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  1. Artikel ; Online: Reply to Baylis et al., "External Quality Assessment (EQA) of Molecular Detection of Zika Virus: Value of the 1st World Health Organization International Standard".

    Reusken, Chantal B / Charrel, Remi

    Journal of clinical microbiology

    2018  Band 56, Heft 3

    Mesh-Begriff(e) Humans ; World Health Organization ; Zika Virus ; Zika Virus Infection
    Sprache Englisch
    Erscheinungsdatum 2018-02-22
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.02023-17
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Response to letter of concern by Oladimeji and Pickford of PrimerDesign.

    van Kasteren, Puck B / van der Veer, Bas / Reusken, Chantal B E M / Meijer, Adam

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2020  Band 129, Seite(n) 104526

    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-29
    Erscheinungsland Netherlands
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2020.104526
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  3. Artikel: Possible host-adaptation of SARS-CoV-2 due to improved ACE2 receptor binding in mink.

    Welkers, Matthijs R A / Han, Alvin X / Reusken, Chantal B E M / Eggink, Dirk

    Virus evolution

    2021  Band 7, Heft 1, Seite(n) veaa094

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on mink farms are increasingly observed in several countries, leading to the massive culling of animals on affected farms. Recent studies showed multiple (anthropo)zoonotic ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on mink farms are increasingly observed in several countries, leading to the massive culling of animals on affected farms. Recent studies showed multiple (anthropo)zoonotic transmission events between humans and mink on these farms. Mink-derived SARS-CoV-2 sequences from The Netherlands and Denmark contain multiple substitutions in the S protein receptor binding domain (RBD). Molecular modeling showed that these substitutions increase the mean binding energy, suggestive of potential adaptation of the SARS-CoV-2 S protein to the mink angiotensin-converting enzyme 2 (ACE2) receptor. These substitutions could possibly also impact human ACE2 binding affinity as well as humoral immune responses directed to the RBD region of the SARS-CoV-2 S protein in humans. We wish to highlight these observations to raise awareness and urge for the continued surveillance of mink (and other animal)-related infections.
    Sprache Englisch
    Erscheinungsdatum 2021-01-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2818949-8
    ISSN 2057-1577
    ISSN 2057-1577
    DOI 10.1093/ve/veaa094
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Rescue and in vitro characterization of a divergent TBEV-Eu strain from the Netherlands.

    Hoornweg, Tabitha E / Godeke, Gert-Jan / Hoogerwerf, Marieke N / van Kasteren, Puck B / de Vries, Ankje / Sprong, Hein / Verjans, Georges M G M / van Riel, Debby / Reimerink, Johan H J / Rockx, Barry / Reusken, Chantal B E M

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 2872

    Abstract: Tick-borne encephalitis virus (TBEV) may cause tick-borne encephalitis (TBE), a potential life-threatening infection of the central nervous system in humans. Phylogenetically, TBEVs can be subdivided into three main subtypes, which differ in endemic ... ...

    Abstract Tick-borne encephalitis virus (TBEV) may cause tick-borne encephalitis (TBE), a potential life-threatening infection of the central nervous system in humans. Phylogenetically, TBEVs can be subdivided into three main subtypes, which differ in endemic region and pathogenic potential. In 2016, TBEV was first detected in the Netherlands. One of two detected strains, referred to as Salland, belonged to the TBEV-Eu subtype, yet diverged ≥ 2% on amino acid level from other members of this subtype. Here, we report the successful rescue of this strain using infectious subgenomic amplicons and its subsequent in vitro characterization by comparison to two well-characterized TBEV-Eu strains; Neudoerfl and Hypr. In the human alveolar epithelial cell line A549, growth kinetics of Salland were comparable to the high pathogenicity TBEV-Eu strain Hypr, and both strains grew considerably faster than the mildly pathogenic strain Neudoerfl. In the human neuroblastoma cell line SK-N-SH, Salland replicated faster and to higher infectious titers than both reference strains. All three TBEV strains infected primary human monocyte-derived dendritic cells to a similar extent and interacted with the type I interferon system in a similar manner. The current study serves as the first in vitro characterization of the novel, divergent TBEV-Eu strain Salland.
    Mesh-Begriff(e) Humans ; Netherlands ; Encephalitis Viruses, Tick-Borne ; Encephalitis, Tick-Borne ; Central Nervous System
    Sprache Englisch
    Erscheinungsdatum 2023-02-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29075-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variants compared with Alpha variant in vaccinated individuals.

