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Artikel ; Online: Feasibility of the J-PET to monitor the range of therapeutic proton beams.

Baran, Jakub / Borys, Damian / Brzeziński, Karol / Gajewski, Jan / Silarski, Michał / Chug, Neha / Coussat, Aurélien / Czerwiński, Eryk / Dadgar, Meysam / Dulski, Kamil / Eliyan, Kavya V / Gajos, Aleksander / Kacprzak, Krzysztof / Kapłon, Łukasz / Klimaszewski, Konrad / Konieczka, Paweł / Kopeć, Renata / Korcyl, Grzegorz / Kozik, Tomasz /

Krzemień, Wojciech / Kumar, Deepak / Lomax, Antony J / McNamara, Keegan / Niedźwiecki, Szymon / Olko, Paweł / Panek, Dominik / Parzych, Szymon / Perez Del Rio, Elena / Raczyński, Lech / Simbarashe, Moyo / Sharma, Sushil / Shivani / Shopa, Roman Y / Skóra, Tomasz / Skurzok, Magdalena / Stasica, Paulina / Stępień, Ewa Ł / Tayefi, Keyvan / Tayefi, Faranak / Weber, Damien C / Winterhalter, Carla / Wiślicki, Wojciech / Moskal, Paweł / Ruciński, Antoni

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2024 Band 118, Seite(n) 103301

Abstract: ... Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring.: Methods: The Monte Carlo ... J-PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil ... geometries for the J-PET scanner prototype dedicated to the proton beam range assessment.: Results ...

Abstract	Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J-PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread-Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J-PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double-layer cylindrical and triple-layer double-head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10
Mesh-Begriff(e)	Protons ; Feasibility Studies ; Positron-Emission Tomography ; Proton Therapy/methods ; Phantoms, Imaging ; Monte Carlo Method
Chemische Substanzen	Protons
Sprache	Englisch
Erscheinungsdatum	2024-01-29
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2024.103301
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Feasibility of the J-PET to monitor range of therapeutic proton beams

Baran, Jakub / Borys, Damian / Brzeziński, Karol / Gajewski, Jan / Silarski, Michał / Chug, Neha / Coussat, Aurélien / Czerwiński, Eryk / Dadgar, Meysam / Dulski, Kamil / Eliyan, Kavya V. / Kacprzak, Aleksander Gajos Krzysztof / Kapłon, Łukasz / Klimaszewski, Konrad / Konieczka, Paweł / Kopeć, Renata / Korcyl, Grzegorz / Kozik, Tomasz / Krzemień, Wojciech /

2023

Abstract: ... Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring. Approach: The Monte Carlo ... J-PET scanner geometries (three dual-heads and three cylindrical). We simulated proton irradiation ... we indicated potentially optimal geometries for the J-PET scanner prototype dedicated to the proton beam range ...

Abstract	Objective: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring. Approach: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J-PET scanner geometries (three dual-heads and three cylindrical). We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread-Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J-PET scanner prototype dedicated to the proton beam range assessment. Main results: The investigations indicate that the double-layer cylindrical and triple-layer double-head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10$^{-5}$ coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple-layer dual-head geometry. Significance: We performed simulation studies demonstrating that the feasibility of the J-PET detector for PET-based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre-clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double-layer cylindrical and triple-layer dual-head J-PET geometry configurations seem promising for the future clinical application. Experimental tests are needed to confirm these findings. Comment: 19 pages, 7 pages
Schlagwörter	Physics - Medical Physics
Thema/Rubrik (Code)	621
Erscheinungsdatum	2023-02-28
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study.

Brzezinski, Karol Wiktor / Baran, Jakub / Borys, Damian / Gajewski, Jan / Chug, Neha / Coussat, Aurelien / Czerwiński, Eryk / Dadgar, Meysam / Dulski, Kamil / Eliyan, Kavya Valsan / Gajos, Aleksander / Kacprzak, Krzysztof / Kapłon, Łukasz / Klimaszewski, Konrad / Konieczka, Paweł / Kopec, Renata / Korcyl, Grzegorz / Kozik, Tomasz / Krzemień, Wojciech /

Physics in medicine and biology

2023

Abstract: Objective: The Jagiellonian PET (J-PET) technology, based on plastic scintillators, has been ... investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation ... to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated ...

