pulses is essential for sustaining today’s global, hyper-connected society. One approach for achieving high spectral and temporal purity is to combine optical nonlinear materials with spectral filtering devices. In ...

    Abstract Abstract Generation of high-speed laser pulses is essential for sustaining today’s global, hyper-connected society. One approach for achieving high spectral and temporal purity is to combine optical nonlinear materials with spectral filtering devices. In this work, a graphene-coated microresonator integrates a nonlinear material and a spectral filtering platform into a single device, creating a tunable GHz repetition rate mode-locked fiber laser. The graphene is directly synthesized on the non-planar surface of microresonator, resulting in a uniform, conformal coating with minimal optical loss in the device. The whispering gallery modes of the resonator filter the propagating modes, and the remaining modes from the interaction with graphene lock their relative phases to form short pulses at an elevated repetition rate relying on inter-modal spectral distance. Additionally, by leveraging the photo-thermal effect, all-optical tuning of the repetition rate is demonstrated. With optimized device parameters, repetition rates of 150 GHz and tuning of 6.1 GHz are achieved.
    Schlagwörter Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 535
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Association Between Parental BMI and Offspring's Blood Pressure by Mediation Analysis: A Study Using Data From the Korean National Health and Nutrition Examination Survey.

    Choi, Hyowon / Lee, Hunju / Ahn, Yeon-Soon

    Journal of preventive medicine and public health = Yebang Uihakhoe chi

    2023  Band 56, Heft 6, Seite(n) 533–541

    Abstract: Objectives: This study analyzed the relationship between parental body mass index (BMI; BMI_p) and hypertension in their adolescent offspring (HTN_a), focusing on the mediating effect of adolescents' BMI (BMI_a).: Methods: Utilizing data from the ... ...

    Abstract Objectives: This study analyzed the relationship between parental body mass index (BMI; BMI_p) and hypertension in their adolescent offspring (HTN_a), focusing on the mediating effect of adolescents' BMI (BMI_a).
    Methods: Utilizing data from the Korea National Health and Nutrition Examination Survey, including participants aged 12-18, we conducted a mediation analysis while controlling for confounding factors such as age, sex, physical activity, dietary habits, household income quartile, and parents' alcohol and smoking habits.
    Results: The study included a total of 5731 participants, of whom 3381 and 5455 participants had data on fathers' and mothers' BMI, respectively. For adolescent systolic blood pressure (SBP_a), the father's BMI (BMI_f) had a significant total effect (β, 0.23; 95% confidence interval [CI], 0.12 to 0.34) and average controlled mediated effect (ACME) (β, 0.27; 95% CI, 0.23 to 0.32), but the average direct effect (ADE) was not significant. The mother's BMI (BMI_m) had a significant total effect (β, 0.17; 95% CI, 0.09 to 0.25), ACME (β, 0.25; 95% CI, 0.22 to 0.28) and ADE (β, -0.08; 95% CI, -0.16 to 0.00). For adolescent diastolic blood pressure, both BMI_f and BMI_m had significant ACMEs (β, 0.10; 95% CI, 0.08 to 0.12 and β, 0.09; 95% CI, 0.07 to 0.12, respectively), BMI_m had a significant ADE (β, -0.09; 95% CI, -0.16 to -0.02) but BMI_f had an insignificant ADE and total effect.
    Conclusions: The study found that parental BMI had a significant effect on SBP_a, mediated through BMI_a. Therefore, a high BMI in parents could be a risk factor, mediated through BMI_a, for systolic hypertension in adolescents, necessitating appropriate management.
    Mesh-Begriff(e) Female ; Adolescent ; Humans ; Body Mass Index ; Blood Pressure ; Nutrition Surveys ; Parents ; Hypertension/epidemiology ; Republic of Korea/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2023-10-30
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2620879-9
    ISSN 2233-4521 ; 2233-4521
    ISSN (online) 2233-4521
    ISSN 2233-4521
    DOI 10.3961/jpmph.23.289
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A flexible, thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording.

    Lim, Jongcheon / Zoss, Peter A / Powley, Terry L / Lee, Hyowon / Ward, Matthew P

    Microsystems & nanoengineering

    2024  Band 10, Seite(n) 16

    Abstract: The vagus nerve (VN) plays an important role in regulating physiological conditions in the gastrointestinal (GI) tract by communicating via the parasympathetic pathway to the enteric nervous system (ENS). However, the lack of knowledge in the ... ...

    Abstract The vagus nerve (VN) plays an important role in regulating physiological conditions in the gastrointestinal (GI) tract by communicating via the parasympathetic pathway to the enteric nervous system (ENS). However, the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the VN. To better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology, it is necessary to use an advanced device enabled by microfabrication technologies. Among several candidates including intraneural probe array and extraneural cuff electrodes, microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel structures. Previous microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200 µm. The thick design can potentially harm the delicate tissue structures, including the nerve itself. In this paper, we present a flexible thin film based microchannel electrode array device (thickness: 11.5 µm) that can interface with one of the subdiaphragmatic nerve branches of the VN in a rat. We demonstrated recording evoked compound action potentials (ECAP) from a transected nerve ending that has multiple nerve fibers. Moreover, our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.
    Sprache Englisch
    Erscheinungsdatum 2024-01-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2055-7434
    ISSN (online) 2055-7434
    DOI 10.1038/s41378-023-00637-6
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  5. Artikel ; Online: A CRISPR/Cas12 trans-cleavage reporter enabling label-free colorimetric detection of SARS-CoV-2 and its variants.

