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  1. Article ; Online: The Potential Clinical Application of Induced Tolerogenic Macrophages.

    Xu, Hong / Suire, Colby / Ildstad, Suzanne T

    Transplantation

    2022  Volume 107, Issue 1, Page(s) 23–24

    MeSH term(s) Macrophages ; Immune Tolerance ; Dendritic Cells
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 509: Show issues

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  2. Article ; Online: Impact of lysosome status on extracellular vesicle content and release.

    Eitan, Erez / Suire, Caitlin / Zhang, Shi / Mattson, Mark P

    Ageing research reviews

    2016  Volume 32, Page(s) 65–74

    Abstract: Extracellular vesicles (EVs) are nanoscale size bubble-like membranous structures released from cells. EVs contain RNA, lipids and proteins and are thought to serve various roles including intercellular communication and removal of misfolded proteins. ... ...

    Abstract Extracellular vesicles (EVs) are nanoscale size bubble-like membranous structures released from cells. EVs contain RNA, lipids and proteins and are thought to serve various roles including intercellular communication and removal of misfolded proteins. The secretion of misfolded and aggregated proteins in EVs may be a cargo disposal alternative to the autophagy-lysosomal and ubiquitin-proteasome pathways. In this review we will discuss the importance of lysosome functionality for the regulation of EV secretion and content. Exosomes are a subtype of EVs that are released by the fusion of multivesicular bodies (MVB) with the plasma membrane. MVBs can also fuse with lysosomes, and the trafficking pathway of MVBs can therefore determine whether or not exosomes are released from cells. Here we summarize data from studies of the effects of lysosome inhibition on the secretion of EVs and on the possibility that cells compensate for lysosome malfunction by disposal of potentially toxic cargos in EVs. A better understanding of the molecular mechanisms that regulate trafficking of MVBs to lysosomes and the plasma membrane may advance an understanding of diseases in which pathogenic proteins, lipids or infectious agents accumulate within or outside of cells.
    MeSH term(s) Aging/physiology ; Autophagy/physiology ; Cell Membrane/physiology ; Exosomes/physiology ; Humans ; Lysosomes/physiology ; Multivesicular Bodies/physiology ; Neurodegenerative Diseases/metabolism ; Protein Transport/physiology
    Language English
    Publishing date 2016-05-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2016.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5579: Show issues Location:
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  3. Article ; Online: Isolation of the stromal-vascular fraction of mouse bone marrow markedly enhances the yield of clonogenic stromal progenitors.

    Suire, Colby / Brouard, Nathalie / Hirschi, Karen / Simmons, Paul J

    Blood

    2012  Volume 119, Issue 11, Page(s) e86–95

    Abstract: The low incidence of CFU-F significantly complicates the isolation of homogeneous populations of mouse bone marrow stromal cells (BMSCs), a common problem being contamination with hematopoietic cells. Taking advantage of burgeoning evidence demonstrating ...

    Abstract The low incidence of CFU-F significantly complicates the isolation of homogeneous populations of mouse bone marrow stromal cells (BMSCs), a common problem being contamination with hematopoietic cells. Taking advantage of burgeoning evidence demonstrating the perivascular location of stromal cell stem/progenitors, we hypothesized that a potential reason for the low yield of mouse BMSCs is the flushing of the marrow used to remove single-cell suspensions and the consequent destruction of the marrow vasculature, which may adversely affect recovery of BMSCs physically associated with the abluminal surface of blood vessels. Herein, we describe a simple methodology based on preparation and enzymatic disaggregation of intact marrow plugs, which yields distinct populations of both stromal and endothelial cells. The recovery of CFU-F obtained by pooling the product of each digestion (1631.8 + 199) reproducibly exceeds that obtained using the standard BM flushing technique (14.32 + 1.9) by at least 2 orders of magnitude (P < .001; N = 8) with an accompanying 113.95-fold enrichment of CFU-F frequency when plated at low oxygen (5%). Purified BMSC populations devoid of hematopoietic contamination are readily obtained by FACS at P0 and from freshly prepared single-cell suspensions. Furthermore, this population demonstrates robust multilineage differentiation using standard in vivo and in vitro bioassays.
    MeSH term(s) Animals ; Bone Marrow Cells/cytology ; Cell Differentiation ; Cells, Cultured ; Colony-Forming Units Assay ; Endothelium, Vascular/cytology ; Flow Cytometry ; Fluorescent Antibody Technique ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, SCID ; Stem Cells/cytology ; Stromal Cells/cytology
    Language English
    Publishing date 2012-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2011-08-372334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  4. Article: Charles Jean Hebant (1941-1982) [Botanists, bryology, France]