Abstract	Objective: The Jagiellonian PET (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach: Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualised in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results: Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r^2 = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance: The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment. .
Sprache	Englisch
Erscheinungsdatum	2023-06-09
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/acdd4c
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Associations of Sex Hormones With Surface Electrocardiogram J Point Amplitude in Healthy Volunteers.

McNamara, David A / Ng, Jason / Ilkhanoff, Leonard / Schaechter, Andi / Goldberger, Jeffrey J / Kadish, Alan H

The American journal of cardiology

2017 Band 119, Heft 11, Seite(n) 1877–1882

Abstract: Gender differences in J point height exist. Previous studies suggest male sex hormones mediate ... whether male and female sex hormones are associated with J point amplitude in healthy subjects. We conducted ... male). Baseline J point amplitude (JPA) was obtained from continuous surface electrocardiograms. Plasma ...

Abstract	Gender differences in J point height exist. Previous studies suggest male sex hormones mediate effects on cardiovascular disease through myocardial repolarization. Our objective was to assess whether male and female sex hormones are associated with J point amplitude in healthy subjects. We conducted a cross-sectional study of 475 healthy, mixed racial population of men, and premenopausal women (age 33 ± 9 years, 56% male). Baseline J point amplitude (JPA) was obtained from continuous surface electrocardiograms. Plasma testosterone (T), dihydrotestosterone, estrone, 17-estradiol (E2), and sex hormone-binding globulin were measured. A free testosterone index (FTI) was calculated. Multivariate regression analysis stratified by gender and electrocardiographic lead location was used to determine independent predictors of maximum JPA. Regression analysis demonstrated FTI levels were positively associated with JPA in lateral leads (β = +0.01, p <0.05) in men but not in women. Total testosterone was positively associated with anterior electrocardiographic lead JPA in women (β = +0.5, p <0.02), but not in men. E2 was positively associated with inferior lead JPA (β = +1.2, p <0.03) in men but not in women. Total testosterone levels were positively associated with JPA in anterior leads (β = +0.054, p <0.05) in women. Male volunteers in the highest tertile of FTI demonstrated greater lateral JPA compared with the lowest tertile (p <0.05). Women in the highest tertile of FTI demonstrated greater anterior lead JPA compared with the lowest tertile (p <0.05). In conclusion, in a young, healthy population, the female sex hormone E2 and an FTI are independent determinants of JPA in men, whereas T is associated with JPA in women.
Mesh-Begriff(e)	Adult ; Aging ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/physiopathology ; Cross-Sectional Studies ; Electrocardiography/methods ; Female ; Fluoroimmunoassay ; Gonadal Steroid Hormones/blood ; Healthy Volunteers ; Humans ; Male ; Sex Factors
Chemische Substanzen	Biomarkers ; Gonadal Steroid Hormones
Sprache	Englisch
Erscheinungsdatum	2017-03-15
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Multicenter Study
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2017.02.035
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Corrigendum to "A multi-national, multi-disciplinary Delphi consensus study on using omega-3 polyunsaturated fatty acids (n-3 PUFAs) for the treatment of major depressive disorder". [J Affect Disord. 15 (2020) 233-238].

Guu, Ta-Wei / Mischoulon, David / Sarris, Jerome / Hibbeln, Joseph / McNamara, Robert K / Hamazaki, Kei / Freeman, Marlene P / Maes, Michael / Matsuoka, Yutaka J / Belmaker, R H / Marx, Wolfgang / Pariante, Carmine / Berk, Michael / Jacka, Felice / Su, Kuan-Pin

Journal of affective disorders

2020 Band 274, Seite(n) 1226–1227

Sprache	Englisch
Erscheinungsdatum	2020-06-22
Erscheinungsland	Netherlands
Dokumenttyp	Published Erratum
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2020.06.007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Re: Response to: Giutini V, Vangelisti A, Masucci C, Efisio Defraia C, McNamara J, Franchi L. Treatment effects produced by the Twin-block appliance vs the Forsus Fatigue Resistant Device in growing Class II patients. The Angle Orthodontist. 2015;85: 784-789.