    Kim, Hansol / Jang, Hyowon / Song, Jayeon / Lee, Sang Mo / Lee, Seoyoung / Kwon, Hyung-Jun / Kim, Sunjoo / Kang, Taejoon / Park, Hyun Gyu

    Biosensors & bioelectronics

    2024  Band 251, Seite(n) 116102

    Abstract: We present a label-free colorimetric CRISPR/Cas-based method enabling affordable molecular diagnostics for SARS-CoV-2. This technique utilizes 3,3'-diethylthiadicarbocyanine iodide ( ... ...

    Abstract We present a label-free colorimetric CRISPR/Cas-based method enabling affordable molecular diagnostics for SARS-CoV-2. This technique utilizes 3,3'-diethylthiadicarbocyanine iodide (DISC
    Mesh-Begriff(e) Humans ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; CRISPR-Cas Systems/genetics ; Colorimetry ; RNA, Viral ; Biosensing Techniques ; Adenine ; Nucleic Acid Amplification Techniques
    Chemische Substanzen RNA, Viral ; Adenine (JAC85A2161)
    Sprache Englisch
    Erscheinungsdatum 2024-02-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2024.116102
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  6. Artikel ; Online: Flow Analysis of PM/NO X Aftertreatment System for Emergency Generator

    Giyoung Park / Hyowon Bang / Seangwock Lee

    Applied Sciences, Vol 12, Iss 4404, p

    2022  Band 4404

    Abstract: Emergency generators normally use diesel engines. The generators need to conduct weekly no-load operation inspections to ensure stable performance in emergency situations. In particular, the generators with large diesel engines mainly use rectangle-type ... ...

    Abstract Emergency generators normally use diesel engines. The generators need to conduct weekly no-load operation inspections to ensure stable performance in emergency situations. In particular, the generators with large diesel engines mainly use rectangle-type filter substrates. To minimize hazardous emissions generated by generators, optimizing the reduction efficiency through computational fluid dynamics (CFD) analysis of flow characteristics of particulate matter (PM)/NO X reduction system is important. In this study, we analyzed internal flow by CFD, which is difficult to confirm by experimental method. The main factors in our numerical study are the changes of flow uniformity and back pressure. As a result, the flow distribution characteristics according to the cross-sectional shape are similar at high engine loads. Spraying urea in the reverse direction increases static pressure, greatly improving flow uniformity. Raising the selective catalyst reduction (SCR) diffuser angle to 30 degrees improves both back pressure and flow uniformity characteristics, and when the porosity increases, both flow uniformity and back pressure decrease.
    Schlagwörter emergency generator ; aftertreatment system ; CFD (computational fluid dynamics) ; uniformity index ; porosity ; DPF (diesel particulate filter) ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 532 ; 621
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Complete genome sequence of tulip virus X, a Korean isolate from

    Bak, Sangmin / Jeong, Hyowon / Son, Su-Jin / Kim, Minseok / Lim, Taegun / Lee, Su-Heon

    Microbiology resource announcements

    2023  Band 13, Heft 1, Seite(n) e0094823

    Abstract: In this study, the presence of tulip virus X (TVX) in Korean tulips was confirmed through high-throughput RNA sequencing. Its complete genome sequence of 6,056 nucleotides was determined via Sanger sequencing, exhibiting a 99.24% nucleotide identity with ...

    Abstract In this study, the presence of tulip virus X (TVX) in Korean tulips was confirmed through high-throughput RNA sequencing. Its complete genome sequence of 6,056 nucleotides was determined via Sanger sequencing, exhibiting a 99.24% nucleotide identity with TVX-J isolate. This signifies a previously unreported presence of TVX outside Japan.
    Sprache Englisch
    Erscheinungsdatum 2023-12-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00948-23
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  8. Artikel ; Online: Publisher Correction: Biporous silica nanostructure-induced nanovortex in microfluidics for nucleic acid enrichment, isolation, and PCR-free detection.

    Jeon, Eunyoung / Koo, Bonhan / Kim, Suyeon / Kim, Jieun / Yu, Yeonuk / Jang, Hyowon / Lee, Minju / Kim, Sung-Han / Kang, Taejoon / Kim, Sang Kyung / Kwak, Rhokyun / Shin, Yong / Lee, Joonseok

    Nature communications

    2024  Band 15, Heft 1, Seite(n) 1993

    Sprache Englisch
    Erscheinungsdatum 2024-03-05
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46401-w
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  9. Artikel: Association between loneliness and cognitive function, and brain volume in community-dwelling elderly.

    Lee, Hunju / Yong, Sang Yeol / Choi, Hyowon / Yoon, Ga Young / Koh, Sangbaek

    Frontiers in aging neuroscience

    2024  Band 16, Seite(n) 1389476

    Abstract: Introduction: We investigated the relationship between loneliness, cognitive impairment, and regional brain volume among elderly individuals residing in the Korean community.: Methods: Data from the ARIRANG aging-cognition sub-cohort, collected ... ...

