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  1. Buch: SARS-CoV-2 and Coronacrisis

    Sharov, Konstantin S. / Legach, Fr Archpriest Evgeny I.

    Epidemiological Challenges, Social Policies and Administrative Strategies

    2021  

    Verfasserangabe Dr. Evgeny Ivanovich Legach, Ph.D., Dr. habil, ThM, Professor, is an Ukrainian biologist, an epidemiologist, a clinical surgeon, a medicine theoretician, an Orthodox archpriest, and a theologian. He is the Dean of Temple of St. Transfiguration and the Dean of St. Anthony's Temple in Karazin National University in Kharkov. He is a member of the Ukrainian Surgery Society, Ukrainian ¿ransplantation Society, Ukrainian Cryobiology Society, and UNESCO Chair for Cryobiology. He received the prestigious Award of National Academy of Science of Ukraine for young scientists and Prize of Ukrainian President for young scientists. Dr. Konstantin Sergeevich Sharov, Ph.D., ThM, is a Russian chemist, a clinical microbiologist, a sociologist, a lay theologian, and an author of several monographs and more than 150 research papers in peer-reviewed periodical journals. His areas of expertise include: epidemiology, surveillance, public health, gender, and political / legal regulation of healthcare sect
    Schlagwörter SARS-CoV-2Containment ; FightingCOVID-19 ; SARS-CoV-2inEurope ; EpidemiologyofSARS-CoV-2 ; novelcoronavirus ; ClinicalInvestigation ; clinicalmicrobiology ; SurveillancePrograms ; PublicHealthSupport ; HealthcareReorganization ; SARS-CoV-2 Containment ; Fighting COVID-19 ; SARS-CoV-2 in Europe ; Epidemiology of SARS-CoV-2 ; Novel Coronavirus ; Clinical Investigation ; Clinical Microbiology ; Surveillance Programs ; Public Health Support ; Healthcare Reorganization
    Sprache Englisch
    Umfang 412 p.
    Ausgabenhinweis 1
    Verlag Springer Nature Singapore
    Dokumenttyp Buch
    Anmerkung PDA Manuell_11
    Format 160 x 241 x 28
    ISBN 9789811626043 ; 9811626049
    Datenquelle PDA

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  2. Buch ; Online ; E-Book: SARS-CoV-2 and Coronacrisis

    Legach, Evgeny I. / Sharov, Konstantin S.

    Epidemiological Challenges, Social Policies and Administrative Strategies

    2021  

    Abstract: This book is useful for administrators of different levels involved in counteracting COVID-19, surveillance professionals, clinicians, researchers specializing in epidemiology, microbiology, and infectious diseases, and politicians / legislators engaged ... ...

    Verfasserangabe edited by Fr archpriest Evgeny I. Legach, Konstantin S. Sharov
    Abstract This book is useful for administrators of different levels involved in counteracting COVID-19, surveillance professionals, clinicians, researchers specializing in epidemiology, microbiology, and infectious diseases, and politicians / legislators engaged in public health sector. We use an innovative approach of combining both epidemiological and sociological analyses, as the very problem is mainly an issue of correct governance. A team of authors from Europe, Russia and China summarizes their experience and knowledge useful for containing SARS-CoV-2 and overcoming social and managerial consequences of the pandemic. The editors are sure that sharing our different experience would help to elaborate necessary strategies, protocols, and principles that may be effectively applied in the future to avoid dramatic consequences of not only COVID-19 but also any possible epidemiological hazards for people and medicine.
    Schlagwörter Public health ; Epidemiology ; Public Health
    Thema/Rubrik (Code) 614.592414
    Sprache Englisch
    Umfang 1 online resource (394 pages)
    Ausgabenhinweis 1st ed. 2021.
    Verlag Springer Nature Singapore ; Imprint: Springer
    Erscheinungsort Singapore
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-16-2605-7 ; 981-16-2604-9 ; 978-981-16-2605-0 ; 978-981-16-2604-3
    DOI 10.1007/978-981-16-2605-0
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Artikel ; Online: Global Biobank Meta-analysis Initiative: How can global health benefit by its use?

    Alpeeva, Elena V / Sharov, Konstantin S

    Journal of global health

    2023  Band 13, Seite(n) 3054

    Mesh-Begriff(e) Humans ; Biological Specimen Banks ; Global Health
    Sprache Englisch
    Erscheinungsdatum 2023-10-27
    Erscheinungsland Scotland
    Dokumenttyp Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.13.03054
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: 8806 Russian patients demonstrate T cell count as better marker of COVID-19 clinical course severity than SARS-CoV-2 viral load.

