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  2. AU=Fessler M Margaret
  3. AU=Ashrafzadeh Sepideh AU=Ashrafzadeh Sepideh
  4. AU="Kellie Leigh"
  5. AU="Nogueira, Fábio"
  6. AU="Davidson, Rose K."
  7. AU="Belkin, Igor M."
  8. AU="Cui, Rongxin"
  9. AU="Lassmann-Vague, V"
  10. AU="Schmit, Megan"
  11. AU="Donato, Federica"
  12. AU="Bommineni, Yugendar R"
  13. AU="Qi, Zhaoyu"
  14. AU=Campos Daniel Melo De Oliveira AU=Campos Daniel Melo De Oliveira
  15. AU="Ashish, Kumar"
  16. AU="Franziska Press"
  17. AU=Eickmann Markus
  18. AU=Shukla Prashant
  19. AU="Fernández-Fernández, Luis"
  20. AU="Hall, Dylan"
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  26. AU="Palomar-Bonet, Miriam"
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  28. AU="Proux-Gillardeaux, Veronique"
  29. AU="Menon, Kartikeya M"
  30. AU="Pantell, Matthew" AU="Pantell, Matthew"
  31. AU="Maria Papadopoulou"
  32. AU="Wu, Jianrong"
  33. AU="Rodrigues, Daniel Sobreira"
  34. AU="Angello R. Retamal-Díaz"
  35. AU="Nicole C. Deziel"
  36. AU="Shajrawi, Abedalmajeed Methqal"
  37. AU=Aydin Seckin AU=Aydin Seckin
  38. AU="Narwal, Vikrant"
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  1. Artikel ; Online: Effect of enhanced p CO 2 levels on the production of DOC and TEP in short-term bioassay experiments

    G. A. MacGilchrist / T. Shi / T. Tyrrell / S. Richier / C. M. Moore / C. Dumousseaud / E. P. Achterberg

    Biogeosciences Discussions, Vol 11, Iss 3, Pp 3701-

    2014  Band 3730

    Abstract: It has been proposed that increasing levels of p CO 2 in the surface ocean will lead to more ... experiments that considered the effect of four different p CO 2 scenarios (ambient, 550, 750 and 1000 μatm ... conditions, varied considerably between locations. We did not observe any strong or consistent effect of p CO 2 ...

    Abstract It has been proposed that increasing levels of p CO 2 in the surface ocean will lead to more partitioning of the organic carbon fixed by marine primary production into the dissolved rather than the particulate fraction. This process may result in enhanced accumulation of dissolved organic carbon (DOC) in the surface ocean and/or concurrent accumulation of transparent exopolymer particles (TEP), with important implications for the functioning of the marine carbon cycle. We investigated this in shipboard bioassay experiments that considered the effect of four different p CO 2 scenarios (ambient, 550, 750 and 1000 μatm) on unamended natural phytoplankton communities from a range of locations in the northwest European shelf seas. The environmental settings, in terms of nutrient availability, phytoplankton community structure and growth conditions, varied considerably between locations. We did not observe any strong or consistent effect of p CO 2 on DOC production. There was a significant but highly variable effect of p CO 2 on the production of TEP. In three of the five experiments, variation of TEP production between p CO 2 treatments was caused by the effect of p CO 2 on phytoplankton growth rather than a direct effect on TEP production. In one of the five experiments, there was evidence of enhanced TEP production at high p CO 2 (twice as much production over the 96 h incubation period in the 750 μatm treatment compared with the ambient treatment) independent of indirect effects, as hypothesised by previous studies. Our results suggest that the environmental setting of experiments (community structure, nutrient availability and occurrence of phytoplankton growth) is a key factor determining the TEP response to p CO 2 perturbations.
    Schlagwörter Geology ; QE1-996.5 ; Science ; Q ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2014-03-01T00:00:00Z
    Verlag Copernicus GmbH
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Effect of enhanced p CO 2 levels on the production of dissolved organic carbon and transparent exopolymer particles in short-term bioassay experiments

    G. A. MacGilchrist / T. Shi / T. Tyrrell / S. Richier / C. M. Moore / C. Dumousseaud / E. P. Achterberg

    Biogeosciences, Vol 11, Iss 13, Pp 3695-

    2014  Band 3706

    Abstract: It has been proposed that increasing levels of p CO 2 in the surface ocean will lead to more ... experiments that considered the effect of four different p CO 2 scenarios (ambient, 550, 750 and 1000 μatm ... conditions, varied considerably between locations. We did not observe any strong or consistent effect of p CO 2 ...

