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  1. AU=Deng Lisi AU=Deng Lisi
  2. AU=Deshmukh V
  3. AU="Gutiérrez-García, Carmen"
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  5. AU="Sousa, Amanda Freire Tamburini"
  6. AU="Cronin, Chunxia"
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  9. AU="Jiang, Shimin"
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  11. AU="Carlos Augusto de Mattos"
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  13. AU="Nagata, Kosei"
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  1. Artikel ; Online: New Insights Into the Lineage-Specific Expansion and Functional Diversification of Lamprey AID/APOBEC Family.

    Chen, Yan / Luo, Lingjie / Deng, Lisi / Tian, Xiaoxue / Chen, Shangwu / Xu, Anlong / Yuan, Shaochun

    Frontiers in immunology

    2022  Band 13, Seite(n) 822616

    Abstract: The AID/APOBEC family which converts cytidine to uridine on RNA or DNA experienced dynamic expansion in primates in order to resist exogenous viruses and endogenous retrotransposons. Recently, expansion of AID/APOBEC-like homologs has also been observed ... ...

    Abstract The AID/APOBEC family which converts cytidine to uridine on RNA or DNA experienced dynamic expansion in primates in order to resist exogenous viruses and endogenous retrotransposons. Recently, expansion of AID/APOBEC-like homologs has also been observed in the extant jawless vertebrate lamprey. To reveal what causes such expansion and leads to the functional diversification of lamprey cytosine deaminases (CDAs), we reassessed the
    Mesh-Begriff(e) Animals ; Cytidine ; Cytidine Deaminase/genetics ; DNA/metabolism ; Lampreys/genetics ; Lampreys/metabolism ; Vertebrates/metabolism
    Chemische Substanzen Cytidine (5CSZ8459RP) ; DNA (9007-49-2) ; Cytidine Deaminase (EC 3.5.4.5)
    Sprache Englisch
    Erscheinungsdatum 2022-03-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.822616
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Clinical and electroencephalographic characteristics of 34 infant with onset of epileptic spasms before three months of age.

    Chen, Min / Yan, Lisi / Deng, Yu / Chen, Jin / Xie, Lingling / Hu, Yue / Hong, Siqi / Jiang, Li

    Epilepsy & behavior : E&B

    2023  Band 149, Seite(n) 109530

    Abstract: Epileptic spasms (ES) occur mostly between age 3 months and 24 months. ES beginning before 3 months of age were called early-onset ES in previous studies. The aim of this study was to identify clinical and electroencephalographic characteristics of ... ...

    Abstract Epileptic spasms (ES) occur mostly between age 3 months and 24 months. ES beginning before 3 months of age were called early-onset ES in previous studies. The aim of this study was to identify clinical and electroencephalographic characteristics of patients with ES onset before 3 months of age. In total, 34 ES patients were retrospectively identified at Children's Hospital of Chongqing Medical University from January 1, 2020 to October 1, 2022. Our patients had diverse etiologies, including genetic (32.3 %), genetic-structural (11.8 %), structural-acquired (11.8 %), structural-congenital (8.8 %), and metabolic (5.9 %), with 29.4 % of patients having unknown etiology. Some patients experienced ES in clusters (either symmetrical or flexional) that occurred most often during awakening after sleep, and a minority of ES were characterized as isolated or asymmetrical, occurred during sleep, and could also manifest as relatively subtle. Approximately 35.3 % of patients also experienced other seizure types concurrently, including 10 focal seizures and 2 generalized seizures, and only half of the focal seizures had structural causes. The other seizure types occurred alone or sequentially with ES. Interictal electroencephalography revealed hypsarrhythmia or its variants, multifocal discharge, or burst suppression. 18 patients had no seizures lasting for more than 2 months, however, at the last follow-up visit, 5 of them had relapsed. All patients had different degrees of psychomotor retardation.
    Mesh-Begriff(e) Child ; Infant ; Humans ; Spasms, Infantile/complications ; Spasms, Infantile/diagnosis ; Retrospective Studies ; Seizures/diagnosis ; Seizures/etiology ; Electroencephalography/adverse effects ; Spasm
    Sprache Englisch
    Erscheinungsdatum 2023-11-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2023.109530
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  3. Artikel ; Online: GlmS plays a key role in the virulence factor expression and biofilm formation ability of

    Ni, Lijia / Shen, Rui / Luo, Hua / Li, Xuexue / Zhang, Xiaofan / Huang, Lisi / Deng, Yawen / Liao, Xiaoyan / Wu, Yonglin / Duan, Chaohui / Xie, Xiaoying

    Virulence

    2024  Band 15, Heft 1, Seite(n) 2352476

    Abstract: Staphylococcus aureus (S. aureus) ...

