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  1. Artikel: Bidirectional Effects of Mao Jian Green Tea and Its Flavonoid Glycosides on Gastrointestinal Motility.

    Wu, Lei / Jin, Xiang / Zheng, Canwen / Ma, Fengjing / Zhang, Xue / Gao, Pengfei / Gao, Jianhua / Zhang, Liwei

    Foods (Basel, Switzerland)

    2023  Band 12, Heft 4

    Abstract: Mao Jian Tea (MJT) has been generally consumed as a digestive aid for more than a hundred years ... investigated the effect of Mao Jian Green Tea (MJGT) on gastrointestinal motility. The biphasic effects ...

    Abstract Mao Jian Tea (MJT) has been generally consumed as a digestive aid for more than a hundred years in the Shanxi province of China. However, determination of its efficacy still remains elusive. This study investigated the effect of Mao Jian Green Tea (MJGT) on gastrointestinal motility. The biphasic effects of the hydro extracts of MJGT on gastric emptying and small intestinal propulsion of rats were identified in vivo; namely, the low (MJGT_L) and medium (MJGT_M) concentrations promoted gastrointestinal motility (
    Sprache Englisch
    Erscheinungsdatum 2023-02-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12040854
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A comprehensive review of the classical prescription Yiguan Jian: Phytochemistry, quality control, clinical applications, pharmacology, and safety profile.

    Lu, Changcheng / Zhang, Siyuan / Lei, Si San / Wang, Danni / Peng, Bo / Shi, Ruipeng / Chong, Cheong-Meng / Zhong, Zhangfeng / Wang, Yitao

    Journal of ethnopharmacology

    2023  Band 319, Heft Pt 2, Seite(n) 117230

    Abstract: Ethnopharmacological relevance: Yiguan Jian (YGJ) is a classical prescription, which employs 6 ...

    Abstract Ethnopharmacological relevance: Yiguan Jian (YGJ) is a classical prescription, which employs 6 kinds of medicinal herbs including Rehmanniae Radix, Lycii Fructus, Angelicae sinensis Radix, Glehniae Radix, Ophiopogonis Radix, and Toosendan Fructus. YGJ decoction is originally prescribed in Qing Dynasty (1636 CE ∼ 1912 CE) in China, and is commonly used to treat liver diseases. There remain abundant literature investigating YGJ decoction from multiple aspects, but few reviews summarized the research and gave a precise definition, which impedes further applications and commercialization of YGJ decoction.
    Aim of the review: The aim of this review is to provide comprehensive descriptions of YGJ decoction, tackling with issues in the research and development of YGJ decoction.
    Materials and methods: The literature and clinical reports were obtained from the databases including Web of Science, Science Direct, PubMed, Google Scholar, China National Knowledge Infrastructure, China Science Periodical Database, China Science and Technology Journal Database, and SinoMed since 2000. The phytochemical characteristics, quality control, pharmaceutical forms, clinical position, pharmacological effects, and toxic events of YGJ decoction were included for analysis.
    Result: This review firstly summarized the progress of the chemical existences of YGJ decoction and discussed the advanced methods in monitoring quality of YGJ decoction and its herbal ingredients, particularly in the form of granules. Whilst this review aims to identify the pharmacological actions and clinical impacts of YGJ decoction, the medicinal materials that could provide these benefits were observed in the remaining herbs to exert the anti-fibrotic effects, anti-inflammatory activities, anti-cancer, and anti-diabetic effects, and to universally treat liver and gastric diseases. This review provided supplementary descriptions on the safety issues, especially in Glehniae Radix and Toosendan Fructus, to define the alterations between hepatoprotective activities and unclear toxics in YGJ decoction application.
    Conclusions: Our comprehensively organized review discussed the chemical characteristics and the research in altering or identifying these essences. The effects of YGJ decoction on the non-clinical and clinical tests exert the good management of sophisticated diseases. In this review, current issues are discussed to inform and inspire subsequent research of YGJ decoction and other classical prescriptions.
    Mesh-Begriff(e) Medicine, Chinese Traditional ; Drugs, Chinese Herbal/adverse effects ; Quality Control ; Phytochemicals/pharmacology
    Chemische Substanzen yiguan ; rehmannia root (1BEM3U6LQQ) ; Drugs, Chinese Herbal ; Phytochemicals
    Sprache Englisch
    Erscheinungsdatum 2023-09-29
    Erscheinungsland Ireland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117230
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  3. Artikel: Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway.

