Article ; Online: M
2019 Volume 85, Issue 12, Page(s) 989–1000
Abstract: ... tools to assess the involvement of M: Results: M: Conclusions: M ...
Abstract | Background: The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given context. In psychiatric disorders such as posttraumatic stress disorder, PFC hyperactivity is associated with inappropriate fear in safe situations. We previously reported a form of muscarinic acetylcholine receptor (mAChR)-dependent long-term depression in the PFC that we hypothesize is involved in appropriate fear responding and could serve to reduce cortical hyperactivity following stress. However, it is unknown whether this long-term depression occurs at fear-related inputs. Methods: Using optogenetics with extracellular and whole-cell electrophysiology, we assessed the effect of mAChR activation on the synaptic strength of specific PFC inputs. We used selective pharmacological tools to assess the involvement of M Results: M Conclusions: M |
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MeSH term(s) | Animals ; Basolateral Nuclear Complex/physiology ; Conditioning, Classical ; Extinction, Psychological/physiology ; Fear/physiology ; Hippocampus/physiology ; Long-Term Synaptic Depression ; Mediodorsal Thalamic Nucleus/physiology ; Mice, Inbred C57BL ; Neural Pathways/physiology ; Neurons/physiology ; Prefrontal Cortex/physiology ; Receptor, Muscarinic M1/physiology ; Stress Disorders, Post-Traumatic/physiopathology ; Synaptic Transmission/physiology |
Chemical Substances | Receptor, Muscarinic M1 |
Language | English |
Publishing date | 2019-03-07 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 209434-4 |
ISSN | 1873-2402 ; 0006-3223 |
ISSN (online) | 1873-2402 |
ISSN | 0006-3223 |
DOI | 10.1016/j.biopsych.2019.02.020 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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