    Sharov, Konstantin S

    Scientific reports

    2021  Band 11, Heft 1, Seite(n) 9440

    Abstract: The article presents a comparative analysis of SARS-CoV-2 viral load (VL), T lymphocyte count and respiratory index ... ...

    Abstract The article presents a comparative analysis of SARS-CoV-2 viral load (VL), T lymphocyte count and respiratory index PaO
    Mesh-Begriff(e) COVID-19 ; Cohort Studies ; Critical Care ; Humans ; Lymphocyte Count ; Prospective Studies ; Risk Factors ; Russia ; SARS-CoV-2 ; Viral Load
    Sprache Englisch
    Erscheinungsdatum 2021-05-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-88714-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: SARS-CoV-2 spread in different biosocial strata in Russia in 2020: Groups of risk and victimised groups.

    Sharov, Konstantin S

    Journal of global health

    2021  Band 11, Seite(n) 3006

    Mesh-Begriff(e) COVID-19/epidemiology ; COVID-19/transmission ; COVID-19 Testing/statistics & numerical data ; Crime Victims ; Emigration and Immigration/legislation & jurisprudence ; Health Status Disparities ; Humans ; Risk Assessment ; Russia/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2021-04-24
    Erscheinungsland Scotland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.11.03066
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Trends in adaptation of fifteen European countries population to SARS-CoV-2 in March-May 2020: Can Taiwanese experience be adopted?

    Sharov, Konstantin S

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2020  Band 120, Heft 1 Pt 3, Seite(n) 679–687

    Abstract: Background: The purpose of the work is to analyze population adaptation to SARS-CoV-2 in Europe in March-May 2020, predict herd immunity formation in the nearest several months on the basis of our SIR modified epidemiological model of the virus spread ... ...

    Abstract Background: The purpose of the work is to analyze population adaptation to SARS-CoV-2 in Europe in March-May 2020, predict herd immunity formation in the nearest several months on the basis of our SIR modified epidemiological model of the virus spread and elaborate recommendations to governments regarding a second wave of COVID-19 pandemic.
    Methods: Outer (1,006,512 RT-PCR tests results for SARS-CoV-2) and proprietary (34,660 respiratory samples) epidemiological data was used. Fifteen European countries were studied. Dates of research: March 2 - May 22, 2020.
    Results: As of April 21, 2020, the mean population infection rate (PIR) for the European countries considered, was 9.66%. It decreased to 6.85% by May 22, 2020. The model predicted 5.68% PIR, giving accuracy of 79.40%. SARS-CoV-2 basic reproduction number is limited by an extremum that may be observed for closed communities. A concept of effective reproduction number is introduced as a function of r
    Conclusion: In case of a second wave of COVID-19 disease in Europe, it will coincide with seasonal common cold surge, spanning from mid-September 2020 to mid-February 2021, with a median in November-December 2020. Strict epidemiological surveillance must be observed in Europe at that time.
    Mesh-Begriff(e) Adaptation, Physiological/immunology ; Basic Reproduction Number/statistics & numerical data ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Nucleic Acid Testing/methods ; Coinfection/epidemiology ; Coinfection/prevention & control ; Common Cold/epidemiology ; Common Cold/prevention & control ; Communicable Disease Control/organization & administration ; Communicable Disease Control/statistics & numerical data ; Disease Transmission, Infectious/prevention & control ; Disease Transmission, Infectious/statistics & numerical data ; Epidemiological Monitoring ; Europe/epidemiology ; Humans ; Immunity, Herd ; Models, Statistical ; SARS-CoV-2/isolation & purification ; Seasons
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-31
    Erscheinungsland Singapore
    Dokumenttyp Journal Article
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2020.07.038
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: HIV/SARS-CoV-2 co-infection: T cell profile, cytokine dynamics and role of exhausted lymphocytes.

    Sharov, Konstantin S

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Band 102, Seite(n) 163–169

    Abstract: Objectives: The aim was to investigate if there is synergy in HIV infection and COVID-19 in their influence on human immunity, if there is an exacerbation of HIV patients' immune status caused by SARS-CoV-2; and if HIV infection without antiretroviral ... ...

