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  1. Artikel: Editorial: Brain injury associated secondary injury and remote organ injury.

    Tang, Lujia / Shi, Kaibin / Zhang, Yanjun / Fu, Ying / Gao, Jie / Zhao, Zilong

    Frontiers in neuroscience

    2024  Band 18, Seite(n) 1398800

    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1398800
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Noninvasive Monitoring of Early Cardiac Fibrosis in Diabetic Mice by [

    Lin, Kaibin / Shi, Dai / Wang, Ai / Ge, Junbo / Cheng, Dengfeng / Yan, Yan

    ACS omega

    2024  Band 9, Heft 15, Seite(n) 17195–17203

    Abstract: Cardiac fibrosis represents one of the representative pathological characteristics in the diabetic heart. Active fibroblasts play an essential role in the progression of cardiac fibrosis. The technologies for noninvasive monitoring of activated ... ...

    Abstract Cardiac fibrosis represents one of the representative pathological characteristics in the diabetic heart. Active fibroblasts play an essential role in the progression of cardiac fibrosis. The technologies for noninvasive monitoring of activated fibroblasts still have to be investigated. The purpose of this study was to evaluate the feasibility of targeted fibroblast activation protein (FAP) molecular imaging in the early evaluation of diabetic cardiac fibrosis using [
    Sprache Englisch
    Erscheinungsdatum 2024-04-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c10061
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Neurovascular Inflammation and Complications of Thrombolysis Therapy in Stroke.

    Liu, Qiang / Shi, Kaibin / Wang, Yongjun / Shi, Fu-Dong

    Stroke

    2023  Band 54, Heft 10, Seite(n) 2688–2697

    Abstract: Intravenous thrombolysis via tPA (tissue-type plasminogen activator) is the only approved pharmacological treatment for acute ischemic stroke, but its benefits are limited by hemorrhagic transformation. Emerging evidence reveals that tPA swiftly ... ...

    Abstract Intravenous thrombolysis via tPA (tissue-type plasminogen activator) is the only approved pharmacological treatment for acute ischemic stroke, but its benefits are limited by hemorrhagic transformation. Emerging evidence reveals that tPA swiftly mobilizes immune cells which extravasate into the brain parenchyma via the cerebral vasculature, augmenting neurovascular inflammation, and tissue injury. In this review, we summarize the pronounced alterations of immune cells induced by tPA in patients with stroke and experimental stroke models. We argue that neuroinflammation, triggered by ischemia-induced cell death and exacerbated by tPA, compromises neurovascular integrity and the microcirculation, leading to hemorrhagic transformation. Finally, we discuss current and future approaches to attenuate thrombolysis-associated hemorrhagic transformation via uncoupling immune cells from the neurovascular unit.
    Mesh-Begriff(e) Humans ; Ischemic Stroke ; Stroke/drug therapy ; Thrombolytic Therapy/adverse effects ; Inflammation/drug therapy ; Brain
    Sprache Englisch
    Erscheinungsdatum 2023-09-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.123.044123
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Autonomic dysfunction and treatment strategies in intracerebral hemorrhage.

    Kang, Kaijiang / Shi, Kaibin / Liu, Jiexin / Li, Na / Wu, Jianwei / Zhao, Xingquan

    CNS neuroscience & therapeutics

    2024  Band 30, Heft 2, Seite(n) e14544

    Abstract: Aims: Autonomic dysfunction with central autonomic network (CAN) damage occurs frequently after intracerebral hemorrhage (ICH) and contributes to a series of adverse outcomes. This review aims to provide insight and convenience for future clinical ... ...

