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  1. Artikel ; Online: Dengue and post-infection fatigue: findings from a prospective cohort-the Colombo Dengue Study.

    Sigera, Ponsuge C / Rajapakse, Senaka / Weeratunga, Praveen / De Silva, Nipun L / Gomes, Laksiri / Malavige, Gathsaurie N / Rodrigo, Chaturaka / Fernando, Sumadhya D

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2022  Band 115, Heft 6, Seite(n) 669–676

    Abstract: Background: Previous studies on post-infection fatigue in dengue are few but suggest that up to 25% of dengue patients may suffer from fatigue. This study aimed to evaluate the prevalence and associations of post-infection fatigue in dengue patients ... ...

    Abstract Background: Previous studies on post-infection fatigue in dengue are few but suggest that up to 25% of dengue patients may suffer from fatigue. This study aimed to evaluate the prevalence and associations of post-infection fatigue in dengue patients compared with non-dengue fever patients.
    Methods: Post-infection fatigue and its demographic and clinical associations were assessed in adult dengue and non-dengue fever patients 2 months after the acute infection in a prospective cohort study in Sri Lanka. Fatigue at 2 months (primary endpoint) was assessed with the fatigue questionnaire as a dichotomous outcome based on a pre-recommended cut-off (score ≥4) and as the total score from the questionnaire (higher score indicates more fatigue).
    Results: Of 260 patients, 158 had dengue and, of these, 51 (32%) had fatigue at 2 months. Risk was higher in dengue patients (vs non-dengue; relative risk [RR] 4.93 [95% confidence interval {CI} 2.3 to 10.4]) and more so in female dengue patients (vs male dengue patients; RR 2.45 [95% CI 1.24 to 4.86]). Severe dengue patients had a higher mean fatigue score (p=0.024).
    Conclusions: Post-infection fatigue is an underappreciated burden of this widely prevalent infection. Our findings are useful to triage patients at risk of fatigue for follow-up.
    Mesh-Begriff(e) Adult ; Cohort Studies ; Dengue/complications ; Dengue/epidemiology ; Fatigue/epidemiology ; Fatigue/etiology ; Female ; Humans ; Male ; Prospective Studies ; Sri Lanka/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2022-05-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/traa110
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  2. Artikel ; Online: Success of malaria chemoprophylaxis for outbound civil and military travellers in prevention of reintroduction of malaria in Sri Lanka.

    Fernando, Sumadhya D / Ranaweera, Dewanee / Weerasena, Methnie S / Booso, Rahuman / Wickramasekara, Thamara / Madurapperuma, Chirath P / Danansuriya, Manjula / Rodrigo, Chaturaka / Herath, Hemantha

    International health

    2020  Band 12, Heft 4, Seite(n) 332–338

    Abstract: Background: Sri Lanka was certified as malaria-free in September 2016. However, the continuous presence of the malaria vector poses serious risks of reintroduction of the disease. Chemoprophylaxis and advice on malaria preventive behaviour for ... ...

    Abstract Background: Sri Lanka was certified as malaria-free in September 2016. However, the continuous presence of the malaria vector poses serious risks of reintroduction of the disease. Chemoprophylaxis and advice on malaria preventive behaviour for international travellers is a key strategy adopted to reduce the risk of imported malaria.
    Methods: We conducted an efficiency study of malaria chemoprophylaxis for civilian and military travellers who requested travel advice from the Anti Malaria Campaign (AMC) prior to departure. The AMC is the only agency that can issue malaria chemoprophylaxis to travellers and hence this sample is representative of all such individuals seeking travel advice in Sri Lanka.
    Results: A total of 544 (400 civilians and 144 military) travellers were interviewed prior to departure and after return. The majority travelled to African destinations (516/544 [94.8%]) and were prescribed mefloquine (517/544 [95%]). Chemoprophylaxis was well tolerated and discontinuation due to adverse events was minimal. Regular chemoprophylaxis was reported by 505 (92.8%) participants while overseas. The protective efficacy of chemoprophylaxis was 100% among those who complied with the full course.
    Conclusions: The compliance with chemoprophylaxis and its protective efficacy were satisfactory in this study. It is an effective tool in preventing imported malaria to post-elimination Sri Lanka.
    Mesh-Begriff(e) Adult ; Animals ; Antimalarials/therapeutic use ; Chemoprevention/statistics & numerical data ; Disease Transmission, Infectious/prevention & control ; Female ; Humans ; Malaria/prevention & control ; Malaria/transmission ; Male ; Middle Aged ; Military Personnel/statistics & numerical data ; Sri Lanka ; Travel/statistics & numerical data
    Chemische Substanzen Antimalarials
    Sprache Englisch
    Erscheinungsdatum 2020-01-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2526175-7
    ISSN 1876-3405 ; 1876-3413
    ISSN (online) 1876-3405
    ISSN 1876-3413
    DOI 10.1093/inthealth/ihz094
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  3. Artikel ; Online: Severe Dengue Epidemic, Sri Lanka, 2017

    Hasitha A. Tissera / Bernard D.W. Jayamanne / Rajendra Raut / Sakunthala M.D. Janaki / Yesim Tozan / Preshila C. Samaraweera / Prasad Liyanage / Azhar Ghouse / Chaturaka Rodrigo / Aravinda M. de Silva / Sumadhya D. Fernando

    Emerging Infectious Diseases, Vol 26, Iss 4, Pp 682-

    2020  Band 691

    Abstract: In 2017, a dengue epidemic of unexpected magnitude occurred in Sri Lanka. A total of 186,101 suspected cases and 440 dengue-related deaths occurred. We conducted a comprehensive analysis of this epidemic by comparing national surveillance data for 2017 ... ...

    Abstract In 2017, a dengue epidemic of unexpected magnitude occurred in Sri Lanka. A total of 186,101 suspected cases and 440 dengue-related deaths occurred. We conducted a comprehensive analysis of this epidemic by comparing national surveillance data for 2017 with data from the preceding 5 years. In all Sri Lanka districts, dengue incidence in 2017 increased significantly over incidence during the previous 5 years. Older schoolchildren and young adults were more clinically symptomatic than those at extremes of age. Limited virologic surveillance showed the dominant circulating variant was dengue virus type 2 cosmopolitan genotype in the most affected district. One quarter of total annual cases were reported 5 weeks after the southwest monsoon started. Changes in vector abundance were not predictive of the increased incidence. Direct government expenditures on dengue control activities in 2017 were US $12.7 million. The lessons learned from this outbreak are useful for other tropical nations facing increasing dengue incidence.
    Schlagwörter Dengue ; epidemic ; Sri Lanka ; surveillance ; serotype ; age group ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Sprache Englisch
    Erscheinungsdatum 2020-04-01T00:00:00Z
    Verlag Centers for Disease Control and Prevention
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Severe Dengue Epidemic, Sri Lanka, 2017.

    Tissera, Hasitha A / Jayamanne, Bernard D W / Raut, Rajendra / Janaki, Sakunthala M D / Tozan, Yesim / Samaraweera, Preshila C / Liyanage, Prasad / Ghouse, Azhar / Rodrigo, Chaturaka / de Silva, Aravinda M / Fernando, Sumadhya D

    Emerging infectious diseases

    2020  Band 26, Heft 4, Seite(n) 682–691

    Abstract: In 2017, a dengue epidemic of unexpected magnitude occurred in Sri Lanka. A total of 186,101 suspected cases and 440 dengue-related deaths occurred. We conducted a comprehensive analysis of this epidemic by comparing national surveillance data for 2017 ... ...

    Abstract In 2017, a dengue epidemic of unexpected magnitude occurred in Sri Lanka. A total of 186,101 suspected cases and 440 dengue-related deaths occurred. We conducted a comprehensive analysis of this epidemic by comparing national surveillance data for 2017 with data from the preceding 5 years. In all Sri Lanka districts, dengue incidence in 2017 increased significantly over incidence during the previous 5 years. Older schoolchildren and young adults were more clinically symptomatic than those at extremes of age. Limited virologic surveillance showed the dominant circulating variant was dengue virus type 2 cosmopolitan genotype in the most affected district. One quarter of total annual cases were reported 5 weeks after the southwest monsoon started. Changes in vector abundance were not predictive of the increased incidence. Direct government expenditures on dengue control activities in 2017 were US $12.7 million. The lessons learned from this outbreak are useful for other tropical nations facing increasing dengue incidence.
    Mesh-Begriff(e) Child ; Dengue/epidemiology ; Dengue Virus/genetics ; Epidemics ; Humans ; Severe Dengue/diagnosis ; Severe Dengue/epidemiology ; Sri Lanka/epidemiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-03-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2604.190435
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  5. Artikel ; Online: Malaria is an important differential diagnosis in visitors returning from Sri Lankan National Safari Parks.

    Fernando, Sumadhya D / Paranavitane, Sarath / Galappaththy, Gawrie N L

    Journal of travel medicine

    2011  Band 18, Heft 5, Seite(n) 361–362

    Abstract: Diagnostic confusion may occur between dengue and malaria when febrile patients with thrombocytopenia return from travel to previous malaria endemic areas. Laboratory tests should include blood smear examination for malaria parasites even though current ... ...

    Abstract Diagnostic confusion may occur between dengue and malaria when febrile patients with thrombocytopenia return from travel to previous malaria endemic areas. Laboratory tests should include blood smear examination for malaria parasites even though current malaria endemicity in Sri Lanka is low.
    Mesh-Begriff(e) Child ; Dengue/diagnosis ; Diagnosis, Differential ; Endemic Diseases ; Female ; Humans ; Malaria/diagnosis ; Malaria/epidemiology ; Male ; Sri Lanka/epidemiology ; Travel
    Sprache Englisch
    Erscheinungsdatum 2011-09
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1111/j.1708-8305.2011.00542.x
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  6. Artikel ; Online: The 'hidden' burden of malaria

    Rodrigo Chaturaka / Fernando Sumadhya D / Rajapakse Senaka

    Malaria Journal, Vol 9, Iss 1, p

    cognitive impairment following infection

    2010  Band 366

    Abstract: Abstract Background The burden of post-malaria cognitive impairment is often overlooked. Given the large number of infections occurring worldwide, the magnitude of the problem is likely to be substantial. The objectives of this paper are; (i) to assess ... ...

    Abstract Abstract Background The burden of post-malaria cognitive impairment is often overlooked. Given the large number of infections occurring worldwide, the magnitude of the problem is likely to be substantial. The objectives of this paper are; (i) to assess the evidence on post malarial cognitive impairment or impact on school education; (ii) to assess the possible positive impact of malaria drug prophylaxis on cognition; and (iii) to suggest recommendations on minimizing the burden of post-malarial cognitive impairment Methods PUBMED and SCOPUS were searched for all articles with the key word 'Malaria' in the title field and 'cognitive impairment' in any field. Google Scholar was searched for the same keywords anywhere in the article. The search was restricted to articles published in English within the last 15 years (1995-2010). After filtering of abstracts from the initial search, 44 papers had research evidence on this topic. Results & Discussion Cognitive abilities and school performance were shown to be impaired in sub-groups of patients (with either cerebral malaria or uncomplicated malaria) when compared with healthy controls. Studies comparing cognitive functions before and after treatment for acute malarial illness continued to show significantly impaired school performance and cognitive abilities even after recovery. Malaria prophylaxis was shown to improve cognitive function and school performance in clinical trials when compared to placebo groups. The implications of these findings are discussed.
    Schlagwörter Arctic medicine. Tropical medicine ; RC955-962 ; Infectious and parasitic diseases ; RC109-216
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2010-12-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Clinical features and sociodemographic factors affecting Trichomonas vaginalis infection in women attending a central sexually transmitted diseases clinic in Sri Lanka

    Sumadhya D Fernando / Sathya Herath / Chaturaka Rodrigo / Lalani Rajapakse

    Indian Journal of Sexually Transmitted Diseases, Vol 33, Iss 1, Pp 25-

    2012  Band 31

    Abstract: Introduction: Trichomoniasis is a relatively neglected area of research in Sri Lanka. Given the number of infections observed, an analysis of sociodemographic characteristics of patients would be valuable in prevention. Materials and Methods: Data were ... ...

