LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 101

Suchoptionen

  1. Buch: Organic cation transporters

    Ciarimboli, Giuliano / Gautron, Sophie / Schlatter, Eberhard

    integration of physiology, pathology, and pharmacology

    2016  

    Schlagwörter Molecular biology ; Cytoplasm ; Structural biology ; Cell Membrane ; Genetics
    Sprache Englisch
    Umfang XIV, 264 S. : Ill., graph. Darst., 235 mm x 155 mm, 0 g
    Verlag Springer
    Erscheinungsort Cham u.a.
    Erscheinungsland Schweiz
    Dokumenttyp Buch
    HBZ-ID HT018861923
    ISBN 978-3-319-23792-3 ; 978-3-319-23793-0 ; 3-319-23792-6 ; 3-319-23793-4
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2016 A 137 ausleihbar (Lesesaal) Lesesaal EG

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Regulation of Transporters for Organic Cations by High Glucose.

    Steinbüchel, Martin / Menne, Johannes / Schröter, Rita / Neugebauer, Ute / Schlatter, Eberhard / Ciarimboli, Giuliano

    International journal of molecular sciences

    2023  Band 24, Heft 18

    Abstract: Endogenous positively charged organic substances, including neurotransmitters and cationic uremic toxins, as well as exogenous organic cations such as the anti-diabetic medication metformin, serve as substrates for organic cation transporters (OCTs) and ... ...

    Abstract Endogenous positively charged organic substances, including neurotransmitters and cationic uremic toxins, as well as exogenous organic cations such as the anti-diabetic medication metformin, serve as substrates for organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs). These proteins facilitate their transport across cell membranes. Vectorial transport through the OCT/MATE axis mediates the hepatic and renal excretion of organic cations, regulating their systemic and local concentrations. Organic cation transporters are part of the remote sensing and signaling system, whose activity can be regulated to cope with changes in the composition of extra- and intracellular fluids. Glucose, as a source of energy, can also function as a crucial signaling molecule, regulating gene expression in various organs and tissues. Its concentration in the blood may fluctuate in specific physiological and pathophysiological conditions. In this work, the regulation of the activity of organic cation transporters was measured by incubating human embryonic kidney cells stably expressing human OCT1 (hOCT1), hOCT2, or hMATE1 with high glucose concentrations (16.7 mM). Incubation with this high glucose concentration for 48 h significantly stimulated the activity of hOCT1, hOCT2, and hMATE1 by increasing their maximal velocity (V
    Mesh-Begriff(e) Humans ; Organic Cation Transport Proteins/metabolism ; Organic Cation Transporter 2/genetics ; Metformin/pharmacology ; Metformin/metabolism ; Cations/metabolism ; RNA, Messenger
    Chemische Substanzen Organic Cation Transport Proteins ; Organic Cation Transporter 2 ; Metformin (9100L32L2N) ; Cations ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2023-09-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814051
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Unexpected localization of AQP3 and AQP4 induced by migration of primary cultured IMCD cells.

    Rose, Ralph / Kemper, Björn / Schwab, Albrecht / Schlatter, Eberhard / Edemir, Bayram

    Scientific reports

    2021  Band 11, Heft 1, Seite(n) 11930

    Abstract: Aquaporin-2-4 (AQP) are expressed in the principal cells of the renal collecting duct (CD). Beside their role in water transport across membranes, several studies showed that AQPs can influence the migration of cells. It is unknown whether this also ... ...

    Abstract Aquaporin-2-4 (AQP) are expressed in the principal cells of the renal collecting duct (CD). Beside their role in water transport across membranes, several studies showed that AQPs can influence the migration of cells. It is unknown whether this also applies for renal CD cells. Another fact is that the expression of these AQPs is highly modulated by the external osmolality. Here we analyzed the localization of AQP2-4 in primary cultured renal inner medullary CD (IMCD) cells and how osmolality influences the migration behavior of these cells. The primary IMCD cells showed a collective migration behavior and there were no differences in the migration speed between cells cultivated either at 300 or 600 mosmol/kg. Acute increase from 300 to 600 mosmol/kg led to a marked reduction and vice versa an acute decrease from 600 to 300 mosmol/kg to a marked increase in migration speed. Interestingly, none of the analyzed AQPs were localized at the leading edge. While AQP3 disappeared within the first 2-3 rows of cells, AQP4 was enriched at the rear end. Further analysis indicated that migration induced lysosomal degradation of AQP3. This could be prevented by activation of the protein kinase A, inducing localization of AQP3 and AQP2 at the leading edge and increasing the migration speed.
    Mesh-Begriff(e) Animals ; Aquaporin 3/genetics ; Aquaporin 3/metabolism ; Aquaporin 4/genetics ; Aquaporin 4/metabolism ; Bucladesine/pharmacology ; Cell Movement/drug effects ; Cell Movement/physiology ; Cell Shape ; Cells, Cultured ; Kidney Medulla/cytology ; Kidney Tubules, Collecting/cytology ; Kidney Tubules, Collecting/drug effects ; Kidney Tubules, Collecting/metabolism ; Microscopy, Fluorescence/methods ; Osmolar Concentration ; Primary Cell Culture ; Rats ; Sodium-Hydrogen Exchanger 1/metabolism ; beta Catenin/metabolism
    Chemische Substanzen Aquaporin 4 ; Sodium-Hydrogen Exchanger 1 ; beta Catenin ; Aquaporin 3 (158801-98-0) ; Bucladesine (63X7MBT2LQ)
    Sprache Englisch
    Erscheinungsdatum 2021-06-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-91369-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Buch: METABOLISMUS UND EXKRETION VON PEPTIDHORMONEN IN DER NIERE

