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Buch: Xia

Wang, Shaozeng

zi, ji, cong bu

(Qing shi gao yi wen zhi shi yi : 清史稿藝文志拾遺 ; / Wang shao zeng zhu bian ; 2)

2000

Serientitel	Qing shi gao yi wen zhi shi yi : 清史稿藝文志拾遺 / Wang shao zeng zhu bian ; 2
Schlagwörter	China
Sprache	Chinesisch
Umfang	S. 1035-2560, 21 cm
Ausgabenhinweis	Di 1 ban
Verlag	Zhong hua shu ju
Erscheinungsort	Bei jing
Dokumenttyp	Buch
ISBN	7101013643 ; 9787101013641
Datenquelle	Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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Artikel ; Online: The Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, an Oral Small Molecule Factor XIa Inhibitor, in Healthy Chinese Volunteers.

Xu, Junyu / Zhao, Nan / Huang, Jie / Li, Jinlei / Zhao, Xia / Xiang, Qian / Yang, Sibo / Dong, Yanli / Wang, Honghui / Li, Yijing / Yang, Guoping / Cui, Yimin

Clinical drug investigation

2023 Band 43, Heft 6, Seite(n) 435–445

Abstract: Background and objective: There is an unmet need for a safer anticoagulant since bleeding remains a concern with currently approved anticoagulants. Coagulation factor XI (FXI) is an attractive anticoagulant drug target with limited a role in ... ...

Abstract	Background and objective: There is an unmet need for a safer anticoagulant since bleeding remains a concern with currently approved anticoagulants. Coagulation factor XI (FXI) is an attractive anticoagulant drug target with limited a role in physiological hemostasis. The objective of this study was to evaluate the safety, pharmacokinetics, and pharmacodynamics of SHR2285, a novel small molecule FXIa inhibitor, in healthy Chinese volunteers. Methods: The study consisted of single ascending doses part (part 1: 25-600 mg) and multiple ascending doses part (part 2: 100, 200, 300, and 400 mg). In both parts, subjects were randomized in a 3:1 ratio to receive SHR2285 or placebo orally. Blood, urine and feces samples were collected to describe its pharmacokinetic and pharmacodynamic profile. Results: In total, 103 healthy volunteers completed the study. SHR2285 was well tolerated. SHR2285 was absorbed rapidly with median time to maximum plasma concentration (T Conclusions: SHR2285 was generally safe and well tolerated in healthy subjects across a wide range of doses. SHR2285 exhibited a predictable pharmacokinetic profile and an exposure-related pharmacodynamic profile. Clinicaltrials: gov Identifier NCT04472819; registered on July 15, 2020.
Mesh-Begriff(e)	Humans ; Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/pharmacokinetics ; Anticoagulants/pharmacology ; Area Under Curve ; Dose-Response Relationship, Drug ; Double-Blind Method ; East Asian People ; Factor XIa/antagonists & inhibitors ; Healthy Volunteers
Chemische Substanzen	Anticoagulants ; Factor XIa (EC 3.4.21.27)
Sprache	Englisch
Erscheinungsdatum	2023-06-16
Erscheinungsland	New Zealand
Dokumenttyp	Randomized Controlled Trial ; Journal Article
ZDB-ID	1220136-4
ISSN	1179-1918 ; 0114-2402 ; 1173-2563
ISSN (online)	1179-1918
ISSN	0114-2402 ; 1173-2563
DOI	10.1007/s40261-023-01281-8
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and Perspectives.

Xie, Zhouling / Meng, Zhiwei / Yang, Xiaoxiao / Duan, Yajun / Wang, Qin / Liao, Chenzhong

Journal of medicinal chemistry

2023 Band 66, Heft 8, Seite(n) 5332–5363

Abstract: Factor XIa (FXIa) in the intrinsic pathway of the coagulation process has been proven to be ...

