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  1. AU=Sommerstein Rami AU=Sommerstein Rami
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  1. Artikel ; Online: Association of a coronavirus disease 2019 (COVID-19) vaccine booster with control of a COVID-19 outbreak in a long-term care facility in Switzerland, November to December 2021.

    Leiblein, Thomas W / Winistörfer, Annemarie / Seiler, Kurt / Hauri, Rudolf / Sommerstein, Rami

    Infection control and hospital epidemiology

    2023  Band 45, Heft 4, Seite(n) 543–545

    Abstract: Coronavirus disease 2019 (COVID-19) outbreaks in long-term care facilities are often correlated with high case fatality rates. We describe the association of administration of an mRNA booster with the control of an outbreak. Our findings highlight the ... ...

    Abstract Coronavirus disease 2019 (COVID-19) outbreaks in long-term care facilities are often correlated with high case fatality rates. We describe the association of administration of an mRNA booster with the control of an outbreak. Our findings highlight the possibility of vaccine booster early in an outbreak as a promising method to mitigate the spread of infection.
    Mesh-Begriff(e) Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; Switzerland/epidemiology ; Long-Term Care ; Nursing Homes ; Disease Outbreaks/prevention & control
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2023-12-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2023.240
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: OP-Design reduziert Spitalinfektionen

    Sommerstein, Rami

    Hygiene + Medizin: Zeitschrift für angewandte Hygiene in Krankenhäusern und Praxis

    2016  Band 42, Heft 11, Seite(n) 293

    Abstract: Nach grossen Herzoperationen kann es in seltenen Fällen zu Infektionen mit M.chimaera kommen. Ein Gerät zur Regulation der Körperwärme ist dafür verantwortlich. Seit der Entdeckung erarbeitet das Berner Inselspital Richtlinien zur Infektionsprävention. ...

    Abstract Nach grossen Herzoperationen kann es in seltenen Fällen zu Infektionen mit M.chimaera kommen. Ein Gerät zur Regulation der Körperwärme ist dafür verantwortlich. Seit der Entdeckung erarbeitet das Berner Inselspital Richtlinien zur Infektionsprävention.
    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 518696-1
    ISSN 0172-3790
    ISSN 0172-3790
    Datenquelle Literaturdatenbank des Gesundheitswesens

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  3. Artikel ; Online: Invasive Mycobacterium chimaera Infections and Heater-Cooler Devices in Cardiac Surgery.

    Sommerstein, Rami / Hasse, Barbara / Widmer, Andreas F

    Emerging infectious diseases

    2020  Band 26, Heft 3, Seite(n) 632–633

    Mesh-Begriff(e) Cardiac Surgical Procedures ; Chimera ; Global Health ; Humans ; Mycobacterium ; Mycobacterium Infections
    Sprache Englisch
    Erscheinungsdatum 2020-02-24
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2603.191818
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Meticillin-resistant

    Bächli, Magi / Sommerstein, Rami / Casanova, Carlo / Droz, Sara / Küffer, Marianne / Marschall, Jonas

    Infection prevention in practice

    2022  Band 4, Heft 2, Seite(n) 100211

    Abstract: Background: The optimal screening strategy in hospitals to identify secondary cases after contact with a meticillin-resistant : Method: Single center, retrospective, nested case-control study. We evaluated the screening strategy in our 950 bed ... ...

    Abstract Background: The optimal screening strategy in hospitals to identify secondary cases after contact with a meticillin-resistant
    Method: Single center, retrospective, nested case-control study. We evaluated the screening strategy in our 950 bed tertiary care hospital from 2008 - 2014. Room and ward contacts of MRSA index patients present at time of MRSA identification were screened. We compared characteristics of
    Results: Among 270,000 inpatients from 2008 - 2014, 215 MRSA screenings yielded 3013 contact patients, and 6 (0.2%) spa-type matched pairs. We included 225 controls for the nested case-control study. The contact type for the cases was more frequently "same room" and less frequently "same ward" compared with the controls (
    Conclusion: The extensive MRSA screening strategy revealed only few index/contact matches based on spa-typing. Prolonged exposure time and a shared room were significantly associated with MRSA transmission. A targeted screening strategy may be more useful in a low prevalence setting than screening entire wards.
    Sprache Englisch
    Erscheinungsdatum 2022-02-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2022.100211
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Infections postchirurgie artérielle des membres inférieurs : peut-on mieux faire?

    Catho, Gaud / Moulin, Estelle / Sommerstein, Rami / Deslarzes, Céline / Arts, Laure / Danzer, Daniel / Haller, Claude / Berthod, Delphine

    Revue medicale suisse

    2023  Band 19, Heft 845, Seite(n) 1824–1829

    Abstract: Infections associated with arterial reconstructions of the lower limbs are associated with high morbidity. This article reviews the risk factors for infection associated with this surgery and the preventive measures. These include smoking cessation and ... ...