    Schlatter, Eberhard

    1980  

    Umfang 83 S.
    Dokumenttyp Buch
    Anmerkung HANNOVER, UNIV., FAK. FUER MATHEMATIK U. NATURWISS., DISS., 1981
    HBZ-ID HT002598341
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    81 D 1489 bestellbar zur Ausleihe Magazin

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel ; Online: Unexpected localization of AQP3 and AQP4 induced by migration of primary cultured IMCD cells

    Ralph Rose / Björn Kemper / Albrecht Schwab / Eberhard Schlatter / Bayram Edemir

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 12

    Abstract: Abstract Aquaporin-2–4 (AQP) are expressed in the principal cells of the renal collecting duct (CD). Beside their role in water transport across membranes, several studies showed that AQPs can influence the migration of cells. It is unknown whether this ... ...

    Abstract Abstract Aquaporin-2–4 (AQP) are expressed in the principal cells of the renal collecting duct (CD). Beside their role in water transport across membranes, several studies showed that AQPs can influence the migration of cells. It is unknown whether this also applies for renal CD cells. Another fact is that the expression of these AQPs is highly modulated by the external osmolality. Here we analyzed the localization of AQP2–4 in primary cultured renal inner medullary CD (IMCD) cells and how osmolality influences the migration behavior of these cells. The primary IMCD cells showed a collective migration behavior and there were no differences in the migration speed between cells cultivated either at 300 or 600 mosmol/kg. Acute increase from 300 to 600 mosmol/kg led to a marked reduction and vice versa an acute decrease from 600 to 300 mosmol/kg to a marked increase in migration speed. Interestingly, none of the analyzed AQPs were localized at the leading edge. While AQP3 disappeared within the first 2–3 rows of cells, AQP4 was enriched at the rear end. Further analysis indicated that migration induced lysosomal degradation of AQP3. This could be prevented by activation of the protein kinase A, inducing localization of AQP3 and AQP2 at the leading edge and increasing the migration speed.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  6. Artikel: Who Wins the Competition: TRPV5 or Calbindin-D28K?

    Schlatter, Eberhard

    Journal of the American Society of Nephrology : JASN

    2006  Band 17, Heft 11, Seite(n) 2954–2956

    Mesh-Begriff(e) Animals ; Calbindin 1 ; Calbindins ; Calcium Channels/physiology ; Mice ; S100 Calcium Binding Protein G/physiology ; TRPV Cation Channels/physiology
    Chemische Substanzen Calb1 protein, mouse ; Calbindin 1 ; Calbindins ; Calcium Channels ; S100 Calcium Binding Protein G ; TRPV Cation Channels ; Trpv5 protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2006-11
    Erscheinungsland United States
    Dokumenttyp Comment ; Editorial
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2006080935
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3344: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Buch: Organic cation transporters

    Ciarimboli, Giuliano / Gautron, Sophie / Schlatter, Eberhard

    integration of physiology, pathology, and pharmacology

    2016  

    Verfasserangabe Giuliano Ciarimboli, Sophie Gautron, Eberhard Schlatter, editors
    Mesh-Begriff(e) Organic Cation Transport Proteins/physiology ; Organic Cation Transport Proteins/pharmacology
    Sprache Englisch
    Umfang xv, 264 pages :, illustrations (chiefly color) ;, 25 cm
    Dokumenttyp Buch
    ISBN 9783319237923 ; 3319237926 ; 9783319237930 ; 3319237934
    Datenquelle Katalog der US National Library of Medicine (NLM)

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Buch ; Online ; Dissertation / Habilitation: Untersuchungen zur "repaired defect" Hypothese der glomerulären Kapillarwand

    Repp, Viktor [Verfasser] / Schlatter, Eberhard [Akademischer Betreuer]

    2016  

    Verfasserangabe Viktor Repp ; Betreuer: Eberhard Schlatter
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Universitäts- und Landesbibliothek Münster
    Erscheinungsort Münster
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  9. Artikel ; Online: Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1.

    Aschauer, Lydia / Carta, Giada / Vogelsang, Nadine / Schlatter, Eberhard / Jennings, Paul

    Toxicology in vitro : an international journal published in association with BIBRA

    2014  Band 30, Heft 1 Pt A, Seite(n) 95–105

    Abstract: The kidney is a major target for drug-induced injury, primarily due the fact that it transports a wide variety of chemical entities into and out of the tubular lumen. Here, we investigated the expression of the main xenobiotic transporters in the human ... ...