    Abstract Staphylococcus aureus (S. aureus)
    Mesh-Begriff(e) Biofilms/growth & development ; Staphylococcus aureus/genetics ; Staphylococcus aureus/pathogenicity ; Virulence Factors/genetics ; Glycation End Products, Advanced/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Staphylococcal Infections/microbiology ; Sigma Factor/genetics ; Sigma Factor/metabolism ; Humans
    Chemische Substanzen Virulence Factors ; Glycation End Products, Advanced ; Bacterial Proteins ; Sigma Factor ; SigB protein, Bacteria
    Sprache Englisch
    Erscheinungsdatum 2024-05-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2024.2352476
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  4. Artikel ; Online: Clinical and electroencephalography characteristics of 41 children with epileptic spasms onset after 1 year of age.

    Yan, Lisi / Deng, Yu / Chen, Jin / Hu, Yue / Hong, Siqi / Jiang, Li

    Epilepsy & behavior : E&B

    2022  Band 135, Seite(n) 108902

    Abstract: The incidence of epileptic spasms (ES) that begin after the first year of life is much lower than that before 1 year of age. The aim of this study was to identify clinical and electroencephalography (EEG) characteristics, etiologies, treatments, and ... ...

    Abstract The incidence of epileptic spasms (ES) that begin after the first year of life is much lower than that before 1 year of age. The aim of this study was to identify clinical and electroencephalography (EEG) characteristics, etiologies, treatments, and prognoses in pediatric patients with ES onset after 1 year of age. Forty-one children were retrospectively identified in Children's Hospital of Chongqing Medical University between January 1, 2020 and December 1, 2021. ES onset after 1 year of age have diverse presentations. Although most occur in clusters, are symmetrical and flexional, and occur frequently during awakening, some are characterized as isolated and asymmetrical, have a tonic component, and can also occur during sleep. The hypsarrhythmia variants and focal or multifocal discharges occur alternately in the interictal period, and the focal spikes and slow waves predominated in the unilateral temporal or frontotemporal areas. These patients had diverse etiologies, including structural (51.2 % of patients) and genetic (22.0 %) ones, and 11 patients (26.8 %) had an unknown etiology. No patients in our study had an infectious or immune-mediated etiology. Forty-eight percent of patients responded to hydrocortisone and/or adrenocorticotropic hormone. The efficacy of antiepileptic drug therapy was lower in patients who did not receive concurrent steroid therapy. However, ES onset after 1 year of age caused by a tumor, brain malformation, or other focal lesions, may be cured by focal cortical resection despite a lack of clearly localized EEG surface anomalies. Delays in motor, language, and cognitive development, or behavioral problems were observed in all but three patients.
    Mesh-Begriff(e) Adrenocorticotropic Hormone/therapeutic use ; Anticonvulsants/therapeutic use ; Child ; Electroencephalography ; Humans ; Hydrocortisone ; Infant ; Retrospective Studies ; Spasm ; Spasms, Infantile/diagnosis ; Spasms, Infantile/drug therapy
    Chemische Substanzen Anticonvulsants ; Adrenocorticotropic Hormone (9002-60-2) ; Hydrocortisone (WI4X0X7BPJ)
    Sprache Englisch
    Erscheinungsdatum 2022-09-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2022.108902
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5289: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Artikel ; Online: Wogonin inhibits latent HIV-1 reactivation by downregulating histone crotonylation.

    Zhang, Haitao / Cai, Jinfeng / Li, Chunna / Deng, Lisi / Zhu, Hongqiong / Huang, Ting / Zhao, Jiacong / Zhou, Jiasheng / Deng, Kai / Hong, Zhongsi / Xia, Jinyu

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2023  Band 116, Seite(n) 154855

    Abstract: Background: Wogonin, a flavone isolated from Scutellaria baicalensis Georgi, is a commonly used phytochemical with anti-inflammatory and antitumor properties. However, the antiviral activity of wogonin against human immunodeficiency virus type 1 (HIV-1) ...