    Abstract Aims: Autonomic dysfunction with central autonomic network (CAN) damage occurs frequently after intracerebral hemorrhage (ICH) and contributes to a series of adverse outcomes. This review aims to provide insight and convenience for future clinical practice and research on autonomic dysfunction in ICH patients.
    Discussion: We summarize the autonomic dysfunction in ICH from the aspects of potential mechanisms, clinical significance, assessment, and treatment strategies. The CAN structures mainly include insular cortex, anterior cingulate cortex, amygdala, hypothalamus, nucleus of the solitary tract, ventrolateral medulla, dorsal motor nucleus of the vagus, nucleus ambiguus, parabrachial nucleus, and periaqueductal gray. Autonomic dysfunction after ICH is closely associated with neurological functional outcomes, cardiac complications, blood pressure fluctuation, immunosuppression and infection, thermoregulatory dysfunction, hyperglycemia, digestive dysfunction, and urogenital disturbances. Heart rate variability, baroreflex sensitivity, skin sympathetic nerve activity, sympathetic skin response, and plasma catecholamine concentration can be used to assess the autonomic functional activities after ICH. Risk stratification of patients according to autonomic functional activities, and development of intervention approaches based on the restoration of sympathetic-parasympathetic balance, would potentially improve clinical outcomes in ICH patients.
    Conclusion: The review systematically summarizes the evidence of autonomic dysfunction and its association with clinical outcomes in ICH patients, proposing that targeting autonomic dysfunction could be potentially investigated to improve the clinical outcomes.
    Mesh-Begriff(e) Humans ; Autonomic Nervous System/physiology ; Sympathetic Nervous System/physiology ; Autonomic Nervous System Diseases/etiology ; Autonomic Nervous System Diseases/therapy ; Vagus Nerve/physiology ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/therapy ; Heart Rate/physiology
    Sprache Englisch
    Erscheinungsdatum 2024-02-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2423461-8
    ISSN 1755-5949 ; 1755-5930
    ISSN (online) 1755-5949
    ISSN 1755-5930
    DOI 10.1111/cns.14544
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Primary Central Nervous System Lymphoma With Symmetrical Pyramidal Tract Hyperintensity.

    Shi, Kaibin / Shen, Junlin / Yue, Xuanye

    JAMA neurology

    2021  Band 78, Heft 7, Seite(n) 876–877

    Mesh-Begriff(e) Central Nervous System Neoplasms/diagnostic imaging ; Central Nervous System Neoplasms/pathology ; Female ; Humans ; Lymphoma/diagnostic imaging ; Lymphoma/pathology ; Magnetic Resonance Imaging ; Middle Aged ; Pyramidal Tracts/pathology
    Sprache Englisch
    Erscheinungsdatum 2021-05-17
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2021.1165
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Brain injury instructs bone marrow cellular lineage destination to reduce neuroinflammation.

    Shi, Samuel X / Shi, Kaibin / Liu, Qiang

    Science translational medicine

    2021  Band 13, Heft 589

    Abstract: Acute brain injury mobilizes circulating leukocytes to transmigrate into the perivascular space and brain parenchyma. This process amplifies neural injury. Bone marrow hematopoiesis replenishes the exhausted peripheral leukocyte pools. However, it is not ...

    Abstract Acute brain injury mobilizes circulating leukocytes to transmigrate into the perivascular space and brain parenchyma. This process amplifies neural injury. Bone marrow hematopoiesis replenishes the exhausted peripheral leukocyte pools. However, it is not known whether brain injury influences the development of bone marrow lineages and how altered hematopoietic cell lineages affect neurological outcome. Here, we showed that bone marrow hematopoietic stem cells (HSCs) can be swiftly skewed toward the myeloid lineage in patients with intracerebral hemorrhage (ICH) and experimental ICH models. Lineage tracing revealed a predominantly augmented hematopoiesis of Ly6C
    Sprache Englisch
    Erscheinungsdatum 2021-04-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abc7029
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Plasma Neurofilament Light Chain Predicts Mortality and Long-Term Neurological Outcomes in Patients with Intracerebral Hemorrhage.

    Zheng, Pei / Wang, Xuejiao / Chen, Jingshan / Wang, Xinli / Shi, Samuel X / Shi, Kaibin

    Aging and disease

    2023  Band 14, Heft 2, Seite(n) 560–571

    Abstract: Patients with intracerebral hemorrhage (ICH) often suffer from heterogeneous long-term neurological deficits, such as cognitive decline. Our ability to measure secondary brain injury to predict the long-term outcomes of these patients is limited. We ... ...

