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  1. Article ; Online: Vascularized Plexus Allotransplantation: A New Hope in Brachial Plexus Palsy?

    Farkash, Evan A / Leonard, David A

    Transplantation

    2018  Volume 103, Issue 1, Page(s) 17–18

    MeSH term(s) Animals ; Brachial Plexus ; Brachial Plexus Neuropathies ; Paralysis ; Rats ; Rats, Inbred BN ; Rats, Inbred Lew
    Language English
    Publishing date 2018-07-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000002388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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  2. Article ; Online: Authors' Reply.

    Farkash, Evan A / Wilson, Allecia M / Jentzen, Jeffrey M

    Journal of the American Society of Nephrology : JASN

    2020  Volume 31, Issue 9, Page(s) 2225–2226

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2020060847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2.

    Farkash, Evan A / Wilson, Allecia M / Jentzen, Jeffrey M

    Journal of the American Society of Nephrology : JASN

    2020  Volume 31, Issue 8, Page(s) 1683–1687

    Abstract: Background: A significant fraction of patients with coronavirus disease 2019 (COVID-19) display abnormalities in renal function. Retrospective studies of patients hospitalized with COVID-19 in Wuhan, China, report an incidence of 3%-7% progressing to ... ...

    Abstract Background: A significant fraction of patients with coronavirus disease 2019 (COVID-19) display abnormalities in renal function. Retrospective studies of patients hospitalized with COVID-19 in Wuhan, China, report an incidence of 3%-7% progressing to ARF, a marker of poor prognosis. The cause of the renal failure in COVID-19 is unknown, but one hypothesized mechanism is direct renal infection by the causative virus, SARS-CoV-2.
    Methods: We performed an autopsy on a single patient who died of COVID-19 after open repair of an aortic dissection, complicated by hypoxic respiratory failure and oliguric renal failure. We used light and electron microscopy to examine renal tissue for evidence of SARS-CoV-2 within renal cells.
    Results: Light microscopy of proximal tubules showed geographic isometric vacuolization, corresponding to a focus of tubules with abundant intracellular viral arrays. Individual viruses averaged 76
    Conclusions: The presence of viral particles in the renal tubular epithelium that were morphologically identical to SARS-CoV-2, and with viral arrays and other features of virus assembly, provide evidence of a productive direct infection of the kidney by SARS-CoV-2. This finding offers confirmatory evidence that direct renal infection occurs in the setting of AKI in COVID-19. However, the frequency and clinical significance of direct infection in COVID-19 is unclear. Tubular isometric vacuolization observed with light microscopy, which correlates with double-membrane vesicles containing vacuoles observed with electronic microscopy, may be a useful histologic marker for active SARS-CoV-2 infection in kidney biopsy or autopsy specimens.
    MeSH term(s) Acute Kidney Injury/complications ; Acute Kidney Injury/mortality ; Aortic Dissection/surgery ; Autopsy ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Epithelial Cells/pathology ; Humans ; Kidney Tubules/pathology ; Kidney Tubules/ultrastructure ; Kidney Tubules/virology ; Male ; Middle Aged ; Nephritis/physiopathology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Prognosis ; Respiratory Insufficiency ; Retrospective Studies ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2020040432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Successful Extension of Vascularized Composite Allograft Perfusion Cold Storage to 24 h in a Rat Hindlimb Transplant Model.

    Ng, Po'okela K / Yoeli, Dor / Huang, Joy L / Luo, Yuhuan / Wang, Yong / Li, Bing / Wang, Zhaohui / Schold, Jesse / Jain, Swati / Su, An-Jey A / Mathes, David W / Washington, Kia M / Farkash, Evan / Jani, Alkesh H / Huang, Christene A

    Transplantation direct

    2024  Volume 10, Issue 6, Page(s) e1623

    Abstract: Background: Vascularized composite allograft transplantation is a treatment option for complex tissue injuries; however, ischemia reperfusion injury and high acute rejection rates remain a challenge. Hypothermic machine perfusion using acellular storage ...

