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  1. Artikel ; Online: Oxygen vacancy enhanced photocatalytic activity of Cu

    Qian, Hong / Yuan, Binxia / Liu, Yuhao / Zhu, Rui / Luan, Weiling / Zhang, Chengxi

    iScience

    2024  Band 27, Heft 5, Seite(n) 109578

    Abstract: In this study, a method was developed to create oxygen vacancies in ... ...

    Abstract In this study, a method was developed to create oxygen vacancies in Cu
    Sprache Englisch
    Erscheinungsdatum 2024-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109578
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The Role of mRNA Alternative Splicing in Macrophages Infected with

    Hong, Weiling / Yang, Hongxing / Wang, Xiao / Shi, Jingyi / Zhang, Jian / Xie, Jianping

    Molecules (Basel, Switzerland)

    2024  Band 29, Heft 8

    Abstract: Mycobacterium ... ...

    Abstract Mycobacterium tuberculosis
    Mesh-Begriff(e) Alternative Splicing ; Mycobacterium tuberculosis/immunology ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/microbiology ; Tuberculosis/immunology ; Tuberculosis/genetics ; Tuberculosis/microbiology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcriptome ; Gene Expression Regulation ; Interleukin-4/genetics ; Interleukin-4/metabolism ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology
    Chemische Substanzen RNA, Messenger ; Interleukin-4 (207137-56-2)
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29081798
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: CuS quantum dots activated DNAzyme for ratiometric electrochemical detection of telomerase activity.

    Sun, Yujie / Dong, Qi / Yang, Huan / Song, Weiling / Zhou, Hong

    Analytica chimica acta

    2023  Band 1248, Seite(n) 340884

    Abstract: Telomerase activity detection has attracted much attention concerning its importance for early cancer diagnosis. Here, we established a ratiometric electrochemical biosensor for telomerase detection based on CuS quantum dots (CuS QDs) dependent DNAzyme- ... ...

    Abstract Telomerase activity detection has attracted much attention concerning its importance for early cancer diagnosis. Here, we established a ratiometric electrochemical biosensor for telomerase detection based on CuS quantum dots (CuS QDs) dependent DNAzyme-regulated dual signals. The telomerase substrate probe was used as the linker to combine the DNA fabricated magnetic beads and CuS QDs. In this way, telomerase extended the substrate probe with repeated sequence to from hairpin structure, releasing CuS QDs as an input to DNAzyme modified electrode. DNAzyme was cleaved with high current of ferrocene (Fc) and low current of methylene blue (MB). On the basis of the obtained ratiometric signals, telomerase activity detection was achieved in the range of 1.0 × 10
    Mesh-Begriff(e) Humans ; DNA, Catalytic/chemistry ; Telomerase/metabolism ; Quantum Dots/chemistry ; DNA/chemistry ; HeLa Cells ; Biosensing Techniques ; Electrochemical Techniques ; Limit of Detection
    Chemische Substanzen DNA, Catalytic ; Telomerase (EC 2.7.7.49) ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2023-01-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2023.340884
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: An "off-on-off" type electrochemical biosensor for detecting multiple biomarkers with DNAzyme-mediated entropy-driven catalytic and DSN enzyme-assisted recycling amplification.

    Yang, Huan / Dong, Qi / Xu, Dandan / Feng, Xinmiao / He, Peng / Song, Weiling / Zhou, Hong

    Analytica chimica acta

    2023  Band 1283, Seite(n) 341978

    Abstract: In this work, an intelligent and versatile electrochemical biosensor was constructed to detect two types of biomarkers by utilizing "off-on-off" switching. Firstly, human apurinic/apyrimidinic endonuclease1(APE1) mediated specific cleavage of the AP site, ...

    Abstract In this work, an intelligent and versatile electrochemical biosensor was constructed to detect two types of biomarkers by utilizing "off-on-off" switching. Firstly, human apurinic/apyrimidinic endonuclease1(APE1) mediated specific cleavage of the AP site, initiating activation DNAzyme and entropy-driven catalytic (EDC) reaction. Subsequently, large amounts of ferrocene labeled single-stranded DNA was released and captured with a remarkable electrochemical signal, achieving "off-on" state. In the presence of microRNA 21(miRNA-21), the DNA/RNA heteroduplexes were formed and cleaved by duplex-specific nuclease (DSN) with recovery the target miRNA-21, causing the current suppression in an "on-off" state. This sensor achieved highly sensitive detection of APE1 and miRNA-21 with a detection limit of 2.5 mU·mL
    Mesh-Begriff(e) Humans ; DNA, Catalytic ; MicroRNAs/analysis ; Entropy ; Reproducibility of Results ; Biosensing Techniques
    Chemische Substanzen DNA, Catalytic ; MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2023-10-28
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2023.341978
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: RAPID Software to the Clinical Application Value of Acute Basilar Artery Occlusion with Endovascular Treatment.

