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  1. Artikel: Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19.

    Lega, Sara / Naviglio, Samuele / Volpi, Stefano / Tommasini, Alberto

    Vaccines

    2020  Band 8, Heft 2

    Abstract: As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort ... This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host ...

    Abstract As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort is being made to understand the disease pathogenesis and host factors that predispose to disease progression in an attempt to find a window of opportunity for intervention. In addition to the direct cytopathic effect of the virus, the host hyper-inflammatory response has emerged as a key factor in determining disease severity and mortality. Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. So far, Covid-19 management remains mainly supportive. However, many researches are underway to clarify the role of antiviral and immunomodulating drugs in changing morbidity and mortality in patients who become severely ill. This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host immune system and discusses recent findings on proposed pharmacologic treatments.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines8020224
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch ; Online: Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19

    Sara Lega / Samuele Naviglio / Stefano Volpi / Alberto Tommasini

    Vaccines ; Volume 8 ; Issue 2

    2020  

    Abstract: As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort ... This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host ...

    Abstract As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort is being made to understand the disease pathogenesis and host factors that predispose to disease progression in an attempt to find a window of opportunity for intervention. In addition to the direct cytopathic effect of the virus, the host hyper-inflammatory response has emerged as a key factor in determining disease severity and mortality. Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. So far, Covid-19 management remains mainly supportive. However, many researches are underway to clarify the role of antiviral and immunomodulating drugs in changing morbidity and mortality in patients who become severely ill. This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host immune system and discusses recent findings on proposed pharmacologic treatments.
    Schlagwörter coronavirus ; Covid-19 ; SARS-CoV-2 ; immune response ; T cell repertoire ; cytokine storm ; antiviral immunity ; covid19
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-05-14
    Verlag Multidisciplinary Digital Publishing Institute
    Erscheinungsland ch
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  3. Artikel ; Online: Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19

    Sara Lega / Samuele Naviglio / Stefano Volpi / Alberto Tommasini

    Vaccines, Vol 8, Iss 224, p

    2020  Band 224

    Abstract: As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort ... This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host ...

    Abstract As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort is being made to understand the disease pathogenesis and host factors that predispose to disease progression in an attempt to find a window of opportunity for intervention. In addition to the direct cytopathic effect of the virus, the host hyper-inflammatory response has emerged as a key factor in determining disease severity and mortality. Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. So far, Covid-19 management remains mainly supportive. However, many researches are underway to clarify the role of antiviral and immunomodulating drugs in changing morbidity and mortality in patients who become severely ill. This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host immune system and discusses recent findings on proposed pharmacologic treatments.
    Schlagwörter coronavirus ; Covid-19 ; SARS-CoV-2 ; immune response ; T cell repertoire ; cytokine storm ; Medicine ; R ; covid19
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Is carotid screening redundant for patients undergoing coronary artery bypass grafting?

    Volpi, Sara / Ali, Jason M

    Journal of cardiac surgery

    2020  Band 35, Heft 9, Seite(n) 2297–2306

    Abstract: Objectives: Stroke is a devastating complication following coronary artery bypass grafting, which thankfully occurs with low incidence. The role of preoperative carotid ultrasound remains unclear. Whilst it is a cheap and reliable way of diagnosing ... ...

    Abstract Objectives: Stroke is a devastating complication following coronary artery bypass grafting, which thankfully occurs with low incidence. The role of preoperative carotid ultrasound remains unclear. Whilst it is a cheap and reliable way of diagnosing carotid stenosis (CS), it is unclear if and how this knowledge should impact on subsequent patient management.
    Methods: A systematic review of the literature was performed using the PRISMA guideline. A literature search was conducted on the MEDLINE database from 1950 to May 2020 using the OVID interface. Fifteen papers out of a total of 5931 were identified for inclusion.
    Results: The evidence overall suggests that patients with severe CS are likely to have an increased incidence of postoperative stroke-however, the prevalence of severe CS is low, and even in this cohort of patients, the incidence is not particularly high.
    Conclusion: In screened patients identified to have severe CS, there appears to be a generally low appetite for undertaking carotid intervention internationally either before or concurrently with the coronary artery bypass grafting. Putting this all together, the widespread screening of asymptomatic patients would appear to not be justified.
    Mesh-Begriff(e) Carotid Arteries ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/epidemiology ; Carotid Stenosis/surgery ; Coronary Artery Bypass ; Humans ; Risk Factors ; Stroke/epidemiology ; Stroke/etiology
    Sprache Englisch
    Erscheinungsdatum 2020-07-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Systematic Review
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14771
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: A case report of unusual recurrent bronchopneumonia infections in Mounier-Kuhn syndrome.

    Rossi, Sara / Volpi, Federica / Castellana, Roberto / Pancani, Roberta / Dente, Federico / Gaeta, Roberta / Carrozzi, Laura / Neri, Emanuele / Romei, Chiara

    Radiology case reports

    2024  Band 19, Heft 6, Seite(n) 2525–2530

    Abstract: Mounier-Kuhn syndrome is a rare airway disease characterized by tracheal and bronchial dilatation, primarily affecting middle-aged men. We present a case of Mounier-Kuhn syndrome in a 40-year-old man with a history of recurrent respiratory infections ... ...

