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  1. AU="Ao, Jun-Li" AU="Ao, Jun-Li"
  2. AU="Hijazi, Amjad" AU="Hijazi, Amjad"
  3. AU="Leonidov, Atanas"
  4. AU="Wright, D M" AU="Wright, D M"
  5. AU="Zahra Shova, Fatema Tuj"
  6. AU="Wan-Xia Yang"
  7. AU="Theiß, Janine"
  8. AU="Romanov, L V"
  9. AU="Demertzis, Konstantinos"
  10. AU="Berking, Helmuth"
  11. AU="Shea, Puigi Catherine"
  12. AU="Dragana Tričković-Vukić"
  13. AU="Schilpp, Carolin"
  14. AU="Sasaki, Shugo"
  15. AU=Saito Hazime AU=Saito Hazime
  16. AU="King, Kindra M"
  17. AU="Prousi, George S" AU="Prousi, George S"
  18. AU="Bredov, Denis V" AU="Bredov, Denis V"
  19. AU="Saeki, Harumi"
  20. AU="Pillière, Rémy"
  21. AU="Gurung, Janita"
  22. AU=O'Malley Dennis P
  23. AU="Khlestkina, Maria S"
  24. AU="Ebina-Shibuya, Risa"
  25. AU="Vogel, Ida"
  26. AU="Facchiano, Angelo"
  27. AU="Tara Rava Zolnikov"
  28. AU="Akther, Tahmina"
  29. AU=Chung Eugene S
  30. AU=Josephson M E

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  1. Artikel ; Online: Phomopsterone B Alleviates Liver Fibrosis through mTOR-Mediated Autophagy and Apoptosis Pathway.

    Peng, Mei-Lin / Zhang, Li-Jie / Luo, Yan / Xu, Shi-Ying / Long, Xing-Mei / Ao, Jun-Li / Liao, Shang-Gao / Zhu, Qin-Feng / He, Xun / Xu, Guo-Bo

    Molecules (Basel, Switzerland)

    2024  Band 29, Heft 2

    Abstract: Liver fibrosis is the initial pathological process of many chronic liver diseases. Targeting hepatic stellate cell (HSC) activation is an available strategy for the therapy of liver fibrosis. We aimed to explore the anti-liver fibrosis activity and ... ...

    Abstract Liver fibrosis is the initial pathological process of many chronic liver diseases. Targeting hepatic stellate cell (HSC) activation is an available strategy for the therapy of liver fibrosis. We aimed to explore the anti-liver fibrosis activity and potential mechanism of phomopsterone B (PB) in human HSCs. The results showed that PB effectively attenuated the proliferation of TGF-β1-stimulated LX-2 cells in a concentration-dependent manner at doses of 1, 2, and 4 μM. Quantitative real-time PCR and Western blot assays displayed that PB significantly reduced the expression levels of α-SMA and collagen I/III. AO/EB and Hoechst33342 staining and flow cytometry assays exhibited that PB promoted the cells' apoptosis. Meanwhile, PB diminished the number of autophagic vesicles and vacuolated structures, and the LC3B fluorescent spots indicated that PB could effectively inhibit the accretion of autophagosomes in LX-2 cells. Moreover, rapamycin and MHY1485 were utilized to further investigate the effect of mTOR in autophagy and apoptosis. The results demonstrated that PB regulated autophagy and apoptosis via the mTOR-dependent pathway in LX-2 cells. In summary, this is the first evidence that PB effectively alleviates liver fibrosis in TGF-β1-stimulated LX-2 cells, and PB may be a promising candidate for the prevention of liver fibrosis.
    Mesh-Begriff(e) Humans ; Transforming Growth Factor beta1 ; Autophagy ; Liver Cirrhosis/drug therapy ; Autophagosomes ; Apoptosis
    Chemische Substanzen Transforming Growth Factor beta1
    Sprache Englisch
    Erscheinungsdatum 2024-01-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29020417
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Hefte anzeigen

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  2. Artikel ; Online: Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.

    Wang, Fu-Rui / Peng, Mei-Lin / Zhu, Qin-Feng / Yu, Ling-Ling / Zhang, Li-Jie / Xu, Shi-Ying / Wang, Qian / Li, Jing / He, Xun / Liao, Shang-Gao / Ao, Jun-Li / Xu, Guo-Bo

    Journal of ethnopharmacology

    2024  Band 325, Seite(n) 117830

    Abstract: Ethnopharmacological relevance: Physalis angulata L., a traditional Chinese medicine called "Kuzhi" in China, was used traditionally to treat liver diseases (eg. icterus, hepatitis) as well as malaria, asthma, and rheumatism.: Aim of the study: Our ... ...