    Li, Weiling / Hong, Weijun / Wang, En / Jiang, Yiqing

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2021  Band 30, Heft 12, Seite(n) 106147

    Abstract: Objective: To investigate the clinical application value of RAPID software based on computed tomography perfusion imaging (CTP) in the endovascular treatment of acute basilar artery occlusion (BAO).: Materials and methods: The data of patients with ... ...

    Abstract Objective: To investigate the clinical application value of RAPID software based on computed tomography perfusion imaging (CTP) in the endovascular treatment of acute basilar artery occlusion (BAO).
    Materials and methods: The data of patients with acute basilar artery occlusion who received endovascular treatment in Taizhou Hospital, Zhejiang Province, between January 2020 and April 2021 were retrospectively analysed. The patients were divided into a perfusion imaging and a no-perfusion imaging group based on whether the image analysis results were obtained by RAPID software. Age, preoperative National Institute of Health stroke scale (NIHSS) score, onset to puncture time (OPT), operation methods, good prognosis at 3 months after surgery (modified Rankin scale (mRS) score ≤3), symptomatic intracranial haemorrhage (sICH) and other clinical data were compared between the two groups. Multivariate logistic regression analysis was used to identify the independent factors affecting the prognosis of BAO patients.
    Results: In total, 61 patients with acute BAO were included: 31 patients in the perfusion imaging group and 30 patients in the no-perfusion imaging group. There were no statistically significant differences between the two groups in age, NIHSS score or operation methods (all P >0.05). However, OPT and the good prognosis rate were significantly higher in the perfusion imaging group than in the no-perfusion imaging group (χ
    Conclusions: RAPID software based on CTP can be used for preoperative screening of patients with acute basilar artery occlusion to identify those suitable for endovascular treatment, which is worthy of clinical promotion.
    Mesh-Begriff(e) Arterial Occlusive Diseases/diagnostic imaging ; Arterial Occlusive Diseases/surgery ; Basilar Artery/diagnostic imaging ; Basilar Artery/pathology ; Basilar Artery/surgery ; Endovascular Procedures ; Humans ; Mass Screening/methods ; Preoperative Care ; Retrospective Studies ; Software
    Sprache Englisch
    Erscheinungsdatum 2021-10-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2021.106147
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: RNA secondary structures in

    Hong, Weiling / Shi, Yang / Xu, Bingbing / Jin, Yongfeng

    RNA (New York, N.Y.)

    2020  Band 26, Heft 9, Seite(n) 1086–1093

    Abstract: ... ...

    Abstract The
    Mesh-Begriff(e) Animals ; Cell Adhesion Molecules/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Evolution, Molecular ; Exons/genetics ; Nucleic Acid Conformation ; Protein Isoforms/genetics ; RNA/genetics ; RNA Splicing/genetics
    Chemische Substanzen Cell Adhesion Molecules ; Drosophila Proteins ; Dscam1 protein, Drosophila ; Protein Isoforms ; RNA (63231-63-0)
    Sprache Englisch
    Erscheinungsdatum 2020-05-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1241540-6
    ISSN 1469-9001 ; 1355-8382
    ISSN (online) 1469-9001
    ISSN 1355-8382
    DOI 10.1261/rna.075259.120
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Polyhedral Au Nanoparticle/MoO

    Zhao, Lin / Li, Tiantian / Xu, Xinlin / Xu, Yang / Li, Dongxiang / Song, Weiling / Zhan, Tianrong / He, Peng / Zhou, Hong / Xu, Jing-Juan / Chen, Hong-Yuan

    Analytical chemistry

    2023  Band 95, Heft 24, Seite(n) 9271–9279

    Abstract: A novel homologous surface-enhanced Raman scattering (SERS)-electrochemical (EC) dual-mode biosensor based on a 3D/2D polyhedral Au nanoparticle/ ... ...

    Abstract A novel homologous surface-enhanced Raman scattering (SERS)-electrochemical (EC) dual-mode biosensor based on a 3D/2D polyhedral Au nanoparticle/MoO
    Mesh-Begriff(e) Humans ; MicroRNAs/analysis ; Gold/chemistry ; Limit of Detection ; Metal Nanoparticles/chemistry ; Biosensing Techniques/methods ; Spectrum Analysis, Raman/methods ; DNA/chemistry
    Chemische Substanzen MicroRNAs ; Gold (7440-57-5) ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2023-06-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c01062
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Engineering Assembly of Plasmonic Virus-Like Gold SERS Nanoprobe Guided by Intelligent Dual-Machine Nanodevice for High-Performance Analysis of Tetracycline.

