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  1. Artikel ; Online: In Vitro Modeling of Feline Morbillivirus Infections Using Primary Feline Kidney Cells.

    Sieg, Michael / Busch, Johannes / Böttcher, Denny / Vahlenkamp, Thomas W

    Methods in molecular biology (Clifton, N.J.)

    2024  Band 2808, Seite(n) 153–165

    Abstract: Domestic cats are the natural host of feline morbilliviruses (FeMV). Although other species can also be infected (such as dogs and opossums), no laboratory animal infection model is established so far. In vitro models for studying the molecular ... ...

    Abstract Domestic cats are the natural host of feline morbilliviruses (FeMV). Although other species can also be infected (such as dogs and opossums), no laboratory animal infection model is established so far. In vitro models for studying the molecular pathogenesis are therefore needed. For this purpose, propagation and titration of FeMV are key techniques. Unlike other morbilliviruses, such as canine distemper virus (CDV) or measles virus (MV), FeMV is a slow growing virus in cell culture and is difficult to titrate using classical plaque techniques. Here we describe methods for the efficient isolation of FeMV from natural sources (e.g., urine), the propagation of viral stocks, and their titration. In addition, we establish the generation of a three-dimensional infection model mimicking the feline tubular epithelium.
    Mesh-Begriff(e) Animals ; Cats ; Morbillivirus/pathogenicity ; Morbillivirus/genetics ; Morbillivirus/physiology ; Morbillivirus Infections/veterinary ; Morbillivirus Infections/virology ; Kidney/virology ; Kidney/cytology ; Cat Diseases/virology ; Cells, Cultured ; Virus Cultivation/methods ; Disease Models, Animal ; Primary Cell Culture/methods
    Sprache Englisch
    Erscheinungsdatum 2024-05-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3870-5_12
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Borna disease in an adult free-ranging Eurasian beaver (Castor fiber albicus).

    Ellenberger, Christin / Heenemann, Kristin / Vahlenkamp, Thomas W / Grothmann, Pierre / Herden, Christiane / Heinrich, Anja

    Journal of comparative pathology

    2024  Band 209, Seite(n) 31–35

    Abstract: Borna disease (BD) associated with a peracute bacterial septicaemia with Escherichia coli was diagnosed in an adult female, naturally infected, free-ranging Eurasian beaver of the subspecies Castor fiber albicus, clinically characterized by weight loss, ... ...

    Abstract Borna disease (BD) associated with a peracute bacterial septicaemia with Escherichia coli was diagnosed in an adult female, naturally infected, free-ranging Eurasian beaver of the subspecies Castor fiber albicus, clinically characterized by weight loss, depression, weakness and gurgled peristaltic sounds. The beaver was euthanized humanely. Necropsy and light microscopy revealed a non-purulent meningoencephalitis with typical mononuclear perivascular cuffs and parenchymal infiltrates. The diagnosis of BD was confirmed by detection of viral antigen and RNA by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). The PCR product was sequenced and cluster analysis revealed a close relationship between endemic clusters in Saxony-Anhalt. This is the first report of naturally occurring BD in a free-ranging Eurasian beaver.
    Mesh-Begriff(e) Female ; Animals ; Borna Disease ; Antigens, Viral ; Autopsy/veterinary ; Meningoencephalitis/veterinary ; Sepsis/veterinary
    Chemische Substanzen Antigens, Viral
    Sprache Englisch
    Erscheinungsdatum 2024-02-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 390920-7
    ISSN 1532-3129 ; 0021-9975
    ISSN (online) 1532-3129
    ISSN 0021-9975
    DOI 10.1016/j.jcpa.2024.01.003
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  3. Artikel ; Online: [A world beyond SARS-CoV-2, as well

    Michael Sieg / Thomas W. Vahlenkamp

    Berliner und Münchener Tierärztliche Wochenschrift, Vol

    Coronaviruses in zoo and wildlife animals]

    2021  Band 134

    Abstract: The family of Coronaviridae comprises numerous virus species, some of which play an outstanding role in veterinary medicine. In addition to infections of the respiratory and/or the gastrointestinal tract, which are usually mild, severe systemic ... ...