    Abstract The kidney is a major target for drug-induced injury, primarily due the fact that it transports a wide variety of chemical entities into and out of the tubular lumen. Here, we investigated the expression of the main xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1 at an mRNA and/or protein level. RPTEC/TERT1 cells expressed OCT2, OCT3, OCTN2, MATE1, MATE2, OAT1, OAT3 and OAT4. The functionality of the OCTs was demonstrated by directional transport of the fluorescent dye 4-Di-1-ASP. In addition, P-glycoprotein activity in RPTEC/TERT1 cells was verified by fluorescent dye retention in presence of various P-glycoprotein inhibitors. In comparison to proliferating cells, contact inhibited RPTEC/TERT1 cells expressed increased mRNA levels of several ABC transporter family members and were less sensitive to cyclosporine A. We conclude that differentiated RPTEC/TERT1 cells are well suited for utilisation in xenobiotic transport and pharmacokinetic studies.
    Mesh-Begriff(e) Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Line ; Gene Expression Regulation/physiology ; Humans ; Kidney Tubules, Proximal/cytology ; Kidney Tubules, Proximal/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
    Chemische Substanzen Carrier Proteins ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2014-12-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639064-x
    ISSN 1879-3177 ; 0887-2333
    ISSN (online) 1879-3177
    ISSN 0887-2333
    DOI 10.1016/j.tiv.2014.12.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2223: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  10. Artikel ; Online: Notch Signaling Activity Determines Uptake and Biological Effect of Imatinib in Systemic Sclerosis Dermal Fibroblasts.

    Harrach, Saliha / Barz, Vivien / Pap, Thomas / Pavenstädt, Hermann / Schlatter, Eberhard / Edemir, Bayram / Distler, Jörg / Ciarimboli, Giuliano / Bertrand, Jessica

    The Journal of investigative dermatology

    2018  Band 139, Heft 2, Seite(n) 439–447

    Abstract: Tyrosine kinase inhibitors have emerged as a therapeutic option for rheumatic diseases such as systemic sclerosis (SSc). Because tyrosine kinases like c-Abl kinase are important for fibroblast activation and fibrosis development in SSc, the c-Abl ... ...

    Abstract Tyrosine kinase inhibitors have emerged as a therapeutic option for rheumatic diseases such as systemic sclerosis (SSc). Because tyrosine kinases like c-Abl kinase are important for fibroblast activation and fibrosis development in SSc, the c-Abl inhibitor imatinib was proposed for SSc treatment. Transporters for organic cations have become increasingly recognized as an important determinant for uptake and efficacy of tyrosine kinase inhibitors. Therefore, we investigated the role of organic cation transporters in the uptake of imatinib. Moreover, the influence of important SSc pathogenetic factors, like PDGF and Notch pathway activation on these uptake processes, has been studied. We showed that organic cation transporters OCT1-3, novel organic cation transporters OCTN1/2, and the multidrug and toxin extrusion protein MATE1 are expressed in healthy dermal and SSc fibroblasts. Decreased expression levels of MATE1 and decreased imatinib uptake were measured in SSc fibroblasts. In small interfering RNA experiments, MATE1 was identified as key transporter for imatinib uptake and biological effect in dermal fibroblasts. Furthermore, PDGF reduced imatinib uptake by decreasing MATE1 expression in SSc fibroblasts, but not in healthy fibroblasts. Blocking the Notch pathway in SSc fibroblasts increased MATE1 transporter expression and imatinib uptake. In conclusion, MATE1-mediated transport governs therapeutic efficacy of imatinib in SSc.
    Mesh-Begriff(e) Biopsy ; Cells, Cultured ; Dermis/cytology ; Dermis/metabolism ; Dermis/pathology ; Fibroblasts/metabolism ; Gene Knockdown Techniques ; Humans ; Imatinib Mesylate/pharmacokinetics ; Imatinib Mesylate/therapeutic use ; Organic Cation Transport Proteins/genetics ; Organic Cation Transport Proteins/metabolism ; Platelet-Derived Growth Factor/metabolism ; Primary Cell Culture ; Protein Kinase Inhibitors/pharmacokinetics ; Protein Kinase Inhibitors/therapeutic use ; RNA, Small Interfering/metabolism ; Receptors, Notch/metabolism ; Scleroderma, Systemic/drug therapy ; Scleroderma, Systemic/pathology ; Signal Transduction
    Chemische Substanzen Organic Cation Transport Proteins ; Platelet-Derived Growth Factor ; Protein Kinase Inhibitors ; RNA, Small Interfering ; Receptors, Notch ; SLC47A1 protein, human ; Imatinib Mesylate (8A1O1M485B)
    Sprache Englisch
    Erscheinungsdatum 2018-09-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2018.08.021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ui VI Zs.124: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang