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  1. Artikel ; Online: Why should we consider methotrexate in future trials of steroid-resistant immune thrombocytopenic purpura? - Correspondence.

    Abdelwahab, Omar Ahmed / Seif, Ali Mohamed / Sherif, Mohamed El-Sebaey

    Immunology letters

    2023  Band 254, Seite(n) 39–40

    Mesh-Begriff(e) Humans ; Purpura, Thrombocytopenic, Idiopathic ; Methotrexate ; Steroids
    Chemische Substanzen Methotrexate (YL5FZ2Y5U1) ; Steroids
    Sprache Englisch
    Erscheinungsdatum 2023-01-23
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2023.01.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis.

    Abdelwahab, Omar Ahmed / Akil, Khaled / Seif, Ali / Allam, Mahmoud / Sherif, Mohamed El-Sebaey / Al-Alfy, Mohamed N

    Medicine

    2023  Band 102, Heft 6, Seite(n) e32937

    Abstract: Background: As an antioxidant, vitamin E (VitE) may benefit the erythrocytes by protecting glutathione from oxidation by free radicals and peroxide-generating processes.: Methods: We followed the Preferred Reporting Items for Systematic Reviews and ... ...

    Abstract Background: As an antioxidant, vitamin E (VitE) may benefit the erythrocytes by protecting glutathione from oxidation by free radicals and peroxide-generating processes.
    Methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines when reporting this systematic review. We searched 6 electronic databases (PubMed, Scopus, Web of Science, and Cochrane Library) until May 8, 2022. We included all relevant studies. According to the study design, the Cochrane assessment tool (Risk of Bias 2), Risk Of Bias In Non-randomized Studies - of Interventions checklists, and National Institutes of Health tools were used to assess the risk of bias.Continuous data were pooled as a mean difference (MD) with a relative 95% confidence interval. The protocol was registered on PROSPERO (CRD42022333848).
    Results: Six studies were included in the meta-analysis with a total of 181 patients. Compared with the control group, VitE significantly improved the hemoglobin level for chronic hemolysis (MD = 2.72 g/dL, P < .0001) and for acute hemolysis (MD = 1.18 g/dL, P < .0001). It also decreased the reticulocyte level for chronic hemolysis (MD = -1.39 P < .0001) and for acute hemolysis (MD = -1.42%, P < .0001). For before and after studies, the use of VitE significantly improved the level of packed cell volume (MD = 0.56%, P < .00001), red blood cell half-life (MD = 2.19 days, P < .0001), and decreased the reticulocytes level (MD = -1.41%, P < .00001).
    Conclusion: Among patients with glucose-6-phosphate dehydrogenase deficiency, VitE might provide benefits such as increasing the hemoglobin, packed cell volume levels, red blood cell half-life, and decreasing the reticulocyte level, so reducing hemolysis. Further high-quality, well-designed randomized controlled trials are recommended.
    Mesh-Begriff(e) Humans ; Vitamin E/therapeutic use ; Glucosephosphate Dehydrogenase Deficiency/complications ; Hemolysis ; Bias
    Chemische Substanzen Vitamin E (1406-18-4)
    Sprache Englisch
    Erscheinungsdatum 2023-01-05
    Erscheinungsland United States
    Dokumenttyp Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000032937
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Intravascular lithotripsy to treat an underexpanded coronary stent during index procedure: A case report study.

    Seif, Sherif / Kumar, Abhishek / Arya, Sanjay / Karthikeyan, Vellore J

    Avicenna journal of medicine

    2021  Band 11, Heft 1, Seite(n) 54–57

    Abstract: Management of heavily calcified lesions during percutaneous coronary intervention (PCI) is often associated with high incidence of complications and long-term adverse outcomes. There is growing evidence of the efficacy of intravascular lithotripsy (IVL) ... ...

