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  1. Article ; Online: Arnold Bernard Scheibel, M.D. (1923-2017).

    Jacobs, Bob

    The Journal of comparative neurology

    2017  Volume 525, Issue 11, Page(s) 2459–2464

    MeSH term(s) Animals ; History, 20th Century ; History, 21st Century ; Humans ; Neurosciences/history ; United States
    Language English
    Publishing date 2017-04-13
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.24231
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    Ub I Zs.66: Show issues Location:
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  2. Article: Charles Brenner, M.D.

    Jacobs, Theodore

    The International journal of psycho-analysis

    2009  Volume 90, Issue 4, Page(s) 953–955

    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Male ; Neurology/history ; Neurophysiology/history ; Psychiatry/history ; Psychoanalysis/history ; Psychoanalytic Theory ; United States
    Language English
    Publishing date 2009-08
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 220636-5
    ISSN 1745-8315 ; 0020-7578
    ISSN (online) 1745-8315
    ISSN 0020-7578
    DOI 10.1111/j.1745-8315.2009.00202.x
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    Zs.A 1179: Show issues Location:
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  3. Article: A conversation with new MMA president Donald Jacobs, M.D.

    Jacobs, Donald

    Minnesota medicine

    2014  Volume 97, Issue 11-12, Page(s) 35–37

    MeSH term(s) Animals ; Cats ; General Surgery/history ; History, 21st Century ; Leadership ; Minnesota ; Societies, Medical/history
    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Biography ; Historical Article ; Interview ; Portraits
    ZDB-ID 391068-4
    ISSN 1945-3051 ; 0026-556X
    ISSN (online) 1945-3051
    ISSN 0026-556X
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    Zs.A 218: Show issues Location:
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  4. Article ; Online: Closing the Caregiving Gap: Considerations for Pancreatic and Periampullary Cancer Caregivers.

    Willis, Kelcie D / Jacobs, Jamie M

    JCO oncology practice

    2023  Volume 19, Issue 8, Page(s) 523–525

    MeSH term(s) Humans ; Caregivers ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.23.00274
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  5. Article: Guyanin, a novel tetranortriterpenoid. Structure elucidation by 2-D N.M.R. spectroscopy

    Jacobs, H / Ramdayal, F

    Tetrahedron letters. 1986. v. 27 (13)

    1986  

    Keywords Rutaceae ; terpenoids ; nuclear magnetic resonance spectroscopy
    Language English
    Size p. 1453-1456.
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
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    Zs.A 2837: Show issues Location:
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  6. Article ; Online: 15 Unique yeast-derived prebiotic supports joint health and reduced systemic inflammation in senior horses

    Jacobs, R.D. / Gordon, M.E. / Cassells, M.

    Journal of Equine Veterinary Science. 2023 May, v. 124 p.104317-

    2023  

    Abstract: ... treatment (TRT) group. Horses in both groups were offered 4.54 kg/d Purina® Equine Senior® (CP = 14.5%, Ca ... daily. Horses were additionally offered 0.45 kg/d of a pellet containing AA (TRT) or not (CON ...