Abstract	Factor XIa (FXIa) in the intrinsic pathway of the coagulation process has been proven to be an effective and safe target for anticoagulant discovery with limited or no bleeding. Numerous small-molecule FXIa inhibitors (SMFIs) with various scaffolds have been identified in the early stages of drug discovery. They have served as the foundation for the recent discovery of additional promising SMFIs with improved potency, selectivity, and pharmacokinetic profiles, some of which have entered clinical trials for the treatment of thrombosis. After reviewing the coagulation process and structure of FXIa, this perspective discusses the rational or structure-based design, discovery, structure-activity relationships, and development of SMFIs disclosed in recent years. Strategies for identifying more selective and druggable SMFIs are provided, paving the way for the design and discovery of more useful SMFIs for anticoagulation therapy.
Mesh-Begriff(e)	Humans ; Factor XIa ; Blood Coagulation ; Anticoagulants/pharmacology ; Thrombosis/drug therapy ; Drug Discovery
Chemische Substanzen	Factor XIa (EC 3.4.21.27) ; Anticoagulants
Sprache	Englisch
Erscheinungsdatum	2023-04-10
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c02130
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Qing Xia Jie Yi Formula granules alleviated acute pancreatitis through inhibition of M1 macrophage polarization by suppressing glycolysis.

Han, Xiao / Bao, Jingpiao / Ni, Jianbo / Li, Bin / Song, Pengli / Wan, Rong / Wang, Xingpeng / Hu, Guoyong / Chen, Congying

Journal of ethnopharmacology

2024 Band 325, Seite(n) 117750

Abstract: ... of the study: This study aimed to evaluate the effect of Qing Xia Jie Yi Formula (QXJYF) granules on AP and ...

Abstract	Ethnopharmacological relevance: Herbal formulas from Traditional Chinese Medicine are common and well-established practice for treating acute pancreatitis (AP) patients. However, little is known about their bioactive ingredients and mechanisms, such as their targets and pathways to inhibit inflammation. Aim of the study: This study aimed to evaluate the effect of Qing Xia Jie Yi Formula (QXJYF) granules on AP and discuss the molecular mechanisms involved. Materials and methods: Major compounds in QXJYF granules were identified using UPLC-quadrupole-Orbitrap mass spectrometry (UPLC-Q-Orbitrap MS). The effect of QXJYF granules on experimental AP models both in vitro and in vivo, and detailed mechanisms were clarified. Two AP models were induced in mice by intraperitoneally injections of caerulein or L-arginine, and QXJYF granules were used to treat AP mice in vivo. Histological evaluation of pancreas and lung, serum amylase and lipase levels, serum inflammatory cytokines, inflammatory cell infiltration and macrophage phenotype were assessed. Bone marrow derived macrophages (BMDMs) were cultured and treated with QXJYF granules in vitro. BMDM phenotype and glycolysis levels were measured. Lastly, clinical effect of QXJYF granules on AP patients was verified. Predicted severe AP (pSAP) patients eligible for inclusion were assessed for enrollment. Results: Nine major compounds were identified in QXJYF granules. Data showed that QXJYF granules significantly alleviated AP severity both in caerulein and L-arginine-induced AP models in vivo, pancreatic injury and inflammatory cell infiltration, systematic inflammation, lung injury and inflammatory cell infiltration were all improved after QXJYF treatment. QXJYF granules significantly reduced M1 macrophages during AP both in vivo and in vitro; besides, the mRNA expression levels of M1 genes such as inos, Tnfα, Il1β and Il6 were significantly lower after QXJYF treatment in M1 macrophages. Mechanistically, we found that HK2, PFKFB3, PKM, LDHα levels were increased in M1 macrophages, but significantly decreased after QXJYF treatment. Clinical data indicated that QXJYF granules could significantly reduce CRP levels and shorten the duration of organ failure, thereby reducing the incidence of SAP and preventing pSAP patients from progressing to SAP. Conclusion: QXJYF granules alleviated AP through the inhibition of M1 macrophage polarization by suppressing glycolysis.
Mesh-Begriff(e)	Humans ; Mice ; Animals ; Pancreatitis/metabolism ; Ceruletide/adverse effects ; Acute Disease ; Inflammation/drug therapy ; Macrophages ; Arginine
Chemische Substanzen	Ceruletide (888Y08971B) ; Arginine (94ZLA3W45F)
Sprache	Englisch
Erscheinungsdatum	2024-01-10
Erscheinungsland	Ireland
Dokumenttyp	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117750
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch: Du Xia

Wang, Aihe

(Wuming (No Name) Painting Catalogue : 无名画集 ; / Ed. by Wang Aihe[...])

