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  1. Artikel ; Online: Glucose metabolism partially regulates β-cell function through epigenomic changes.

    Kim, Yong Kyung / Won, Kyu Chang / Sussel, Lori

    Journal of diabetes investigation

    2024  

    Abstract: ... flexibility to productively respond to shifts in environmental conditions and changes in glucose availability ... that the resulting changes in cellular metabolites can impact the epigenome, causing transient and lasting ... alterations in gene expression. This review explores the intricate interplay between metabolism and ...

    Abstract The β-cell relies predominantly on glucose utilization to generate adenosine triphosphate, which is crucial for both cell viability and insulin secretion. The β-cell has evolved remarkable metabolic flexibility to productively respond to shifts in environmental conditions and changes in glucose availability. Although these adaptive responses are important for maintaining optimal cellular function, there is emerging evidence that the resulting changes in cellular metabolites can impact the epigenome, causing transient and lasting alterations in gene expression. This review explores the intricate interplay between metabolism and the epigenome, providing valuable insights into the molecular mechanisms leading to β-cell dysfunction in diabetes. Understanding these mechanisms will be critical for developing targeted therapeutic strategies to preserve and enhance β-cell function, offering potential avenues for interventions to improve glycemic control in individuals with diabetes.
    Sprache Englisch
    Erscheinungsdatum 2024-03-04
    Erscheinungsland Japan
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14173
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: DMJ, Better than Yesterday, More Brilliant Tomorrow.

    Won, Kyu Chang

    Diabetes & metabolism journal

    2019  Band 43, Heft 1, Seite(n) 1–2

    Sprache Englisch
    Erscheinungsdatum 2019-02-21
    Erscheinungsland Korea (South)
    Dokumenttyp Editorial
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6079
    ISSN (online) 2233-6087
    ISSN 2233-6079
    DOI 10.4093/dmj.2019.0030
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  3. Artikel: A Short but Long Journey with You.

    Won, Kyu Chang

    Diabetes & metabolism journal

    2018  Band 42, Heft 1, Seite(n) 1–2

    Sprache Englisch
    Erscheinungsdatum 2018-02
    Erscheinungsland Korea (South)
    Dokumenttyp Editorial
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6079
    ISSN (online) 2233-6087
    ISSN 2233-6079
    DOI 10.4093/dmj.2018.42.1.1
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  4. Artikel: Deep Learning Super-Resolution Technique Based on Magnetic Resonance Imaging for Application of Image-Guided Diagnosis and Surgery of Trigeminal Neuralgia.

    Hwang, Jun Ho / Park, Chang Kyu / Kang, Seok Bin / Choi, Man Kyu / Lee, Won Hee

    Life (Basel, Switzerland)

    2024  Band 14, Heft 3

    Abstract: This study aimed to implement a deep learning-based super-resolution (SR) technique that can assist in the diagnosis and surgery of trigeminal neuralgia (TN) using magnetic resonance imaging (MRI). Experimental methods applied SR to MRI data examined ... ...

    Abstract This study aimed to implement a deep learning-based super-resolution (SR) technique that can assist in the diagnosis and surgery of trigeminal neuralgia (TN) using magnetic resonance imaging (MRI). Experimental methods applied SR to MRI data examined using five techniques, including T2-weighted imaging (T2WI), T1-weighted imaging (T1WI), contrast-enhancement T1WI (CE-T1WI), T2WI turbo spin-echo series volume isotropic turbo spin-echo acquisition (VISTA), and proton density (PD), in patients diagnosed with TN. The image quality was evaluated using the peak signal-to-noise ratio (PSNR) and structural similarity index (SSIM). High-quality reconstructed MRI images were assessed using the Leksell coordinate system in gamma knife radiosurgery (GKRS). The results showed that the PSNR and SSIM values achieved by SR were higher than those obtained by image postprocessing techniques, and the coordinates of the images reconstructed in the gamma plan showed no differences from those of the original images. Consequently, SR demonstrated remarkable effects in improving the image quality without discrepancies in the coordinate system, confirming its potential as a useful tool for the diagnosis and surgery of TN.
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14030355
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  5. Artikel ; Online: Mitochondrial ALDH2 improves ß-cell survival and function against doxorubicin-induced apoptosis by targeting CK2 signaling.

    Karunakaran, Udayakumar / Ha, Eun Yeong / Elumalai, Suma / Won, Kyu Chang / Moon, Jun Sung

    Journal of diabetes investigation

    2024  

    Abstract: Aims: The aim of this study was to better understand how the chemotherapy drug doxorubicin contributes to the development of β-cell dysfunction and to explore its relationship with mitochondrial aldehyde dehydrogenase-2 (ALDH2).: Materials and methods! ...