    Abstract It has been proposed that increasing levels of p CO 2 in the surface ocean will lead to more partitioning of the organic carbon fixed by marine primary production into the dissolved rather than the particulate fraction. This process may result in enhanced accumulation of dissolved organic carbon (DOC) in the surface ocean and/or concurrent accumulation of transparent exopolymer particles (TEPs), with important implications for the functioning of the marine carbon cycle. We investigated this in shipboard bioassay experiments that considered the effect of four different p CO 2 scenarios (ambient, 550, 750 and 1000 μatm) on unamended natural phytoplankton communities from a range of locations in the northwest European shelf seas. The environmental settings, in terms of nutrient availability, phytoplankton community structure and growth conditions, varied considerably between locations. We did not observe any strong or consistent effect of p CO 2 on DOC production. There was a significant but highly variable effect of p CO 2 on the production of TEPs. In three of the five experiments, variation of TEP production between p CO 2 treatments was caused by the effect of p CO 2 on phytoplankton growth rather than a direct effect on TEP production. In one of the five experiments, there was evidence of enhanced TEP production at high p CO 2 (twice as much production over the 96 h incubation period in the 750 μatm treatment compared with the ambient treatment) independent of indirect effects, as hypothesised by previous studies. Our results suggest that the environmental setting of experiments (community structure, nutrient availability and occurrence of phytoplankton growth) is a key factor determining the TEP response to p CO 2 perturbations.
    Schlagwörter Ecology ; QH540-549.5 ; Life ; QH501-531 ; Geology ; QE1-996.5
    Sprache Englisch
    Erscheinungsdatum 2014-07-01T00:00:00Z
    Verlag Copernicus Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Relation of pulse pressure to long-distance gait speed in community-dwelling older adults: findings from the LIFE-P study.

    Heffernan, Kevin S / Manini, Todd M / Hsu, Fang-Chi / Blair, Steven N / Nicklas, Barbara J / Kritchevsky, Stephen B / Newman, Anne B / Sutton-Tyrrell, Kim / Church, Timothy S / Haskell, William L / Fielding, Roger A

    PloS one

    2012  Band 7, Heft 11, Seite(n) e49544

    Abstract: ... in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study.: Methods: Brachial ... speed than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was ... significantly and inversely associated with 400-meter gait speed (p<0.05). Other significant predictors of gait ...

    Abstract Background: Reduced gait speed is associated with falls, late-life disability, hospitalization/institutionalization and cardiovascular morbidity and mortality. Aging is also accompanied by a widening of pulse pressure (PP) that contributes to ventricular-vascular uncoupling. The purpose of this study was to test the hypothesis that PP is associated with long-distance gait speed in community-dwelling older adults in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study.
    Methods: Brachial blood pressure and 400-meter gait speed (average speed maintained over a 400-meter walk at "usual" pace) were assessed in 424 older adults between the ages of 70-89 yrs at risk for mobility disability (mean age=77 yrs; 31% male). PP was calculated as systolic blood pressure (BP) - diastolic BP.
    Results: Patients with a history of heart failure and stroke (n=42) were excluded leaving 382 participants for final analysis. When categorized into tertiles of PP, participants within the highest PP tertile had significantly slower gait speed than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was significantly and inversely associated with 400-meter gait speed (p<0.05). Other significant predictors of gait speed included: handgrip strength, body weight, age and history of diabetes mellitus (p<0.05). Mean arterial pressure, systolic BP and diastolic BP were not predictors of gait speed.
    Conclusions: Pulse pressure is associated long-distance gait speed in community-dwelling older adults. Vascular senescence and altered ventricular-vascular coupling may be associated with the deterioration of mobility and physical function in older adults.
    Mesh-Begriff(e) Accidental Falls/prevention & control ; Aged ; Aged, 80 and over ; Blood Pressure/physiology ; Exercise ; Female ; Gait/physiology ; Heart Rate ; Humans ; Life Style ; Male ; ROC Curve ; Regression Analysis ; Walking
    Sprache Englisch
    Erscheinungsdatum 2012-11-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0049544
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: A.P.C. viruses and respiratory disease in Northern England.

    ZAIMAN, E / BALDUCCI, D / TYRRELL, D A

    Lancet (London, England)

    2003  Band 269, Heft 6890, Seite(n) 595–596

    Mesh-Begriff(e) England ; Humans ; Respiration Disorders ; Respiratory System ; Respiratory Tract Diseases ; Virus Diseases ; Viruses
    Sprache Englisch
    Erscheinungsdatum 2003-03-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(55)92590-3
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  5. Artikel: Relation of Pulse Pressure to Long-Distance Gait Speed in Community-Dwelling Older Adults: Findings from the LIFE-P Study

    Heffernan, Kevin S / Blair, Steven N / Church, Timothy S / Fielding, Roger A / Haskell, William L / Hsu, Fang-Chi / Kritchevsky, Stephen B / Manini, Todd M / Newman, Anne B / Nicklas, Barbara J / Scuteri, Angelo / Sutton-Tyrrell, Kim

    PloS one. , v. 7, no. 11

    2012  

    Abstract: ... in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Brachial blood pressure and 400 ... than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was significantly and inversely ... associated with 400-meter gait speed (p<0.05). Other significant predictors of gait speed included: handgrip ...