    Abstract Management of heavily calcified lesions during percutaneous coronary intervention (PCI) is often associated with high incidence of complications and long-term adverse outcomes. There is growing evidence of the efficacy of intravascular lithotripsy (IVL) in de novo coronary lesion preparation; however, little experience has been documented within freshly deployed stent underexpansion. We report a 66-year-old male with a marked stent underexpansion despite extensive lesion preparation due to severe underlying calcification. The stent was resistant to balloon postdilatation; therefore, IVL was applied, resulting in excellent stent expansion. IVL could be considered for treating acute stent underexpansion caused by severe underlying calcification.
    Sprache Englisch
    Erscheinungsdatum 2021-01-05
    Erscheinungsland India
    Dokumenttyp Case Reports
    ZDB-ID 2664414-9
    ISSN 2249-4464 ; 2231-0770
    ISSN (online) 2249-4464
    ISSN 2231-0770
    DOI 10.4103/ajm.ajm_200_20
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  4. Artikel ; Online: Short and long terms clinical outcomes of Paclitaxel drug-eluting balloons applied for de-novo coronary artery lesions in the context of acute coronary syndrome: A real world experience.

    Ayuna, Ahmed / Seif, Sherif / MacDonald, John / Sultan, Ayyaz

    Indian heart journal

    2021  Band 73, Heft 3, Seite(n) 385–386

    Abstract: A single-centre retrospective observational study aimed at observing the outcomes of using DEB in ACS patients. All-comer ninety patients were included with a follow-up of 12-36 months. DEBs were deployed successfully yielding TIMI 3 without significant ... ...

    Abstract A single-centre retrospective observational study aimed at observing the outcomes of using DEB in ACS patients. All-comer ninety patients were included with a follow-up of 12-36 months. DEBs were deployed successfully yielding TIMI 3 without significant coronary dissection. MACE was 1.1% and 3.3% for 30 days and 12-36 months respectively.
    Mesh-Begriff(e) Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/therapy ; Angioplasty, Balloon, Coronary ; Cardiovascular Agents ; Coronary Angiography ; Coronary Artery Disease/diagnosis ; Drug-Eluting Stents ; Humans ; Paclitaxel ; Pharmaceutical Preparations ; Treatment Outcome
    Chemische Substanzen Cardiovascular Agents ; Pharmaceutical Preparations ; Paclitaxel (P88XT4IS4D)
    Sprache Englisch
    Erscheinungsdatum 2021-03-27
    Erscheinungsland India
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2021.03.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 616: Hefte anzeigen Standort:
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  5. Artikel ; Online: Massive coronary thrombosis caused primary percutaneous coronary intervention to fail in a COVID-19 patient with ST-elevation myocardial infarction.

    Seif, Sherif / Ayuna, Ahmed / Kumar, Abhishek / Macdonald, John

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2020  Band 97, Heft 5, Seite(n) E667–E669

    Abstract: COVID-19 is a new viral infection that has a significant impact on global health and economy. Because of its rapid spread worldwide, it may influence the prognosis of other medical conditions, such as ST-segment elevation myocardial infarction (STEMI). ... ...

    Abstract COVID-19 is a new viral infection that has a significant impact on global health and economy. Because of its rapid spread worldwide, it may influence the prognosis of other medical conditions, such as ST-segment elevation myocardial infarction (STEMI). We report a case of a 58-year female patient admitted with an infero-posterior STEMI on the background of recently positive COVID-19 swab. Reperfusion was attempted through primary PCI but unfortunately failed to restore coronary blood flow due to massive thrombotic burden despite several attempts of balloon dilatation and aspiration thrombectomy. She sadly died later on because of hemodynamic deterioration. This scenario raises concerns about Neutrophil Extracellular Traps (NETS) which might potentially have propagated inflammation and thrombosis via platelets' aggregation leading to enhanced coagulopathy and massive coronary thrombosis. Therefore, we suggest primary PCI as the first-choice of revascularization in patients with combined COVID-19 and STEMI. Additionally, we emphasize on the importance of using the potent new generation P2Y12 inhibitors along with GPIIb/IIIa inhibitors in every STEMI patient with COVID-19 to achieve favorable conditions for primary PCI as well as favorable outcomes after stent implantation.
    Mesh-Begriff(e) COVID-19/complications ; COVID-19/epidemiology ; Coronary Angiography ; Coronary Thrombosis/diagnosis ; Coronary Thrombosis/etiology ; Coronary Thrombosis/surgery ; Female ; Humans ; Middle Aged ; Pandemics ; Percutaneous Coronary Intervention/adverse effects ; SARS-CoV-2 ; ST Elevation Myocardial Infarction/complications ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/surgery ; Treatment Failure
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-30
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.29050
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Intravascular lithotripsy to treat an underexpanded coronary stent during index procedure