    Andeweg, Stijn P / Vennema, Harry / Veldhuijzen, Irene / Smorenburg, Naomi / Schmitz, Dennis / Zwagemaker, Florian / van Gageldonk-Lafeber, Arianne B / Hahné, Susan J M / Reusken, Chantal / Knol, Mirjam J / Eggink, Dirk

    Science translational medicine

    2023  Band 15, Heft 684, Seite(n) eabn4338

    Abstract: ... of infection by the Beta (B.1.351), Gamma (P.1), or Delta (B.1.617.2) variants compared with the Alpha (B.1.1.7 ...

    Abstract The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) break through infection- or vaccine-induced immunity is not well understood. We analyzed 28,578 sequenced SARS-CoV-2 samples from individuals with known immune status obtained through national community testing in the Netherlands from March to August 2021. We found evidence of an increased risk of infection by the Beta (B.1.351), Gamma (P.1), or Delta (B.1.617.2) variants compared with the Alpha (B.1.1.7) variant after vaccination. No clear differences were found between vaccines. However, the effect was larger in the first 14 to 59 days after complete vaccination compared with ≥60 days. In contrast to vaccine-induced immunity, there was no increased risk for reinfection with Beta, Gamma, or Delta variants relative to the Alpha variant in individuals with infection-induced immunity.
    Mesh-Begriff(e) Humans ; COVID-19 ; SARS-CoV-2 ; Vaccination
    Sprache Englisch
    Erscheinungsdatum 2023-02-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abn4338
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Orthohantavirus Pathogenesis and Cell Tropism.

    Noack, Danny / Goeijenbier, Marco / Reusken, Chantal B E M / Koopmans, Marion P G / Rockx, Barry H G

    Frontiers in cellular and infection microbiology

    2020  Band 10, Seite(n) 399

    Abstract: Orthohantaviruses are zoonotic viruses that are naturally maintained by persistent infection in specific reservoir species. Although these viruses mainly circulate among rodents worldwide, spill-over infection to humans occurs. Orthohantavirus infection ... ...

    Abstract Orthohantaviruses are zoonotic viruses that are naturally maintained by persistent infection in specific reservoir species. Although these viruses mainly circulate among rodents worldwide, spill-over infection to humans occurs. Orthohantavirus infection in humans can result in two distinct clinical outcomes: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). While both syndromes develop following respiratory transmission and are associated with multi-organ failure and high mortality rates, little is known about the mechanisms that result in these distinct clinical outcomes. Therefore, it is important to identify which cell types and tissues play a role in the differential development of pathogenesis in humans. Here, we review current knowledge on cell tropism and its role in pathogenesis during orthohantavirus infection in humans and reservoir rodents. Orthohantaviruses predominantly infect microvascular endothelial cells (ECs) of a variety of organs (lungs, heart, kidney, liver, and spleen) in humans. However, in this review we demonstrate that other cell types (e.g., macrophages, dendritic cells, and tubular epithelium) are infected as well and may play a role in the early steps in pathogenesis. A key driver for pathogenesis is increased vascular permeability, which can be direct effect of viral infection in ECs or result of an imbalanced immune response in an attempt to clear the virus. Future studies should focus on the role of identifying how infection of organ-specific endothelial cells as well as other cell types contribute to pathogenesis.
    Mesh-Begriff(e) Endothelial Cells ; Hantavirus ; Hantavirus Infections ; Hemorrhagic Fever with Renal Syndrome ; Humans ; Tropism
    Sprache Englisch
    Erscheinungsdatum 2020-08-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.00399
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Towards a sensitive and accurate interpretation of molecular testing for SARS-CoV-2: a rapid review of 264 studies.