    Titelvarianten Aging, Pulse Pressure and Gait Speed
    Abstract Reduced gait speed is associated with falls, late-life disability, hospitalization/institutionalization and cardiovascular morbidity and mortality. Aging is also accompanied by a widening of pulse pressure (PP) that contributes to ventricular-vascular uncoupling. The purpose of this study was to test the hypothesis that PP is associated with long-distance gait speed in community-dwelling older adults in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Brachial blood pressure and 400-meter gait speed (average speed maintained over a 400-meter walk at “usual” pace) were assessed in 424 older adults between the ages of 70–89 yrs at risk for mobility disability (mean age = 77 yrs; 31% male). PP was calculated as systolic blood pressure (BP) – diastolic BP. Patients with a history of heart failure and stroke (n = 42) were excluded leaving 382 participants for final analysis. When categorized into tertiles of PP, participants within the highest PP tertile had significantly slower gait speed than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was significantly and inversely associated with 400-meter gait speed (p<0.05). Other significant predictors of gait speed included: handgrip strength, body weight, age and history of diabetes mellitus (p<0.05). Mean arterial pressure, systolic BP and diastolic BP were not predictors of gait speed. Pulse pressure is associated long-distance gait speed in community-dwelling older adults. Vascular senescence and altered ventricular-vascular coupling may be associated with the deterioration of mobility and physical function in older adults.
    Schlagwörter body weight ; diabetes mellitus ; elderly ; gait ; heart failure ; lifestyle ; males ; morbidity ; mortality ; patients ; risk ; stroke ; systolic blood pressure
    Sprache Englisch
    Erscheinungsverlauf 2012-1121
    Erscheinungsort Public Library of Science
    Dokumenttyp Artikel
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0049544
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  6. Artikel ; Online: P.014 VASCULAR MARKERS OF PREMATURE ATHEROSCLEROSIS IN PAEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS AND DISEASE, THERAPY, METABOLIC AND INFLAMMATORY CORRELATES

    T. Bradley* / L. Nukumizu / C. Boros / C. Slorach / P. Tyrrell / M. Cheung / B. McCrindle / E. Silverman

    Artery Research, Vol 1, Iss

    2007  Band 1

    Schlagwörter Specialties of internal medicine ; RC581-951 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
    Sprache Englisch
    Erscheinungsdatum 2007-06-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel: Comparative in vitro activities of retapamulin (SB-275833) against 141 clinical isolates of Propionibacterium spp., including 117 P. acnes isolates.

    Goldstein, Ellie J C / Citron, Diane M / Merriam, C Vreni / Warren, Yumi A / Tyrrell, Kerin L / Fernandez, Helen T

    Antimicrobial agents and chemotherapy

    2005  Band 50, Heft 1, Seite(n) 379–381

    Abstract: Using the NCCLS agar dilution method, we studied the in vitro activity of retapamulin (SB-275833) against 141 clinical isolates of Propionibacterium species, including seven multiresistant strains, and found retapamulin to be the most active agent among ... ...

    Abstract Using the NCCLS agar dilution method, we studied the in vitro activity of retapamulin (SB-275833) against 141 clinical isolates of Propionibacterium species, including seven multiresistant strains, and found retapamulin to be the most active agent among those tested with MICs of < or = 1 microg/ml against all isolates.
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Diterpenes/pharmacology ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Microbial Sensitivity Tests ; Polycyclic Compounds ; Propionibacterium/drug effects ; Propionibacterium/isolation & purification ; Propionibacterium acnes/drug effects ; Propionibacterium acnes/isolation & purification ; Pleuromutilins
    Chemische Substanzen Anti-Bacterial Agents ; Bridged Bicyclo Compounds, Heterocyclic ; Diterpenes ; Polycyclic Compounds ; retapamulin (4MG6O8991R)
    Sprache Englisch
    Erscheinungsdatum 2005-12-23
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.50.1.379-381.2006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Analysis of NIH K99/R00 awards and the career progression of awardees.

    Woitowich, Nicole C / Hengel, Sarah R / Solis, Christopher / Vilgalys, Tauras P / Babdor, Joel / Tyrrell, Daniel J

    eLife

    2024  Band 12

    Abstract: Many postdoctoral fellows and scholars who hope to secure tenure-track faculty positions in the United States apply to the National Institutes of Health (NIH) for a Pathway to Independence Award. This award has two phases (K99 and R00) and provides ... ...

