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  1. Artikel: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers

    YingRui, Wang / Zheng, Liu / GuoYan, Liu / Hongjie, Wang / YuLian, Liu / BoWen, Wang

    Pharmacological research. 2022,

    2022  

    Abstract: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification ... the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain ... enrichment, and finally Cytoscape software used to construct the " Gong Ying detoxification lotion component ...

    Abstract Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers. We used the traditional Chinese medicine system pharmacology analysis platform (Tcmsp) and the BATMAN-TCM database to retrieve the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain the predicted target and to explore the potential targets of the Diabetic foot ulcers; the String platform was used to construct the protein interaction Action network; the data were analyzed by GO and KEGG pathway enrichment, and finally Cytoscape software used to construct the " Gong Ying detoxification lotion component-Diabetic foot ulcers target-pathway" network. The core active ingredients of Gong Ying detoxification lotion in the treatment of Diabetic foot ulcers were found to be quercetin, choline, wogonin. The biological pathways mainly involved involve classical pathways operating in cancer including the HIF-1 signaling pathway. This study in reveals the characteristics of multi-target and multi-path combination of Gong Ying to treat Diabetic foot ulcers, and provides research ideas and theoretical basis for further treatment of Diabetic foot ulcers.
    Schlagwörter Oriental traditional medicine ; choline ; computer software ; databases ; diabetic foot ; drugs ; pharmacology ; quercetin ; research
    Sprache Englisch
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ISSN 2667-1425
    DOI 10.1016/j.prmcm.2022.100084
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers

    Wang YingRui / Liu Zheng / Liu GuoYan / Wang Hongjie / Liu YuLian / Wang BoWen

    Pharmacological Research - Modern Chinese Medicine, Vol 3, Iss , Pp 100084- (2022)

    2022  

    Abstract: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification ... the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain ... enrichment, and finally Cytoscape software used to construct the '' Gong Ying detoxification lotion component ...

    Abstract Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers. We used the traditional Chinese medicine system pharmacology analysis platform (Tcmsp) and the BATMAN-TCM database to retrieve the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain the predicted target and to explore the potential targets of the Diabetic foot ulcers; the String platform was used to construct the protein interaction Action network; the data were analyzed by GO and KEGG pathway enrichment, and finally Cytoscape software used to construct the '' Gong Ying detoxification lotion component-Diabetic foot ulcers target-pathway'' network. The core active ingredients of Gong Ying detoxification lotion in the treatment of Diabetic foot ulcers were found to be quercetin, choline, wogonin. The biological pathways mainly involved involve classical pathways operating in cancer including the HIF-1 signaling pathway. This study in reveals the characteristics of multi-target and multi-path combination of Gong Ying to treat Diabetic foot ulcers, and provides research ideas and theoretical basis for further treatment of Diabetic foot ulcers.
    Schlagwörter Public antidote wasolytic wash ; Network pharmacology ; Diabetic foot ulcers ; Molecular mechanism ; External treatment of traditional chinese medicine ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
    Thema/Rubrik (Code) 004
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Quality evaluation of Sinopodophyllum hexandrum (Royle) Ying based on active compounds, bioactivities and RP-HPLC fingerprint

    Liu, Wei / Yin, Dong-xue / Tang, Nan / Zhang, Tong / Wang, Jia / Qin, De-hua / Zhang, Zheng

    Industrial crops and products. 2021 Dec. 15, v. 174

    2021  

    Abstract: Sinopodophyllum hexandrum (Royle) Ying is a perennial medicinal plant that produces the anti-cancer ...

    Abstract Sinopodophyllum hexandrum (Royle) Ying is a perennial medicinal plant that produces the anti-cancer lignan compositions especially podophyllotoxin. Since podophyllotoxin commercial production via chemical synthesis, biotechnological intervention or cultivation has yet to meet the increasing demand, mining the potentially available plant organs to discover more natural podophyllotoxin sources is essential. This study investigated the reversed-phase high performance liquid chromatography (RP-HPLC) fingerprint, active chemicals (lignans, flavonoids, and phenolic profiles), and bioactivities (antimicrobial and cytotoxic activities) of distinct S. hexandrum plant organs. Among different plant organs, the rhizome is a preponderant organ due to high active compounds especially podophyllotoxin at 71.615☓10³ μg/mL, high bioactivity with low minimum inhibitory concentration (MIC)/minimal bactericidal concentration (MBC)/minimal fungicidal concentration (MFC) value of 5/5/5 mg/mL, and low CIR₅₀ value of 0.0718 μg/mL, followed by root. Chemometrics analysis techniques, including correlation analysis (CA), similarity analysis (SA), hierarchical cluster analysis (HCA), principal component analysis (PCA), and discriminant analysis (DA), were further employed to facilitate accurate quality assessment of different plant organs from S. hexandrum. The findings unambiguously validated the clustering of seven samples into four major groups (G1–G4), with G1 (rhizome)>G2 (root)>G4 (fruit, blossom, and leaf)>G3 (stem and petiole) as the consistent quality ordering, despite significant differences in chemical compositions and bioactivities. Considered the practical application, the rhizome is, therefore, a preferred medicinal organ, and root could be considered as a substitute resource. The rhizome or root extraction could be used as a potential raw material source for natural antimicrobial agents and cancer cell inhibitors in the food, medicine, and healthcare industries. This research added to our understanding of the integrated exploitation and utilization extension of S. hexandrum resources. RP-HPLC fingerprinting in combination with chemometrics approaches was also confirmed as a highly reliable method for assessing the quality of S. hexandrum and other industrial crops.
    Schlagwörter Podophyllum hexandrum ; chemometrics ; cluster analysis ; cytotoxicity ; discriminant analysis ; flavonoids ; fruits ; health services ; medicinal plants ; medicine ; minimum inhibitory concentration ; neoplasm cells ; petioles ; podophyllotoxin ; principal component analysis ; raw materials ; reversed-phase high performance liquid chromatography ; rhizomes ; synthesis
    Sprache Englisch
    Erscheinungsverlauf 2021-1215
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2021.114159
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Buch: Ying Han, Han Ying shen jing nei ke ci hui shou ce