    Abstract Ethnopharmacological relevance: Physalis angulata L., a traditional Chinese medicine called "Kuzhi" in China, was used traditionally to treat liver diseases (eg. icterus, hepatitis) as well as malaria, asthma, and rheumatism.
    Aim of the study: Our study aimed to investigate the withanolides with anti-hepatic fibrosis effect from P. angulate.
    Materials and methods: Withanolides were obtained from the EtOH extract of P. angulate by bioassay-molecular networking analysis-guided isolation using column chromatography and normal/reversed-phase semipreparative HPLC. The structures of new withanolides were elucidated by combinations of spectroscopic techniques with NMR and ECD calculations. MTT cell viability assay, AO/EB staining method, cell wound healing assay, ELISA and Western blot experiments were employed to evaluate the anti-hepatic fibrosis activity and to uncover related mechanism. Molecular docking analysis and cellular thermal shift assay were used to evaluate and verify the interaction between the active withanolides and their potential targets.
    Results: Eight unreported withanolides, withagulides A-H (1-8), along with twenty-eight known ones were obtained from P. angulate. Withanolides 6, 9, 10, 24, 27, and 29-32 showed marked anti-hepatic fibrosis effect with COL1A1 expression inhibition above 50 %. Physalin F (9), the main component in the active fraction, significantly decreased the TGF β1-stimulated expressions of collagen I and α-SMA in LX-2 cells. Mechanism study revealed that physalin F exerted its anti-hepatic fibrosis effect via the PI3K/AKT/mTOR signaling pathway.
    Conclusion: This study suggested that withanolides were an important class of natural products with marked anti-hepatic fibrosis effect. The main withanolide physalin F might be a promising candidate for hepatic fibrosis treatment. The work provided experimental foundation for the use of P. angulate to treat hepatic fibrosis.
    Mesh-Begriff(e) Withanolides/pharmacology ; Withanolides/therapeutic use ; Withanolides/chemistry ; Physalis/chemistry ; Molecular Docking Simulation ; Phosphatidylinositol 3-Kinases ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry
    Chemische Substanzen Withanolides ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117830
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Uric acid-lowering effect of harpagoside and its protective effect against hyperuricemia-induced renal injury in mice.

    Fu, Qiong / Zhang, Jin-Juan / Zhu, Qin-Feng / Yu, Ling-Ling / Wang, Fang / Li, Jing / He, Xun / Ao, Jun-Li / Xu, Guo-Bo / Wei, Mao-Chen / Liao, Xing-Jiang / Liao, Shang-Gao

    Biochemical and biophysical research communications

    2024  Band 716, Seite(n) 150038

    Abstract: Hyperuricemia (HUA) is caused by increased synthesis and/or insufficient excretion of uric acid (UA). Long-lasting HUA may lead to a number of diseases including gout and kidney injury. Harpagoside (Harp) is a bioactive compound with potent anti- ... ...

    Abstract Hyperuricemia (HUA) is caused by increased synthesis and/or insufficient excretion of uric acid (UA). Long-lasting HUA may lead to a number of diseases including gout and kidney injury. Harpagoside (Harp) is a bioactive compound with potent anti-inflammatory activity from the roots of Scrophularia ningpoensis. Nevertheless, its potential effect on HUA was not reported. The anti-HUA and nephroprotective effects of Harp on HUA mice were assessed by biochemical and histological analysis. The proteins responsible for UA production and transportation were investigated to figure out its anti-HUA mechanism, while proteins related to NF-κB/NLRP3 pathway were evaluated to reveal its nephroprotective mechanism. The safety was evaluated by testing its effect on body weight and organ coefficients. The results showed that Harp significantly reduced the SUA level and protected the kidney against HUA-induced injury but had no negative effect on safety. Mechanistically, Harp significantly reduced UA production by acting as inhibitors of xanthine oxidase (XOD) and adenosine deaminase (ADA) and decreased UA excretion by acting as activators of ABCG2, OAT1 and inhibitors of GLUT9 and URAT1. Moreover, Harp markedly reduced infiltration of inflammatory cells and down-regulated expressions of TNF-α, NF-κB, NLRP3 and IL-1β in the kidney. Harp was a promising anti-HUA agent.
    Mesh-Begriff(e) Animals ; Hyperuricemia/drug therapy ; Hyperuricemia/metabolism ; Uric Acid/blood ; Male ; Glycosides/pharmacology ; Glycosides/therapeutic use ; Pyrans/pharmacology ; Pyrans/therapeutic use ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Kidney/drug effects ; Kidney/pathology ; Kidney/metabolism ; NF-kappa B/metabolism ; Mice, Inbred C57BL
    Sprache Englisch
    Erscheinungsdatum 2024-04-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.150038
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 116: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Artikel ; Online: New Meroterpenoid and Isocoumarins from the Fungus

    Li, Kai-Yu / Zhu, Qin-Feng / Ao, Jun-Li / Wang, Fu-Rui / Long, Xing-Mei / Liao, Shang-Gao / Xu, Guo-Bo

    Molecules (Basel, Switzerland)

    2022  Band 27, Heft 23

    Abstract: Three new compounds including a meroterpenoid ( ...

    Abstract Three new compounds including a meroterpenoid (
    Sprache Englisch
    Erscheinungsdatum 2022-11-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238223
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Three New Selaginellin Derivatives from Selaginella pulvinata and Their α-Glucosidase Inhibitory Activity.

    Zhu, Qin-Feng / Luo, Tian-Tian / Chen, Qian / Gao, Bei-Bei / Zeng, Ai-Fen / Ao, Jun-Li / Xu, Guo-Bo / Liao, Shang-Gao / He, Xun

    Chemistry & biodiversity

    2023  Band 20, Heft 4, Seite(n) e202300109

    Abstract: Three new selaginellin derivatives, selaginpulvilins V-X (1-3), together with seven known analogs (4-10) were isolated from whole plants of Selaginella pulvinata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR, ...

    Abstract Three new selaginellin derivatives, selaginpulvilins V-X (1-3), together with seven known analogs (4-10) were isolated from whole plants of Selaginella pulvinata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR, HR-ESI-MS and chemical derivatization method. Compound 1 represents a rare example of naturally occurring selaginellin with an alkynylphenol-trimmed skeleton. Biological evaluation showed that compounds 2, 6 and 8 displayed moderate inhibition against α-glucosidase with IC
    Mesh-Begriff(e) Molecular Structure ; Selaginellaceae/chemistry ; alpha-Glucosidases ; Magnetic Resonance Spectroscopy
    Chemische Substanzen alpha-Glucosidases (EC 3.2.1.20)
    Sprache Englisch
    Erscheinungsdatum 2023-02-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202300109
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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