    Abstract Introduction: Trichomoniasis is a relatively neglected area of research in Sri Lanka. Given the number of infections observed, an analysis of sociodemographic characteristics of patients would be valuable in prevention. Materials and Methods: Data were collected from 359 newly registered women at a tertiary level sexually transmitted diseases clinic over a period of 18 months. Trichomoniasis was diagnosed by culture of vaginal swabs collected from the posterior fornix. Results: The prevalence of trichomoniasis in the sample was 7.2%. Of those who tested positive for trichomoniasis, 76% were in the age group of 21-45 years, 68% were married and living with a spouse and 60% were unemployed. A diagnosis of Trichomoniasis was associated with being married (OR, 1.6; CI, 0.56-4.41), age over 33 years (OR=1.3, CI, 0.55-2.9), being employed (OR, 1.3; CI, 0.56 - 2.94), having an education of less than ten years at school (OR, 3.0; CI 1.28-7.26) and not using condoms during the last sexual act (OR 2.0, CI 0.84-4.86). The risk was less among commercial sex workers (OR, 0.3, CI: 0.14-0.85), those with multiple sexual partners (OR, 0.2; CI; 0.073-0.408) and women reporting extramarital sexual relationships (OR, 0.3; CI, 0.128-0.733). Conclusions: Education on safe sex and recognition of symptoms is currently targeted at high risk groups such as commercial sex workers. Extending these programmes to the rest of the community will further reduce the risk of transmission of trichomonas.
    Schlagwörter Sexually transmitted diseases ; socioeconomic factors ; trichomonas vaginalis ; Infectious and parasitic diseases ; RC109-216 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: The 'hidden' burden of malaria: cognitive impairment following infection.

    Fernando, Sumadhya D / Rodrigo, Chaturaka / Rajapakse, Senaka

    Malaria journal

    2010  Band 9, Seite(n) 366

    Abstract: Background: The burden of post-malaria cognitive impairment is often overlooked. Given the large number of infections occurring worldwide, the magnitude of the problem is likely to be substantial. The objectives of this paper are; (i) to assess the ... ...

    Abstract Background: The burden of post-malaria cognitive impairment is often overlooked. Given the large number of infections occurring worldwide, the magnitude of the problem is likely to be substantial. The objectives of this paper are; (i) to assess the evidence on post malarial cognitive impairment or impact on school education; (ii) to assess the possible positive impact of malaria drug prophylaxis on cognition; and (iii) to suggest recommendations on minimizing the burden of post-malarial cognitive impairment.
    Methods: PUBMED and SCOPUS were searched for all articles with the key word 'Malaria' in the title field and 'cognitive impairment' in any field. Google Scholar was searched for the same keywords anywhere in the article. The search was restricted to articles published in English within the last 15 years (1995-2010). After filtering of abstracts from the initial search, 44 papers had research evidence on this topic.
    Results & discussion: Cognitive abilities and school performance were shown to be impaired in sub-groups of patients (with either cerebral malaria or uncomplicated malaria) when compared with healthy controls. Studies comparing cognitive functions before and after treatment for acute malarial illness continued to show significantly impaired school performance and cognitive abilities even after recovery. Malaria prophylaxis was shown to improve cognitive function and school performance in clinical trials when compared to placebo groups. The implications of these findings are discussed.
    Mesh-Begriff(e) Cognition Disorders/epidemiology ; Cognition Disorders/prevention & control ; Humans ; Malaria/complications ; Malaria/drug therapy ; Malaria/prevention & control
    Sprache Englisch
    Erscheinungsdatum 2010-12-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ISSN 1475-2875
    ISSN (online) 1475-2875
    DOI 10.1186/1475-2875-9-366
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  9. Artikel ; Online: Improving diagnosis of trichomonas vaginalis infection in resource limited health care settings in sri lanka.

    Fernando, Sumadhya D / Herath, Sathya / Rodrigo, Chaturaka / Rajapakse, Senaka

    Journal of global infectious diseases

    2012  Band 3, Heft 4, Seite(n) 324–328

    Abstract: Objective: This study was designed to compare diagnosis of trichomoniasis by culture, wet smear examination, and Giemsa stain. A modified technique was used to transport and prepare the specimen to ensure parasite viability prior to Giemsa staining.: ... ...

