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  1. Artikel ; Online: General autophagy-dependent and -independent lipophagic processes collaborate to regulate the overall level of lipophagy in yeast.

    Kang, Na / Tan, Jinling / Yan, Sisi / Lin, Leiying / Gao, Qiang

    Autophagy

    2024  

    Abstract: Lipophagy in the ... ...

    Abstract Lipophagy in the yeast
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2024.2325297
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: High-Altitude Hypoxia Induces Excessive Erythrocytosis in Mice via Upregulation of the Intestinal

    Zhou, Sisi / Yan, Jun / Song, Kang / Ge, Ri-Li

    Biomedicines

    2023  Band 11, Heft 11

    Abstract: Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE. The intestinal hypoxia-inducible factor 2 alpha ( ...

    Abstract Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE. The intestinal hypoxia-inducible factor 2 alpha (
    Sprache Englisch
    Erscheinungsdatum 2023-11-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11112992
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  3. Artikel ; Online: Identification of a Novel Peptide with Alcohol Dehydrogenase Activating Ability from Ethanol-Induced

    Chen, Sisi / Yi, Juanjuan / Kang, Qiaozhen / Song, Mo / Raubenheimer, David / Lu, Jike

    Journal of agricultural and food chemistry

    2024  Band 72, Heft 11, Seite(n) 5746–5756

    Abstract: Alcohol dehydrogenase (ADH) is a crucial rate-limiting enzyme in alcohol metabolism. Our previous research found that ethanol-induced intracellular extracts ... ...

    Abstract Alcohol dehydrogenase (ADH) is a crucial rate-limiting enzyme in alcohol metabolism. Our previous research found that ethanol-induced intracellular extracts of
    Mesh-Begriff(e) Mice ; Animals ; Ethanol/metabolism ; Lactococcus lactis/metabolism ; Blood Alcohol Content ; Alcohol Dehydrogenase/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; Molecular Docking Simulation ; NF-E2-Related Factor 2/metabolism ; Liver/metabolism
    Chemische Substanzen Ethanol (3K9958V90M) ; Blood Alcohol Content ; Alcohol Dehydrogenase (EC 1.1.1.1) ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c07632
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  4. Artikel ; Online: Deciphering the molecular pathways underlying dopaminergic neuronal damage in Parkinson's disease associated with SARS-CoV-2 infection.

    Xu, Qiuhan / Jiang, Sisi / Kang, Ruiqing / Wang, Yiling / Zhang, Baorong / Tian, Jun

    Computers in biology and medicine

    2024  Band 171, Seite(n) 108200

    Abstract: Background: The COVID-19 pandemic caused by SARS-CoV-2 has led to significant global morbidity and mortality, with potential neurological consequences, such as Parkinson's disease (PD). However, the underlying mechanisms remain elusive.: Methods: To ... ...

    Abstract Background: The COVID-19 pandemic caused by SARS-CoV-2 has led to significant global morbidity and mortality, with potential neurological consequences, such as Parkinson's disease (PD). However, the underlying mechanisms remain elusive.
    Methods: To address this critical question, we conducted an in-depth transcriptome analysis of dopaminergic (DA) neurons in both COVID-19 and PD patients. We identified common pathways and differentially expressed genes (DEGs), performed enrichment analysis, constructed protein‒protein interaction networks and gene regulatory networks, and employed machine learning methods to develop disease diagnosis and progression prediction models. To further substantiate our findings, we performed validation of hub genes using a single-cell sequencing dataset encompassing DA neurons from PD patients, as well as transcriptome sequencing of DA neurons from a mouse model of MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced PD. Furthermore, a drug-protein interaction network was also created.
    Results: We gained detailed insights into biological functions and signaling pathways, including ion transport and synaptic signaling pathways. CD38 was identified as a potential key biomarker. Disease diagnosis and progression prediction models were specifically tailored for PD. Molecular docking simulations and molecular dynamics simulations were employed to predict potential therapeutic drugs, revealing that genistein holds significant promise for exerting dual therapeutic effects on both PD and COVID-19.
    Conclusions: Our study provides innovative strategies for advancing PD-related research and treatment in the context of the ongoing COVID-19 pandemic by elucidating the common pathogenesis between COVID-19 and PD in DA neurons.
    Mesh-Begriff(e) Animals ; Mice ; Humans ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/therapeutic use ; Molecular Docking Simulation ; Pandemics ; COVID-19 ; SARS-CoV-2 ; Disease Models, Animal
    Chemische Substanzen 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (9P21XSP91P)
    Sprache Englisch
    Erscheinungsdatum 2024-02-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108200
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Long-Term High-Fat Diet Inhibits the Recovery of Myocardial Mitochondrial Function After Chronic Hypoxia Reoxygenation in Rats.