    Sherif Seif / Abhishek Kumar / Sanjay Arya / Vellore J. Karthikeyan

    Avicenna Journal of Medicine, Vol 11, Iss 01, Pp 54-

    A case report study

    2021  Band 57

    Abstract: Management of heavily calcified lesions during percutaneous coronary intervention (PCI) is often associated with high incidence of complications and long-term adverse outcomes. There is growing evidence of the efficacy of intravascular lithotripsy (IVL) ... ...

    Abstract Management of heavily calcified lesions during percutaneous coronary intervention (PCI) is often associated with high incidence of complications and long-term adverse outcomes. There is growing evidence of the efficacy of intravascular lithotripsy (IVL) in de novo coronary lesion preparation; however, little experience has been documented within freshly deployed stent underexpansion. We report a 66-year-old male with a marked stent underexpansion despite extensive lesion preparation due to severe underlying calcification. The stent was resistant to balloon postdilatation; therefore, IVL was applied, resulting in excellent stent expansion. IVL could be considered for treating acute stent underexpansion caused by severe underlying calcification.
    Schlagwörter calcified coronary lesions ; complication ; coronary artery disease ; intravascular lithotripsy ; percutaneous coronary intervention ; stent underexpansion ; stents ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Thieme Medical and Scientific Publishers Pvt. Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  7. Artikel ; Online: In-silico development and assessment of a Kalman filter motor decoder for prosthetic hand control.

    Gamal, Mai / Mousa, Mohamed H / Eldawlatly, Seif / Elbasiouny, Sherif M

    Computers in biology and medicine

    2021  Band 132, Seite(n) 104353

    Abstract: Up to 50% of amputees abandon their prostheses, partly due to rapid degradation of the control systems, which require frequent recalibration. The goal of this study was to develop a Kalman filter-based approach to decoding motoneuron activity to identify ...

    Abstract Up to 50% of amputees abandon their prostheses, partly due to rapid degradation of the control systems, which require frequent recalibration. The goal of this study was to develop a Kalman filter-based approach to decoding motoneuron activity to identify movement kinematics and thereby provide stable, long-term, accurate, real-time decoding. The Kalman filter-based decoder was examined via biologically varied datasets generated from a high-fidelity computational model of the spinal motoneuron pool. The estimated movement kinematics controlled a simulated MuJoCo prosthetic hand. This clear-box approach showed successful estimation of hand movements under eight varied physiological conditions with no retraining. The mean correlation coefficient of 0.98 and mean normalized root mean square error of 0.06 over these eight datasets provide proof of concept that this decoder would improve long-term integrity of performance while performing new, untrained movements. Additionally, the decoder operated in real-time (~0.3 ms). Further results include robust performance of the Kalman filter when re-trained to more severe post-amputation limitations in the type and number of motoneurons remaining. An additional analysis shows that the decoder achieves better accuracy when using the firing of individual motoneurons as input, compared to using aggregate pool firing. Moreover, the decoder demonstrated robustness to noise affecting both the trained decoder parameters and the decoded motoneuron activity. These results demonstrate the utility of a proof of concept Kalman filter decoder that can support prosthetics' control systems to maintain accurate and stable real-time movement performance.
    Mesh-Begriff(e) Algorithms ; Amputees ; Artificial Limbs ; Computer Simulation ; Humans ; Movement
    Sprache Englisch
    Erscheinungsdatum 2021-03-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2021.104353
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Massive coronary thrombosis caused primary percutaneous coronary intervention to fail in a COVID ‐19 patient with ST ‐elevation myocardial infarction