    Wu, Lei / Gao, Liming / Jin, Xiang / Chen, Zhikang / Qiao, Xutong / Cui, Xiting / Gao, Jianhua / Zhang, Liwei

    Foods (Basel, Switzerland)

    2023  Band 12, Heft 5

    Abstract: In a previous study, we demonstrated that the hydro extract of Mao Jian Green Tea (MJGT) promotes ...

    Abstract In a previous study, we demonstrated that the hydro extract of Mao Jian Green Tea (MJGT) promotes gastrointestinal motility. In this study, the effect of MJGT ethanol extract (MJGT_EE) in treating irritable bowel syndrome with constipation (IBS-C) in a rat model constructed via maternal separation combined with an ice water stimulation was investigated. First, a successful model construction was confirmed through the determination of the fecal water content (FWC) and the smallest colorectal distension (CRD) volume. Then, the overall regulatory effects of MJGT_EE on the gastrointestinal tract were preliminarily evaluated through gastric emptying and small intestinal propulsion tests. Our findings indicated that MJGT_EE significantly increased FWC (
    Sprache Englisch
    Erscheinungsdatum 2023-03-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12051101
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Jin-Wu-Jian-Gu Formulation Attenuates Rheumatoid Arthritis by Inhibiting the IL33-ST2 Signaling Pathway.

    Lu, Daomin / Huang, Ying / Ma, Wukai / Chen, Changming / Hou, Lei

    Evidence-based complementary and alternative medicine : eCAM

    2022  Band 2022, Seite(n) 6821388

    Abstract: The present research attempted to investigate the molecular mechanism of Jin-Wu-Jian-Gu Formulation ...

    Abstract The present research attempted to investigate the molecular mechanism of Jin-Wu-Jian-Gu Formulation (JWJGF) in inhibiting rheumatoid arthritis (RA) in a pharmacological approach for analysis and experimental validation. First, the potential targets and pathways of JWJGF for RA were predicted by network pharmacology. Second, the effect of JWJGF on RA was observed by hematoxylin-eosin (HE) staining and enzyme-linked immunosorbent assay (ELISA). Further, we observed the effects of JWJGF on the IL33-ST2 signaling pathway by Western blot and quantitative real-time PCR (qPCR) experiments, and finally, we studied the effects of Liquiritigenin on rheumatoid arthritis synovial fibroblast (RASF) cells and the IL33-ST2 signaling pathway. Network pharmacology results showed that the key component of JWJGF was Liquiritigenin and the core target of JWJGF was IL-33. The results of HE and ELISA showed that JWJGF could alleviate RA. Western blot and qPCR findings indicated that JWJGF could inhibit the IL33-ST2 signaling pathway. Furthermore, JWJGF could inhibit the proliferation of RASF cells and the IL33-ST2 signaling pathway. In conclusion, this study revealed that JWJGF attenuated RA by inhibiting the IL33-ST2 signaling pathway.
    Sprache Englisch
    Erscheinungsdatum 2022-01-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/6821388
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Bidirectional Effects of Mao Jian Green Tea and Its Flavonoid Glycosides on Gastrointestinal Motility

    Wu, Lei / Jin, Xiang / Zheng, Canwen / Ma, Fengjing / Zhang, Xue / Gao, Pengfei / Gao, Jianhua / Zhang, Liwei

    Foods. 2023 Feb. 16, v. 12, no. 4

    2023  

    Abstract: Mao Jian Tea (MJT) has been generally consumed as a digestive aid for more than a hundred years ... investigated the effect of Mao Jian Green Tea (MJGT) on gastrointestinal motility. The biphasic effects ...

    Abstract Mao Jian Tea (MJT) has been generally consumed as a digestive aid for more than a hundred years in the Shanxi province of China. However, determination of its efficacy still remains elusive. This study investigated the effect of Mao Jian Green Tea (MJGT) on gastrointestinal motility. The biphasic effects of the hydro extracts of MJGT on gastric emptying and small intestinal propulsion of rats were identified in vivo; namely, the low (MJGT_L) and medium (MJGT_M) concentrations promoted gastrointestinal motility (p < 0.05), whereas the high concentration (MJGT_H) showed the opposite effect (p < 0.01). The expression levels of the gastric hormones, GAS, MTL and VIP (p < 0.05) were consistent with the gastrointestinal motility variation, with the exception of MTL in MJGT_H group (p > 0.01). Two flavonoids, eriodictyol (0.152 mg/mL) and luteolin (0.034 mg/mL), and the corresponding glycosides eriodictyol-7-O-glucoside (0.637 mg/mL) and luteolin-7-O-glucoside (0.216 mg/mL), dominated the hydro extracts identified by HPLC and UPLC-ESI-MS. These compounds can regulate the muscle strip contractions isolated from the gastrointestinal tissues. Additionally, the different concentrations also influenced the gut microbiota accordingly characterized by 16S rDNA gene sequencing. The MJGT_L boosted several probiotic bacteria, such as Muribaculaceae (1.77-fold), Prevotellaceae (1.85-fold) and Lactobacillaceae (2.47-fold), and suppressed the pathogenic species such as Staphylococcaceae (0.03-fold) that, conversely, was enriched in the MJGT_H group (1.92-fold). Therefore, the biphasic effect indicated that the dosage of the herbal tea should not be overlooked.
    Schlagwörter Lactobacillaceae ; Staphylococcaceae ; gastrointestinal motility ; genes ; glycosides ; green tea ; herbal tea ; intestinal microorganisms ; intestines ; luteolin ; muscles ; probiotics ; China
    Sprache Englisch
    Erscheinungsverlauf 2023-0216
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel ; Online
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12040854
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel: Dietary Taraxacum mongolicum polysaccharide ameliorates the growth, immune response, and antioxidant status in association with NF-κB, Nrf2 and TOR in Jian carp (Cyprinus carpio var. Jian)

    Yu, Zhe / Zhao, Lei / Zhao, Jun-Liang / Xu, Wanxin / Guo, Zehao / Zhang, Ai-Zhong / Li, Mu-Yang

    Aquaculture. 2022 Jan. 30, v. 547

    2022  

    Abstract: ... the NF-κB, Nrf2 and TOR signalling pathway-related genes in Jian carp. The juvenile fish were randomly ... signalling pathway-related genes in Jian carp. ...

    Abstract Taraxacum mongolicum polysaccharide (TMP) is a highly effective anti-inflammatory and antioxidant agent, but it has not been studied in aquatic feed. Here, the objective of this study was to evaluate the effects of dietary TMP on the growth, digestive enzyme activity, immune response, antioxidant status, and the NF-κB, Nrf2 and TOR signalling pathway-related genes in Jian carp. The juvenile fish were randomly distributed into four groups according to the TMP concentrations (0, 0.5, 1.0 and 2.0 g/kg) for 56 days. Our results indicated that the growth, enzyme activity and immune factors in fish increased in a concentration-dependent manner, and the dietary supplementation with TMP (1.0 g/kg) increased the WG, SGR, PER, amylase, lipase and protease activity. Meanwhile, the serum immune response (except for ACP) and hepatopancreas antioxidant enzyme activity were positively regulated by TMP. However, MDA, PC, COR and LDH contents were negatively correlated with the dietary supplementation with TMP. Furthermore, the trend in the expression of genes related to the NF-κB, Nrf2 and TOR signalling pathways were similar to that of the enzyme activity, which increased with the increase in dietary supplementation with TMP (except for proinflammatory factors, tgf-β and keap1). Among them, il-10, il-2, ho-1, nrf2, sod-(Cu-Zn) and gpx showed sharp increases. These results elucidate that dietary supplementation with TMP may greatly ameliorate the growth, digestive enzyme activity, immune response and antioxidant status and regulate the expression of NF-κB, Nrf2 and TOR signalling pathway-related genes in Jian carp.
    Schlagwörter Cyprinus carpio ; Taraxacum mongolicum ; amylases ; antioxidant enzymes ; aquaculture ; blood serum ; carboxylic ester hydrolases ; carp ; dietary supplements ; digestive enzymes ; enzyme activity ; hepatopancreas ; immune response ; interleukin-10 ; interleukin-2 ; juveniles ; polysaccharides
    Sprache Englisch
    Erscheinungsverlauf 2022-0130
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 185380-6
    ISSN 0044-8486 ; 0044-8516
    ISSN 0044-8486 ; 0044-8516
    DOI 10.1016/j.aquaculture.2021.737522
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway

    Wu, Lei / Gao, Liming / Jin, Xiang / Chen, Zhikang / Qiao, Xutong / Cui, Xiting / Gao, Jianhua / Zhang, Liwei

    Foods. 2023 Mar. 04, v. 12, no. 5

    2023  

    Abstract: In a previous study, we demonstrated that the hydro extract of Mao Jian Green Tea (MJGT) promotes ...

    Abstract In a previous study, we demonstrated that the hydro extract of Mao Jian Green Tea (MJGT) promotes gastrointestinal motility. In this study, the effect of MJGT ethanol extract (MJGT_EE) in treating irritable bowel syndrome with constipation (IBS-C) in a rat model constructed via maternal separation combined with an ice water stimulation was investigated. First, a successful model construction was confirmed through the determination of the fecal water content (FWC) and the smallest colorectal distension (CRD) volume. Then, the overall regulatory effects of MJGT_EE on the gastrointestinal tract were preliminarily evaluated through gastric emptying and small intestinal propulsion tests. Our findings indicated that MJGT_EE significantly increased FWC (p < 0.01) and the smallest CRD volume (p < 0.05) and promoted gastric emptying and small intestinal propulsion (p < 0.01). Furthermore, mechanistically, MJGT_EE reduced intestinal sensitivity by regulating the expression of proteins related to the serotonin (5-hydroxytryptamine; 5-HT) pathway. More specifically, it decreased tryptophan hydroxylase (TPH) expression (p < 0.05) and increased serotonin transporter (SERT) expression (p < 0.05), thereby decreasing 5-HT secretion (p < 0.01), activating the calmodulin (CaM)/myosin light chain kinase (MLCK) pathway, and increasing 5-HT₄ receptor (5-HT₄R) expression (p < 0.05). Moreover, MJGT_EE enhanced the diversity of gut microbiota, increased the proportion of beneficial bacteria, and regulated the number of 5-HT-related bacteria. Flavonoids may play the role of being active ingredients in MJGT_EE. These findings suggest that MJGT_EE could serve as a potential therapeutic pathway for IBS-C.
    Schlagwörter animal models ; calmodulin ; constipation ; digestive tract ; ethanol ; flavonoids ; gastrointestinal motility ; green tea ; ice ; intestinal microorganisms ; intestines ; irritable bowel syndrome ; secretion ; serotonin ; therapeutics ; tryptophan ; water content
    Sprache Englisch
    Erscheinungsverlauf 2023-0304
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel ; Online
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12051101
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Jin-Wu-Jian-Gu Formulation Attenuates Rheumatoid Arthritis by Inhibiting the IL33-ST2 Signaling Pathway

    Daomin Lu / Ying Huang / Wukai Ma / Changming Chen / Lei Hou

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Band 2022

    Abstract: The present research attempted to investigate the molecular mechanism of Jin-Wu-Jian-Gu Formulation ...

    Abstract The present research attempted to investigate the molecular mechanism of Jin-Wu-Jian-Gu Formulation (JWJGF) in inhibiting rheumatoid arthritis (RA) in a pharmacological approach for analysis and experimental validation. First, the potential targets and pathways of JWJGF for RA were predicted by network pharmacology. Second, the effect of JWJGF on RA was observed by hematoxylin-eosin (HE) staining and enzyme-linked immunosorbent assay (ELISA). Further, we observed the effects of JWJGF on the IL33-ST2 signaling pathway by Western blot and quantitative real-time PCR (qPCR) experiments, and finally, we studied the effects of Liquiritigenin on rheumatoid arthritis synovial fibroblast (RASF) cells and the IL33-ST2 signaling pathway. Network pharmacology results showed that the key component of JWJGF was Liquiritigenin and the core target of JWJGF was IL-33. The results of HE and ELISA showed that JWJGF could alleviate RA. Western blot and qPCR findings indicated that JWJGF could inhibit the IL33-ST2 signaling pathway. Furthermore, JWJGF could inhibit the proliferation of RASF cells and the IL33-ST2 signaling pathway. In conclusion, this study revealed that JWJGF attenuated RA by inhibiting the IL33-ST2 signaling pathway.
    Schlagwörter Other systems of medicine ; RZ201-999
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Huang Bai Jian Pi decoction alleviates diarrhea and represses inflammatory injury via PI3K/Akt/NF-κB pathway: In vivo and in vitro studies.

    Yan, Zunxiang / Zhang, Kai / Zhang, Kang / Wang, Guibo / Wang, Lei / Zhang, Jingyan / Qiu, Zhengying / Guo, Zhiting / Kang, Yandong / Song, Xiaoping / Li, Jianxi

    Journal of ethnopharmacology

    2022  Band 292, Seite(n) 115212

    Abstract: Ethnopharmacological relevance: Huang Bai Jian Pi (HBJP) decoction, a Chinese herbal formula based ...

    Abstract Ethnopharmacological relevance: Huang Bai Jian Pi (HBJP) decoction, a Chinese herbal formula based on the Pulsatilla decoction (PD) and Si Junzi decoction, is efficacy to treat clinical diarrhea in calves.
    Aim of the study: The mechanism of HBJP decoction to treat calf diarrhea remains unclear. This study was to investigate the therapeutic effect and anti-inflammatory mechanism of HBJP decoction on diarrhea in rats.
    Materials and methods: Thirty-six Sprague Dawley rats were randomly divided into control group, model group, PD group and three treated groups with HBJP decoction. The diarrheal model in rats was established by multiple factors including high-sugar and fat diet, high temperature and dampness environment, biological pathogenic factors. The diarrheal animals were treated with HBJP decoction or PD for 5 days. The inflammatory model of the intestinal epithelioid cell line 6 (IEC-6) was induced by TNF-α. The clinical symptoms, blood routine and biochemistry parameters, histopathology of main organs were detected. The proteins associated with PI3K/Akt/NF-κB pathway and the expression levels of cytokines associated with inflammation were detected in vivo and in vitro by Western blot and ELISA.
    Results: The model rats showed obvious diarrheal symptoms, and the obvious systemic inflammatory response accompanied with abnormal change in blood routine, biochemistry parameters and histopathology. HBJP decoction alleviated obviously the clinical symptoms, and pathological changes of the liver, colon and lung, and abnormal blood routine and biochemistry indexes in rats. The expression of P-PI3K, P-Akt, P-NF-κB, IL-1β, IL-6 was significantly increased, and the expression of IL-10 was markedly decreased in diarrheal rats and IEC-6 with inflammation. HBJP decoction significantly inhibited the PI3K/AKT/NF-κB signal pathway and adjusted the expression of these inflammatory cytokines.
    Conclusions: The finding suggested that HBJP decoction alleviate the inflammation in diarrhea through inhibiting the PI3K/Akt/NF-κB signal pathway, which provides scientific evidences for the clinical application of HBJP decoction in diarrhea.
    Mesh-Begriff(e) Animals ; Cattle ; Cytokines ; Diarrhea/drug therapy ; Drugs, Chinese Herbal ; Inflammation/drug therapy ; NF-kappa B/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley
    Chemische Substanzen Cytokines ; Drugs, Chinese Herbal ; NF-kappa B ; huangbai ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2022-03-22
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115212
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Huang Bai Jian Pi decoction alleviates diarrhea and represses inflammatory injury via PI3K/Akt/NF-κB pathway: In vivo and in vitro studies