    Zheng, Liangcheng

    2008  

    Verfasserangabe zhu bian Zheng Liangcheng, Zhou Chilong, Xie Peizeng
    Mesh-Begriff(e) Neurology ; Nervous System ; Nervous System Diseases
    Sprache Chinesisch
    Umfang 752 p.
    Ausgabenhinweis Di 1 ban.
    Verlag Jun shi yi xue ke xue chu ban she
    Erscheinungsort Beijing
    Dokumenttyp Buch
    ISBN 9787802450578 ; 7802450578
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  5. Buch: Ying han zi dong hua ci hui

    Zheng, Dazhong

    2010  

    Titelvarianten Ying-han zidonghua cihui ; An Englisch-Chinese dictionary of automation
    Verfasserangabe Zheng da zhong bian
    Sprache Chinesisch ; Englisch
    Umfang 872 S
    Verlag Qing hua da xue chu ban she
    Erscheinungsort Bei jing
    Dokumenttyp Buch
    ISBN 9787302213734 ; 7302213739
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  6. Buch: Ying Han pi fu bing xue ci hui

    Zheng, Maorong

    2010  

    Titelvarianten English-Chinese dictionary of dermatology
    Verfasserangabe zhu bian Zheng Maorong
    Mesh-Begriff(e) Skin Diseases
    Sprache Chinesisch
    Umfang ii, 423 p. ;, 21 cm.
    Ausgabenhinweis Di 1 ban.
    Verlag Di 2 jun yi da xue chu ban she
    Erscheinungsort Shanghai
    Dokumenttyp Buch
    ISBN 9787810609678 ; 781060967X
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  7. Buch: Yi xue ying xiang yi nan bing li jie du

    Zheng, Suisheng

    2013  

    Verfasserangabe zhu bian Zheng Suisheng, Liu Bin, Luan Weizhi
    Mesh-Begriff(e) Diagnostic Imaging
    Sprache Chinesisch
    Umfang 6, 609 pages :, illustrations
    Ausgabenhinweis Di 1 ban.
    Dokumenttyp Buch
    ISBN 9787533755713 ; 7533755715
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  8. Buch: Jing luo shu xue xue (Han ying dui zhao)

    Zheng, Meifeng

    2012  

    Titelvarianten Meridians and acupoints (Chinese-English)
    Verfasserangabe zhu bian (yi), Zheng Meifeng ; fu zhu bian, Wu Qiang ; bian (yi) wei (an xing shi bi hua pai xu), Ji Feng [and 10 others] ; zhu bian dan wei, Fujian Zhong yi yao da xue = Meridians and acupoints (Chinese-English) / compiler and translator-in-chief, Zheng Meifeng ; vice-compiler-in-chief, Wu Qiang ; compiling and translating committee, Ji Feng [and 10 others] ; Editors' unit, Fujian University of TCM
    Mesh-Begriff(e) Meridians ; Acupuncture Therapy/methods
    Sprache Chinesisch ; Englisch
    Umfang 8, 483 pages :, illustrations
    Ausgabenhinweis Di 1 ban.
    Dokumenttyp Buch
    ISBN 9787513205825 ; 7513205825
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  9. Buch: Bian ying xing bi yan

    Zheng, Hongxiang

    1999  

    Titelübersetzung Rhinallergosis.
    Verfasserangabe Zheng Hongxiang zhu bian
    Mesh-Begriff(e) Rhinitis
    Sprache Chinesisch
    Umfang 3, 239 p. :, ill.
    Ausgabenhinweis Di 1 ban.
    Verlag Beijing yi ke da xue chu ban she
    Erscheinungsort Beijing
    Dokumenttyp Buch
    ISBN 9787810349796 ; 7810349791
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  10. Buch: Mao zhu jing ying xue

    Zheng, Yushan / Hong, Wei

    1999  

    Verfasserangabe Zheng Yushan, Hong Wei bian zhu
    Schlagwörter Bamboo.
    Sprache Chinesisch
    Umfang 2, 4, 521 p., [4] p. of plates :, ill. (some col.) ;, 26 cm.
    Ausgabenhinweis Di 1 ban.
    Verlag Xiamen da xue chu ban she
    Erscheinungsort Fuzhou Shi
    Dokumenttyp Buch
    ISBN 756151428X ; 9787561514283
    Datenquelle NAL Katalog (AGRICOLA)

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