2010

Serientitel	Wuming (No Name) Painting Catalogue : 无名画集 / Ed. by Wang Aihe[...]
Sprache	Chinesisch ; Englisch
Umfang	120 p, Mostly ill.
Verlag	Hong Kong University Press
Erscheinungsort	Hong Kong
Dokumenttyp	Buch
ISBN	9789888028214 ; 9888028219
Datenquelle	Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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Artikel ; Online: Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis.

Wang, Xinkang / Li, Qiu / Du, Fuyong / Shukla, Neetu / Nawrocki, Andrea R / Chintala, Madhu

TH open : companion journal to thrombosis and haemostasis

2023 Band 7, Heft 2, Seite(n) e97–e104

Abstract: ... ...

Abstract	Background
Sprache	Englisch
Erscheinungsdatum	2023-04-24
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2901738-5
ISSN	2512-9465 ; 2567-3459
ISSN (online)	2512-9465
ISSN	2567-3459
DOI	10.1055/a-2061-3311
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis.

Sun, Feilong / Wang, Weihao / Li, Zhengyang / Li, Yitong / Guo, Wei / Kong, Yi

Bioorganic chemistry

2023 Band 142, Seite(n) 106951

Abstract: Thrombotic diseases, such as myocardial infarction, stroke, and deep vein thrombosis, severely threaten human health, and anticoagulation is an effective way to prevent such illnesses. However, most anticoagulant drugs in the clinic have different ... ...

Abstract	Thrombotic diseases, such as myocardial infarction, stroke, and deep vein thrombosis, severely threaten human health, and anticoagulation is an effective way to prevent such illnesses. However, most anticoagulant drugs in the clinic have different bleeding risks. Previous studies have shown that coagulation factor XI is an ideal target for safe anticoagulant drug development. Here, we designed the FXIa inhibitory peptide DX-88mut by replacing Loop1 (DGPCRAAHPR) and Loop2 (IYGGC) in DX-88, which is a clinical drug targeting PKa for the treatment of hereditary angioedema, using Loop1 (TGPCRAMISR) and Loop2 (FYGGC) in the FXIa inhibitory peptide PN2KPI, respectively. DX-88mut selectively inhibited FXIa against a panel of serine proteases with an IC
Mesh-Begriff(e)	Humans ; Rats ; Mice ; Animals ; Factor XIa/metabolism ; Factor XIa/pharmacology ; Blood Coagulation ; Anticoagulants/pharmacology ; Thrombosis/drug therapy ; Peptides/pharmacology
Chemische Substanzen	Factor XIa (EC 3.4.21.27) ; Anticoagulants ; Peptides
Sprache	Englisch
Erscheinungsdatum	2023-10-29
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2023.106951
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Macrocyclic factor XIa inhibitors.

Wang, Cailan / Corte, James R / Rossi, Karen A / Bozarth, Jeffrey M / Wu, Yiming / Sheriff, Steven / Myers, Joseph E / Luettgen, Joseph M / Seiffert, Dietmar A / Wexler, Ruth R / Quan, Mimi L

Bioorganic & medicinal chemistry letters

2017 Band 27, Heft 17, Seite(n) 4056–4060

Abstract: A series of macrocyclic factor XIa (FXIa) inhibitors was designed based on an analysis ...

Abstract	A series of macrocyclic factor XIa (FXIa) inhibitors was designed based on an analysis of the crystal structures of the acyclic phenylimidazole compounds. Further optimization using structure-based design led to inhibitors with pM affinity for FXIa, excellent selectivity against a panel of relevant serine proteases, and good potency in the activated partial thromboplastin time (aPTT) clotting assay.
Mesh-Begriff(e)	Dose-Response Relationship, Drug ; Factor XIa/antagonists & inhibitors ; Factor XIa/metabolism ; Humans ; Imidazoles/chemical synthesis ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Macrocyclic Compounds/chemical synthesis ; Macrocyclic Compounds/chemistry ; Macrocyclic Compounds/pharmacology ; Molecular Structure ; Serine Proteinase Inhibitors/chemical synthesis ; Serine Proteinase Inhibitors/chemistry ; Serine Proteinase Inhibitors/pharmacology ; Structure-Activity Relationship
Chemische Substanzen	Imidazoles ; Macrocyclic Compounds ; Serine Proteinase Inhibitors ; imidazole (7GBN705NH1) ; Factor XIa (EC 3.4.21.27)
Sprache	Englisch
Erscheinungsdatum	2017--01
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2017.07.048
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Generation of a human induced pluripotent stem cell line (FDCHi010-A) from a patient with Xia-Gibbs syndrome carrying AHDC1 mutation (c.2062C > T).