    Xu, Xinlin / Li, Tiantian / Liu, Yue / Zhou, Luxiao / Li, Yingying / Luo, Yu / Xu, Yang / Zhao, Lin / Song, Weiling / Jiang, Degang / He, Peng / Zhou, Hong

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Seite(n) e2309502

    Abstract: Accurate detection of trace tetracyclines (TCs) in complex matrices is of great significance for food and environmental safety monitoring. However, traditional recognition and amplification tools exhibit poor specificity and sensitivity. Herein, a novel ... ...

    Abstract Accurate detection of trace tetracyclines (TCs) in complex matrices is of great significance for food and environmental safety monitoring. However, traditional recognition and amplification tools exhibit poor specificity and sensitivity. Herein, a novel dual-machine linkage nanodevice (DMLD) is proposed for the first time to achieve high-performance analysis of TC, with a padlock aptamer component as the initiation command center, nucleic acid-encoded multispike virus-like Au nanoparticles (nMVANs) as the signal indicator, and cascade walkers circuit as the processor. The existence of spike vertices and interspike nanogaps in MVANs enables intense electromagnetic near-field focusing, allowing distinct surface-enhanced Raman scattering (SERS) activity. Moreover, through the sequential activation between multistage walker catalytic circuits, the DLMD system converts the limited TC recognition into massive engineering assemblies of SERS probes guided by DNA amplicons, resulting in synergistic enhancement of bulk plasmonic hotspot entities. The continuously guaranteed target recognition and progressively promoted signal enhancement ensure highly specific amplification analysis of TC, with a detection limit as low as 7.94 × 10
    Sprache Englisch
    Erscheinungsdatum 2024-01-28
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202309502
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Cost-Utility Analysis of Screening for Diabetic Retinopathy in China.

    Zhang, Yue / Bai, Weiling / Li, Ruyue / Du, Yifan / Sun, Runzhou / Li, Tao / Kang, Hong / Yang, Ziwei / Tang, Jianjun / Wang, Ningli / Liu, Hanruo

    Health data science

    2022  Band 2022, Seite(n) 9832185

    Abstract: ... ...

    Abstract Background
    Sprache Englisch
    Erscheinungsdatum 2022-03-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2765-8783
    ISSN (online) 2765-8783
    DOI 10.34133/2022/9832185
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Anti-PD-1 immunotherapy combined with stereotactic body radiation therapy and GM-CSF for the treatment of advanced malignant PEComa: A case report.

    Wang, Yunfan / Li, Weiling / Zuo, Xin / Min, Ke / Tang, Yuehua / Chen, Hong / Wang, Weimin / Zhou, Yan

    Frontiers in oncology

    2023  Band 13, Seite(n) 1045119

    Abstract: Background: Perivascular epithelioid cell neoplasm (PEComa) is a rare mesenchymal tumour. Due to its low incidence, a standard treatment regimen for PEComa has not yet been established. Radiotherapy has a synergistic effect with PD-1 inhibitors and GM- ... ...

    Abstract Background: Perivascular epithelioid cell neoplasm (PEComa) is a rare mesenchymal tumour. Due to its low incidence, a standard treatment regimen for PEComa has not yet been established. Radiotherapy has a synergistic effect with PD-1 inhibitors and GM-CSF. We treated advanced malignant PEComa with a triple regimen of PD-1 inhibitor, SBRT and GM-CSF to provide better therapeutic effect.
    Case presentation: A 63-year-old woman was diagnosed with malignant PEComa after presenting with postmenopausal vaginal bleeding. Despite two surgeries, the neoplasm eventually metastasized throughout the body. We formulated triple therapy with SBRT, a PD-1 inhibitor, and GM-CSF for the patient. The patient's local symptoms were controlled at the radiotherapy site, and the lesions at the unirradiated sites were also relieved.
    Conclusions: For the first time, a triple regimen of PD-1 inhibitor, SBRT and GM-CSF was used in the treatment of malignant PEComa and achieved good efficacy. Considering the lack of prospective clinical studies in PEComa, we believe that this triple therapy is a good-quality regimen for advanced malignant PEComa.
    Sprache Englisch
    Erscheinungsdatum 2023-04-18
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1045119
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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