    Abstract [The family of Coronaviridae comprises numerous virus species, some of which play an outstanding role in veterinary medicine. In addition to infections of the respiratory and/or the gastrointestinal tract, which are usually mild, severe systemic infections and even fatal outcomes can occur. Wild and zoo animals are just as affected by coronavirus infections as their domesticated counterparts. In many cases, however, other virus species or virus variants are found in wild animals, which so far have not been characterized in detail. Knowledge of the virus reservoirs, the transmission mechanisms, the virus evolution and the underlying pathomechanisms is a basic requirement for combating relevant infections in pets and farm animals. In the area of coronaviruses in zoo and wild animals, there is still a considerable need for research in order to be able to answer pestering questions regarding the zoonotic potential and possible cross-species transmissions between wild and domesticated animals.] Die Familie der Coronaviridae umfasst zahlreiche Virusspezies, die im Tierreich teils von großer Bedeutung sind. Neben Infektionen der Atemwege und/oder des Magen-Darm-Traktes, welche in der Regel mild verlaufen, können auch schwere systemische Infektionen bis hin zu tödlichen Krankheitsverläufen vorkommen. Wild- und Zootiere sind dabei von Infektionen mit Coronaviren genauso betroffen wie deren domestizierte Artgenossen. Allerdings findet man in wild lebenden Tieren in vielen Fällen noch weitere Virusspezies oder Virusvarianten, welche bis dato schlecht oder kaum charakterisiert sind. Dabei ist die Kenntnis des Virusreservoirs, der Übertragungsmechanismen, der Virusevolution und der zugrunde liegenden Pathomechanismen Grundvoraussetzung zur Bekämpfung entsprechender Infektionen bei Haus- und Nutztieren. Hinsichtlich der Coronaviren von Zoo- und Wildtieren besteht hierbei noch erheblicher Forschungsbedarf, um wichtige Fragen bezüglich des zoonotischen Potenzials und möglicher Spezies-Übertritte zwischen Wild- und ...
    Schlagwörter reservoir ; zoonosis ; enteritis ; respiratory infections ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 801
    Sprache Deutsch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag Schlütersche Fachmedien GmbH
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Case Series of Disseminated Xanthogranulomatosis in Red-crowned Parakeets (

    Konicek, Cornelia / Heenemann, Kristin / Cramer, Kerstin / Vahlenkamp, Thomas W / Schmidt, Volker

    Animals : an open access journal from MDPI

    2022  Band 12, Heft 18

    Abstract: Xanthogranulomatosis is a common dermatological disease in birds. This form of inflammation, possibly associated with lipometabolic disorders, can also be seen in visceral organs, which as yet has only rarely been described in avian medicine. In general, ...

    Abstract Xanthogranulomatosis is a common dermatological disease in birds. This form of inflammation, possibly associated with lipometabolic disorders, can also be seen in visceral organs, which as yet has only rarely been described in avian medicine. In general, diseases related to impaired lipid metabolism are frequently reported in avian medicine, with hepatic steatosis and atherosclerosis being the most common. In human medicine, infectious agents-especially some strains of adenovirus-were implicated in contributing to lipometabolic disorders; this has also been described for chicken. Here, a case series of six Red-crowned Parakeets (
    Sprache Englisch
    Erscheinungsdatum 2022-09-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12182316
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Seroprevalence of Infection with Feline Morbilliviruses Is Associated with FLUTD and Increased Blood Creatinine Concentrations in Domestic Cats.

    Busch, Johannes / Heilmann, Romy M / Vahlenkamp, Thomas W / Sieg, Michael

    Viruses

    2021  Band 13, Heft 4

    Abstract: Feline morbilliviruses (FeMV) are fairly newly discovered paramyxoviruses found in cats. The first description indicated an association with widely distributed chronic kidney disease (CKD) in the host species. In various studies, a global prevalence and ... ...

    Abstract Feline morbilliviruses (FeMV) are fairly newly discovered paramyxoviruses found in cats. The first description indicated an association with widely distributed chronic kidney disease (CKD) in the host species. In various studies, a global prevalence and a further genotype, designated FeMV-2, and the involvement of other organ systems in infected individuals were shown. Using an immunofluorescence assay, we detected an overall seroprevalence of FeMV in almost half of the cats investigated (
    Mesh-Begriff(e) Animals ; Animals, Domestic/virology ; Cats ; Creatinine/blood ; Female ; Genotype ; Kidney/virology ; Male ; Morbillivirus/genetics ; Morbillivirus/immunology ; Morbillivirus Infections/immunology ; Morbillivirus Infections/veterinary ; Phylogeny ; Prevalence ; RNA, Viral/genetics ; Renal Insufficiency, Chronic/veterinary ; Renal Insufficiency, Chronic/virology ; Seroepidemiologic Studies ; Urologic Diseases/veterinary ; Urologic Diseases/virology
    Chemische Substanzen RNA, Viral ; Creatinine (AYI8EX34EU)
    Sprache Englisch
    Erscheinungsdatum 2021-03-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13040578
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Avian leukosis virus (ALV) is highly prevalent in fancy-chicken flocks in Saxony.

