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  1. Artikel ; Online: Lysosomal channels sensing forces.

    Riederer, Erika / Ren, Dejian

    Nature cell biology

    2024  Band 26, Heft 3, Seite(n) 318–320

    Mesh-Begriff(e) Lysosomes
    Sprache Englisch
    Erscheinungsdatum 2024-02-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-024-01347-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Morphological analysis of posterior-medial intertrochanteric fracture patterns using fracture-mapping technique.

    Ren, Hanru / Zhang, Xu / Liang, Yakun / Yi, Chengqing / Li, Dejian

    Frontiers in bioengineering and biotechnology

    2023  Band 11, Seite(n) 1275204

    Abstract: Introduction: ...

    Abstract Introduction:
    Sprache Englisch
    Erscheinungsdatum 2023-11-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1275204
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?

    Riederer, Erika / Cang, Chunlei / Ren, Dejian

    Annual review of pharmacology and toxicology

    2022  Band 63, Seite(n) 19–41

    Abstract: Lysosomes play fundamental roles in material digestion, cellular clearance, recycling, exocytosis, wound repair, ... ...

    Abstract Lysosomes play fundamental roles in material digestion, cellular clearance, recycling, exocytosis, wound repair, Ca
    Mesh-Begriff(e) Humans ; Ion Channels/metabolism ; Signal Transduction ; Lysosomes/chemistry ; Lysosomes/metabolism ; Neurodegenerative Diseases/metabolism
    Chemische Substanzen Ion Channels
    Sprache Englisch
    Erscheinungsdatum 2022-09-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-051921-013755
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Two-pore channels regulate endomembrane tension to enable remodeling and resolution of phagolysosomes.

    Chadwick, Sarah R / Barreda, Dante / Wu, Jing Ze / Ye, Gang / Yusuf, Bushra / Ren, Dejian / Freeman, Spencer A

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Band 121, Heft 8, Seite(n) e2309465121

    Abstract: Phagocytes promptly resolve ingested targets to replenish lysosomes and maintain their responsiveness. The resolution process requires that degradative hydrolases, solute transporters, and proteins involved in lipid traffic are delivered and made active ... ...

    Abstract Phagocytes promptly resolve ingested targets to replenish lysosomes and maintain their responsiveness. The resolution process requires that degradative hydrolases, solute transporters, and proteins involved in lipid traffic are delivered and made active in phagolysosomes. It also involves extensive membrane remodeling. We report that cation channels that localize to phagolysosomes were essential for resolution. Specifically, the conductance of Na
    Mesh-Begriff(e) Mice ; Animals ; Two-Pore Channels ; Phagosomes/metabolism ; Lysosomes/metabolism ; Hydrolases/metabolism ; Cholesterol/metabolism
    Chemische Substanzen Two-Pore Channels ; Hydrolases (EC 3.-) ; Cholesterol (97C5T2UQ7J)
    Sprache Englisch
    Erscheinungsdatum 2024-02-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2309465121
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Hefte anzeigen Standort:
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  5. Artikel: An alternative explosion criterion of combustible dusts based on combustion duration time: Applications for minimum explosion concentration and limiting oxygen concentration

    Guo, Yongzheng / Ren, Kaiyue / Huang, Weixing / Wu, Dejian

    Powder technology. 2022 Sept., v. 409

    2022  

    Abstract: A novel method based on combustion duration time was newly proposed as an explosion criterion to determine minimum explosion concentration (MEC) and limiting oxygen concentration (LOC) in our recent works. This work further studies the reasonability and ... ...

    Abstract A novel method based on combustion duration time was newly proposed as an explosion criterion to determine minimum explosion concentration (MEC) and limiting oxygen concentration (LOC) in our recent works. This work further studies the reasonability and reliability of the alternative method experimentally and theoretically. Six different dust samples were tested via a 20-L spherical explosion chamber. The experimental results showed that the data of MEC and LOC determined by using the alternative and the standardized methods are in good agreement. The minimum flame propagation velocity (Sf) and the corresponding maximum combustion duration time (tc) were found at its MEC and LOC, suggesting that the theoretical analysis can well explain all the experimental data. It is the first time to study the theoretical basis of the explosion criterion, thus helping to improve our understandings of dust explosion characteristics, and to amend the explosion criterion in future test standards.
    Schlagwörter combustion ; dust ; oxygen ; technology
    Sprache Englisch
    Erscheinungsverlauf 2022-09
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ISSN 0032-5910
    DOI 10.1016/j.powtec.2022.117851
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel: Finite Element Analysis of Channel Screw and Conventional Plate Technique in Tile B2 Pelvic Fracture.