    Abstract Background: Wogonin, a flavone isolated from Scutellaria baicalensis Georgi, is a commonly used phytochemical with anti-inflammatory and antitumor properties. However, the antiviral activity of wogonin against human immunodeficiency virus type 1 (HIV-1) has not been reported.
    Purpose: The current study aimed to explore whether wogonin can suppress latent HIV-1 reactivation and the mechanism of wogonin in inhibiting proviral HIV-1 transcription.
    Methods: We assessed the effects of wogonin on HIV-1 reactivation using flow cytometry, cytotoxicity assay, quantitative PCR (qPCR), viral quality assurance (VQA), and western blot analysis.
    Results: Wogonin, a flavone isolated from S. baicalensis, significantly inhibited the reactivation of latent HIV-1 in cellular models and in primary CD4+ T cells from antiretroviral therapy (ART)-suppressed individuals ex vivo. Wogonin exhibited low cytotoxicity and long-lasting inhibition of HIV-1 transcription. Triptolide is a latency-promoting agent (LPA) that inhibits HIV-1 transcription and replication; wogonin had a stronger ability to inhibit HIV-1 latent reactivation than triptolide. Mechanistically, wogonin inhibited the reactivation of latent HIV-1 by inhibiting the expression of p300, a histone acetyltransferase, and decreasing the crotonylation of histone H3/H4 in the HIV-1 promoter region.
    Conclusion: Our study found that wogonin is a novel LPA that can inhibit HIV-1 transcription by HIV-1 epigenetic silencing, which could bear promising significance for future applications of HIV-1 functional cure.
    Mesh-Begriff(e) Humans ; Histones/metabolism ; HIV-1/physiology ; Virus Latency/physiology ; HIV Infections/drug therapy ; HIV Infections/metabolism ; CD4-Positive T-Lymphocytes
    Chemische Substanzen Histones ; triptolide (19ALD1S53J) ; wogonin (POK93PO28W)
    Sprache Englisch
    Erscheinungsdatum 2023-05-03
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2023.154855
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  6. Artikel ; Online: Fueling sentinel node via reshaping cytotoxic T lymphocytes with a flex-patch for post-operative immuno-adjuvant therapy.

    Li, Bei / Wang, Guohao / Miao, Kai / Zhang, Aiping / Sun, Liangyu / Yu, Xinwang / Lei, Josh Haipeng / Xie, Lisi / Yan, Jie / Li, Wenxi / Deng, Chu-Xia / Dai, Yunlu

    Nature communications

    2023  Band 14, Heft 1, Seite(n) 2518

    Abstract: Clinical updates suggest conserving metastatic sentinel lymph nodes (SLNs) of breast cancer (BC) patients during surgery; however, the immunoadjuvant potential of this strategy is unknown. Here we leverage an immune-fueling flex-patch to animate ... ...

    Abstract Clinical updates suggest conserving metastatic sentinel lymph nodes (SLNs) of breast cancer (BC) patients during surgery; however, the immunoadjuvant potential of this strategy is unknown. Here we leverage an immune-fueling flex-patch to animate metastatic SLNs with personalized antitumor immunity. The flex-patch is implanted on the postoperative wound and spatiotemporally releases immunotherapeutic anti-PD-1 antibodies (aPD-1) and adjuvants (magnesium iron-layered double hydroxide, LDH) into the SLN. Genes associated with citric acid cycle and oxidative phosphorylation are enriched in activated CD8
    Mesh-Begriff(e) Female ; Mice ; Animals ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node Biopsy ; CD8-Positive T-Lymphocytes ; T-Lymphocytes, Cytotoxic ; Neoplasm Recurrence, Local/pathology ; Adjuvants, Immunologic/therapeutic use ; Lymph Nodes/pathology
    Chemische Substanzen Adjuvants, Immunologic
    Sprache Englisch
    Erscheinungsdatum 2023-05-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38245-7
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  7. Artikel ; Online: Dolutegravir plus lamivudine versus efavirenz plus tenofovir disoproxil fumarate and lamivudine in antiretroviral-naive adults with HIV-1 infection.

    Deng, Lisi / Li, Chunna / Chen, Ping / Luo, Xiaoqing / Zheng, Xinchun / Zhou, Lanlan / Zhou, Yi / Xia, Jinyu / Hong, Zhongsi

    BMC infectious diseases

    2022  Band 22, Heft 1, Seite(n) 17

    Abstract: Background: Concerns regarding potential toxicity and drug-drug interactions during long-term treatment with three-drug active antiretroviral therapy (ART) regimens have been attracting increasing attention. We aimed to evaluate the efficacy and safety ... ...