    Freick, Markus / Schreiter, Ruben / Weber, Jim / Vahlenkamp, Thomas W / Heenemann, Kristin

    Archives of virology

    2022  Band 167, Heft 4, Seite(n) 1169–1174

    Abstract: The current prevalence of avian leukosis virus (ALV) in fancy chickens in Germany is unknown. Therefore, 537 cloacal swabs from 50 purebred fancy-chicken flocks in Saxony were tested for the presence of the ALV p27 protein using a commercial antigen- ... ...

    Abstract The current prevalence of avian leukosis virus (ALV) in fancy chickens in Germany is unknown. Therefore, 537 cloacal swabs from 50 purebred fancy-chicken flocks in Saxony were tested for the presence of the ALV p27 protein using a commercial antigen-capture ELISA. The detection rate was 28.7% at the individual-animal level and 56.0% at the flock level. Phylogenetic analysis of PCR products obtained from 22 different flocks revealed the highest similarity to ALV subtype K. When classifying breeds by their origin, ALV detection rates differed significantly. Evaluation of questionnaire data revealed no significant differences between ALV-positive and negative flocks regarding mortality.
    Mesh-Begriff(e) Animals ; Avian Leukosis/epidemiology ; Avian Leukosis Virus/genetics ; Chickens ; Germany/epidemiology ; Phylogeny
    Sprache Englisch
    Erscheinungsdatum 2022-03-17
    Erscheinungsland Austria
    Dokumenttyp Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-022-05404-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.110: Hefte anzeigen Standort:
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  7. Artikel ; Online: Mutated Measles Virus Matrix and Fusion Protein Influence Viral Titer In Vitro and Neuro-Invasion in Lewis Rat Brain Slice Cultures.

    Busch, Johannes / Chey, Soroth / Sieg, Michael / Vahlenkamp, Thomas W / Liebert, Uwe G

    Viruses

    2021  Band 13, Heft 4

    Abstract: Measles virus (MV) can cause severe acute diseases as well as long-lasting clinical deteriorations due to viral-induced immunosuppression and neuronal manifestation. How the virus enters the brain and manages to persist in neuronal tissue is not fully ... ...

    Abstract Measles virus (MV) can cause severe acute diseases as well as long-lasting clinical deteriorations due to viral-induced immunosuppression and neuronal manifestation. How the virus enters the brain and manages to persist in neuronal tissue is not fully understood. Various mutations in the viral genes were found in MV strains isolated from patient brains. In this study, reverse genetics was used to introduce mutations in the fusion, matrix and polymerase genes of MV. The generated virus clones were characterized in cell culture and used to infect rat brain slice cultures. A mutation in the carboxy-terminal domain of the matrix protein (R293Q) promoted the production of progeny virions. This effect was observed in Vero cells irrespective of the expression of the signaling lymphocyte activation molecule (SLAM). Furthermore, a mutation in the fusion protein (I225M) induced syncytia formation on Vero cells in the absence of SLAM and promoted viral spread throughout the rat brain slices. In this study, a solid ex vivo model was established to elucidate the MV mutations contributing to neural manifestation.
    Mesh-Begriff(e) Animals ; Brain/virology ; Chlorocebus aethiops ; HEK293 Cells ; Humans ; In Vitro Techniques ; Measles/virology ; Measles virus/genetics ; Measles virus/pathogenicity ; Measles virus/physiology ; Mutation ; Neurons/virology ; Rats, Inbred Lew ; Reverse Genetics ; Signaling Lymphocytic Activation Molecule Family Member 1/genetics ; Signaling Lymphocytic Activation Molecule Family Member 1/metabolism ; Vero Cells ; Viral Fusion Proteins/genetics ; Viral Proteins/genetics ; Viral Tropism/genetics ; Rats
    Chemische Substanzen Viral Fusion Proteins ; Viral Proteins ; Signaling Lymphocytic Activation Molecule Family Member 1 (169535-43-7)
    Sprache Englisch
    Erscheinungsdatum 2021-04-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13040605
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Avian leukosis virus (ALV) is highly prevalent in fancy-chicken flocks in Saxony

    Freick, Markus / Schreiter, Ruben / Weber, Jim / Vahlenkamp, Thomas W. / Heenemann, Kristin

    Archives of virology. 2022 Apr., v. 167, no. 4

    2022  

    Abstract: The current prevalence of avian leukosis virus (ALV) in fancy chickens in Germany is unknown. Therefore, 537 cloacal swabs from 50 purebred fancy-chicken flocks in Saxony were tested for the presence of the ALV p27 protein using a commercial antigen- ... ...