    Li, Dejian / Ren, Hanru / Zhang, Xu / Ao, Rongguang / Yi, Chengqing / Yu, Baoqing

    Journal of personalized medicine

    2023  Band 13, Heft 3

    Abstract: Objective: This study aims to analyze the biomechanical characteristics of tile B2 pelvic fractures using finite element analysis when the superior ramus of the pubis was fixed by a plate or hollow screws in standing and sitting positions, respectively.! ...

    Abstract Objective: This study aims to analyze the biomechanical characteristics of tile B2 pelvic fractures using finite element analysis when the superior ramus of the pubis was fixed by a plate or hollow screws in standing and sitting positions, respectively.
    Methods: A three-dimensional digital model of the tile B2 pelvic fracture was obtained by CT scanning the patient. The main ligament structure was then reconstructed based on the anatomical characteristics to create a finite element model of the tile B2 pelvic fracture. The posterior pelvic ring was fixed by sacroiliac joint screws, while the anterior ring injury of the superior ramus of the pubis was fixed by plates and hollow compression screws, respectively. The degrees of freedom of the bilateral acetabulum or two sides of the ischial tuberosity were constrained in the two models. A vertical load of 600 N was applied to the upper surface of the sacrum to measure the displacement and stress distribution of the pelvis in the standing and sitting positions.
    Results: The displacement distribution of both the healthy and the affected side of the pelvis was relatively uniform in both the plate group and the hollow screw group according to the finite element simulation results. The maximum displacement value in the sitting position was greater than the standing position, and the maximum displacement value of the hollow screw fixation was greater than that of the plate fixation. In the four groups of fixation models, the maximum displacement value of the pelvis in the hollow screw sitting position group was 1616.80 × 10
    Conclusion: The anterior ring of patients with Tile B2 pelvic fractures fixed with hollow screws or plates in both standing and sitting positions can achieve satisfactory biomechanical results with significant safety margins for plates and screws.
    Sprache Englisch
    Erscheinungsdatum 2023-03-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13030506
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Finite Element Analysis of Channel Screw and Conventional Plate Technique in Tile B2 Pelvic Fracture

    Dejian Li / Hanru Ren / Xu Zhang / Rongguang Ao / Chengqing Yi / Baoqing Yu

    Journal of Personalized Medicine, Vol 13, Iss 506, p

    2023  Band 506

    Abstract: Objective: This study aims to analyze the biomechanical characteristics of tile B2 pelvic fractures using finite element analysis when the superior ramus of the pubis was fixed by a plate or hollow screws in standing and sitting positions, respectively. ... ...

    Abstract Objective: This study aims to analyze the biomechanical characteristics of tile B2 pelvic fractures using finite element analysis when the superior ramus of the pubis was fixed by a plate or hollow screws in standing and sitting positions, respectively. Methods: A three-dimensional digital model of the tile B2 pelvic fracture was obtained by CT scanning the patient. The main ligament structure was then reconstructed based on the anatomical characteristics to create a finite element model of the tile B2 pelvic fracture. The posterior pelvic ring was fixed by sacroiliac joint screws, while the anterior ring injury of the superior ramus of the pubis was fixed by plates and hollow compression screws, respectively. The degrees of freedom of the bilateral acetabulum or two sides of the ischial tuberosity were constrained in the two models. A vertical load of 600 N was applied to the upper surface of the sacrum to measure the displacement and stress distribution of the pelvis in the standing and sitting positions. Results: The displacement distribution of both the healthy and the affected side of the pelvis was relatively uniform in both the plate group and the hollow screw group according to the finite element simulation results. The maximum displacement value in the sitting position was greater than the standing position, and the maximum displacement value of the hollow screw fixation was greater than that of the plate fixation. In the four groups of fixation models, the maximum displacement value of the pelvis in the hollow screw sitting position group was 1616.80 × 10 −3 mm, which was greater than that of the other three groups, and in this group the total displacement value of the hollow screw in the anterior ring was 556.31 × 10 −3 mm. The stress distribution of the pelvis in the various models was similar in the four groups of models, in which the maximum stress of the pelvis in the hollow screw sitting position group was the largest, which was 201.33 MPa, while the maximum stress in the standing position was ...
    Schlagwörter finite element analysis ; channel screw ; plate ; pelvic fracture ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  8. Buch: Regulation of lysosomal function by organelle sodium and potassium channels

    Ren, Dejian

    (NIH neuroscience seminar)

    2015  

    Abstract: ... to breathing and heart beating. The major interests of Dr. Ren"s lab concern the regulation of cellular ...