    Abstract Objectives: The aim was to investigate if there is synergy in HIV infection and COVID-19 in their influence on human immunity, if there is an exacerbation of HIV patients' immune status caused by SARS-CoV-2; and if HIV infection without antiretroviral therapy (ART) leads to a more serious COVID-19 course than HIV infection with ART.
    Design: Anonymised blood samples and clinical data were collected in 47 hospitals, clinics and medical centres in six Russian cities/regions in the period from 20 March to 15 June 2020. Three hundred and seventy-six HIV/COVID-19 patients were studied (171 without ART and 205 with ART). The control group consisted of 382 SARS-CoV-2-positive patients without HIV infection. Lymphocyte and cytokine amounts were measured by flow cytometry and ELISA. This work is a retrospective study.
    Results: COVID-19 led to rapid augmentation of the process of T-cell exhaustion initially caused by HIV, and this T cell degradation was most pronounced in patients without ART. A rise in IL-10 and TGFβ serum concentrations was observed. Diminishing CD4
    Conclusions: HIV infection without ART may be a very serious comorbidity of COVID-19, whereas immunity of HIV/COVID-19 patients with proper ART is not generally affected by SARS-CoV-2. HIV-1 and SARS-CoV-2 are likely to exhibit a synergic effect, and exhausted T lymphocyte dynamics may be its effective marker.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; COVID-19/immunology ; Coinfection/immunology ; Cytokines/blood ; HIV Infections/drug therapy ; HIV Infections/immunology ; Humans ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; T-Lymphocytes/immunology ; T-Lymphocytes/physiology ; Young Adult
    Chemische Substanzen Cytokines
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-25
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.10.049
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  8. Artikel: Creating and applying SIR modified compartmental model for calculation of COVID-19 lockdown efficiency.

    Sharov, Konstantin S

    Chaos, solitons, and fractals

    2020  Band 141, Seite(n) 110295

    Abstract: We propose a Susceptible-Infected-Recovered (SIR) modified model for Coronavirus disease - 2019 (COVID-19) spread to estimate the efficacy of lockdown measures introduced during the pandemic. As input data, we used COVID-19 epidemiological information ... ...

    Abstract We propose a Susceptible-Infected-Recovered (SIR) modified model for Coronavirus disease - 2019 (COVID-19) spread to estimate the efficacy of lockdown measures introduced during the pandemic. As input data, we used COVID-19 epidemiological information collected in fifteen European countries either in private surveys or using official statistics. Thirteen countries implemented lockdown measures, two countries (Sweden, Iceland) not. As output parameters, we studied herd immunity level and time of formation. Comparison of these parameters was used as an indicator of effectiveness / ineffectiveness of lockdown measures. In the absence of a medical vaccine, herd immunity may be regarded as a factor of population adaptation to severe acute respiratory syndrome-related coronavirus-2, the viral pathogen causing COVID-19 disease (SARS-CoV-2), and hence COVID-19 spreading stop. We demonstrated that there is no significant difference between lockdown and no-lockdown modes of COVID-19 containment, in terms of both herd immunity level and the time of achieving its maximum. The rationale for personal and business lockdowns may be found in the avoidance of healthcare system overburdening. However, lockdowns do not prevent any virus with droplet transmission (including SARS-CoV-2) from spreading. Therefore, in case of a future viral pathogen emergence, lockdown measures efficiency should not be overestimated, as it was done almost universally in the world during COVID-19 pandemic.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2003919-0
    ISSN 1873-2887 ; 0960-0779
    ISSN (online) 1873-2887
    ISSN 0960-0779
    DOI 10.1016/j.chaos.2020.110295
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  9. Artikel ; Online: SARS-CoV-2-related pneumonia cases in pneumonia picture in Russia in March-May 2020: Secondary bacterial pneumonia and viral co-infections.

    Sharov, Konstantin S

    Journal of global health

    2020  Band 10, Heft 2, Seite(n) 20504

    Abstract: Background: We are communicating the results of investigating statistics on SARS-CoV-2-related pneumonias in Russia: percentage, mortality, cases with other viral agents, cases accompanied by secondary bacterial pneumonias, age breakdown, clinical ... ...