    Yan, Jun / Song, Kang / Zhou, Sisi / Ge, Ri-Li

    High altitude medicine & biology

    2021  Band 22, Heft 3, Seite(n) 327–334

    Abstract: Yan, Jun, Kang Song, Sisi Zhou, and Ri-Li Ge. Long-term high-fat diet inhibits the recovery ...

    Abstract Yan, Jun, Kang Song, Sisi Zhou, and Ri-Li Ge. Long-term high-fat diet inhibits the recovery of myocardial mitochondrial function after chronic hypoxia reoxygenation in rats.
    Mesh-Begriff(e) Animals ; Diet, High-Fat/adverse effects ; Hypoxia ; Mitochondria, Heart ; Myocardium ; Rats ; Rats, Sprague-Dawley
    Sprache Englisch
    Erscheinungsdatum 2021-06-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2076262-8
    ISSN 1557-8682 ; 1527-0297
    ISSN (online) 1557-8682
    ISSN 1527-0297
    DOI 10.1089/ham.2021.0056
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  6. Artikel ; Online: Differentiation of intestinal stem cells toward goblet cells under systemic iron overload stress are associated with inhibition of Notch signaling pathway and ferroptosis.

    Zhao, Jing / Ma, Wan / Wang, Sisi / Zhang, Kang / Xiong, Qingqing / Li, Yunqin / Yu, Hong / Du, Huahua

    Redox biology

    2024  Band 72, Seite(n) 103160

    Abstract: Iron overload can lead to oxidative stress and intestinal damage and happens frequently during blood transfusions and iron supplementation. However, how iron overload influences intestinal mucosa remains unknown. Here, the aim of current study was to ... ...

    Abstract Iron overload can lead to oxidative stress and intestinal damage and happens frequently during blood transfusions and iron supplementation. However, how iron overload influences intestinal mucosa remains unknown. Here, the aim of current study was to investigate the effects of iron overload on the proliferation and differentiation of intestinal stem cells (ISCs). An iron overload mouse model was established by intraperitoneal injection of 120 mg/kg body weight iron dextran once a fortnight for a duration of 12 weeks, and an iron overload enteroid model was produced by treatment with 3 mM or 10 mM of ferric ammonium citrate for 24 h. We found that iron overload caused damage to intestinal morphology with a 64 % reduction in villus height/crypt depth ratio, and microvilli injury in the duodenum. Iron overload mediated epithelial function by inhibiting the expression of nutrient transporters and enhancing the expression of secretory factors in the duodenum. Meanwhile, iron overload inhibited the proliferation of ISCs and regulated their differentiation into secretory mature cells, such as goblet cells, through inhibiting Notch signaling pathway both in mice and enteroid. Furthermore, iron overload caused oxidative stress and ferroptosis in intestinal epithelial cells. In addition, ferroptosis could also inhibit Notch signaling pathway, and affected the proliferation and differentiation of ISCs. These findings reveal the regulatory role of iron overload on the proliferation and differentiation of ISCs, providing a new insight into the internal mechanism of iron overload affecting intestinal health, and offering important theoretical basis for the scientific application of iron nutrition regulation.
    Sprache Englisch
    Erscheinungsdatum 2024-04-15
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103160
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  7. Artikel ; Online: Probiotic properties and proteomics analysis of ethanol-induced Lactococcus lactis subsp. lactis IL1403.

    Chen, Sisi / Yi, Juanjuan / Suo, Keke / Kang, Qiaozhen / Lu, Laizheng / Lu, Jike

    World journal of microbiology & biotechnology

    2023  Band 39, Heft 8, Seite(n) 197

    Abstract: Our previous study indicated that ethanol-induced intracellular extracts (E-IEs) of Lactococcus lactis subsp. Lactis IL1403 (L. lactis IL1403) alleviated hangovers more effectively in mice than untreated intracellular extracts (U-IEs), but the material ... ...

    Abstract Our previous study indicated that ethanol-induced intracellular extracts (E-IEs) of Lactococcus lactis subsp. Lactis IL1403 (L. lactis IL1403) alleviated hangovers more effectively in mice than untreated intracellular extracts (U-IEs), but the material basis was unclear. Considering that stress-related proteins might play a significant role, the effects of ethanol induction on probiotic properties of L. lactis IL1403 and the associated stress response mechanism were initially explored in this study. E-IEs of L. lactis IL1403 showed better biological activities, significantly increased bacteria survival rates in oxidative stress environments, increased ADH activity, and enhanced proliferation in RAW264.7 and AML-12 cells. Proteomic analyses revealed that 414 proteins were significantly changed in response to ethanol induction. The expression of proteins involved in the universal stress response, DNA repair, oxidative stress response, and ethanol metabolism was rapidly upregulated under ethanol stress, and quantitative real-time PCR (qRT-PCR) results were consistent with proteomic data. KEGG pathway analysis indicated that citrate metabolism, starch and sucrose metabolism, and pyruvate metabolism were significantly enriched during ethanol stress to increase energy requirements and survival rates of stressed cells. Based on this observation, the active induction is an effective strategy for increasing the biological activity of L. lactis IL1403. Exploring the molecular mechanism and material basis of their functions in vivo can help us understand the adaptive regulatory mechanism of microorganisms.
    Mesh-Begriff(e) Animals ; Mice ; Lactococcus lactis/genetics ; Lactococcus lactis/metabolism ; Ethanol/metabolism ; Proteomics
    Chemische Substanzen Ethanol (3K9958V90M)
    Sprache Englisch
    Erscheinungsdatum 2023-05-15
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1499109-3
    ISSN 1573-0972 ; 0959-3993
    ISSN (online) 1573-0972
    ISSN 0959-3993
    DOI 10.1007/s11274-023-03627-y
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  8. Artikel ; Online: The spectrum of opportunistic infections and malignancies among women on antiretroviral therapy in Ethiopia.

