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  1. Book: Radiotherapy for head and neck cancers

    Ang, K. Kian / Garden, Adam S.

    indications and techniques

    2012  

    Author's details K. Kian Ang ; Adam Garden
    Keywords Head and Neck Neoplasms / radiotherapy ; Radiotherapy / methods
    Language English
    Size VI, 292 S. : zahlr. Ill., graph. Darst., 28 cm
    Edition 4. ed.
    Publisher Wolters Kluwer, Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    Accompanying material Zugang zu paralleler Internetausgabe über Code
    HBZ-ID HT017008900
    ISBN 978-1-608-31686-1 ; 1-608-31686-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 4377 order for loan Magazin
    Zugang zu papralleler Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book: Radiation oncology

    Cox, James D. / Ang, Kie Kian

    rationale, technique and results

    (Expert consult)

    2010  

    Author's details James D. Cox ; K. Kian Ang
    Series title Expert consult
    Keywords Neoplasms / radiotherapy ; Cancer--Radiotherapy
    Subject code 616.9940642
    Language English
    Size XII, 1072 S. : Ill., graph. Darst., 29 cm
    Edition 9. ed.
    Publisher Mosby Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT016141017
    ISBN 978-0-323-04971-9 ; 0-323-04971-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 5820 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Book ; Online: Radiotherapy for head and neck cancers

    Ang, K. K. / Garden, Adam S.

    indications and techniques

    2006  

    Author's details K. Kian Ang, Adam S. Garden
    Keywords Head and neck neoplasms - radiotherapy ; Radiotherapy - methods
    Language English
    Size 1 Online-Ressource (xi, 212 Seiten), Illustrationen
    Edition 3rd ed.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia
    Document type Book ; Online
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-7817-6093-5 ; 0-7817-6093-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Book: Radiotherapy for head and neck cancers

    Ang, Kie Kian / Garden, Adam S.

    indications and techniques

    2006  

    Author's details K. Kian Ang ; Adam S. Garden
    Keywords Head and Neck Neoplasms / radiotherapy ; Radiotherapy / methods ; Head/Cancer/Radiotherapy ; Neck/Cancer/Radiotherapy
    Subject code 616.994910642
    Language English
    Size XI, 212 S. : zahlr. Ill.
    Edition 3. ed.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index. - Previous ed.: 2001
    HBZ-ID HT014532823
    ISBN 0-7817-6093-3 ; 978-0-7817-6093-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 5141 order for loan Magazin

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  5. Article: Association of Triglyceride Glucose Index with Prevalence and Incidence of Diabetic Retinopathy in a Singaporean Population.

    Neelam, Kumari / Aung, Khin Chaw Yu / Ang, Keven / Tavintharan, Subramaniam / Sum, Chee Fang / Lim, Su Chi

    Clinical ophthalmology (Auckland, N.Z.)

    2023  Volume 17, Page(s) 445–454

    Abstract: Objective: To examine the association of triglyceride glucose (TyG) index (product of fasting triglyceride and glucose) with prevalence and incidence of diabetic retinopathy (DR) in type 2 diabetes.: Methods: 1339 patients from an ongoing Singapore ... ...

    Abstract Objective: To examine the association of triglyceride glucose (TyG) index (product of fasting triglyceride and glucose) with prevalence and incidence of diabetic retinopathy (DR) in type 2 diabetes.
    Methods: 1339 patients from an ongoing Singapore Study of Macro-angiopathy and Micro-Vascular Reactivity in Type 2 Diabetes (SMART2D) were included in this study. Fasting triglyceride and glucose levels were quantified and color fundus photographs were assessed for DR presence and severity. Logistic regression models were used to evaluate associations of TyG index with DR prevalence and incidence (median follow-up period = 3.2 years).
    Results: Mean TyG index was higher in patients with DR than no DR (9.24±0.7 versus 9.04± 0.6, p<0.001). TyG index was significantly associated with DR prevalence (OR=1.4, CI 1.1-1.7, p=0.002) and incidence (OR=1.8, CI 1.04-2.9, p=0.03), after adjusting for confounders. In a stratified analysis, the association between TyG index and DR prevalence reached significance only in the subgroup with HbA1c levels < 7.0% (OR=2, CI 1.1-3.8, p=0.03). TyG index significantly predicted DR prevalence and incidence with area under receiver operating curve as 0.77 (CI 0.74-0.80, p <0.001) and 0.66 (CI 0.57-0.76, p value <0.01), respectively.
    Conclusion: TyG index is a good predictor for DR prevalence and incidence. It can also be a secondary treatment target for patients with optimally controlled levels of HbA1c.
    Language English
    Publishing date 2023-02-02
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S382336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A case report of acquired Haemophilia A: A rare medical emergency.