    Abstract Patients with intracerebral hemorrhage (ICH) often suffer from heterogeneous long-term neurological deficits, such as cognitive decline. Our ability to measure secondary brain injury to predict the long-term outcomes of these patients is limited. We investigated whether the blood neurofilament light chain (NfL) can monitor brain injury and predict long-term outcomes in patients with ICH. We enrolled 300 patients with first-episode ICH within 24 h recruited in the Chinese Cerebral Hemorrhage Mechanisms and Intervention study cohort from January 2019 to June 2020. Patients were prospectively followed up for 12 months. Blood samples were collected from 153 healthy participants. Plasma NfL levels determined using a single-molecule array revealed a biphasic increase in plasma NfL in ICH patients compared to healthy controls, with the first peak at around 24 h and a second elevation from day 7 through day 14 post-ICH. Plasma NfL levels were positively correlated with hemorrhage volume, National Institute of Health Stroke Scale, and Glasgow Coma Scale scores of ICH patients. Higher NfL concentration within 72 h after ictus was independently associated with 6- and 12-month worsened functional outcomes (modified Rankin Scale ≥ 3) and higher all-cause mortality. Magnetic resonance imaging and cognitive function evaluation were available for 26 patients at 6 months post-ICH, and NfL levels measured 7 days post-ictus correlated with decreased white matter fiber integrity and poor cognitive function at 6 months after stroke. These findings suggest that blood NfL is a sensitive marker for monitoring axonal injury post-ICH and can predict long-term functional ability and survival.
    Sprache Englisch
    Erscheinungsdatum 2023-04-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2022.21020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: CD4

    Shi, Samuel X / Xiu, Yuwen / Li, Yan / Yuan, Meng / Shi, Kaibin / Liu, Qiang / Wang, Xiaoying / Jin, Wei-Na

    Science advances

    2023  Band 9, Heft 23, Seite(n) eabq0712

    Abstract: Leukocyte infiltration accelerates brain injury following intracerebral hemorrhage (ICH). Yet, the involvement of T lymphocytes in this process has not been fully elucidated. Here, we report that ... ...

    Abstract Leukocyte infiltration accelerates brain injury following intracerebral hemorrhage (ICH). Yet, the involvement of T lymphocytes in this process has not been fully elucidated. Here, we report that CD4
    Mesh-Begriff(e) Mice ; Animals ; T-Lymphocytes/metabolism ; Brain/metabolism ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/metabolism ; Brain Injuries/etiology ; Brain Injuries/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; Disease Models, Animal
    Sprache Englisch
    Erscheinungsdatum 2023-06-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abq0712
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Evaluation of hydrophobic charge-induction ligand efficiency for protein adsorption in one single cycle.

    Shi, Wei / Zhang, Xiaobin / Kong, Xinya / Fu, Jiaxue / Zhang, Siqi / Li, Kaibin / Han, Deman

    Journal of chromatography. A

    2022  Band 1668, Seite(n) 462923

    Abstract: Ligand is an essential part of the cost of adsorbent preparation, which needs to be carefully selected and evaluated. In this paper, we introduced ligand efficiency ( ... ...

    Abstract Ligand is an essential part of the cost of adsorbent preparation, which needs to be carefully selected and evaluated. In this paper, we introduced ligand efficiency (L
    Mesh-Begriff(e) Adsorption ; Hydrophobic and Hydrophilic Interactions ; Ligands ; Proteins/chemistry ; Spectroscopy, Fourier Transform Infrared
    Chemische Substanzen Ligands ; Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-02-28
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2022.462923
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Visualizing Seizure Propagation in Freely-moving Mice via Miniature Two-photon Microscopy.

    Zhang, Zhuoran / Jiang, Shihe / Shi, Kaibin / Li, Yan / Jin, Wei-Na / Liu, Qiang / Zhao, Ting / Cheng, Heping / Shi, Fu-Dong

    Neuroscience bulletin

    2022  Band 38, Heft 12, Seite(n) 1593–1597

    Mesh-Begriff(e) Animals ; Mice ; Microscopy ; Seizures ; Brain
    Sprache Englisch
    Erscheinungsdatum 2022-09-26
    Erscheinungsland Singapore
    Dokumenttyp Letter
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-022-00947-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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