    Abstract Background: Vascularized composite allograft transplantation is a treatment option for complex tissue injuries; however, ischemia reperfusion injury and high acute rejection rates remain a challenge. Hypothermic machine perfusion using acellular storage perfusate is a potential solution. This study evaluated the University of Wisconsin Kidney Preservation Solution-1 (KPS-1) compared with normal saline (NS) for preservation of donor rat hindlimbs subjected to 24 h of ex vivo perfusion cold storage.
    Methods: Hindlimbs were subjected to 24-h perfusion cold storage with heparinized KPS-1 (n = 6) or heparinized NS (n = 6). Flow, resistance, and pH were measured continuously. At the end of the 24-h period, tissue was collected for histological analysis of edema and apoptosis.
    Results: KPS-1 perfused limbs showed significantly less edema than the NS group, as evidenced by lower limb weight gain (
    Conclusions: Perfusion with KPS-1 can successfully extend vascularized composite allograft perfusion cold storage for 24 h in a rat hindlimb model without significant edema or cell death.
    Language English
    Publishing date 2024-05-15
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2

    Farkash, Evan A / Wilson, Allecia M / Jentzen, Jeffrey M

    J Am Soc Nephrol

    Abstract: BACKGROUND: A significant fraction of patients with coronavirus disease 2019 (COVID-19) display abnormalities in renal function. Retrospective studies of patients hospitalized with COVID-19 in Wuhan, China, report an incidence of 3%-7% progressing to ARF, ...

    Abstract BACKGROUND: A significant fraction of patients with coronavirus disease 2019 (COVID-19) display abnormalities in renal function. Retrospective studies of patients hospitalized with COVID-19 in Wuhan, China, report an incidence of 3%-7% progressing to ARF, a marker of poor prognosis. The cause of the renal failure in COVID-19 is unknown, but one hypothesized mechanism is direct renal infection by the causative virus, SARS-CoV-2. METHODS: We performed an autopsy on a single patient who died of COVID-19 after open repair of an aortic dissection, complicated by hypoxic respiratory failure and oliguric renal failure. We used light and electron microscopy to examine renal tissue for evidence of SARS-CoV-2 within renal cells. RESULTS: Light microscopy of proximal tubules showed geographic isometric vacuolization, corresponding to a focus of tubules with abundant intracellular viral arrays. Individual viruses averaged 76 µm in diameter and had an envelope studded with crown-like, electron-dense spikes. Vacuoles contained double-membrane vesicles suggestive of partially assembled virus. CONCLUSIONS: The presence of viral particles in the renal tubular epithelium that were morphologically identical to SARS-CoV-2, and with viral arrays and other features of virus assembly, provide evidence of a productive direct infection of the kidney by SARS-CoV-2. This finding offers confirmatory evidence that direct renal infection occurs in the setting of AKI in COVID-19. However, the frequency and clinical significance of direct infection in COVID-19 is unclear. Tubular isometric vacuolization observed with light microscopy, which correlates with double-membrane vesicles containing vacuoles observed with electronic microscopy, may be a useful histologic marker for active SARS-CoV-2 infection in kidney biopsy or autopsy specimens.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #186288
    Database COVID19

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  7. Article ; Online: A case of cryocrystalglobulinemia.

    Avedschmidt, Sarah E / Farkash, Evan A / Yamada, Chisa

    Transfusion

    2016  Volume 56, Issue 7, Page(s) 1678–1679

    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.13528
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 284: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Double Trouble.

    Smith, Christopher / Dhaliwal, Gurpreet / Saint, Sanjay / Farkash, Evan A / Garg, Puneet

    The New England journal of medicine

    2019  Volume 381, Issue 19, Page(s) 1854–1860

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Anti-Glomerular Basement Membrane Disease/complications ; Anti-Glomerular Basement Membrane Disease/diagnosis ; Antibodies, Antineutrophil Cytoplasmic/blood ; Arthralgia/etiology ; Autoantibodies/blood ; Biopsy ; Cough/etiology ; Diagnosis, Differential ; Fatigue/etiology ; Fever/etiology ; Humans ; Kidney/diagnostic imaging ; Kidney/pathology ; Male ; Middle Aged ; Pleural Effusion/diagnostic imaging ; Radiography, Thoracic
    Chemical Substances Anti-Bacterial Agents ; Antibodies, Antineutrophil Cytoplasmic ; Autoantibodies ; antiglomerular basement membrane antibody
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Case Reports ; Clinical Conference ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcps1810654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Encapsulated Allografts Preclude Host Sensitization and Promote Ovarian Endocrine Function in Ovariectomized Young Rhesus Monkeys and Sensitized Mice.