    Ang, K T / Joyce Gan, M Y / Syed, E S

    The Medical journal of Malaysia

    2022  Volume 77, Issue 3, Page(s) 388–392

    Abstract: Acquired Haemophilia A (AHA) is a rare potentially lifethreatening bleeding disorder caused by the presence of autoantibodies against coagulation factors. It is usually characterised by severe spontaneous haemorrhage, which can lead to high morbidity and ...

    Abstract Acquired Haemophilia A (AHA) is a rare potentially lifethreatening bleeding disorder caused by the presence of autoantibodies against coagulation factors. It is usually characterised by severe spontaneous haemorrhage, which can lead to high morbidity and mortality. The diagnosis is often challenging. Treatment requires vigilant and accurate laboratory investigations, control of bleeding episodes, and eradication of inhibitors using bypassing agents and/or immunosuppressive agents. Hereby, we present a case report of unusual bleeding episodes with isolated raised activated partial thromboplastin time (APTT).
    MeSH term(s) Autoantibodies ; Hemophilia A/complications ; Hemophilia A/diagnosis ; Hemorrhage/diagnosis ; Hemorrhage/etiology ; Humans ; Partial Thromboplastin Time
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-05-31
    Publishing country Malaysia
    Document type Case Reports ; Journal Article
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1206: Show issues Location:
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  7. Book: Radiation oncology

    Cox, James D. / Ang, Kie Kian

    rationale, technique, results

    2003  

    Author's details James D. Cox ; K. Kian Ang
    Keywords Neoplasms / radiotherapy ; Cancer/Radiotherapy
    Subject code 616.9920642
    Language English
    Size XIV, 1036 S. : Ill., graph. Darst.
    Edition 8. ed.
    Publisher Mosby
    Publishing place St. Louis
    Publishing country United States
    Document type Book
    Old title 7. Aufl. u.d.T. Moss' radiation oncology
    HBZ-ID HT013575446
    ISBN 0-323-01258-2 ; 978-0-323-01258-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 595 order for loan Magazin

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  8. Article ; Online: Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes.

    Gurung, Resham L / Liu, Sylvia / Liu, Jian-Jun / M, Yiamunaa / Zheng, Huili / Chan, Clara / Ang, Keven / Subramaniam, Tavintharan / Sum, Chee Fang / Lim, Su Chi

    Cardiovascular diabetology

    2024  Volume 23, Issue 1, Page(s) 70

    Abstract: Background: Angiogenin, an enzyme belonging to the ribonucleases A superfamily, plays an important role in vascular biology. Here, we sought to study the association of plasma angiogenin and major adverse cardiovascular events (MACEs) in patients with ... ...

    Abstract Background: Angiogenin, an enzyme belonging to the ribonucleases A superfamily, plays an important role in vascular biology. Here, we sought to study the association of plasma angiogenin and major adverse cardiovascular events (MACEs) in patients with type 2 diabetes (T2D).
    Methods: This prospective study included 1083 T2D individuals recruited from a secondary hospital and a primary care facility. The primary outcome was a composite of four-point MACE (nonfatal myocardial infarction, stroke, unstable angina pectoris leading to hospitalization and cardiovascular death). Circulating angiogenin was measured by a proximity extension assay. Cox regression models were used to evaluate the association of baseline plasma angiogenin with the risk of MACE.
    Results: During a median follow-up of 9.3 years, 109 (10%) MACE were identified. Plasma angiogenin was significantly higher in participants with MACE than in those without MACE (P < 0.001). Doubling of plasma angiogenin concentration was associated with a 3.10-fold (95% CI 1.84-5.22) increased risk for MACE. The association was only moderately attenuated after adjustment for demographic and cardiometabolic risk factors (adjusted HR 2.38, 95% CI 1.34-4.23) and remained statistically significant after additional adjustment for estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (uACR) (adjusted HR 1.90, 95% CI 1.02-3.53). A consistent outcome was obtained when plasma angiogenin was analysed as a categorical variable in tertiles.
    Conclusions: Plasma angiogenin was associated with the risk of future cardiovascular events in patients with T2D and may be a promising novel biomarker for identifying high-risk T2D patients for early management.
    MeSH term(s) Humans ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/complications ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Myocardial Infarction/complications ; Prospective Studies ; Ribonuclease, Pancreatic ; Risk Factors
    Chemical Substances angiogenin (EC 3.1.27.-) ; Ribonuclease, Pancreatic (EC 3.1.27.5)
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2093769-6
    ISSN 1475-2840 ; 1475-2840
    ISSN (online) 1475-2840
    ISSN 1475-2840
    DOI 10.1186/s12933-024-02156-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Association between Plasma LRG1 and Lower Cognitive Function in Asians with Type 2 Diabetes Mellitus.

