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  1. Buch ; Online ; E-Book: Bioenvironmental issues affecting men's reproductive and sexual health

    Sikka, Suresh C. / Hellstrom, Wayne J. G.

    2018  

    Verfasserangabe edited by Suresh C. Sikka, Wayne J.G. Hellstrom
    Schlagwörter Sexual disorders ; Men/Health and hygiene ; Generative organs, Male/Diseases
    Thema/Rubrik (Code) 616.69
    Sprache Englisch
    Umfang 1 Online-Ressource (xxxix, 597 Seiten)
    Verlag Elsevier Academic Press
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019515959
    ISBN 978-0-12-801313-7 ; 9780128012994 ; 0-12-801313-3 ; 0128012994
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Current Updates on Involvement of Artificial Intelligence and Machine Learning in Semen Analysis.

    Panner Selvam, Manesh Kumar / Moharana, Ajaya Kumar / Baskaran, Saradha / Finelli, Renata / Hudnall, Matthew C / Sikka, Suresh C

    Medicina (Kaunas, Lithuania)

    2024  Band 60, Heft 2

    Abstract: Background and ... ...

    Abstract Background and Objectives
    Mesh-Begriff(e) Male ; Humans ; Artificial Intelligence ; Semen ; Machine Learning ; Semen Analysis ; Infertility, Male
    Sprache Englisch
    Erscheinungsdatum 2024-02-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60020279
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Molecular Interactions Associated with Oxidative Stress-Mediated Male Infertility: Sperm and Seminal Plasma Proteomics.

    Panner Selvam, Manesh Kumar / Durairajanayagam, Damayanthi / Sikka, Suresh C

    Advances in experimental medicine and biology

    2022  Band 1358, Seite(n) 63–76

    Abstract: Male factor issues are responsible for 50% of couples infertility. Seminal oxidative stress is one of the major factors that affect the normal physiological aspects of sperm function such as motility and progression, hyperactivation, capacitation, ... ...

    Abstract Male factor issues are responsible for 50% of couples infertility. Seminal oxidative stress is one of the major factors that affect the normal physiological aspects of sperm function such as motility and progression, hyperactivation, capacitation, acrosome reaction and zona-pellucida penetration prior to fertilization. In recent times, high-throughput proteomic platforms are used to identify the proteins associated with these aspects of sperm function as associated with oxidative stress. In this review, we have provided a workflow that includes an overview of advanced proteomic techniques and bioinformatic tools used to interpret proteomic results. Furthermore, we have highlighted proteins associated with dysregulated molecular pathways in sperm and seminal plasma due to oxidative stress. We have also described the molecular interactions between proteins associated with oxidative stress and their potential role in male infertility.
    Mesh-Begriff(e) Humans ; Infertility, Male/genetics ; Infertility, Male/metabolism ; Male ; Oxidative Stress ; Proteins/metabolism ; Proteomics/methods ; Semen/metabolism ; Spermatozoa/physiology
    Chemische Substanzen Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-05-31
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-89340-8_4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Eurycoma longifolia

    Leisegang, Kristian / Finelli, Renata / Sikka, Suresh C / Panner Selvam, Manesh Kumar

    Medicina (Kaunas, Lithuania)

    2022  Band 58, Heft 8

    Abstract: Background and ... ...

    Abstract Background and Objectives
    Mesh-Begriff(e) Eurycoma ; Humans ; Hypogonadism/drug therapy ; Male ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plants, Medicinal ; Testosterone/therapeutic use
    Chemische Substanzen Plant Extracts ; Testosterone (3XMK78S47O)
    Sprache Englisch
    Erscheinungsdatum 2022-08-04
    Erscheinungsland Switzerland
    Dokumenttyp Systematic Review ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58081047
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: A Scientometric Evaluation of COVID-19 and Male Reproductive Research.

    Panner Selvam, Manesh Kumar / Kapoor, Anika / Baskaran, Saradha / Moharana, Ajaya Kumar / Sikka, Suresh C

    Clinics and practice

    2023  Band 13, Heft 6, Seite(n) 1319–1330

    Abstract: The COVID-19 pandemic due to the SARS-CoV-2 coronavirus showed acute and prolonged effects on human health. In addition, over the past four years, there has been a tremendous surge in COVID-19-related scientific publications, as shown by bibliometric and ...