    Abstract Background: Concerns regarding potential toxicity and drug-drug interactions during long-term treatment with three-drug active antiretroviral therapy (ART) regimens have been attracting increasing attention. We aimed to evaluate the efficacy and safety of dolutegravir (DTG) plus lamivudine (3TC) in ART-naive adults in China.
    Methods: This prospective observational cohort study enrolled HIV-naive inpatients treated with DTG + 3TC (2DR arm) or efavirenz (EFV) plus tenofovir disoproxil fumarate (TDF) and 3TC (3DR arm). There were no limits on baseline viral load. Inflammatory biomarkers were also investigated in the 2DR arm.
    Results: Between September 2019 and January 2020, 27 patients treated with DTG + 3TC and 28 patients treated with EFV + TDF + 3TC were enrolled in the study. At week 12, the proportion of patients with viral loads < 50 copies/mL in the 2DR arm was 81.5% (22/27) compared with 53.6% (15/28) in the 3DR arm (p < 0.01). At week 24, the proportion of patients with viral loads < 50 copies/mL in the 2DR arm was 100% (26/26) compared with 83.3% (20/24) in the 3DR arm (p < 0.05). Mean changes in CD4 cell counts from baseline at week 12 were 125.46 cells/µL in the 2DR arm and 41.20 cells/µL in the 3DR arm (p < 0.05). Mean changes in CD4 cell counts from baseline at week 24 were 209.68 cells/µL in the 2DR arm and 73.28 cells/µL in the 3DR arm (p < 0.05).
    Conclusions: DTG + 3TC achieved virologic suppression more rapidly than EFV + TDF + 3TC after 12 and 24 weeks. DTG + 3TC could represent an optimal regimen for advanced patients. Clinical Trial Registration ChiCTR1900027640 (22/November/2019).
    Mesh-Begriff(e) Alkynes ; Anti-HIV Agents/adverse effects ; Benzoxazines/adverse effects ; Cyclopropanes ; HIV Infections/drug therapy ; HIV-1 ; Heterocyclic Compounds, 3-Ring ; Humans ; Lamivudine/therapeutic use ; Oxazines ; Piperazines ; Prospective Studies ; Pyridones ; Tenofovir/therapeutic use
    Chemische Substanzen Alkynes ; Anti-HIV Agents ; Benzoxazines ; Cyclopropanes ; Heterocyclic Compounds, 3-Ring ; Oxazines ; Piperazines ; Pyridones ; Lamivudine (2T8Q726O95) ; Tenofovir (99YXE507IL) ; dolutegravir (DKO1W9H7M1) ; efavirenz (JE6H2O27P8)
    Sprache Englisch
    Erscheinungsdatum 2022-01-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Observational Study
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-06991-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Differential Diagnosis of COVID-19 Pneumonia in Cancer Patients Received Radiotherapy.

    Zeng, Qi / Tang, Caihua / Deng, Lisi / Li, Sheng / Liu, Jiani / Wang, Siyang / Shan, Hong

    International journal of medical sciences

    2020  Band 17, Heft 16, Seite(n) 2561–2569

    Abstract: Background: ...

    Abstract Background:
    Mesh-Begriff(e) Adult ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/diagnostic imaging ; Diagnosis, Differential ; Esophageal Neoplasms/diagnostic imaging ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/radiotherapy ; Female ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/radiotherapy ; Male ; Middle Aged ; Nasopharyngeal Neoplasms/diagnostic imaging ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/radiotherapy ; Neoplasms/radiotherapy ; Neoplasms/virology ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Radiation Pneumonitis/diagnostic imaging ; Retrospective Studies ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-16
    Erscheinungsland Australia
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.46133
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  9. Artikel ; Online: NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer.

    Liu, Zefu / Zheng, Xianchong / Chen, Jiawei / Zheng, Lisi / Ma, Zikun / Chen, Lei / Deng, Minhua / Tang, Huancheng / Zhou, Liwen / Kang, Tiebang / Wu, Yuanzhong / Liu, Zhuowei

    Cell reports

    2023  Band 42, Heft 8, Seite(n) 112963

    Abstract: Dysregulation of transcription is a hallmark of cancer, including bladder cancer (BLCA). CRISPR-Cas9 screening using a lentivirus library with single guide RNAs (sgRNAs) targeting human transcription factors and chromatin modifiers is used to reveal ... ...

