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  1. Artikel ; Online: Response to Wei Y-S, Liu W-L, Bai R, Li D-H, Zhao Z-Q, Wang Y, et al. The use of a transolecranon pin joystick technique in the treatment of multidirectionally unstable supracondylar humeral fractures in children. J Pediatr Orthop B 2020; 29:452-457.

    Jeevannavar, Santosh S / Srinath, K M / Patil, Naveenkumar / Shetty, Deekshith

    Journal of pediatric orthopedics. Part B

    2021  Band 31, Heft 1, Seite(n) e107

    Sprache Englisch
    Erscheinungsdatum 2021-11-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1473-5865
    ISSN (online) 1473-5865
    DOI 10.1097/BPB.0000000000000904
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Comments on the Usage of External Breast Prosthesis by Indian Women Undergoing Mastectomy.

    Krishna, Kanyadhara Lohita / Srinath, B S

    Indian journal of surgical oncology

    2022  Band 13, Heft 3, Seite(n) 516–517

    Sprache Englisch
    Erscheinungsdatum 2022-01-26
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-022-01513-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Syringocystadenocarcinoma Papilliferum of Thigh-a Rare Cutaneous Malignancy with Unusual Histology and Clinical Presentation.

    Naskar, Sudipta / Manohar, Archana / H G, Srivatsa / V, Divya / Kumar, Rekha V / Srinath, B S

    Indian journal of surgical oncology

    2023  Band 14, Heft 4, Seite(n) 900–903

    Sprache Englisch
    Erscheinungsdatum 2023-09-06
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-023-01808-7
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  4. Artikel: Comparative Evaluation of the Placement of Drain Versus Normal Suturing to Eliminate Postoperative Complications After the Surgical Removal of Impacted Third Molar.

    Selvaraj, Sarmatha / Periyasamy, Indra Kumar / Elangovan, Gayathri P / Su, Arrvinthan / Srinath, K / Sivaragahvi, B

    Cureus

    2024  Band 16, Heft 1, Seite(n) e51517

    Abstract: ... of 30. After extraction, Group A received a corrugated flat rubber drain and Group B had only ... in all postoperative challenges in contrast to Group B with normal sutures. The intergroup comparison indicates ... trismus was also at its peak before surgery for both groups. However, in contrast to Group A, Group B ...

    Abstract Objective This study aimed to compare the efficiency of corrugated rubber drains and sutures in preventing complications after the surgical removal of impacted mandibular molars. Methodology Sixty patients enrolled for surgical extraction of wisdom teeth were studied. The patients were divided into two groups of 30. After extraction, Group A received a corrugated flat rubber drain and Group B had only conventional knotted sutures in the extraction site. Patients were evaluated for postoperative pain, edema, and trismus. Before the procedure and on postoperative days 1, 2, and 7, all parameters were measured and compared. Results Patients in Group A with surgical drains showed a significant reduction in all postoperative challenges in contrast to Group B with normal sutures. The intergroup comparison indicates that pain was highest before surgery and showed a significant reduction by day 7 in both groups. Similarly, trismus was also at its peak before surgery for both groups. However, in contrast to Group A, Group B with suturing alone demonstrated a substantial reduction in trismus by day 7. By the end of day 7, edema had substantially decreased in both groups, but it was not statistically significant (
    Sprache Englisch
    Erscheinungsdatum 2024-01-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.51517
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  5. Artikel ; Online: Serpent strikes, sapien sways: A rare case of bilateral cerebellar infarct following viper bite.

    Srinath, K M / Sethi, Mahim / Madhu, B / Prasad, M C / Sangappa, Sunila B

    Annals of African medicine

    2024  Band 23, Heft 1, Seite(n) 104–106

    Abstract: ... bilateral cerebellum and occipital lobe following Russell's viper bite in a previously healthy individual ...

    Abstract Ischemic stroke following snake bite is rare. We report a posterior circulation infarct involving bilateral cerebellum and occipital lobe following Russell's viper bite in a previously healthy individual. A 50 years old healthy individual, soon after being bitten by the Russel viper on the left foot he developed pain and swelling followed by drooping of eyelids, slurring of speech and giddiness with multiple episodes of vomiting. The patient was administered ASV as well as neostigmine and atropine injections. Following this, the neurological manifestations resolved except dysarthria. CT brain study done was normal. On day 2 of hospitalization, he developed left cerebellar signs (positive finger nose finger test, rebound phenomenon, dysdiadochokinesia, a positive heel shin test). Subsequently, an MRI with MR angiogram was done which showed acute infarcts in bilateral cerebellar hemispheres, with the left superior cerebellar peduncle showing restricted diffusion and low ADC values. Ischemic infarction following viper envenomation has been described by only few authors. In majority of the cases reported, ischemic infarction involved the anterior circulation. The possible mechanisms of infarction in this scenario are discussed. Patient was treated with anti-snake venom and showed a good recovery. Early imaging and early treatment with anti-snake venom is important for a favourable outcome.
    Mesh-Begriff(e) Male ; Animals ; Humans ; Middle Aged ; Snake Bites/complications ; Snake Bites/therapy ; Brain Ischemia ; Magnetic Resonance Imaging ; Daboia ; Infarction ; Antivenins
    Chemische Substanzen Antivenins
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland India
    Dokumenttyp Case Reports
    ZDB-ID 2165792-0
    ISSN 0975-5764 ; 0975-5764
    ISSN (online) 0975-5764
    ISSN 0975-5764
    DOI 10.4103/aam.aam_44_23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Differential role of glucocorticoid receptor based on its cell type specific expression on tumor cells and infiltrating lymphocytes.