    Abstract Many postdoctoral fellows and scholars who hope to secure tenure-track faculty positions in the United States apply to the National Institutes of Health (NIH) for a Pathway to Independence Award. This award has two phases (K99 and R00) and provides funding for up to 5 years. Using NIH data for the period 2006-2022, we report that ~230 K99 awards were made every year, representing up to ~$250 million annual investment. About 40% of K99 awardees were women and ~89% of K99 awardees went on to receive an R00 award annually. Institutions with the most NIH funding produced the most recipients of K99 awards and recruited the most recipients of R00 awards. The time between a researcher starting an R00 award and receiving a major NIH award (such as an R01) ranged between 4.6 and 7.4 years, and was significantly longer for women, for those who remained at their home institution, and for those hired by an institution that was not one of the 25 institutions with the most NIH funding. Shockingly, there has yet to be a K99 awardee at a historically Black college or university. We go on to show how K99 awardees flow to faculty positions, and to identify various factors that influence the future success of individual researchers and, therefore, also influence the composition of biomedical faculty at universities in the United States.
    Mesh-Begriff(e) Humans ; Female ; United States ; Male ; Biomedical Research ; National Institutes of Health (U.S.) ; Awards and Prizes ; Health Personnel ; Research Personnel
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88984
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption.

    Klievik, Brinley J / Tyrrell, Aidan D / Chen, Chuck T / Bazinet, Richard P

    Pharmacology & therapeutics

    2023  Band 248, Seite(n) 108437

    Abstract: Docosahexaenoic acid (DHA, 22:6n-3) accretion in brain phospholipids is critical for maintaining the structural fluidity that permits proper assembly of protein complexes for signaling. Furthermore, membrane DHA can be released by phospholipase ... ...

    Abstract Docosahexaenoic acid (DHA, 22:6n-3) accretion in brain phospholipids is critical for maintaining the structural fluidity that permits proper assembly of protein complexes for signaling. Furthermore, membrane DHA can be released by phospholipase A
    Mesh-Begriff(e) Mice ; Animals ; Docosahexaenoic Acids/chemistry ; Docosahexaenoic Acids/metabolism ; Brain/metabolism ; Inflammation/metabolism ; Signal Transduction ; Oxidative Stress
    Chemische Substanzen Docosahexaenoic Acids (25167-62-8)
    Sprache Englisch
    Erscheinungsdatum 2023-05-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2023.108437
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  10. Artikel: Diversity of Planctomycetes in Soil in Relation to Soil History and Environmental Heterogeneity [Erratum: 2006 Sept., v. 72, no. 9, p. 6429.]

    Buckley, Daniel H / Huangyutitham, Varisa / Nelson, Tyrrell A / Rumberger, Angelika / Thies, Janice E

    Applied and environmental microbiology. 2006 July, v. 72, no. 7

    2006  

    Abstract: Members of the Planctomycetes, which were once thought to occur primarily in aquatic environments, have been discovered in soils on five continents, revealing that these Bacteria are a widespread and numerically abundant component of microbial ... ...

    Abstract Members of the Planctomycetes, which were once thought to occur primarily in aquatic environments, have been discovered in soils on five continents, revealing that these Bacteria are a widespread and numerically abundant component of microbial communities in soil. We examined the diversity of Planctomycetes in soil samples obtained from experimental plots at an agricultural site in order to assess the extent of Planctomycetes diversity in soil, to determine whether management effects such as past land cover and compost addition affected the composition of the Planctomycetes community, and to determine whether the observations made could provide insight into the ecological distribution of these organisms. Analysis of Planctomycetes 16S rRNA gene sequences revealed a total of 312 ± 35 unique phylotypes in the soil at the site examined. The majority of these Planctomycetes sequences were unique, and the sequences had phylogenetic affiliations that included all major lineages in the Planctomycetaceae, as well as several novel groups of deeply divergent PLANCTOMYCETES: Both soil management history and compost amendment had significant effects on the Planctomycetes diversity, and variations in soil organic matter, Ca²⁺ content, and pH were associated with variations in the Planctomycetes community composition. In addition, Planctomycetes richness increased in proportion to the area sampled and was correlated with the spatial heterogeneity of nitrate, which was associated with the soil management history at the orchard site examined. This report provides the first systematic assessment of the diversity of Planctomycetes in soil and also provides evidence that the diversity of this group increases with area as defined by the general power law description of the taxon-area relationship.
    Schlagwörter Planctomycetales ; soil bacteria ; ribosomal RNA ; genes ; nucleotide sequences ; species diversity ; land use change ; orchard soils ; soil amendments ; composted manure ; fertilizers ; fertilizer application ; soil pH ; soil organic matter ; calcium ; New York
    Sprache Englisch
    Erscheinungsverlauf 2006-07
    Umfang p. 4522-4531.
    Erscheinungsort American Society for Microbiology
    Dokumenttyp Artikel
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    Datenquelle NAL Katalog (AGRICOLA)

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