    Abstract Aims: The aim of this study was to better understand how the chemotherapy drug doxorubicin contributes to the development of β-cell dysfunction and to explore its relationship with mitochondrial aldehyde dehydrogenase-2 (ALDH2).
    Materials and methods: In order to investigate this hypothesis, doxorubicin was administered to INS-1 cells, a rat insulinoma cell line, either with or without several target protein activators and inhibitors. ALDH2 activity was detected with a commercial kit and protein levels were determined with western blot. Mitochondrial ROS, membrane potential, and lipid ROS were determined by commercial fluorescent probes. The cell viability was measured by CCK-assay.
    Results: Exposure of INS-1 cells to doxorubicin decreased active insulin signaling resulting in elevated ALDH2 degradation, compared with control cells by the induction of acid sphingomyelinase mediated ceramide induction. Further, ceramide induction potentiated doxorubicin induced mitochondrial dysfunction. Treatment with the ALDH2 agonist, ALDA1, blocked doxorubicin-induced acid sphingomyelinase activation which significantly blocked ceramide induction and mitochondrial dysfunction mediated cell death. Treatment with the ALDH2 agonist, ALDA1, stimulated casein kinase-2 (CK2) mediated insulin signaling activation. CK2 silencing neutralized the function of ALDH2 in the doxorubicin treated INS-1 cells.
    Conclusions: Mitochondrial ALDH2 activation could inhibit the progression of doxorubicin induced pancreatic β-cell dysfunction by inhibiting the acid sphingomyelinase induction of ceramide, by regulating the activation of CK2 signaling. Our research lays the foundation of ALDH2 activation as a therapeutic target for the precise treatment of chemotherapy drug induced β-cell dysfunction.
    Sprache Englisch
    Erscheinungsdatum 2024-05-07
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14230
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Evaluation and Management of Patients With Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement.

    Lee, Kyu-Sun / Noh, Junghyun / Park, Seong-Mi / Choi, Kyung Mook / Kang, Seok-Min / Won, Kyu-Chang / Cho, Hyun-Jai / Moon, Min Kyong

    International journal of heart failure

    2023  Band 5, Heft 1, Seite(n) 1–20

    Abstract: Diabetes mellitus is a major risk factor for the development of heart failure. Furthermore, the prognosis of heart failure is worse in patients with diabetes mellitus than in those without it. Therefore, early diagnosis and proper management of heart ... ...

    Abstract Diabetes mellitus is a major risk factor for the development of heart failure. Furthermore, the prognosis of heart failure is worse in patients with diabetes mellitus than in those without it. Therefore, early diagnosis and proper management of heart failure in patients with diabetes mellitus are important. This review discusses the current criteria for diagnosis and screening tools for heart failure and the currently recommended pharmacological therapies for heart failure. We also highlight the effects of anti-diabetic medications on heart failure.
    Sprache Englisch
    Erscheinungsdatum 2023-01-24
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article ; Review
    ISSN 2636-1558
    ISSN (online) 2636-1558
    DOI 10.36628/ijhf.2022.0028
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  7. Artikel ; Online: Evaluation and Management of Patients with Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement.

    Lee, Kyu-Sun / Noh, Junghyun / Park, Seong-Mi / Choi, Kyung Mook / Kang, Seok-Min / Won, Kyu-Chang / Cho, Hyun-Jai / Moon, Min Kyong

    Diabetes & metabolism journal

    2023  Band 47, Heft 1, Seite(n) 10–26

    Abstract: Diabetes mellitus is a major risk factor for the development of heart failure. Furthermore, the prognosis of heart failure is worse in patients with diabetes mellitus than in those without it. Therefore, early diagnosis and proper management of heart ... ...

    Abstract Diabetes mellitus is a major risk factor for the development of heart failure. Furthermore, the prognosis of heart failure is worse in patients with diabetes mellitus than in those without it. Therefore, early diagnosis and proper management of heart failure in patients with diabetes mellitus are important. This review discusses the current criteria for diagnosis and screening tools for heart failure and the currently recommended pharmacological therapies for heart failure. We also highlight the effects of anti-diabetic medications on heart failure.
    Mesh-Begriff(e) Humans ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Heart Failure/complications ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Risk Factors ; Prognosis ; Republic of Korea/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2023-01-26
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6087
    ISSN (online) 2233-6087
    ISSN 2233-6087
    DOI 10.4093/dmj.2022.0420
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: The Outbreak of COVID-19 and Diabetes in Korea: "We Will Find a Way as We Have Always Done".