    Seif, Sherif / Ayuna, Ahmed / Kumar, Abhishek / Macdonald, John

    Catheterization and Cardiovascular Interventions ; ISSN 1522-1946 1522-726X

    2020  

    Schlagwörter Radiology Nuclear Medicine and imaging ; Cardiology and Cardiovascular Medicine ; General Medicine ; covid19
    Sprache Englisch
    Verlag Wiley
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1002/ccd.29050
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel: Massive coronary thrombosis caused primary percutaneous coronary intervention to fail in a COVID-19 patient with ST-elevation myocardial infarction

    Seif, Sherif / Ayuna, Ahmed / Kumar, Abhishek / Macdonald, John

    Catheter. cardiovasc. interv

    Abstract: COVID-19 is a new viral infection that has a significant impact on global health and economy. Because of its rapid spread worldwide, it may influence the prognosis of other medical conditions, such as ST-segment elevation myocardial infarction (STEMI). ... ...

    Abstract COVID-19 is a new viral infection that has a significant impact on global health and economy. Because of its rapid spread worldwide, it may influence the prognosis of other medical conditions, such as ST-segment elevation myocardial infarction (STEMI). We report a case of a 58-year female patient admitted with an infero-posterior STEMI on the background of recently positive COVID-19 swab. Reperfusion was attempted through primary PCI but unfortunately failed to restore coronary blood flow due to massive thrombotic burden despite several attempts of balloon dilatation and aspiration thrombectomy. She sadly died later on because of hemodynamic deterioration. This scenario raises concerns about Neutrophil Extracellular Traps (NETS) which might potentially have propagated inflammation and thrombosis via platelets' aggregation leading to enhanced coagulopathy and massive coronary thrombosis. Therefore, we suggest primary PCI as the first-choice of revascularization in patients with combined COVID-19 and STEMI. Additionally, we emphasize on the importance of using the potent new generation P2Y12 inhibitors along with GPIIb/IIIa inhibitors in every STEMI patient with COVID-19 to achieve favorable conditions for primary PCI as well as favorable outcomes after stent implantation.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #435007
    Datenquelle COVID19

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  10. Artikel: Intravascular lithotripsy to treat an underexpanded coronary stent during index procedure: A case report study

    Seif, Sherif / Kumar, Abhishek / Arya, Sanjay / Karthikeyan, Vellore J.

    Avicenna Journal of Medicine

    2021  Band 11, Heft 01, Seite(n) 54–57

    Abstract: Management of heavily calcified lesions during percutaneous coronary intervention (PCI) is often associated with high incidence of complications and long-term adverse outcomes. There is growing evidence of the efficacy of intravascular lithotripsy (IVL) ... ...

    Abstract Management of heavily calcified lesions during percutaneous coronary intervention (PCI) is often associated with high incidence of complications and long-term adverse outcomes. There is growing evidence of the efficacy of intravascular lithotripsy (IVL) in de novo coronary lesion preparation; however, little experience has been documented within freshly deployed stent underexpansion. We report a 66-year-old male with a marked stent underexpansion despite extensive lesion preparation due to severe underlying calcification. The stent was resistant to balloon postdilatation; therefore, IVL was applied, resulting in excellent stent expansion. IVL could be considered for treating acute stent underexpansion caused by severe underlying calcification.
    Schlagwörter Calcified coronary lesions ; complication ; coronary artery disease ; intravascular lithotripsy ; percutaneous coronary intervention ; stent underexpansion ; stents
    Sprache Englisch
    Erscheinungsdatum 2021-01-01
    Verlag Thieme Medical and Scientific Publishers Private Ltd.
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2664414-9
    ISSN 2249-4464 ; 2231-0770 ; 2249-4464
    ISSN (online) 2249-4464
    ISSN 2231-0770 ; 2249-4464
    DOI 10.4103/ajm.ajm_200_20
    Datenquelle Thieme Verlag

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