    Getaneh, Yimam / Getnet, Fentabil / Rashid, Abdur / Kang, Li / Chu, Qingfei / Li, Sisi / Yi, Feng / Shao, Yiming

    Emerging microbes & infections

    2023  Band 12, Heft 2, Seite(n) 2271065

    Abstract: Abbreviations: AIDS: acquired immune deficiency syndrome; CI: confidence interval; EPHI: Ethiopian Public Health Institute; HAART: highly active antiretroviral therapy; HIV: human immunodeficiency virus; HR: hazard ratio; Mg/dl: milligram per deciliter; ...

    Abstract Abbreviations: AIDS: acquired immune deficiency syndrome; CI: confidence interval; EPHI: Ethiopian Public Health Institute; HAART: highly active antiretroviral therapy; HIV: human immunodeficiency virus; HR: hazard ratio; Mg/dl: milligram per deciliter; TB: tuberculosis; PCP: pneumocystis carinii pneumonia; ZJU: Zhejiang University.
    Mesh-Begriff(e) Humans ; Female ; Ethiopia/epidemiology ; AIDS-Related Opportunistic Infections/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Acquired Immunodeficiency Syndrome/drug therapy ; Neoplasms ; Antiretroviral Therapy, Highly Active
    Sprache Englisch
    Erscheinungsdatum 2023-10-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2271065
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  9. Artikel ; Online: Fatty Acyl Coenzyme A Synthetase Fat1p Regulates Vacuolar Structure and Stationary-Phase Lipophagy in Saccharomyces cerevisiae.

    Qiu, Fan / Kang, Na / Tan, Jinling / Yan, Sisi / Lin, Leiying / Cai, Lipeng / Goodman, Joel M / Gao, Qiang

    Microbiology spectrum

    2023  Band 11, Heft 1, Seite(n) e0462522

    Abstract: During yeast stationary phase, a single spherical vacuole (lysosome) is created by the fusion of several small ones. Moreover, the vacuolar membrane is reconstructed into two distinct microdomains. Little is known, however, about how cells maintain ... ...

    Abstract During yeast stationary phase, a single spherical vacuole (lysosome) is created by the fusion of several small ones. Moreover, the vacuolar membrane is reconstructed into two distinct microdomains. Little is known, however, about how cells maintain vacuolar shape or regulate their microdomains. Here, we show that Fat1p, a fatty acyl coenzyme A (acyl-CoA) synthetase and fatty acid transporter, and not the synthetases Faa1p and Faa4p, is essential for vacuolar shape preservation, the development of vacuolar microdomains, and cell survival in stationary phase of the yeast Saccharomyces cerevisiae. Furthermore, Fat1p negatively regulates general autophagy in both log- and stationary-phase cells. In contrast, Fat1p promotes lipophagy, as the absence of
    Mesh-Begriff(e) Saccharomyces cerevisiae/metabolism ; Vacuoles/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Fatty Acids/metabolism ; Coenzyme A Ligases/genetics ; Coenzyme A Ligases/metabolism ; Autophagy ; Fatty Acid Transport Proteins/metabolism
    Chemische Substanzen Saccharomyces cerevisiae Proteins ; Fatty Acids ; Coenzyme A Ligases (EC 6.2.1.-) ; FAT1 protein, S cerevisiae ; Fatty Acid Transport Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-01-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.04625-22
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  10. Artikel ; Online: Corrigendum to "Radioprotective effect of radiation-induced Lactococcus lactis cell-free extract against

    Suo, Keke / Chen, Sisi / Li, Xue / Liu, Xin / Yi, Juanjuan / Zhu, Jiaqing / Lu, Laizheng / Hao, Limin / Kang, Qiaozhen / Lu, Jike

    Journal of dairy science

    2022  Band 105, Heft 2, Seite(n) 1815

    Sprache Englisch
    Erscheinungsdatum 2022-01-20
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2022-105-2-1815
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