    Abstract The COVID-19 pandemic due to the SARS-CoV-2 coronavirus showed acute and prolonged effects on human health. In addition, over the past four years, there has been a tremendous surge in COVID-19-related scientific publications, as shown by bibliometric and scientometric studies. However, such analysis of the scientific literature is lacking in the area of male reproduction. The current scientometric study analyzes publication characteristics of articles related to male reproduction and COVID-19 infection. We used the Scopus database to analyze scientometric data (the number of publications, journals, countries, type of documents, and subject area) related to COVID-19 and male reproductive research. Our literature search identified 345 articles related to COVID-19 and male reproductive research. Most of the articles were published in the USA (
    Sprache Englisch
    Erscheinungsdatum 2023-10-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2605724-4
    ISSN 2039-7283 ; 2039-7275
    ISSN (online) 2039-7283
    ISSN 2039-7275
    DOI 10.3390/clinpract13060118
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Telomere Signaling and Maintenance Pathways in Spermatozoa of Infertile Men Treated With Antioxidants: An

    Panner Selvam, Manesh Kumar / Baskaran, Saradha / Sikka, Suresh C

    Frontiers in cell and developmental biology

    2021  Band 9, Seite(n) 768510

    Abstract: Telomere shortening is considered as a marker of cellular senescence and it is regulated by various signaling pathways. Sperm telomere appears to play important role in its longevity and function. Antioxidant intake has been known to prevent the ... ...

    Abstract Telomere shortening is considered as a marker of cellular senescence and it is regulated by various signaling pathways. Sperm telomere appears to play important role in its longevity and function. Antioxidant intake has been known to prevent the shortening of telomere. In the management of male infertility, antioxidants are commonly used to counterbalance the seminal oxidative stress. It is important to understand how antioxidants treatment may modulate telomere signaling in sperm. In the current study, we have identified 377 sperm proteins regulated by antioxidants based on data mining of published literature. Bioinformatic analysis revealed involvement of 399 upstream regulators and 806 master regulators associated with differentially expressed sperm proteins. Furthermore, upstream regulator analysis indicated activation of kinases (EGFR and MAPK3) and transcription factors (CCNE1, H2AX, MYC, RB1, and TP53). Hence, it is evident that antioxidant supplementation activates molecules associated with telomere function in sperm. The outcome of this
    Sprache Englisch
    Erscheinungsdatum 2021-10-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.768510
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Interplay Between SOX9, Wnt/β-Catenin and Androgen Receptor Signaling in Castration-Resistant Prostate Cancer.

    Khurana, Namrata / Sikka, Suresh C

    International journal of molecular sciences

    2019  Band 20, Heft 9

    Abstract: Androgen receptor (AR) signaling plays a key role not only in the initiation of prostate cancer (PCa) but also in its transition to aggressive and invasive castration-resistant prostate cancer (CRPC). However, the crosstalk of AR with other signaling ... ...

    Abstract Androgen receptor (AR) signaling plays a key role not only in the initiation of prostate cancer (PCa) but also in its transition to aggressive and invasive castration-resistant prostate cancer (CRPC). However, the crosstalk of AR with other signaling pathways contributes significantly to the emergence and growth of CRPC. Wnt/β-catenin signaling facilitates ductal morphogenesis in fetal prostate and its anomalous expression has been linked with PCa. β-catenin has also been reported to form complex with AR and thus augment AR signaling in PCa. The transcription factor SOX9 has been shown to be the driving force of aggressive and invasive PCa cells and regulate AR expression in PCa cells. Furthermore, SOX9 has also been shown to propel PCa by the reactivation of Wnt/β-catenin signaling. In this review, we discuss the critical role of SOX9/AR/Wnt/β-catenin signaling axis in the development and progression of CRPC. The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/β-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.
    Mesh-Begriff(e) Animals ; Humans ; Male ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Receptors, Androgen/metabolism ; SOX9 Transcription Factor/metabolism ; Wnt Proteins/metabolism ; beta Catenin/metabolism
    Chemische Substanzen Receptors, Androgen ; SOX9 Transcription Factor ; Wnt Proteins ; beta Catenin
    Sprache Englisch
    Erscheinungsdatum 2019-04-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20092066
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Clomiphene Citrate in the Management of Infertility in Oligospermic Obese Men with Hypogonadism: Retrospective Pilot Study.