    Abstract Background: We are communicating the results of investigating statistics on SARS-CoV-2-related pneumonias in Russia: percentage, mortality, cases with other viral agents, cases accompanied by secondary bacterial pneumonias, age breakdown, clinical course and outcome.
    Methods: We studied two sampling sets (Set 1 and Set 2). Set 1 consisted of results of testing 3382 assays of out-patients and hospital patients (5-88 years old) with community-acquired and hospital-acquired pneumonia of yet undetermined aetiology. Set 2 contained results of 1204 assays of hospital patients (12-94 years old) with pneumonia and COVID-19 already diagnosed by molecular biological techniques in test laboratories. The results were collected in twelve Russian cities/provinces in time range 2 March - 5 May 2020. Assays were analysed for 10 bacterial, 15 viral, 2 fungal and 2 parasitic aetiological agents.
    Results: In Set 1, 4.35% of total pneumonia cases were related to SARS-CoV-2, with substantially larger proportion (18.75%) of deaths of pneumonia with COVID-19 diagnosed. However, studying Set 2, we revealed that 52.82% patients in it were also positive for different typical and atypical aetiological agents usually causing pneumonia. 433 COVID-19 patients (35.96%) were tested positive for various bacterial aetiological agents, with
    Conclusions: SARS-CoV-2, a low-pathogenic virus itself, becomes exceptionally dangerous if secondary bacterial pneumonia attacks a COVID-19 patient as a complication. An essential part of the severest complications and mortality associated with COVID-19 in Russia in March-May 2020, may be attributed to secondary bacterial pneumonia and to a much less extent viral co-infections. The problem of hospital-acquired bacterial infection is exceptionally urgent in treating SARS-CoV-2 patients. The risk of secondary bacterial pneumonia and its further complications, should be given very serious attention in combating SARS-CoV-2.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Coinfection/microbiology ; Coinfection/mortality ; Coronavirus Infections/microbiology ; Coronavirus Infections/mortality ; Female ; Healthcare-Associated Pneumonia/microbiology ; Healthcare-Associated Pneumonia/mortality ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Bacterial/microbiology ; Pneumonia, Bacterial/mortality ; Pneumonia, Viral/microbiology ; Pneumonia, Viral/mortality ; Russia/epidemiology ; SARS-CoV-2 ; Virus Diseases/microbiology ; Virus Diseases/mortality ; Young Adult
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-27
    Erscheinungsland Scotland
    Dokumenttyp Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.10.020504
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Adaptation to SARS-CoV-2 under stress: Role of distorted information.

    Sharov, Konstantin S

    European journal of clinical investigation

    2020  Band 50, Heft 9, Seite(n) e13294

    Abstract: Background: Since the time of global SARS-CoV-2 spread across the earth in February 2020, most of countries faced the problem of massive stress of their healthcare systems. In many cases, the structural stress was a result of incorrect allocation of ... ...

    Abstract Background: Since the time of global SARS-CoV-2 spread across the earth in February 2020, most of countries faced the problem of massive stress of their healthcare systems. In many cases, the structural stress was a result of incorrect allocation of medical care resources. In turn, this misallocation resulted from fear and apprehensions that superseded thorough calculations. A key role in exacerbating the healthcare sector overburdening was played by misleading information on the virus and disease caused by it. In the current paper, we study the situation in Russian healthcare system and advance recommendations how to avoid further crises.
    Materials and methods: (a) Surveying the medical personnel (231 doctors, 317 nurses and 355 ambulance medical workers of lower levels) in five hospitals and six ambulance centres in Moscow. (b) Content analysis of 3164 accounts in Russian segment of social networks (VKontakte, Facebook, Instagram, Twitter, Odnoklassniki); official and unofficial media (TV, informational webpages).
    Results: We revealed positive-feedback loop that threatened the sustainability of Russian care sector. The main knot was occupied by incorrect/exaggerated media coverage of COVID-19. General public scared by misinformation in media and social networks, started to panic. This negative social background undermined the productivity of a significant part of medical workers who were afraid of COVID-19 patients.
    Conclusions: The most serious problems of Russian healthcare sector related to COVID-19 pandemic, were informational problems. The exaggerated information on COVID-19 had big negative influence upon Russian society and healthcare system, despite SARS-CoV-2 relatively low epidemiological hazard.
    Mesh-Begriff(e) Adaptation, Psychological ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Female ; Health Care Surveys/methods ; Health Personnel/psychology ; Humans ; Information Dissemination ; Male ; Mass Media/statistics & numerical data ; Medical Informatics ; Moscow ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Risk Assessment ; Stress, Physiological ; Workload/psychology ; Workload/statistics & numerical data
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13294
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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