    Abstract Objective: This study was designed to compare diagnosis of trichomoniasis by culture, wet smear examination, and Giemsa stain. A modified technique was used to transport and prepare the specimen to ensure parasite viability prior to Giemsa staining.
    Materials and methods: A clinic-based prospective study was carried out in association with the National STD/AIDS Control Programme over a period of 18 months. Three swabs were collected from the posterior fornix of 346 newly registered female patients for diagnosis of trichomoniasis. A wet smear was prepared using the first swab. The second swab was placed in 5 mL of 0.9% saline with three drops of 5% glucose at room temperature and centrifuged twice at a low speed prior to preparation of a Giemsa stained smear. The third swab was for culture. The three tests were performed independently. The specificity and sensitivity of the wet smear and Giemsa stain were compared to culture.
    Results: With culture, the prevalence of trichomoniasis was 6.9% (95% CI: 4.1-9.3%). The Giemsa-stained smear was found to be highly sensitive (100%, 95% CI: 86.2-100%) and specific (99.69%, 95% CI: 98.26-99.95%) compared to culture. The wet smear was less sensitive (95.83%, 95% CI: 79.76-99.26%) but equally specific (100%, 95% CI: 98.82-100%).
    Conclusion: In developing countries, facilities for using culture are limited and wet smear examination in the field is also difficult due to the immediate need for laboratory facilities. Our study demonstrated that, in this setting, using a transport medium prior to Giemsa staining is a feasible alternative, with a high-diagnostic yield.
    Sprache Englisch
    Erscheinungsdatum 2012-01-05
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2545454-7
    ISSN 0974-8245 ; 0974-777X
    ISSN (online) 0974-8245
    ISSN 0974-777X
    DOI 10.4103/0974-777X.91051
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  10. Artikel ; Online: Clinical features and sociodemographic factors affecting Trichomonas vaginalis infection in women attending a central sexually transmitted diseases clinic in Sri Lanka.

    Fernando, Sumadhya D / Herath, Sathya / Rodrigo, Chaturaka / Rajapakse, Lalani

    Indian journal of sexually transmitted diseases and AIDS

    2012  Band 33, Heft 1, Seite(n) 25–31

    Abstract: Introduction: Trichomoniasis is a relatively neglected area of research in Sri Lanka. Given the number of infections observed, an analysis of sociodemographic characteristics of patients would be valuable in prevention.: Materials and methods: Data ... ...

    Abstract Introduction: Trichomoniasis is a relatively neglected area of research in Sri Lanka. Given the number of infections observed, an analysis of sociodemographic characteristics of patients would be valuable in prevention.
    Materials and methods: Data were collected from 359 newly registered women at a tertiary level sexually transmitted diseases clinic over a period of 18 months. Trichomoniasis was diagnosed by culture of vaginal swabs collected from the posterior fornix.
    Results: The prevalence of trichomoniasis in the sample was 7.2%. Of those who tested positive for trichomoniasis, 76% were in the age group of 21-45 years, 68% were married and living with a spouse and 60% were unemployed. A diagnosis of Trichomoniasis was associated with being married (OR, 1.6; CI, 0.56-4.41), age over 33 years (OR=1.3, CI, 0.55-2.9), being employed (OR, 1.3; CI, 0.56 - 2.94), having an education of less than ten years at school (OR, 3.0; CI 1.28-7.26) and not using condoms during the last sexual act (OR 2.0, CI 0.84-4.86). The risk was less among commercial sex workers (OR, 0.3, CI: 0.14-0.85), those with multiple sexual partners (OR, 0.2; CI; 0.073-0.408) and women reporting extramarital sexual relationships (OR, 0.3; CI, 0.128-0.733).
    Conclusions: Education on safe sex and recognition of symptoms is currently targeted at high risk groups such as commercial sex workers. Extending these programmes to the rest of the community will further reduce the risk of transmission of trichomonas.
    Sprache Englisch
    Erscheinungsdatum 2012-04-23
    Erscheinungsland India
    Dokumenttyp Journal Article
    ISSN 2589-0565
    ISSN (online) 2589-0565
    DOI 10.4103/0253-7184.93813
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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