    Low, Serena / Moh, Angela / Pandian, Bhuvaneswari / Tan, Xin Li / Pek, Sharon / Zheng, Huili / Ang, Keven / Tang, Wern Ee / Lim, Ziliang / Subramaniam, Tavintharan / Sum, Chee Fang / Lim, Su Chi

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Context: Leucine-rich α-2-glycoprotein 1 (LRG1) has been implicated in the pathogenesis of diabetic complications, but its association with cognitive function remains unclear.: Objective: Our primary objective is to investigate the longitudinal ... ...

    Abstract Context: Leucine-rich α-2-glycoprotein 1 (LRG1) has been implicated in the pathogenesis of diabetic complications, but its association with cognitive function remains unclear.
    Objective: Our primary objective is to investigate the longitudinal association between LRG1 and cognitive function in patients with type 2 diabetes mellitus (T2DM). Secondarily, we determine the causal relationship using Mendelian Randomization (MR), and the role of arterial stiffness as a potential mediator.
    Methods: T2DM patients (n = 1039; age = 64.1 ± 6.4 years) were followed-up for 5.3 ± 1.2 years. Plasma LRG1 was measured at baseline using enzyme-linked immunosorbent assay. Baseline and follow-up cognitive function was assessed using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). One-sample MR was performed with rs4806985 as plasma LRG1-associated single-nucleotide polymorphism (SNP). Mediation analysis was performed to examine if pulse wave velocity (PWV), an arterial stiffness index, mediated the association between plasma LRG1 and follow-up cognitive function.
    Results: Elevated baseline natural log (Ln)-transformed LRG1 was inversely associated with baseline and follow-up RBANS total score with adjusted coefficients -1.38 (95%CI -2.55 to -0.21; p = 0.021) and -1.38 (95%CI -2.70 to -0.07; p = 0.039), respectively. Genetically-predicted higher levels of plasma LRG1 was associated with lower follow-up RBANS total score with coefficient -7.44 (95%CI -14.14 to -0.74; p = 0.030) per unit increase in LnLRG1. Higher PWV accounted for 27.7% of the association between LnLRG1 and follow-up RBANS total score.
    Conclusions: Baseline plasma LRG1 was associated with lower cognitive function at follow-up in patients with T2DM, mediated by PWV. MR analysis provided evidence of an association between genetically influenced plasma LRG1 and lower cognitive function at follow-up.
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.134: Show issues Location:
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  10. Article ; Online: Plasma proteomics of diabetic kidney disease among Asians with younger-onset type 2 diabetes.

    Gurung, Resham Lal / Zheng, Huili / Koh, Hiromi Wai Ling / Yiamunaa, M / Liu, Jian-Jun / Liu, Sylvia / Chan, Clara / Ang, Keven / Tan, Clara Si Hua / Sobota, Radoslaw Mikolaj / Subramaniam, Tavintharan / Sum, Chee Fang / Lim, Su Chi

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Context: Patients with younger onset of type 2 diabetes (YT2D) have increased risk for kidney failure compared to those with late onset. However, the mechanism of diabetic kidney disease (DKD) progression in this high-risk group is poorly understood.: ...

    Abstract Context: Patients with younger onset of type 2 diabetes (YT2D) have increased risk for kidney failure compared to those with late onset. However, the mechanism of diabetic kidney disease (DKD) progression in this high-risk group is poorly understood.
    Objectives: To identify novel biomarkers and potential causal proteins associated with DKD progression in patients with YT2D.
    Design and participants: Among YT2D (T2D onset age ≤ 40 years), 144 DKD progressors (cases) were matched for T2D onset age, sex, and ethnicity with 292 non-progressors (controls) and divided into discovery and validation sets. DKD progression was defined as decline of estimated glomerular filtration rate (eGFR) of 3ml/min/1.73m2 or greater or 40% decline in eGFR from baseline. 1472 plasma proteins were measured through a multiplex immunoassay that uses a proximity extension assay technology. Multivariable logistic regression was used to identify proteins associated with DKD progression. Mendelian randomization (MR) was used to evaluate causal relationship between plasma proteins and DKD progression.
    Results: 42 plasma proteins were associated with DKD progression, independent of traditional cardio-renal risk factors, baseline eGFR and urine albumin-to-creatinine ratio (uACR). The proteins identified were related to inflammatory and remodelling biological processes. Our findings suggested angiogenin as one of the top signals (odds ratio =5.29, 95% CI 2.39-11.73, P = 4.03 × 10-5). Furthermore, genetically determined plasma angiogenin level was associated with increased odds of DKD progression.
    Conclusion: Large-scale proteomic analysis identified novel proteomic biomarkers for DKD progression in YT2D. Genetic evidence suggest a causal role of plasma angiogenin in DKD progression.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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