    Körperschaft National Institutes of Health (U.S.),
    Verfasserangabe Dejian Ren
    Serientitel NIH neuroscience seminar
    Abstract (CIT): Cellular excitability influences essentially every aspect of life, from fertilization to breathing and heart beating. The major interests of Dr. Ren"s lab concern the regulation of cellular excitability, neuronal network activity and animal behavior by ion channels, G-protein coupled receptors, tyrosine kinases and calcium signaling. A recent focus in the lab is to study the molecular mechanisms of neuronal excitability control by extracelular ions and peptide neurotransmitters. Significant changes in extracellular Ca2+ concentrations ([Ca2+]e) can happen in certain brain areas during physiological and pathological conditions such as seizures and brain ischemia. They are interested in understanding at the molecular level how neurons sense the [Ca2+]e changes, how the information is transmitted to the intracellular second messenger system, and how neuronal circuit function is affected by the signaling. Numerous neuropeptides are used by the nervous systems as chemical signals to regulate physiological processes such as feeding, rewarding, pain sensation, arousal and wakefulness. They are interested in how several neuropeptides influence the electrical properties of individual neurons in various brain regions and spinal cord. Along this line, they discovered a novel ion channel activation mechanism by G-protein coupled receptors: it is independent of G-protein activation but requires the Src family of tyrosine kinases and two largely uncharacterized proteins UNC79 and UNC80. Current efforts in this project focus on uncovering how the receptor activation is coupled to channel opening and how such signaling events contribute to the intrinsic properties of neurons under physiological and pathophysiological conditions. Another area of research in the lab concerns rhythm generation. All animals display long-period rhythmic behaviors such as circadian rhythm (~ 24 hours), as well as ones with shorter periods such as locomotion, heart beating, and breathing (milliseconds to seconds). They are interested in the molecular mechanisms underlying the generation and modulation of the "short-period" rhythms. They use an integrative approach to study the physiological problems. At the molecular level, they use molecular biology and protein chemistry to study channel proteins and their associated partners. They use electrophysiology methods to record the electrical activities from a single molecule (single channel recording), a whole cell, or a nerve bundle. At the cellular level, they use high-speed fluorescence confocal microscopy to image dynamics of ions and protein molecules inside the cells. At the systems level, they modify the genomes of animals and study the consequences of such modifications on whole organism physiology and behavior.
    Mesh-Begriff(e) Lysosomes/physiology ; Sodium Channels ; Potassium Channels ; Sodium-Potassium-Exchanging ATPase/physiology
    Sprache Englisch
    Umfang 1 online resource (1 streaming video file (59 min.)) :, color, sound.
    Dokumenttyp Buch
    Anmerkung Closed-captioned.
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  9. Artikel: Research on the role of LuxS/AI-2 quorum sensing in biofilm of

    Yang, Qinglan / Wang, Ying / An, Qi / Sa, Ren / Zhang, Dejian / Xu, Rihua

    3 Biotech

    2021  Band 11, Heft 4, Seite(n) 189

    Abstract: Leuconostoc citreum: Supplementary information: The online version contains supplementary material available at 10.1007/s13205-021-02747-2. ...

    Abstract Leuconostoc citreum
    Supplementary information: The online version contains supplementary material available at 10.1007/s13205-021-02747-2.
    Sprache Englisch
    Erscheinungsdatum 2021-03-23
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-021-02747-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Tuning Ligands Ratio Allows for Controlling Gold Nanocluster Conformation and Activating a Nonantimicrobial Thiol Fragrance for Effective Treatment of MRSA-Induced Keratitis.

    Pang, Zeyang / Ren, Ning / Wu, Yujie / Qi, Jie / Hu, Fupin / Guo, Yuan / Xie, Yangzhouyun / Zhou, Dejian / Jiang, Xingyu

    Advanced materials (Deerfield Beach, Fla.)

    2023  Band 35, Heft 40, Seite(n) e2303562

    Abstract: Bacterial keratitis is a serious ocular disease that affects millions of people worldwide each year, among which ≈25% are caused by Staphylococcus aureus. With the spread of bacterial resistance, refractory keratitis caused by methicillin-resistant S. ... ...

    Abstract Bacterial keratitis is a serious ocular disease that affects millions of people worldwide each year, among which ≈25% are caused by Staphylococcus aureus. With the spread of bacterial resistance, refractory keratitis caused by methicillin-resistant S. aureus (MRSA) affects ≈120 000-190 000 people annually and is a significant cause of infectious blindness. Atomically precise gold nanoclusters (GNCs) recently emerged as promising antibacterial agents; although how the GNC structure and capping ligands control the antibacterial properties remains largely unexplored. In this study, by adjusting the ratio of a "bulky" thiol fragrance to a linear zwitterionic ligand, the GNC conformation is transformed from Au
    Sprache Englisch
    Erscheinungsdatum 2023-08-17
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202303562
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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