    Day, James R / Flanagan, Colleen L / David, Anu / Hartigan-O'Connor, Dennis J / Garcia de Mattos Barbosa, Mayara / Martinez, Michele L / Lee, Charles / Barnes, Jenna / Farkash, Evan / Zelinski, Mary / Tarantal, Alice / Cascalho, Marilia / Shikanov, Ariella

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 5

    Abstract: Transplantation of allogeneic donor ovarian tissue holds great potential for female cancer survivors who often experience premature ovarian insufficiency. To avoid complications associated with immune suppression and to protect transplanted ovarian ... ...

    Abstract Transplantation of allogeneic donor ovarian tissue holds great potential for female cancer survivors who often experience premature ovarian insufficiency. To avoid complications associated with immune suppression and to protect transplanted ovarian allografts from immune-mediated injury, we have developed an immunoisolating hydrogel-based capsule that supports the function of ovarian allografts without triggering an immune response. Encapsulated ovarian allografts implanted in naïve ovariectomized BALB/c mice responded to the circulating gonadotropins and maintained function for 4 months, as evident by regular estrous cycles and the presence of antral follicles in the retrieved grafts. In contrast to non-encapsulated controls, repeated implantations of encapsulated mouse ovarian allografts did not sensitize naïve BALB/c mice, which was confirmed with undetectable levels of alloantibodies. Further, encapsulated allografts implanted in hosts previously sensitized by the implantation of non-encapsulated allografts restored estrous cycles similarly to our results in naïve recipients. Next, we tested the translational potential and efficiency of the immune-isolating capsule in a rhesus monkey model by implanting encapsulated ovarian auto- and allografts in young ovariectomized animals. The encapsulated ovarian grafts survived and restored basal levels of urinary estrone conjugate and pregnanediol 3-glucuronide during the 4- and 5-month observation periods. We demonstrate, for the first time, that encapsulated ovarian allografts functioned for months in young rhesus monkeys and sensitized mice, while the immunoisolating capsule prevented sensitization and protected the allograft from rejection.
    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10050550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope.

    Miglioranza Scavuzzi, Bruna / van Drongelen, Vincent / Kaur, Bhavneet / Fox, Jennifer Callahan / Liu, Jianhua / Mesquita-Ferrari, Raquel A / Kahlenberg, J Michelle / Farkash, Evan A / Benavides, Fernando / Miller, Frederick W / Sawalha, Amr H / Holoshitz, Joseph

    Communications biology

    2022  Volume 5, Issue 1, Page(s) 751

    Abstract: The HLA-DRB1*03:01 allele is a major genetic risk factor in systemic lupus erythematosus (SLE), but the mechanistic basis of the association is unclear. Here we show that in the presence of interferon gamma (IFN-γ), a short DRB1*03:01-encoded allelic ... ...

    Abstract The HLA-DRB1*03:01 allele is a major genetic risk factor in systemic lupus erythematosus (SLE), but the mechanistic basis of the association is unclear. Here we show that in the presence of interferon gamma (IFN-γ), a short DRB1*03:01-encoded allelic epitope activates a characteristic lupus transcriptome in mouse and human macrophages. It also triggers a cascade of SLE-associated cellular aberrations, including endoplasmic reticulum stress, unfolded protein response, mitochondrial dysfunction, necroptotic cell death, and production of pro-inflammatory cytokines. Parenteral administration of IFN-γ to naïve DRB1*03:01 transgenic mice causes increased serum levels of anti-double stranded DNA antibodies, glomerular immune complex deposition and histopathological renal changes that resemble human lupus nephritis. This study provides evidence for a noncanonical, antigen presentation-independent mechanism of HLA-disease association in SLE and could lay new foundations for our understanding of key molecular mechanisms that trigger and propagate this devastating autoimmune disease.
    MeSH term(s) Alleles ; Animals ; Epitopes/genetics ; Genetic Predisposition to Disease ; HLA-DRB1 Chains/genetics ; Humans ; Interferon-gamma/genetics ; Lupus Erythematosus, Systemic/genetics ; Mice
    Chemical Substances Epitopes ; HLA-DRB1 Chains ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-022-03717-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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