    Abstract Introduction: We investigated the relationship between loneliness, cognitive impairment, and regional brain volume among elderly individuals residing in the Korean community.
    Methods: Data from the ARIRANG aging-cognition sub-cohort, collected between 2020 and 2022, were utilized for the present study. Loneliness was assessed using the UCLA-Loneliness Scale (UCLA-LS) questionnaire and the relevant item from Center for Epidemiologic Studies Depression Scale Korean version (CES-D-K). Cognitive impairment was measured through Mini-Mental State Examination (K-MMSE-2) and Seoul Neuropsychological Screening Battery (SNSB-C), with five sub-categories: attention, memory, visuospatial function, language, and executive function. Logistic regression was employed for prevalence ratios related to cognitive impairment, while linear regression was used for regional brain volume including white matter hyperintensity (WMH) and cortical thickness.
    Results: Our analysis involved 785 participants (292 men and 493 women). We observed increased cognitive impairment assessed by K-MMSE-2 [UCLA-LS: odds ratio (OR) 3.133, 95% confidence interval (CI) 1.536-6.393; loneliness from CES-D: OR 2.823, 95% CI 1.426-5.590] and SNSB-C total score (UCLA-LS: OR 2.145, 95% CI 1.304-3.529) in the lonely group compared to the non-lonely group. Specifically, the lonely group identified by UCLA-LS showed an association with declined visuospatial (OR 1.591, 95% CI 1.029-2.460) and executive function (OR 1.971, 95% CI 1.036-3.750). The lonely group identified by CES-D-K was associated with impaired memory (OR 1.577, 95% CI 1.009-2.466) and executive function (OR 1.863, 95% CI 1.036-3.350). In the regional brain volume analysis, loneliness was linked to reduced brain volume in frontal white matter (left: -1.24, 95% CI -2.37 ∼-0.12; right: -1.16, 95% CI -2.31 ∼ -0.00), putamen (left: -0.07, 95% CI -0.12 ∼-0.02; right: -0.06, 95% CI -0.11 ∼-0.01), and globus pallidus (-15.53, 95% CI -30.13 ∼-0.93). There was no observed association in WMH and cortical thickness.
    Conclusion: Loneliness is associated with cognitive decline and volumetric reduction in the frontal white matter, putamen, and globus pallidus.
    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2024.1389476
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  10. Artikel ; Online: Trends in the effects of socioeconomic position on physical activity levels and sedentary behavior among Korean adolescents.

    Lee, Hunju / Choi, Hyowon / Koh, Sang Baek / Kim, Hyeon Chang

    Epidemiology and health

    2023  Band 45, Seite(n) e2023085

    Abstract: Objectives: We examined trends in physical activity and sedentary behavior in Korean adolescents, and their association with socioeconomic position (SEP).: Methods: We used data from the Korea Youth Risk Behavior Survey, a nationwide study involving ... ...

    Abstract Objectives: We examined trends in physical activity and sedentary behavior in Korean adolescents, and their association with socioeconomic position (SEP).
    Methods: We used data from the Korea Youth Risk Behavior Survey, a nationwide study involving students aged 12-19 conducted between 2009 and 2021. SEP was assessed based on economic status, parental education attainment, and urbanization. Physical activity was categorized into vigorous physical activity, moderate physical activity, and muscle training, and sedentary time was also measured. We conducted the log-binomial regression to calculate prevalence ratios (PRs) and prevalence differences.
    Results: Our analysis included a total of 593,896 students. We observed an increasing trend in physical activity, but a worsening trend in sedentary behavior. A positive association was found between an adolescent's physical activity and SEP indicators, except for urbanization. Adolescents with higher economic status engaged in more vigorous physical activity (high: PR, 1.26; 95% confidence interval [CI], 1.25 to 1.28; middle: PR, 1.03; 95% CI, 1.02 to 1.04). Similar associations were observed for father's education (tertiary or above: PR, 1.11; 95% CI, 1.09 to 1.13; upper secondary: PR, 1.05; 95% CI, 1.03 to 1.07) and mother's education (tertiary or above: PR, 1.17; 95% CI, 1.15 to 1.20; upper secondary: PR, 1.06; 95% CI, 1.04 to 1.08). Adolescents with higher economic status also showed a higher compliance rate with the guideline restricting sedentary time to 2 hours per day (high: PR, 1.28; 95% CI, 1.25 to 1.30; middle: PR, 1.03; 95% CI, 1.01 to 1.05).
    Conclusions: Adolescents with higher SEP exhibited more physical activity and less sedentary time than those with lower SEP.
    Mesh-Begriff(e) Humans ; Adolescent ; Sedentary Behavior ; Exercise ; Socioeconomic Factors ; Educational Status ; Republic of Korea/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2023-09-08
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2590698-7
    ISSN 2092-7193 ; 2092-7193
    ISSN (online) 2092-7193
    ISSN 2092-7193
    DOI 10.4178/epih.e2023085
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