    Suire, C

    Cryptogamie : Bryologie, lichenologie. 1982. v. 3 (4)

    1982  

    Keywords France
    Language French
    Size p. 371-376., ill.
    Document type Article
    Note In French. ; Title in original language could not be transcribed. ; Includes biographical information and a list of his publications.
    ISSN 0181-1576
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Toll-like receptor 2 recognition of the microsporidia Encephalitozoon spp. induces nuclear translocation of NF-kappaB and subsequent inflammatory responses.

    Fischer, Jeffrey / Suire, Colby / Hale-Donze, Hollie

    Infection and immunity

    2008  Volume 76, Issue 10, Page(s) 4737–4744

    Abstract: Microsporidia are obligate intracellular parasites that are ubiquitous in nature and have been recognized as causing an important emerging disease among immunocompromised individuals. Limited knowledge exists about the immune response against these ... ...

    Abstract Microsporidia are obligate intracellular parasites that are ubiquitous in nature and have been recognized as causing an important emerging disease among immunocompromised individuals. Limited knowledge exists about the immune response against these organisms, and virtually nothing is known about the receptors involved in host recognition. Toll-like receptors (TLR) are pattern recognition receptors that bind to specific molecules found on pathogens and signal a variety of inflammatory responses. In this study, we show that both Encephalitozoon cuniculi and Encephalitozoon intestinalis are preferentially recognized by TLR2 and not by TLR4 in primary human macrophages. This is the first demonstration of host receptor recognition of any microsporidian species. TLR2 ligation is known to activate NF-kappaB, resulting in inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interleukin-8 (IL-8). We found that the infection of primary human macrophages leads to the nuclear translocation of NF-kappaB in as early as 1 h and the subsequent production of TNF-alpha and IL-8. To verify the direct role of TLR2 parasite recognition in the production of these cytokines, the receptor was knocked down in primary human macrophages using small interfering RNA. This knockdown resulted in decreases in both the nuclear translocation of NF-kappaB and the levels of TNF-alpha and IL-8 after challenge with spores. Taken together, these experiments directly link the initial inflammatory response induced by Encephalitozoon spp. to TLR2 stimulation in human macrophages.
    MeSH term(s) Cell Nucleus/chemistry ; Cells, Cultured ; Encephalitozoon/immunology ; Gene Silencing ; Humans ; Inflammation/immunology ; Interleukin-8/metabolism ; Macrophages/immunology ; Macrophages/microbiology ; NF-kappa B/metabolism ; RNA, Small Interfering/genetics ; Time Factors ; Toll-Like Receptor 2/immunology ; Toll-Like Receptor 4/immunology ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Interleukin-8 ; NF-kappa B ; RNA, Small Interfering ; Toll-Like Receptor 2 ; Toll-Like Receptor 4 ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2008-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00733-08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 684: Show issues Location:
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  6. Article: Une nouvelle station francaise de Dumortiera hirsuta (Sw.) Reinw., Bl. & Nees

    Suire, C

    Revue bryologique et lichenologique 1976, 42 (2)

    1976  

    Title translation A new French station of Dumortiera hirsuta (Sw.) Rienw., Bl. & Nees.
    Title variant New French station of Dumortiera hirsuta (Sw.) Rienw., Bl. & Nees [Hepataceae]
    Keywords France
    Language French
    Size p. 731-736.
    Document type Article
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Le systeme secreteur chez les hepatiques

    Suire, C

    Bulletin de la Société botanique de France. 1976, 123

    1976  

    Title translation The secretory system of liverworts.
    Title variant Secretory system of liverworts [Hepaticae]
    Keywords Hepaticopsida
    Language French
    Size p. 191-197.
    Document type Article
    ISSN 0037-8941
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Les donnees actuelles sur la chimie des bryophytes

    Suire, C

    Revue bryologique et lichenologique 1975, (new ser.) 41 (2)

