Article: Iron overload.
Clinica chimica acta; international journal of clinical chemistry
2005 Volume 358, Issue 1-2, Page(s) 24–36
Abstract: Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. With the discovery of new proteins and genetic defects we have gained greater insight into their causation at the molecular level and the ... ...
Abstract | Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. With the discovery of new proteins and genetic defects we have gained greater insight into their causation at the molecular level and the complex mechanisms of normal and disordered iron homeostasis. Here we review the normal mechanisms and regulation of gastrointestinal iron absorption and liver iron transport and their dysregulation in iron overload states. Advances in the understanding of the natural history of iron overload disorders and new methods for clinical detection and management of hereditary hemochromatosis are also reviewed. |
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MeSH term(s) | Ceruloplasmin/deficiency ; Ceruloplasmin/metabolism ; Hemochromatosis/metabolism ; Hemochromatosis/pathology ; Humans ; Iron/metabolism ; Iron Overload/etiology ; Iron Overload/metabolism ; Iron Overload/pathology ; Liver Diseases/metabolism ; Liver Diseases/pathology ; Models, Biological ; Transferrin/deficiency ; Transferrin/metabolism |
Chemical Substances | Transferrin ; Iron (E1UOL152H7) ; Ceruloplasmin (EC 1.16.3.1) |
Language | English |
Publishing date | 2005-08 |
Publishing country | Netherlands |
Document type | Journal Article ; Review |
ZDB-ID | 80228-1 |
ISSN | 1873-3492 ; 0009-8981 |
ISSN (online) | 1873-3492 |
ISSN | 0009-8981 |
DOI | 10.1016/j.cccn.2005.02.022 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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