    Abstract Mounier-Kuhn syndrome is a rare airway disease characterized by tracheal and bronchial dilatation, primarily affecting middle-aged men. We present a case of Mounier-Kuhn syndrome in a 40-year-old man with a history of recurrent respiratory infections since adolescence. The diagnostic journey involved a multidisciplinary approach incorporating clinical evaluation, radiological imaging, and bronchoscopy. Computed tomography findings, including maximum intensity projection reconstructions and 3D rendering, facilitated the diagnosis by revealing significant airway dilation and associated abnormalities. Treatment primarily focused on supportive measures, including antibiotic therapy and respiratory physiotherapy. This case underscores the importance of considering Mounier-Kuhn syndrome in patients with recurrent respiratory infections and highlights the role of advanced imaging techniques in diagnosis.
    Sprache Englisch
    Erscheinungsdatum 2024-04-04
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2024.03.028
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Assessing satisfaction in simulation among nursing students: psychometric properties of the Satisfaction with Simulation Experience - Italian Version scale.

    Alberti, Sara / Guasconi, Massimo / Bolzoni, Marina / Donnini, Giulia / Volpi, Paola / Rovesti, Sergio / Monaco, Federico / Bonacaro, Antonio / Ferri, Paola

    BMC nursing

    2024  Band 23, Heft 1, Seite(n) 300

    Abstract: Background: The Satisfaction with Simulation Experience scale is a 5-point Likert scale that measures students' satisfaction in medium and high-fidelity simulation scenarios. This study aims at investigating the psychometric properties of the ... ...

    Abstract Background: The Satisfaction with Simulation Experience scale is a 5-point Likert scale that measures students' satisfaction in medium and high-fidelity simulation scenarios. This study aims at investigating the psychometric properties of the Satisfaction with Simulation Experience - Italian Version scale.
    Methods: A multi-centre cross-sectional study was conducted. The scale was administered to a sample of 266 undergraduate nursing students from two Italian universities after attending a medium- and high-fidelity simulation session in November 2022 and March 2023. Cronbach's alpha coefficient and item-total correlation were sorted out to assess internal consistency and reliability. The test-retest method was used as a measure of scale stability over time as well as the confirmatory factor analysis to verify construct validity.
    Results: The Cronbach's alpha value was 0.94 for the overall scale, indicating excellent reliability, and it was 0.84 or higher for each subscales, indicating good reliability. A large correlation coefficient of 0.60 or higher was found between each item and its subscale and between each item and the overall scale score. A medium test-retest correlation coefficient was found for most items (r > 0.30). The confirmatory factor analysis confirmed the factorial structure found in the original study.
    Conclusions: Satisfaction is an important teaching and learning quality indicator along with the achievement of learning outcomes in simulation. The Satisfaction with Simulation Experience - Italian Version scale showed good reliability and validity; therefore, it could be a useful tool to assess simulation impact in Italian nursing students. The extensive utilization of the Satisfaction with Simulation Experience scale, along with its various validated versions, could facilitate assessing satisfaction in simulation across diverse contexts and enable comparisons of findings across studies in different countries.
    Sprache Englisch
    Erscheinungsdatum 2024-04-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2091496-9
    ISSN 1472-6955
    ISSN 1472-6955
    DOI 10.1186/s12912-024-01974-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Recent insight into SARS-COV2 immunopathology and rationale for potential treatment and preventive strategies in COVID-19

    Lega, Sara / Naviglio, Samuele / Volpi, Stefano / Tommasini, Alberto

    Vaccines

    Abstract: As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort ... This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host ...

    Abstract As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort is being made to understand the disease pathogenesis and host factors that predispose to disease progression in an attempt to find a window of opportunity for intervention. In addition to the direct cytopathic effect of the virus, the host hyper-inflammatory response has emerged as a key factor in determining disease severity and mortality. Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. So far, Covid-19 management remains mainly supportive. However, many researches are underway to clarify the role of antiviral and immunomodulating drugs in changing morbidity and mortality in patients who become severely ill. This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host immune system and discusses recent findings on proposed pharmacologic treatments.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #260121
    Datenquelle COVID19

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  8. Artikel: Actinomyces

    Del Fabro, Giovanni / Volpi, Sara / Fumarola, Benedetta / Migliorati, Manuela / Bertelli, Davide / Signorini, Liana / Matteelli, Alberto / Meschiari, Marianna

    Microorganisms

    2023  Band 11, Heft 12

    Abstract: Background: Actinomycosis represents a challenging and under-reported complication of vascular surgery. Optimal management of : Methods: We conducted a retrospective case-series of : Results: We report five original cases of : Conclusions: This ...

    Abstract Background: Actinomycosis represents a challenging and under-reported complication of vascular surgery. Optimal management of
    Methods: We conducted a retrospective case-series of
    Results: We report five original cases of
    Conclusions: This case-series aims to raise the diagnostic suspicion and to describe the current management of
    Sprache Englisch
    Erscheinungsdatum 2023-12-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11122931
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A proof-of-concept study on the genomic evolution of Sars-Cov-2 in molnupiravir-treated, paxlovid-treated and drug-naïve patients.