    Stanoeva, Kamelia R / van der Eijk, Annemiek A / Meijer, Adam / Kortbeek, Laetitia M / Koopmans, Marion P G / Reusken, Chantal B E M

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2021  Band 26, Heft 10

    Abstract: BackgroundSensitive molecular diagnostics and correct test interpretation are crucial for accurate COVID-19 diagnosis and thereby essential for good clinical practice. Furthermore, they are a key factor in outbreak control where active case finding in ... ...

    Abstract BackgroundSensitive molecular diagnostics and correct test interpretation are crucial for accurate COVID-19 diagnosis and thereby essential for good clinical practice. Furthermore, they are a key factor in outbreak control where active case finding in combination with isolation and contact tracing are crucial.AimWith the objective to inform the public health and laboratory responses to the pandemic, we reviewed current published knowledge on the kinetics of SARS-CoV-2 infection as assessed by RNA molecular detection in a wide range of clinical samples.MethodsWe performed an extensive search on studies published between 1 December 2019 and 15 May 2020, reporting on molecular detection and/or isolation of SARS-CoV-2 in any human laboratory specimen.ResultsWe compiled a dataset of 264 studies including 32,515 COVID-19 cases, and additionally aggregated data points (n = 2,777) from sampling of 217 adults with known infection timeline. We summarised data on SARS-CoV-2 detection in the respiratory and gastrointestinal tract, blood, oral fluid, tears, cerebrospinal fluid, peritoneal fluid, semen, vaginal fluid; where provided, we also summarised specific observations on SARS-CoV-2 detection in pregnancy, infancy, children, adolescents and immunocompromised individuals.ConclusionOptimal SARS-CoV-2 molecular testing relies on choosing the most appropriate sample type, collected with adequate sampling technique, and with the infection timeline in mind. We outlined knowledge gaps and directions for future well-documented systematic studies.
    Mesh-Begriff(e) COVID-19/diagnosis ; COVID-19 Testing ; Humans ; Molecular Diagnostic Techniques ; Sensitivity and Specificity
    Sprache Englisch
    Erscheinungsdatum 2021-03-11
    Erscheinungsland Sweden
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2021.26.10.2001134
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Authors' response: Plenty of coronaviruses but no SARS-CoV-2.

    Reusken, Chantal B / Haagmans, Bart / Meijer, Adam / Corman, Victor M / Papa, Anna / Charrel, Remi / Drosten, Christian / Koopmans, Marion

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2020  Band 25, Heft 8

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Coronavirus Infections/virology ; Middle East Respiratory Syndrome Coronavirus ; Pandemics ; Phylogeny ; Pneumonia, Viral/virology ; SARS Virus ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-03-04
    Erscheinungsland Sweden
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2020.25.8.2000197
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  10. Artikel ; Online: Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022.

    Eggink, Dirk / Andeweg, Stijn P / Vennema, Harry / van Maarseveen, Noortje / Vermaas, Klaas / Vlaemynck, Boris / Schepers, Raf / van Gageldonk-Lafeber, Arianne B / van den Hof, Susan / Reusken, Chantal Bem / Knol, Mirjam J

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2022  Band 27, Heft 4

    Abstract: Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ... ...

    Abstract Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4-3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8-4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant.
    Mesh-Begriff(e) COVID-19 ; COVID-19 Vaccines ; Humans ; Netherlands ; SARS-CoV-2
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2022-01-27
    Erscheinungsland Sweden
    Dokumenttyp Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2022.27.4.2101196
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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