    Abstract Senior horses are commonly afflicted with inflammation-related conditions including chronic or acute joint inflammation, and chronic low-grade systemic inflammation, or “inflamm-aging.” Reducing inflammation, where appropriate, may improve the quality of life and performance of senior horses. To that end, the objective of this trial was to determine whether supplementation of a unique yeast-derived prebiotic (ActivAge®(AA)) to senior horses would promote reduced joint and systemic inflammation. Aged Quarter horses (n = 10; mean age ± SEM = 21.3 ± 1.2yr; mean BW ± SEM = 587.5 ± 10.9kg; mean BCS ± SEM = 6.3 ± 0.2) were utilized in a crossover trial. Horses were randomly assigned to either a control (CON) or treatment (TRT) group. Horses in both groups were offered 4.54 kg/d Purina® Equine Senior® (CP = 14.5%, Ca = 0.76%, P = 0.61%). Horses were offered 1.25% BW as local grass hay (CP = 14.6%, Ca = 0.60%, P = 0.30%) daily. Horses were additionally offered 0.45 kg/d of a pellet containing AA (TRT) or not (CON). Daily ration was split into 2 equal feedings at 0700 and 1300 daily for 42d per period with a 28d washout period during which no TRT or CON pellet was offered. All horses had ad libitum access to fresh clean water and white salt. Serum samples were obtained via jugular venipuncture approximately 2hr post feeding every 2wk foranalysis of the acute phase protein, serum amyloid A (SAA; SAA-Vet, Eiken Chemical Co.). On d42 horses underwent a joint inflammation challenge. Briefly, 1mL of a sterile saline solution containing 0.5ng lipopolysaccharide from E. coli 055:B5 (Sigma-Aldrich) was injected into the radiocarpal joint. The contralateral joint was used as a control with only sterile saline injected. Synovial fluid was collected aseptically immediately before injection and at 5, 24, and 48hr post injection. All data were analyzed via ANOVA utilizing a MIXED procedure in SAS 9.4. Horses in the TRT group had no increase in SAA during supplementation while horses in CON increased by approximately 37% by d42 for a trt x time interaction (P < 0.001). Horses in the CON group in both the control and challenged joint had higher AUC for interleukin-6 (P = 0.02) and tumor-necrosis factor α (P = 0.01) than TRT horses. Interleukin-6 and TNFa were analyzed via species-specific colorimetric assays (RD Systems). Taken together, these data indicate that ActivAge® supplementation reduced systemic inflammation in senior horses while also supporting these horses during a joint inflammation challenge.
    Keywords Escherichia coli ; acute phase proteins ; amyloid ; blood serum ; colorimetry ; cross-over studies ; grass hay ; horses ; inflammation ; interleukin-6 ; lipopolysaccharides ; prebiotics ; quality of life ; sodium chloride ; synovial fluid ; veterinary medicine
    Language English
    Dates of publication 2023-05
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 2102631-2
    ISSN 1542-7412 ; 0737-0806
    ISSN (online) 1542-7412
    ISSN 0737-0806
    DOI 10.1016/j.jevs.2023.104317
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  7. Article ; Online: 70 Ahiflower (Buglosoides Arvensis) oil supplementation alters whole blood and muscle fatty acid profile in mature horses

    Jacobs, R.D. / Gordon, M.E.

    Journal of Equine Veterinary Science. 2023 May, v. 124 p.104372-

    2023  

    Abstract: ... CP = 16.0%, Total omega-3 = 0.79%). All horses were offered 1.81kg/d of Purina® Strategy GX® (CP = 14 ... were offered 2.0% BW as Timothy grass hay (CP = 10.10%, Total omega-3 = 0.35%). On d 0, 30, and 60 ...