Giuntini, Veronica / Vangelisti, Andrea / Masucci, Caterina / Defraia, Efisio / McNamara, James / Franchi, Lorenzo

The Angle orthodontist

2016 Band 86, Heft 2, Seite(n) 345

Mesh-Begriff(e)	Humans ; Malocclusion, Angle Class II/therapy ; Orthodontic Appliances, Functional ; Orthodontists
Sprache	Englisch
Erscheinungsdatum	2016-01-28
Erscheinungsland	United States
Dokumenttyp	Letter ; Comment
ZDB-ID	390289-4
ISSN	1945-7103 ; 0003-3219
ISSN (online)	1945-7103
ISSN	0003-3219
DOI	10.2319/0003-3219-86.2.345
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online ; E-Book: Neonatal hemodynamics

Kluckow, Martin / McNamara, J. Patrick / Polin, Richard A.

(Neonatology questions and controversies series)

2023

Abstract: Dr. Richard Polin's Neonatology Questions and Controversies series highlights the toughest challenges facing physicians and care providers in clinical practice, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In ...

Verfasserangabe	[edited by] Martin Kluckow, Patrick McNamara ; consulting editor, Richard A. Polin
Serientitel	Neonatology questions and controversies series
Abstract	Dr. Richard Polin's Neonatology Questions and Controversies series highlights the toughest challenges facing physicians and care providers in clinical practice, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient.
Mesh-Begriff(e)	Cardiovascular Diseases ; Neonatology/methods ; Hemodynamics ; Infant, Newborn, Diseases
Schlagwörter	Hemodynamics ; Neonatal hematology ; Cardiovascular system/Diseases ; Newborn infants/Diseases
Thema/Rubrik (Code)	618.9212
Sprache	Englisch
Erscheinungsverlauf	2023-2024
Umfang	1 online resource (xviii, 605 pages) :, illustrations (chiefly color)
Ausgabenhinweis	Fourth edition.
Verlag	Elsevier Inc
Erscheinungsort	Philadelphia, PA
Dokumenttyp	Buch ; Online ; E-Book
Bemerkung	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-323-88074-6 ; 9780323880732 ; 978-0-323-88074-9 ; 0323880738
Datenquelle	ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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Artikel: A quasiclassical trajectory study of collisional energy transfer and dissociation in He + H2(v,j) using a new potential energy surface.

Mandy, M E / McNamara, G J

The journal of physical chemistry. A

2006 Band 110, Heft 2, Seite(n) 422–428

Abstract: ... of Boothroyd, Martin, and Peterson (J. Chem. Phys. 2003, 119, 3187) and results for the 348 (v, j) states of H2 ...

Abstract	Quasiclassical trajectories for He + H2 were carried out using the recent ab initio potential of Boothroyd, Martin, and Peterson (J. Chem. Phys. 2003, 119, 3187) and results for the 348 (v, j) states of H2 are compared to those of earlier calculations that used the potential of Wilson, Kapral, and Burns (Chem. Phys. Lett. 1974, 24, 4884). Examined are the cross sections for energy transfer and dissociation, the extent of threshold elevation, and the interconversion of vibrational and rotational energy. Implications for modeling the interstellar medium are discussed.
Sprache	Englisch
Erscheinungsdatum	2006-01-19
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1089-5639
ISSN	1089-5639
DOI	10.1021/jp0529319
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Cytosolic and ER J-domains of mammalian and parasitic origin can functionally interact with DnaK.

Nicoll, W S / Botha, M / McNamara, C / Schlange, M / Pesce, E-R / Boshoff, A / Ludewig, M H / Zimmermann, R / Cheetham, M E / Chapple, J P / Blatch, G L

The international journal of biochemistry & cell biology

2006 Band 39, Heft 4, Seite(n) 736–751

Abstract: ... of protein biogenesis. The Hsp40 signature domain, the J-domain, is required for binding of an Hsp40 ... of chimeric Hsp40 proteins by the replacement of the J-domain of a prokaryotic Hsp40 (DnaJ), we have tested ... the functional equivalence of J-domains from a number of divergent Hsp40s of mammalian and parasitic origin ...