    Alteri, Claudia / Fox, Valeria / Scutari, Rossana / Burastero, Giulia Jole / Volpi, Sara / Faltoni, Matteo / Fini, Vanessa / Granaglia, Annarita / Esperti, Sara / Gallerani, Altea / Costabile, Valentino / Fontana, Beatrice / Franceschini, Erica / Meschiari, Marianna / Campana, Andrea / Bernardi, Stefania / Villani, Alberto / Bernaschi, Paola / Russo, Cristina /
    Guaraldi, Giovanni / Mussini, Cristina / Perno, Carlo Federico

    Communications biology

    2022  Band 5, Heft 1, Seite(n) 1376

    Abstract: Little is known about SARS-CoV-2 evolution under Molnupiravir and Paxlovid, the only antivirals ... approved for COVID-19 treatment. By investigating SARS-CoV-2 variability in 8 Molnupiravir-treated, 7 ...

    Abstract Little is known about SARS-CoV-2 evolution under Molnupiravir and Paxlovid, the only antivirals approved for COVID-19 treatment. By investigating SARS-CoV-2 variability in 8 Molnupiravir-treated, 7 Paxlovid-treated and 5 drug-naïve individuals at 4 time-points (Days 0-2-5-7), a higher genetic distance is found under Molnupiravir pressure compared to Paxlovid and no-drug pressure (nucleotide-substitutions/site mean±Standard error: 18.7 × 10
    Mesh-Begriff(e) Humans ; SARS-CoV-2/genetics ; COVID-19 Drug Treatment ; COVID-19 ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Evolution, Molecular
    Chemische Substanzen molnupiravir (YA84KI1VEW) ; nirmatrelvir and ritonavir drug combination ; Antiviral Agents
    Sprache Englisch
    Erscheinungsdatum 2022-12-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-022-04322-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Resilience and Frailty in People Living With HIV During the COVID Era: Two Complementary Constructs Associated With Health-Related Quality of Life.

    Guaraldi, Giovanni / Milic, Jovana / Barbieri, Sara / Marchiò, Tommaso / Caselgrandi, Agnese / Volpi, Sara / Aprile, Emanuele / Belli, Michela / Venuta, Maria / Mussini, Cristina

    Journal of acquired immune deficiency syndromes (1999)

    2022  Band 89, Heft Suppl 1, Seite(n) S65–S72

    Abstract: Background: Resilience is defined as an individual's positive adaptation to stressors. The COVID-19 pandemic represents a generalized stressor which may affect differently people living with HIV (PLWH). The objective of this study was to characterize ... ...

    Abstract Background: Resilience is defined as an individual's positive adaptation to stressors. The COVID-19 pandemic represents a generalized stressor which may affect differently people living with HIV (PLWH). The objective of this study was to characterize resilience in PLWH with particular regarding the identification of frailty-resilience phenotypes, which may differently affect health-related quality of life (HR-QoL).
    Methods: This was an observational study of PLWH attending Modena HIV Metabolic Clinic. Frailty was assessed in 2019, before the onset of the COVID-19 pandemic by using 37-Item frailty index ranging from 0 to 1. The frailty index score was categorized as fit (<0.25) or frail (>0.25). In January 2021, PLWH were offered to complete a set of electronic questionnaires including the CD-RISC-25 for resilience and EQ-5D5L and SF-36 for HR-QoL. Resilience was defined as CD-RISC-25 score >75.7 (ranging from 0 to 100).
    Results: Of 800 PLWH reached by mail, 575 (72%) completed the questionnaires. The median age and HIV duration were 54.5 and 24.3 years, respectively. Impaired resilience was associated with loneliness [odds ratio (OR = 2.39; 1.20 to 4.76, P < 0.001)]. Predictors for EQ-5D5L <89.7% were the phenotypes "frail/nonresilient" [OR = 5.21, 95% confidence interval (CI): 2.62 to 10.33] and "fit/nonresilient" (OR = 5.48, 95% CI: 2.8 to 10.74). Predictors for SF-36 <64.40 were the phenotypes "frail/nonresilient" (OR = 7.43, 95% CI: 2.57 to 21.22) and "fit/nonresilient" (OR = 6.27, 95% CI: 2.17 to 18.16). Both models were corrected for age, sex, HIV duration, and nadir CD4.
    Conclusions: Resilience characterizes the well-being of PLWH during the COVID-19 crisis. This construct is complementary to frailty in the identification of clinical phenotypes with different impacts on HR-QoL.
    Mesh-Begriff(e) Aged ; Aging ; COVID-19/epidemiology ; COVID-19/psychology ; Cross-Sectional Studies ; Female ; Frail Elderly/psychology ; Frailty/psychology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/psychology ; Humans ; Male ; Pandemics ; Quality of Life/psychology ; Resilience, Psychological ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2022-01-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000002865
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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