    Panner Selvam, Manesh Kumar / Baskaran, Saradha / Tannenbaum, Jacob / Greenberg, Jacob / Shalaby, Hosam Y / Hellstrom, Wayne J G / Sikka, Suresh C

    Medicina (Kaunas, Lithuania)

    2023  Band 59, Heft 11

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    Mesh-Begriff(e) Humans ; Male ; Retrospective Studies ; Pilot Projects ; Semen Analysis ; Semen ; Clomiphene/therapeutic use ; Hypogonadism/complications ; Hypogonadism/drug therapy ; Testosterone/therapeutic use ; Infertility, Male/drug therapy ; Infertility, Male/etiology ; Obesity/complications
    Chemische Substanzen Clomiphene (1HRS458QU2) ; Testosterone (3XMK78S47O)
    Sprache Englisch
    Erscheinungsdatum 2023-10-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59111902
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  9. Artikel ; Online: A Scientometric Evaluation of COVID-19 and Male Reproductive Research

    Manesh Kumar Panner Selvam / Anika Kapoor / Saradha Baskaran / Ajaya Kumar Moharana / Suresh C. Sikka

    Clinics and Practice, Vol 13, Iss 6, Pp 1319-

    2023  Band 1330

    Abstract: The COVID-19 pandemic due to the SARS-CoV-2 coronavirus showed acute and prolonged effects on human health. In addition, over the past four years, there has been a tremendous surge in COVID-19-related scientific publications, as shown by bibliometric and ...

    Abstract The COVID-19 pandemic due to the SARS-CoV-2 coronavirus showed acute and prolonged effects on human health. In addition, over the past four years, there has been a tremendous surge in COVID-19-related scientific publications, as shown by bibliometric and scientometric studies. However, such analysis of the scientific literature is lacking in the area of male reproduction. The current scientometric study analyzes publication characteristics of articles related to male reproduction and COVID-19 infection. We used the Scopus database to analyze scientometric data (the number of publications, journals, countries, type of documents, and subject area) related to COVID-19 and male reproductive research. Our literature search identified 345 articles related to COVID-19 and male reproductive research. Most of the articles were published in the USA ( n = 72), Italy ( n = 55), and China ( n = 51). Such research was mainly focused around medicine (57.1%), followed by biochemistry, genetics, and molecular biology (25.7%). Also, in the area of male reproduction, only 37.1% ( n = 128) of the articles contributed towards original research, whereas 52.8% ( n = 182) were review articles and editorials focusing more on sexual dysfunction than infertility. Such a small number of studies published on COVID-19-related effects on male reproduction warrants a significant increase in research, which is required to decipher the mechanism(s) underlying SARS-CoV-2 infection-associated impairment of male reproductive function.
    Schlagwörter SARS-CoV-2 ; COVID-19 ; scientometrics ; male reproduction ; male infertility ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 001
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Interplay Between SOX9, Wnt/β-Catenin and Androgen Receptor Signaling in Castration-Resistant Prostate Cancer

    Namrata Khurana / Suresh C. Sikka

    International Journal of Molecular Sciences, Vol 20, Iss 9, p

    2019  Band 2066

    Abstract: Androgen receptor (AR) signaling plays a key role not only in the initiation of prostate cancer (PCa) but also in its transition to aggressive and invasive castration-resistant prostate cancer (CRPC). However, the crosstalk of AR with other signaling ... ...

    Abstract Androgen receptor (AR) signaling plays a key role not only in the initiation of prostate cancer (PCa) but also in its transition to aggressive and invasive castration-resistant prostate cancer (CRPC). However, the crosstalk of AR with other signaling pathways contributes significantly to the emergence and growth of CRPC. Wnt/β-catenin signaling facilitates ductal morphogenesis in fetal prostate and its anomalous expression has been linked with PCa. β-catenin has also been reported to form complex with AR and thus augment AR signaling in PCa. The transcription factor SOX9 has been shown to be the driving force of aggressive and invasive PCa cells and regulate AR expression in PCa cells. Furthermore, SOX9 has also been shown to propel PCa by the reactivation of Wnt/β-catenin signaling. In this review, we discuss the critical role of SOX9/AR/Wnt/β-catenin signaling axis in the development and progression of CRPC. The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/β-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.
    Schlagwörter prostate cancer (PCa) ; castration-resistant prostate cancer (CRPC) ; androgen receptor (AR) ; SOX9 ; Wnt/β-catenin ; sulforaphane (SFN) ; curcumin (CUR) ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2019-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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