    Yan, Zunxiang / Zhang, Kai / Zhang, Kang / Wang, Guibo / Wang, Lei / Zhang, Jingyan / Qiu, Zhengying / Guo, Zhiting / Kang, Yandong / Song, Xiaoping / Li, Jianxi

    Journal of ethnopharmacology. 2022 June 28, v. 292

    2022  

    Abstract: Huang Bai Jian Pi (HBJP) decoction, a Chinese herbal formula based on the Pulsatilla decoction (PD ...

    Abstract Huang Bai Jian Pi (HBJP) decoction, a Chinese herbal formula based on the Pulsatilla decoction (PD) and Si Junzi decoction, is efficacy to treat clinical diarrhea in calves. The mechanism of HBJP decoction to treat calf diarrhea remains unclear. This study was to investigate the therapeutic effect and anti-inflammatory mechanism of HBJP decoction on diarrhea in rats. Thirty-six Sprague Dawley rats were randomly divided into control group, model group, PD group and three treated groups with HBJP decoction. The diarrheal model in rats was established by multiple factors including high-sugar and fat diet, high temperature and dampness environment, biological pathogenic factors. The diarrheal animals were treated with HBJP decoction or PD for 5 days. The inflammatory model of the intestinal epithelioid cell line 6 (IEC-6) was induced by TNF-α. The clinical symptoms, blood routine and biochemistry parameters, histopathology of main organs were detected. The proteins associated with PI3K/Akt/NF-κB pathway and the expression levels of cytokines associated with inflammation were detected in vivo and in vitro by Western blot and ELISA. The model rats showed obvious diarrheal symptoms, and the obvious systemic inflammatory response accompanied with abnormal change in blood routine, biochemistry parameters and histopathology. HBJP decoction alleviated obviously the clinical symptoms, and pathological changes of the liver, colon and lung, and abnormal blood routine and biochemistry indexes in rats. The expression of P-PI3K, P-Akt, P–NF-κB, IL-1β, IL-6 was significantly increased, and the expression of IL-10 was markedly decreased in diarrheal rats and IEC-6 with inflammation. HBJP decoction significantly inhibited the PI3K/AKT/NF-κB signal pathway and adjusted the expression of these inflammatory cytokines. The finding suggested that HBJP decoction alleviate the inflammation in diarrhea through inhibiting the PI3K/Akt/NF-κB signal pathway, which provides scientific evidences for the clinical application of HBJP decoction in diarrhea.
    Schlagwörter Pulsatilla ; Western blotting ; blood ; calves ; cell lines ; colon ; diarrhea ; diet ; histopathology ; inflammation ; interleukin-10 ; interleukin-6 ; liver ; lungs ; models ; signal transduction ; temperature ; therapeutics ; traditional medicine
    Sprache Englisch
    Erscheinungsverlauf 2022-0628
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115212
    Datenquelle NAL Katalog (AGRICOLA)

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