    Snijesh, V P / Nimbalkar, Vidya P / Patil, Sharada / Rajarajan, Savitha / Anupama, C E / Mahalakshmi, S / Alexander, Annie / Soundharya, Ramu / Ramesh, Rakesh / Srinath, B S / Jolly, Mohit Kumar / Prabhu, Jyothi S

    Translational oncology

    2024  Band 45, Seite(n) 101957

    Abstract: Background: The glucocorticoid receptor (GR) is frequently expressed in breast cancer (BC), and its prognostic implications are contingent on estrogen receptor (ER) status. To address conflicting reports and explore therapeutic potential, a GR signature ...

    Abstract Background: The glucocorticoid receptor (GR) is frequently expressed in breast cancer (BC), and its prognostic implications are contingent on estrogen receptor (ER) status. To address conflicting reports and explore therapeutic potential, a GR signature (GRsig) independent of ER status was developed. We also investigated cell type-specific GR protein expression in BC tumor epithelial cells and infiltrating lymphocytes.
    Methods: GRsig was derived from Dexamethasone treated cell lines through a bioinformatic pipeline. Immunohistochemistry assessed GR protein expression. Associations between GRsig and tumor phenotypes (proliferation, cytolytic activity (CYT), immune cell distribution, and epithelial-to-mesenchymal transition (EMT) were explored in public datasets. Single-cell RNA sequencing data evaluated context-dependent GR roles, and a cell type-specific prognostic role was assessed in an independent BC cohort.
    Results: High GRsig levels were associated with a favorable prognosis across BC subtypes. Tumor-specific high GRsig correlated with lower proliferation, increased CYT, and anti-tumorigenic immune cells. Single-cell data analysis revealed higher GRsig expression in immune cells, negatively correlating with EMT while a positive correlation was observed with EMT primarily in tumor and stromal cells. Univariate and multivariate analyses demonstrated the robust and independent predictive capability of GRsig for favorable prognosis. GR protein expression on immune cells in triple-negative tumors indicated a favorable prognosis.
    Conclusion: This study underscores the cell type-specific role of GR, where its expression on tumor cells is associated with aggressive features like EMT, while in infiltrating lymphocytes, it predicts a better prognosis, particularly within TNBC tumors. The GRsig emerges as a promising independent prognostic indicator across diverse BC subtypes.
    Sprache Englisch
    Erscheinungsdatum 2024-04-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2024.101957
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  7. Artikel ; Online: Premenopausal women with breast cancer in the early post-partum period show molecular profiles of invasion and are associated with poor prognosis.

    Nimbalkar, Vidya P / Snijesh, V P / Rajarajan, Savitha / Alexander, Annie / Kaluve, Rohini / Ramesh, Rakesh / Srinath, B S / Prabhu, Jyothi S

    Breast cancer research and treatment

    2023  Band 200, Heft 1, Seite(n) 139–149

    Abstract: Purpose: Young premenopausal women develop breast cancer (BC) within 5-10 years of the last childbirth, known as post-partum breast cancers (PPBC), often present with aggressive disease. The exact mechanisms that lead to poor prognosis in these patients ...

    Abstract Purpose: Young premenopausal women develop breast cancer (BC) within 5-10 years of the last childbirth, known as post-partum breast cancers (PPBC), often present with aggressive disease. The exact mechanisms that lead to poor prognosis in these patients are largely unknown.
    Methods: We have evaluated the association of clinical and reproductive factors with BC in a cohort of women ≤ 45 years (N = 155) with long-term follow-up. Based on duration since last childbirth (LCB), grouped patients into PPBC1 (LCB ≤ 5 years), PPBC2 (LCB between 6 and 10 years), PPBC3 (LCB > 10 years), and NPBC (age-matched nulliparous BC patients). We compared disease-free survival and hazard associated with recurrence/metastasis between the groups. RNA sequencing of tumor samples was performed from three parous groups (n = 10), and transcriptomic data were analyzed for differentially expressed genes and altered pathways.
    Results: Women in the PPBC1 group had an early menarche and late age at first and last childbirth compared to other groups. Survival analysis within lymph node-positive tumors showed that PPBC1 tumors had a worse prognosis than PPBC2 and NPBC tumors (p = 0.015 and p = 0.026, respectively). Clustering of the differentially expressed genes between the groups showed distinct expression in early PPBC (E-PPBC) tumors. Pathway analysis revealed upregulation of invasive-related pathways along with T cell exhaustion, extracellular matrix remodeling, angiogenesis, and epithelial-to-mesenchymal transition in E-PPBC tumors.
    Conclusion: Early PPBC is a unique subtype with aggressive clinical features and distinct biology. Further research is needed to accurately project the risk of recurrence and optimal treatment strategies in these young patients.
    Mesh-Begriff(e) Pregnancy ; Female ; Humans ; Breast Neoplasms/pathology ; Postpartum Period ; Parturition ; Prognosis ; Reproductive History
    Sprache Englisch
    Erscheinungsdatum 2023-05-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-023-06956-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Vanillin derivative inhibits quorum sensing and biofilm formation in