    Titelübersetzung Surgical site infection after lower limb arterial reconstruction: can we improve prevention?
    Abstract Infections associated with arterial reconstructions of the lower limbs are associated with high morbidity. This article reviews the risk factors for infection associated with this surgery and the preventive measures. These include smoking cessation and glycemic control preoperatively; avoiding unnecessary exposure to antibiotics or corticosteroids; optimal peripheral wound care; rigorous antisepsis and antibiotic prophylaxis in the operating theatre

    and finally, meticulous post-operative wound monitoring. The benefit of Staphylococcus aureus decolonization in vascular surgery is less clearly established than in cardiac and thoracic surgery, but it is still recommended in cases of implant placement or where there is a high risk of S. aureus infection, depending on the planned approach and type of surgery.
    Mesh-Begriff(e) Humans ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control ; Surgical Wound Infection/drug therapy ; Staphylococcus aureus ; Anti-Bacterial Agents/therapeutic use ; Staphylococcal Infections/drug therapy ; Antibiotic Prophylaxis/adverse effects ; Vascular Surgical Procedures/adverse effects
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Französisch
    Erscheinungsdatum 2023-10-11
    Erscheinungsland Switzerland
    Dokumenttyp Review ; English Abstract ; Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2023.19.845.1824
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Invasive Mycobacterium chimaera Infections and Heater-Cooler Devices in Cardiac Surgery

    Rami Sommerstein / Barbara Hasse / Andreas F. Widmer

    Emerging Infectious Diseases, Vol 26, Iss 3, Pp 632-

    2020  Band 633

    Schlagwörter Mycobacterium chimaera ; surgical site infection ; cardiac surgery ; healthcare-associated infection ; tuberculosis and other mycobacteria ; equipment contamination ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Sprache Englisch
    Erscheinungsdatum 2020-03-01T00:00:00Z
    Verlag Centers for Disease Control and Prevention
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Timing of Cefuroxime Surgical Antimicrobial Prophylaxis and Its Association With Surgical Site Infections.

    Sommerstein, Rami / Troillet, Nicolas / Harbarth, Stephan / de Kraker, Marlieke E A / Vuichard-Gysin, Danielle / Kuster, Stefan P / Widmer, Andreas F

    JAMA network open

    2023  Band 6, Heft 6, Seite(n) e2317370

    Abstract: Importance: World Health Organization guidelines recommend administering surgical antimicrobial prophylaxis (SAP), including cefuroxime, within 120 minutes prior to incision. However, data from clinical settings supporting this long interval is limited.! ...

    Abstract Importance: World Health Organization guidelines recommend administering surgical antimicrobial prophylaxis (SAP), including cefuroxime, within 120 minutes prior to incision. However, data from clinical settings supporting this long interval is limited.
    Objective: To assess whether earlier vs later timing of administration of cefuroxime SAP is associated with the occurrence of surgical site infections (SSI).
    Design, setting, and participants: This cohort study included adult patients who underwent 1 of 11 major surgical procedures with cefuroxime SAP, documented by the Swissnoso SSI surveillance system between January 2009 and December 2020 at 158 Swiss hospitals. Data were analyzed from January 2021 to April 2023.
    Exposures: Timing of cefuroxime SAP administration before incision was divided into 3 groups: 61 to 120 minutes before incision, 31 to 60 minutes before incision, and 0 to 30 minutes before incision. In addition, a subgroup analysis was performed with time windows of 30 to 55 minutes and 10 to 25 minutes as a surrogate marker for administration in the preoperating room vs in the operating room, respectively. The timing of SAP administration was defined as the start of the infusion obtained from the anesthesia protocol.
    Main outcomes and measures: Occurrence of SSI according to Centers for Disease Control and Prevention definitions. Mixed-effects logistic regression models adjusted for institutional, patient, and perioperative variables were applied.
    Results: Of 538 967 surveilled patients, 222 439 (104 047 men [46.8%]; median [IQR] age, 65.7 [53.9-74.2] years), fulfilled inclusion criteria. SSI was identified in 5355 patients (2.4%). Cefuroxime SAP was administered 61 to 120 minutes prior to incision in 27 207 patients (12.2%), 31 to 60 minutes prior to incision in 118 004 patients (53.1%), and 0 to 30 minutes prior to incision in 77 228 patients (34.7%). SAP administration at 0 to 30 minutes was significantly associated with a lower SSI rate (adjusted odds ratio [aOR], 0.85; 95% CI, 0.78-0.93; P < .001), as was SAP administration 31 to 60 minutes prior to incision (aOR, 0.91; 95% CI, 0.84-0.98; P = .01) compared with administration 61 to 120 minutes prior to incision. Administration 10 to 25 minutes prior to incision in 45 448 patients (20.4%) was significantly associated with a lower SSI rate (aOR, 0.89; 95% CI, 0.82-0.97; P = .009) vs administration within 30 to 55 minutes prior to incision in 117 348 patients (52.8%).
    Conclusions and relevance: In this cohort study, administration of cefuroxime SAP closer to the incision time was associated with significantly lower odds of SSI, suggesting that cefuroxime SAP should be administrated within 60 minutes prior to incision, and ideally within 10 to 25 minutes.
    Mesh-Begriff(e) United States ; Male ; Adult ; Humans ; Aged ; Cefuroxime/therapeutic use ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control ; Surgical Wound Infection/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Cohort Studies ; Antibiotic Prophylaxis/methods ; Risk Factors ; Time Factors ; Anti-Infective Agents/therapeutic use
    Chemische Substanzen Cefuroxime (O1R9FJ93ED) ; Anti-Bacterial Agents ; Anti-Infective Agents
    Sprache Englisch
    Erscheinungsdatum 2023-06-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.17370
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Meticillin-resistant Staphylococcus aureus Contact Screening Strategy in a Low Prevalence Setting; a Nested Case-Control Study