Yin, Tingting / Wu, Bingbing / Peng, Ting / Liao, Yunfei / Jiao, Shuangyun / Wang, Huijun

Stem cell research

2023 Band 69, Seite(n) 103118

Abstract: ... the pathogenesis and drug therapy screening of Xia-Gibbs syndrome caused by the AHDC1 gene. ...

Abstract	A human induced pluripotent stem cell line (iPSC), FDCHi010-A, was derived from the peripheral blood of a 3-year-old patient with the c.2062C > T (p.R688*) mutation in the AHDC1 gene. The established cell line displayed a typical human embryonic stem cell-like morphology, exhibited a normal euploid karyotype, and fully expressed pluripotency markers. In addition, it retained the ability to differentiate to three germ layers. This cell line with a specific mutation may provide a useful tool for studying the pathogenesis and drug therapy screening of Xia-Gibbs syndrome caused by the AHDC1 gene.
Mesh-Begriff(e)	Humans ; Child, Preschool ; Induced Pluripotent Stem Cells/metabolism ; Mutation/genetics ; Cell Line ; DNA-Binding Proteins/genetics
Chemische Substanzen	AHDC1 protein, human ; DNA-Binding Proteins
Sprache	Englisch
Erscheinungsdatum	2023-05-06
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2023.103118
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The spatiotemporal evolution of ancient cities from the late Yangshao to Xia and Shang Dynasties in the Central Plains, China

Lijie Yan / Ruixia Yang / Peng Lu / Fei Teng / Xia Wang / Li Zhang / Panpan Chen / Xiang Li / Lanbo Guo / Dong Zhao

Heritage Science, Vol 9, Iss 1, Pp 1-

2021 Band 16

Abstract: ... from the late Yangshao to the Xia and Shang Dynasties, which reflects the evolution of settlement and social ... to establish a spatiotemporal database of ancient cities in the late Yangshao, Longshan, as well as Xia and ... below 500 m and within 3 km from the river during the time interval from the late Yangshao to Xia and ...

Abstract	Abstract The Central Plains has a long history, rich culture, unique geographical advantages, and profound cultural heritage. The occurrence of ancient cities in the Central Plains marks the formation of Chinese state-level societies. The number, size, and distribution of ancient cities have changed greatly from the late Yangshao to the Xia and Shang Dynasties, which reflects the evolution of settlement and social organization. In this study, Geographic Information System (GIS) spatial database technology was used to establish a spatiotemporal database of ancient cities in the late Yangshao, Longshan, as well as Xia and Shang Dynasties in the Central Plains. This paper uses GIS spatial analysis technology to analyze the relationship between the ancient city distribution and the geographical environment, as well as the evolution of ancient city's shapes and sizes. Furthermore, by using the method of the nearest neighbor distance and gravity center analysis, this paper discusses the agglomeration characteristics and gravity center evolution of ancient cities. The results show that: (1) Most of the ancient cities were distributed in areas below 500 m and within 3 km from the river during the time interval from the late Yangshao to Xia and Shang Dynasties; (2) The shape of the ancient cities gradually changed from circles to squares in the Central Plains, which became a unified model for the later ancient city design; (3) The sizes of the 18 ancient cities in the Yangshao period shared high similarity, with an average area of 20 hectares. The sizes of 24 ancient cities in the Longshan period increased significantly, with an average of 39 hectares. During the Xia and Shang Dynasties, there were 22 ancient cities with an average size of 340 hectares, and the grade of sizes became obvious, marking the entrance into Chinese state-level societies; (4) Cities were scattered in the decentralized pattern during the late Yangshao and Longshan periods, whereas they became agglomerative in Xia and Shang Dynasties. This ...
Schlagwörter	Ancient cities ; Spatiotemporal evolution ; GIS analysis ; From the late Yangshao to Xia and Shang Dynasties ; The Central Plains ; Fine Arts ; N ; Analytical chemistry ; QD71-142
Thema/Rubrik (Code)	930
Sprache	Englisch
Erscheinungsdatum	2021-10-01T00:00:00Z
Verlag	SpringerOpen
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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