Abstract	Both prokaryotic and eukaryotic cells contain multiple heat shock protein 40 (Hsp40) and heat shock protein 70 (Hsp70) proteins, which cooperate as molecular chaperones to ensure fidelity at all stages of protein biogenesis. The Hsp40 signature domain, the J-domain, is required for binding of an Hsp40 to a partner Hsp70, and may also play a role in the specificity of the association. Through the creation of chimeric Hsp40 proteins by the replacement of the J-domain of a prokaryotic Hsp40 (DnaJ), we have tested the functional equivalence of J-domains from a number of divergent Hsp40s of mammalian and parasitic origin (malarial Pfj1 and Pfj4, trypanosomal Tcj3, human ERj3, ERj5, and Hsj1, and murine ERj1). An in vivo functional assay was used to test the functionality of the chimeric proteins on the basis of their ability to reverse the thermosensitivity of a dnaJ cbpA mutant Escherichia coli strain (OD259). The Hsp40 chimeras containing J-domains originating from soluble (cytosolic or endoplasmic reticulum (ER)-lumenal) Hsp40s were able to reverse the thermosensitivity of E. coli OD259. In all cases, modified derivatives of these chimeric proteins containing an His to Gln substitution in the HPD motif of the J-domain were unable to reverse the thermosensitivity of E. coli OD259. This suggested that these J-domains exerted their in vivo functionality through a specific interaction with E. coli Hsp70, DnaK. Interestingly, a Hsp40 chimera containing the J-domain of ERj1, an integral membrane-bound ER Hsp40, was unable to reverse the thermosensitivity of E. coli OD259, suggesting that this J-domain was unable to functionally interact with DnaK. Substitutions of conserved amino acid residues and motifs were made in all four helices (I-IV) and the loop regions of the J-domains, and the modified chimeric Hsp40s were tested for functionality using the in vivo assay. Substitution of a highly conserved basic residue in helix II of the J-domain was found to disrupt in vivo functionality for all the J-domains tested. We propose that helix II and the HPD motif of the J-domain represent the fundamental elements of a binding surface required for the interaction of Hsp40s with Hsp70s, and that this surface has been conserved in mammalian, parasitic and bacterial systems.
Mesh-Begriff(e)	Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Base Sequence ; Binding Sites ; Cytosol/metabolism ; Endoplasmic Reticulum/metabolism ; Escherichia coli/genetics ; Escherichia coli/growth & development ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Genetic Complementation Test ; HSP40 Heat-Shock Proteins/genetics ; HSP40 Heat-Shock Proteins/metabolism ; HSP70 Heat-Shock Proteins/chemistry ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Humans ; Mice ; Molecular Sequence Data ; Mutation ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Phylogeny ; Protein Binding ; Protein Structure, Tertiary ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Sequence Homology, Amino Acid ; Temperature
Chemische Substanzen	CbpA protein, E coli ; DNAJB11 protein, human ; Dnajc1 protein, mouse ; Escherichia coli Proteins ; HSP40 Heat-Shock Proteins ; HSP70 Heat-Shock Proteins ; Neoplasm Proteins ; Protozoan Proteins ; dnaK protein, E coli (EC 3.6.1.-)
Sprache	Englisch
Erscheinungsdatum	2006-11-23
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1228429-4
ISSN	1878-5875 ; 1357-2725
ISSN (online)	1878-5875
ISSN	1357-2725
DOI	10.1016/j.biocel.2006.11.006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online ; E-Book: Game theory in biology

McNamara, John / Leimar, Olof

concepts and frontiers

(Oxford series in ecology and evolution)

2020

Abstract: This novel reassessment of the field presents the central concepts in evolutionary game theory and provides an authoritative and up-to-date account. The focus is on concepts that are important for biologists in their attempts to explain observations. ... ...

Verfasserangabe	John M. McNamara, Olof Leimar
Serientitel	Oxford series in ecology and evolution
Abstract	This novel reassessment of the field presents the central concepts in evolutionary game theory and provides an authoritative and up-to-date account. The focus is on concepts that are important for biologists in their attempts to explain observations. This strong connection between concepts and applications is a recurrent theme throughout the book.
Schlagwörter	Biology/Mathematical models
Thema/Rubrik (Code)	570.15118
Sprache	Englisch
Umfang	1 online resource (288 pages) :, illustrations (black and white, and colour).
Ausgabenhinweis	First edition.
Verlag	Oxford University press
Erscheinungsort	Oxford, England
Dokumenttyp	Buch ; Online ; E-Book
Anmerkung	This edition also issued in print: 2020.
Bemerkung	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-19-185345-3 ; 0-19-254783-6 ; 0-19-881577-8 ; 978-0-19-185345-6 ; 978-0-19-254783-5 ; 978-0-19-881577-8
Datenquelle	ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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