    Abstract The current prevalence of avian leukosis virus (ALV) in fancy chickens in Germany is unknown. Therefore, 537 cloacal swabs from 50 purebred fancy-chicken flocks in Saxony were tested for the presence of the ALV p27 protein using a commercial antigen-capture ELISA. The detection rate was 28.7% at the individual-animal level and 56.0% at the flock level. Phylogenetic analysis of PCR products obtained from 22 different flocks revealed the highest similarity to ALV subtype K. When classifying breeds by their origin, ALV detection rates differed significantly. Evaluation of questionnaire data revealed no significant differences between ALV-positive and negative flocks regarding mortality.
    Schlagwörter Avian leukosis virus ; cloaca ; flocks ; mortality ; phylogeny ; purebreds ; questionnaires ; virology ; Germany
    Sprache Englisch
    Erscheinungsverlauf 2022-04
    Umfang p. 1169-1174.
    Erscheinungsort Springer Vienna
    Dokumenttyp Artikel
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-022-05404-y
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Horses as sentinels for the circulation of flaviviruses in eastern-central Germany

    Gothe, Leonard M. R. / Ganzenberg, Stefanie / Ziegler, Ute / Obiegala, Anna / Lohmann, Katharina L. / Sieg, Michael / Vahlenkamp, Thomas W. / Hörügel, Uwe / Pfeffer, Martin*

    2023  

    Schlagwörter abstract_or_summary ; Text ; ddc:570 ; vector-borne zoonoses -- specific antibodies -- risk factors -- Usutu- ; West Nile- and Tick-Borne Encephalitis-Virus
    Sprache Englisch
    Erscheinungsdatum 2023-10-09
    Verlag MDPI AG
    Erscheinungsland de
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Case Series of Disseminated Xanthogranulomatosis in Red-crowned Parakeets (Cyanoramphus novaezelandiae) with Detection of Psittacine Adenovirus 2 (PsAdV-2)

    Konicek, Cornelia / Heenemann, Kristin / Cramer, Kerstin / Vahlenkamp, Thomas W. / Schmidt, Volker

    Animals. 2022 Sept. 06, v. 12, no. 18

    2022  

    Abstract: Xanthogranulomatosis is a common dermatological disease in birds. This form of inflammation, possibly associated with lipometabolic disorders, can also be seen in visceral organs, which as yet has only rarely been described in avian medicine. In general, ...

    Abstract Xanthogranulomatosis is a common dermatological disease in birds. This form of inflammation, possibly associated with lipometabolic disorders, can also be seen in visceral organs, which as yet has only rarely been described in avian medicine. In general, diseases related to impaired lipid metabolism are frequently reported in avian medicine, with hepatic steatosis and atherosclerosis being the most common. In human medicine, infectious agents—especially some strains of adenovirus—were implicated in contributing to lipometabolic disorders; this has also been described for chicken. Here, a case series of six Red-crowned Parakeets (Cyanoramphus novaezelandiae) is presented, all cases being characterized by psittacine adenovirus 2 (PsAdV-2) infection with or without disseminated xanthogranulomatosis. The affected individuals were examined alive by clinical examination. Total body radiographs were taken of two birds, haematology and blood biochemistry results were achieved in one bird. The birds either died immediately after clinical presentation or within two days, two individuals were euthanized due to worsening of their clinical condition. All birds underwent a post-mortem examination. While four birds were finally diagnosed with disseminated xanthogranulomatosis, all six individuals had large eosinophilic intranuclear inclusion bodies in the epithelial cells of the collecting ducts of the kidney and tested positive for PsAdV-2. Further examinations are needed to clarify to what extent PsAdV-2 might elicit lipometabolic disease in birds, or psittacines in general, and, in particular, the Red-crowned Parakeet.
    Schlagwörter Adenoviridae ; Cyanoramphus novaezelandiae ; atherosclerosis ; blood chemistry ; chickens ; clinical examination ; epithelium ; fatty liver ; hematology ; inflammation ; kidneys ; lipid metabolism ; medicine ; necropsy ; parakeets
    Sprache Englisch
    Erscheinungsverlauf 2022-0906
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12182316
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