    Abstract The omega-3 (n-3) profile of common plant-based ingredients are derived from α-linolenic acid (ALA). Previous research has indicated that horses lack the ability to convert ALA or other short-chain polyunsaturated fatty acids (SC-PUFA) into the biologically relevant docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Ahiflower (Buglossoides Arvensis) oil is a novel plant-based source of omega-3 fatty acids derived from n-3 stearidonic acid (SDA), and gamma-linolenic acid (GLA), an omega-6 fatty acid (see Table 1 for fatty acid profile). The objective of this trial was to evaluate how supplementation of Ahiflower oil to horses would alter whole blood and muscle fatty acid composition. Mature Quarter Horses (n = 20) were balanced by age, BW, and BCS and assigned to one of 4 treatment groups. LOW (n = 5; BW = 507.12 ± 2.3kg; BCS = 5.4 ± 0.3) was offered 30mL/day of Ahiflower oil. HIGH (n = 5; BW = 517.45 ± 4.5kg; BCS = 5.7 ± 0.1) was offered 60mL/day of Ahiflower oil. FLAX (n = 5; BW = 497.25 ± 3.5kg; BCS = 6.1 ± 0.7) was offered a flaxseed pellet (CP = 15.42%, Total omega-3 = 3.75%) formulated to provide the same amount of total omega-3′s as LOW was offered. PAST (n = 5; BW = 508.14 ± 3.6kg; BCS = 5.2 ± 0.6) was allowed free-choice access to mixed grass pasture (CP = 16.0%, Total omega-3 = 0.79%). All horses were offered 1.81kg/d of Purina® Strategy GX® (CP = 14.24%, Total omega-3 = 0.44%) daily. LOW, HIGH, and FLAX were housed in drylots by treatment group and were offered 2.0% BW as Timothy grass hay (CP = 10.10%, Total omega-3 = 0.35%). On d 0, 30, and 60 blood samples were collected along with a mid-gluteal muscle sample (∼1g). Samples were analyzed for fatty acid profile via LC-HPLC (UF ATCL).Data were analyzed via ANOVA (SAS 9.4). Horses in the LOW group had a 12.5% increase in total omega-3, while horses in HIGH had a 40.1% increase. Similar differences were observed for EPA (LOW = 19.2%; HIGH = 40.1%), and GLA (LOW = 60.1%; HIGH = 167%). Horses in HIGH had a greater increase from baseline in muscle EPA + DHA compared with all other groups (250%). All differences were significant at P < 0.05. Taken together these data indicate that horses had the ability to convert the PUFA's in Ahiflower oil into EPA. Increased EPA in whole blood and muscle tissue potentially allows for increased production of anti-inflammatory eicosanoids and prostaglandins. Further research is necessary to elucidate the mechanism by which this conversion occurs.
    Keywords Buglossoides arvensis ; Phleum pratense ; blood ; docosahexaenoic acid ; eicosapentaenoic acid ; fatty acid composition ; flax ; gamma-linolenic acid ; grass hay ; grasses ; horses ; linseed ; muscle tissues ; muscles ; oils ; pastures ; prostaglandins ; veterinary medicine
    Language English
    Dates of publication 2023-05
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 2102631-2
    ISSN 1542-7412 ; 0737-0806
    ISSN (online) 1542-7412
    ISSN 0737-0806
    DOI 10.1016/j.jevs.2023.104372
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  8. Article ; Online: Crizanlizumab and sickle cell disease: When should medications have their approval status revoked?

    Jacobs, Jeremy W / Stephens, Laura D / Chooljian, David M / Sharma, Deva / Adkins, Brian D / Booth, Garrett S

    American journal of hematology

    2024  

    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27275
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    Zs.A 1251: Show issues Location:
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  9. Article ; Online: Separating Geometric and Diffusive Contributions to the Surface Nucleation of Dislocations in Nanoparticles.

    Ding, Ruikang / Azadehranjbar, Soodabeh / Padilla Espinosa, Ingrid M / Martini, Ashlie / Jacobs, Tevis D B

    ACS nano

    2024  Volume 18, Issue 5, Page(s) 4170–4179

    Abstract: While metal nanoparticles are widely used, their small size makes them mechanically unstable. Extensive prior research has demonstrated that nanoparticles with sizes in the range of 10-50 nm fail by the surface nucleation of dislocations, which is a ... ...

    Abstract While metal nanoparticles are widely used, their small size makes them mechanically unstable. Extensive prior research has demonstrated that nanoparticles with sizes in the range of 10-50 nm fail by the surface nucleation of dislocations, which is a thermally activated process. Two different contributions have been suggested to cause the weakening of smaller particles: first, geometric effects such as increased surface curvature reduce the barrier for dislocation nucleation; second, surface diffusion happens faster on smaller particles, thus accelerating the formation of surface kinks which nucleate dislocations. These two factors are difficult to disentangle. Here we use
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c09026
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  10. Article ; Online: Prenatal diagnosis of familial porencephaly associated with fetal stroke.

    Shields, A D / Knutzen, D / Khan, M / Sobh, O / Jacobs, K

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

    2023  Volume 62, Issue 1, Page(s) 153–154

    MeSH term(s) Female ; Humans ; Pregnancy ; Porencephaly/diagnosis ; Prenatal Diagnosis/methods ; Stroke/diagnostic imaging ; Stroke/etiology
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Letter
    ZDB-ID 1073183-0
    ISSN 1469-0705 ; 0960-7692
    ISSN (online) 1469-0705
    ISSN 0960-7692
    DOI 10.1002/uog.26168
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