    Shastry, Rajesh P / Ghate, Sudeep D / Sukesh Kumar, B / Srinath, B S / Kumar, Vasanth

    Natural product research

    2021  Band 36, Heft 6, Seite(n) 1610–1615

    Abstract: Vanillin and its derivative, (4-(( ...

    Abstract Vanillin and its derivative, (4-((
    Mesh-Begriff(e) Animals ; Anti-Bacterial Agents/pharmacology ; Benzaldehydes ; Biofilms ; Caenorhabditis elegans ; Molecular Docking Simulation ; Pseudomonas aeruginosa ; Quorum Sensing ; Virulence Factors/metabolism
    Chemische Substanzen Anti-Bacterial Agents ; Benzaldehydes ; Virulence Factors ; vanillin (CHI530446X)
    Sprache Englisch
    Erscheinungsdatum 2021-02-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1887866
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  9. Artikel: A short term comparative evaluation of the efficacy of diode laser with desensitizing toothpastes and mouthwashes in the treatment of dentinal hypersensitivity.

    Acharya, Anirudh B / Chandrashekar, Apoorva / Thakur, Srinath

    Journal of clinical and experimental dentistry

    2022  Band 14, Heft 3, Seite(n) e229–e234

    Abstract: ... syringe, and evaluation of DH was done based on the patient's subjective response using the Visual Analog ...

    Abstract Background: Treatment of dentinal hypersensitivity (DH) has always been challenging with a wide variety of therapeutic options, in-office and home care. The study objective was to compare the clinical efficacy of diode laser [DL] with four commercially available desensitizing agents (two toothpastes and two mouthwashes) in the treatment of DH.
    Material and methods: This study involved 75 participants (25-45 years) who were categorized as Group 1 (n=15) treated with DL, and Groups 2, 3,4 and 5 (n=15 in each) who were prescribed 3% potassium nitrate mouth rinse, a herbal mouth rinse, potassium nitrate tooth paste and a herbal tooth paste, respectively. DH was assessed by air blast stimulation using air blast syringe, and evaluation of DH was done based on the patient's subjective response using the Visual Analog Scale (VAS) at baseline, 1 week and 1 month.
    Results: DL and the desensitizing agents showed significant reduction in DH at 1 month when compared with baseline, except potassium nitrate mouth wash. However, DL showed more percentage reduction in DH when compared with potassium nitrate tooth paste, herbal mouth wash and paste.
    Conclusions: The study implies that even though all five groups showed improvement in terms of DH reduction, DL showed the best results among all the groups.
    Sprache Englisch
    Erscheinungsdatum 2022-03-01
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.59063
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  10. Artikel ; Online: Improvise, Adapt, Overcome: How COVID-19 Transformed Inpatient Pediatric Gastroenterology.

    Say, Daphne S / Ali, Sabina / Srinath, Arvind / Li, B U K / Venkatesh, Rajitha D

    Clinical pediatrics

    2021  Band 60, Heft 14, Seite(n) 569–573

    Abstract: The coronavirus disease-2019 (COVID-19) pandemic has disrupted inpatient pediatric services across the United States, creating opportunities for innovation. A recent Webinar organized by the Telehealth for Pediatric GI Care Now working group and ... ...

    Abstract The coronavirus disease-2019 (COVID-19) pandemic has disrupted inpatient pediatric services across the United States, creating opportunities for innovation. A recent Webinar organized by the Telehealth for Pediatric GI Care Now working group and sponsored by the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition provided insights into how inpatient pediatric gastroenterology services were affected and how physicians adapted during the crisis. These findings suggest the use of telehealth technologies may augment family communication and facilitate multidisciplinary care in the future. We anticipate that these innovative applications of telehealth will comprise a part of a toolkit for gastroenterologists to be used during this public health emergency and beyond.
    Mesh-Begriff(e) COVID-19/epidemiology ; COVID-19/therapy ; Child ; Gastroenterology/education ; Humans ; Pediatrics/education ; Societies, Medical/standards ; Surveys and Questionnaires ; Telemedicine/methods ; United States
    Sprache Englisch
    Erscheinungsdatum 2021-09-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/00099228211044854
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 454: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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