    Won, Kyu Chang / Yoon, Kun Ho

    Diabetes & metabolism journal

    2019  Band 44, Heft 2, Seite(n) 211–212

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus ; Disease Outbreaks ; Humans ; Pandemics ; Pneumonia, Viral ; Republic of Korea ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2019-12-19
    Erscheinungsland Korea (South)
    Dokumenttyp Editorial ; Comment
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6087
    ISSN (online) 2233-6087
    ISSN 2233-6087
    DOI 10.4093/dmj.2020.0092
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  9. Artikel ; Online: Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system

    Udayakumar Karunakaran / Suma Elumalai / Seung Min Chung / Kathrin Maedler / Kyu Chang Won / Jun Sung Moon

    Redox Biology, Vol 69, Iss , Pp 102994- (2024)

    1481  

    Abstract: Progression of β-cell loss in diabetes mellitus is significantly influenced by persistent hyperglycemia. At the cellular level, a number of signaling cascades affect the expression of apoptotic genes, ultimately resulting in β-cell failure; these ... ...

    Abstract Progression of β-cell loss in diabetes mellitus is significantly influenced by persistent hyperglycemia. At the cellular level, a number of signaling cascades affect the expression of apoptotic genes, ultimately resulting in β-cell failure; these cascades have not been elucidated. Mitochondrial aldehyde dehydrogenase-2 (ALDH2) plays a central role in the detoxification of reactive aldehydes generated from endogenous and exogenous sources and protects against mitochondrial deterioration in cells. Here we report that under diabetogenic conditions, ALDH2 is strongly inactivated in β-cells through CDK5-dependent glutathione antioxidant imbalance by glucose-6-phosphate dehydrogenase (G6PD) degradation. Intriguingly, CDK5 inhibition strengthens mitochondrial antioxidant defense through ALDH2 activation. Mitochondrial ALDH2 activation selectively preserves β-cells against high-glucose-induced dysfunction by activating AMPK and Hydrogen Sulfide (H2S) signaling. This is associated with the stabilization and enhancement of the activity of G6PD by SIRT2, a cytoplasmic NAD+-dependent deacetylase, and is thereby linked to an elevation in the GSH/GSSG ratio, which leads to the inhibition of mitochondrial dysfunction under high-glucose conditions. Furthermore, treatment with NaHS, an H2S donor, selectively preserves β-cell function by promoting ALDH2 activity, leading to the inhibition of lipid peroxidation by high-glucose concentrations. Collectively, our results provide the first direct evidence that ALDH2 activation enhances H2S-AMPK-G6PD signaling, leading to improved β-cell function and survival under high-glucose conditions via the glutathione redox balance.
    Schlagwörter Pancreatic β-cells ; Oxidative stress ; Glutathione ; Hydrogen sulfide ; Glucotoxicity ; CDK5/AMPK pathway ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2024-02-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Enhancing Diabetes Care through a Mobile Application: A Randomized Clinical Trial on Integrating Physical and Mental Health among Disadvantaged Individuals.

    Bae, Jae Hyun / Park, Eun Hee / Lee, Hae Kyung / Yoon, Kun Ho / Won, Kyu Chang / Kim, Hyun Mi / Kim, Sin Gon

    Diabetes & metabolism journal

    2024  

    Abstract: ... with usual care or only usual care. Primary outcomes measured changes in psychological status and diabetes ...

    Abstract Background: This study examines integrating physical and mental healthcare for disadvantaged persons with type 2 diabetes mellitus and mild-to-moderate depression in the community, using a mobile application within a public-private-academic partnership.
    Methods: The Korean Diabetes Association has developed a mobile application combining behavioral activation for psychological well-being and diabetes self-management, with conventional medical therapy. Participants were randomly assigned to receive the application with usual care or only usual care. Primary outcomes measured changes in psychological status and diabetes selfmanagement through questionnaires at week 12 from the baseline. Secondary outcomes assessed glycemic and lipid control, with psychological assessments at week 16.
    Results: Thirty-nine of 73 participants completed the study (20 and 19 in the intervention and control groups, respectively) and were included in the analysis. At week 12, the intervention group showed significant reductions in depression severity and perceived stress compared to the control group. Additionally, they reported increased perceived social support and demonstrated improved diabetes self-care behavior. These positive effects persisted through week 16, with the added benefit of reduced anxiety. While fasting glucose levels in the intervention group tended to improve, no other significant differences were observed in laboratory assessments between the groups.
    Conclusion: This study provides compelling evidence for the potential efficacy of a mobile application that integrates physical and mental health components to address depressive symptoms and enhance diabetes self-management in disadvantaged individuals with type 2 diabetes mellitus and depression. Further research involving larger and more diverse populations is warranted to validate these findings and solidify their implications.
    Sprache Englisch
    Erscheinungsdatum 2024-02-02
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6087
    ISSN (online) 2233-6087
    ISSN 2233-6087
    DOI 10.4093/dmj.2023.0298
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