    1975  

    Title translation Current data on the chemistry of Bryophyta.
    Keywords plant physiology ; plant biochemistry
    Language French
    Size p. 105-256.
    Document type Article
    Note Includes summary in English
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Cellular localization of isoprenoid biosynthetic enzymes in Marchantia polymorpha. Uncovering a new role of oil bodies

    Suire, C / Bouvier, F / Backhaus, R.A / Begu, D / Bonneu, M / Camara, B

    Plant physiology (Lancaster, Pa.) Plant physiology. Nov 2000. v. 124 (3)

    2000  

    Abstract: Like seed plants, liverworts synthesize and accumulate a myriad of isoprenoid compounds. Using antibodies raised against several isoprenoid biosynthetic enzymes, we investigated their intracellular compartmentation by in situ immunolocalization from ... ...

    Abstract Like seed plants, liverworts synthesize and accumulate a myriad of isoprenoid compounds. Using antibodies raised against several isoprenoid biosynthetic enzymes, we investigated their intracellular compartmentation by in situ immunolocalization from Marchantia polymorpha. The enzymes examined were deoxy-xylulose phosphate synthase, geranyl diphosphate synthase, farnesyl diphosphate synthase, geranylgeranyl diphosphate synthase, monoterpene synthase, geranylgeranyl diphosphate reductase, phytoene synthase, and phytoene desaturase. Our results show that liverwort oil bodies, which are organelles bound by a single unit membrane, possess isoprenoid biosynthetic enzymes similar to those found in plastids and the cytosol. We postulate that oil bodies play a dynamic role in cell metabolism in addition to their role as sites of essential oil accumulation and sequestration. The occurrence of such enzymes in different cellular compartments might be due to multiple targeting of gene products to various organelles.
    Keywords Marchantia polymorpha ; isoprenoids ; biosynthesis ; metabolism ; chemical reactions ; biochemical pathways ; enzyme activity ; plastids ; cytosol ; lipid bodies ; immunohistochemistry ; chemical constituents of plants ; phytoene synthase
    Language English
    Dates of publication 2000-11
    Size p. 971-987.
    Document type Article
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Oxidative remodeling of chromoplast carotenoids: identification of the carotenoid dioxygenase CsCCD and CsZCD genes involved in Crocus secondary metabolite biogenesis

    Bouvier, F / Suire, C / Mutterer, J / Camara, B

    Plant cell. Jan 2003. v. 15 (1)

    2003  

    Abstract: The accumulation of three major carotenoid derivatives-crocetin glycosides, picrocrocin, and safranal-is in large part responsible for the color, bitter taste, and aroma of saffron, which is obtained from the dried styles of Crocus. We have identified ... ...

    Abstract The accumulation of three major carotenoid derivatives-crocetin glycosides, picrocrocin, and safranal-is in large part responsible for the color, bitter taste, and aroma of saffron, which is obtained from the dried styles of Crocus. We have identified and functionally characterized the Crocus zeaxanthin 7,8(7',8')-cleavage dioxygenase gene (CsZCD), which codes for a chromoplast enzyme that initiates the biogenesis of these derivatives. The Crocus carotenoid 9,10(9',10')-cleavage dioxygenase gene (CsCCD) also has been cloned, and the comparison of substrate specificities between these two enzymes has shown that the CsCCD enzyme acts on a broader range of precursors. CsZCD expression is restricted to the style branch tissues and is enhanced under dehydration stress, whereas CsCCD is expressed constitutively in flower and leaf tissues irrespective of dehydration stress. Electron microscopy revealed that the accumulation of saffron metabolites is accompanied by the differentiation of amyloplasts and chromoplasts and by interactions between chromoplasts and the vacuole. Our data suggest that a stepwise sequence exists that involves the oxidative cleavage of zeaxanthin in chromoplasts followed by the sequestration of modified water-soluble derivatives into the central vacuole.
    Keywords Crocus ; styles ; carotenoids ; glycosides ; biosynthesis ; genes ; oxygenases ; complementary DNA ; nucleotide sequences ; amino acid sequences ; gene expression ; messenger RNA ; metabolites ; plastids ; cell differentiation ; vacuoles ; cytochemistry ; enzyme activity ; amyloplasts ; chromoplasts
    Language English
    Dates of publication 2003-01
    Size p. 47-62.
    Document type Article
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    Database NAL-Catalogue (AGRICOLA)

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