    Abstract Dysregulation of transcription is a hallmark of cancer, including bladder cancer (BLCA). CRISPR-Cas9 screening using a lentivirus library with single guide RNAs (sgRNAs) targeting human transcription factors and chromatin modifiers is used to reveal genes critical for the proliferation and survival of BLCA cells. As a result, the nuclear transcription factor Y subunit gamma (NFYC)-37, but not NFYC-50, is observed to promote cell proliferation and tumor growth in BLCA. Mechanistically, NFYC-37 interacts with CBP and SREBP2 to activate mevalonate pathway transcription, promoting cholesterol biosynthesis. However, NFYC-50 recruits more of the arginine methyltransferase CARM1 than NFYC-37 to methylate CBP, which prevents the CBP-SREBP2 interaction and subsequently inhibits the mevalonate pathway. Importantly, statins targeting the mevalonate pathway can suppress NFYC-37-induced cell proliferation and tumor growth, indicating the need for conducting a clinical trial with statins for treating patients with BLCA and high NFYC-37 levels, as most patients with BLCA have high NFYC-37 levels.
    Mesh-Begriff(e) Humans ; Mevalonic Acid/metabolism ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; RNA, Guide, CRISPR-Cas Systems ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology ; Transcription Factors/metabolism
    Chemische Substanzen Mevalonic Acid (S5UOB36OCZ) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; RNA, Guide, CRISPR-Cas Systems ; Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2023-08-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112963
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  10. Artikel ; Online: Effects of metformin and Exenatide on insulin resistance and AMPKα-SIRT1 molecular pathway in PCOS rats.

    Tao, Xin / Cai, Lisi / Chen, Lei / Ge, Shuqi / Deng, Xuanying

    Journal of ovarian research

    2019  Band 12, Heft 1, Seite(n) 86

    Abstract: Aims: This study was designed to evaluate the protective effects of AMPKα and SIRT1 on insulin resistance in PCOS rats, and to illuminate the underlying mechanisms.: Methods: An in vitro PCOS model was established by DHEA (6 mg/(100 g•d)), and the ... ...

    Abstract Aims: This study was designed to evaluate the protective effects of AMPKα and SIRT1 on insulin resistance in PCOS rats, and to illuminate the underlying mechanisms.
    Methods: An in vitro PCOS model was established by DHEA (6 mg/(100 g•d)), and the rats were randomly divided into the metformin group (MF group, n = 11), the exenatide group (EX group, n = 11), the PCOS group (n = 10), and the normal control group (NC group, n = 10). The MF group was administered MF 300 mg/(kg•d) daily. The EX group was subcutaneously injected EX 10μg/(kg•d) daily. After 4 weeks of continuous administration, fasting blood glucose and serum androgen, luteinizing hormone and other biochemical indicators were measured. Western and Real-time PCR were used to determine the expression of AMPKα and SIRT1 in the ovaries of each group.
    Results: After 4 weeks of drug intervention, compared with untreated PCOS group, EX group and MF group had visibly decreased body weight (222.64 ± 16.57, 218.63 ± 13.18 vs 238.30 ± 12.26 g, P = 0.026), fasting blood glucose (7.71 ± 0.72, 8.17 ± 0.54 vs 8.68 ± 0.47 mmol/L, P < 0.01), HOMA-IR (8.26 ± 2.50, 7.44 ± 1.23 vs 12.66 ± 1.44, P < 0.01) and serum androgen (0.09 ± 0.03, 0.09 ± 0.03 vs 0.53 ± 0.41 ng/ml, P < 0.01) and the expressions of AMPKα and SIRT11 were increased progressively (P < 0.05).
    Conclusions: Both metformin and exenatide can improve the reproductive and endocrine functions of rats with PCOS via the AMPKα-SIRT1 pathway, which may be the molecular mechanism for IR in PCOS and could possibly serve as a therapeutic target.
    Mesh-Begriff(e) AMP-Activated Protein Kinases/genetics ; Androgens/blood ; Animals ; Blood Glucose/drug effects ; Disease Models, Animal ; Exenatide/pharmacology ; Female ; Gene Expression Regulation/drug effects ; Humans ; Insulin Resistance/genetics ; Luteinizing Hormone/genetics ; Metformin/pharmacology ; Polycystic Ovary Syndrome/blood ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/genetics ; Rats ; Sirtuin 1/genetics
    Chemische Substanzen Androgens ; Blood Glucose ; Luteinizing Hormone (9002-67-9) ; Metformin (9100L32L2N) ; Exenatide (9P1872D4OL) ; Prkaa1 protein, rat (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Sirt1 protein, rat (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-)
    Sprache Englisch
    Erscheinungsdatum 2019-09-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2455679-8
    ISSN 1757-2215 ; 1757-2215
    ISSN (online) 1757-2215
    ISSN 1757-2215
    DOI 10.1186/s13048-019-0555-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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