    Magi Bächli / Rami Sommerstein / Carlo Casanova / Sara Droz / Marianne Küffer / Jonas Marschall

    Infection Prevention in Practice, Vol 4, Iss 2, Pp 100211- (2022)

    2022  

    Abstract: Summary: Background: The optimal screening strategy in hospitals to identify secondary cases after contact with a meticillin-resistant Staphylococcus aureus (MRSA) index patient in a low prevalence setting is not well defined. We aimed at identifying ... ...

    Abstract Summary: Background: The optimal screening strategy in hospitals to identify secondary cases after contact with a meticillin-resistant Staphylococcus aureus (MRSA) index patient in a low prevalence setting is not well defined. We aimed at identifying factors associated with documented MRSA transmissions. Method: Single center, retrospective, nested case-control study. We evaluated the screening strategy in our 950 bed tertiary care hospital from 2008 – 2014. Room and ward contacts of MRSA index patients present at time of MRSA identification were screened. We compared characteristics of Staphylococcus aureus Protein A (spa)-type matched contact patients (cases) to negative or spa-type mismatched contact patients (controls). Results: Among 270,000 inpatients from 2008 – 2014, 215 MRSA screenings yielded 3013 contact patients, and 6 (0.2%) spa-type matched pairs. We included 225 controls for the nested case-control study. The contact type for the cases was more frequently “same room” and less frequently “same ward” compared with the controls (P = 0.001). Also, exposure time was longer for cases (median of 6 days [IQR 3–9]) than for controls (1 day [0–3], P=0.016). Conclusion: The extensive MRSA screening strategy revealed only few index/contact matches based on spa-typing. Prolonged exposure time and a shared room were significantly associated with MRSA transmission. A targeted screening strategy may be more useful in a low prevalence setting than screening entire wards.
    Schlagwörter MRSA ; Screening strategy ; Spa type ; Contact patient ; Nosocomial transmission ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Coronavirus Disease 2019 (COVID-19): Do Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Have a Biphasic Effect?

    Sommerstein, Rami / Kochen, Michael M / Messerli, Franz H / Gräni, Christoph

    Journal of the American Heart Association

    2020  Band 9, Heft 7, Seite(n) e016509

    Mesh-Begriff(e) Angiotensin Receptor Antagonists/adverse effects ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Betacoronavirus/drug effects ; COVID-19 ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/drug therapy ; Comorbidity ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Disease Notification ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/drug effects ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index
    Chemische Substanzen Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.016509
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Nosocomial outbreak of vancomycin-resistant

    Piezzi, Vanja / Wassilew, Nasstasja / Atkinson, Andrew / D'Incau, Stéphanie / Kaspar, Tanja / Seth-Smith, Helena Mb / Casanova, Carlo / Bittel, Pascal / Jent, Philipp / Sommerstein, Rami / Buetti, Niccolò / Marschall, Jonas

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2023  Band 27, Heft 48

    Abstract: A large clonal outbreak caused by vancomycin- ... ...

    Abstract A large clonal outbreak caused by vancomycin-resistant
    Mesh-Begriff(e) Humans ; Vancomycin ; Enterococcus faecium/genetics ; Cross Infection/epidemiology ; Switzerland/epidemiology ; Vancomycin-Resistant Enterococci/genetics ; Disease Outbreaks ; Hospitals, University ; Gram-Positive Bacterial Infections/epidemiology
    Chemische Substanzen Vancomycin (6Q205EH1VU)
    Sprache Englisch
    Erscheinungsdatum 2023-01-24
    Erscheinungsland Sweden
    Dokumenttyp Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2022.27.48.2200285
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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