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  1. Artikel ; Online: Assisted dying is not the same as euthanasia.

    Tallis, Ray

    BMJ (Clinical research ed.)

    2014  Band 348, Seite(n) g3532

    Mesh-Begriff(e) Dissent and Disputes ; England ; Euthanasia/legislation & jurisprudence ; Humans ; Pamphlets ; Suicide, Assisted/legislation & jurisprudence ; Terminology as Topic ; Wales
    Sprache Englisch
    Erscheinungsdatum 2014-05-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.g3532
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  2. Artikel ; Online: An ultra-spatially resolved method to quali-quantitative monitor particulate matter in urban environment.

    Baldacchini, Chiara / Sgrigna, Gregorio / Clarke, Woody / Tallis, Matthew / Calfapietra, Carlo

    Environmental science and pollution research international

    2019  Band 26, Heft 18, Seite(n) 18719–18729

    Abstract: ... of tree leaves by scanning electron microscopy combined with X-ray spectroscopy (SEM/EDX). We have tested ...

    Abstract Monitoring the amount and composition of airborne particulate matter (PM) in the urban environment is a crucial aspect to guarantee citizen health. To focus the action of stakeholders in limiting air pollution, fast and highly spatially resolved methods for monitoring PM are required. Recently, the trees' capability in capturing PM inspired the development of several methods intended to use trees as biomonitors; this results in the potential of having an ultra-spatially resolved network of low-cost PM monitoring stations throughout cities, without the needing of on-site stations. Within this context, we propose a fast and reliable method to qualitatively and quantitatively characterize the PM present in urban air based on the analysis of tree leaves by scanning electron microscopy combined with X-ray spectroscopy (SEM/EDX). We have tested our method in the Real Bosco di Capodimonte urban park (Naples, Italy), by collecting leaves from Quercus ilex trees along transects parallel to the main wind directions. The coarse (PM
    Mesh-Begriff(e) Aerosols ; Air Pollutants/analysis ; Cities ; Environmental Monitoring/methods ; Italy ; Particle Size ; Particulate Matter/analysis ; Plant Leaves/chemistry ; Quercus/chemistry ; Wind
    Chemische Substanzen Aerosols ; Air Pollutants ; Particulate Matter
    Sprache Englisch
    Erscheinungsdatum 2019-05-04
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-019-05160-8
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  3. Artikel: Epilepsy in elderly people: management issues.

    Tallis, Ray / Boon, Paul / Perucca, Emilio / Stephen, Linda

    Epileptic disorders : international epilepsy journal with videotape

    2002  Band 4 Suppl 2, Seite(n) S33–9

    Abstract: Epilepsy in elderly people is far more common than many doctors realise. The prevalence and incidence are frequently underestimated due to underdiagnosis or misdiagnosis of the condition. As the proportion of older people in the population grows, the ... ...

    Abstract Epilepsy in elderly people is far more common than many doctors realise. The prevalence and incidence are frequently underestimated due to underdiagnosis or misdiagnosis of the condition. As the proportion of older people in the population grows, the management of epilepsy in this population will become increasingly important. Elderly people are especially susceptible to the consequences of seizures, particularly loss of self-confidence, decreased independence, and "falls" resulting in physical injury. Establishing the diagnosis of epilepsy in old age can be more difficult than in younger patients due to the extensive range of differential diagnoses and a far higher prevalence of concomitant disease. Treatment strategies are demanding; they must allow for the complexities of co-morbidity, co-medication, alterations in drug handling, and drug effects on an aging body. Together with a growing array of antiepileptic medication from which to choose, these factors make the management of epilepsy in elderly people particularly challenging.
    Mesh-Begriff(e) Aged ; Anticonvulsants/therapeutic use ; Diagnosis, Differential ; Epilepsy/diagnosis ; Epilepsy/drug therapy ; Female ; Humans ; Male ; Middle Aged
    Chemische Substanzen Anticonvulsants
    Sprache Englisch
    Erscheinungsdatum 2002-10
    Erscheinungsland France
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2086797-9
    ISSN 1950-6945 ; 1294-9361
    ISSN (online) 1950-6945
    ISSN 1294-9361
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  4. Artikel ; Online: Near-infrared spectroscopy in stroke: from research to clinical practice.

    Hargroves, David R / Tallis, Ray C / Pomeroy, Val M / Bhalla, Ajay

    Stroke

    2004  Band 35, Heft 11, Seite(n) 2430; author reply 2430–1

    Mesh-Begriff(e) Cerebrovascular Disorders/diagnosis ; Diagnostic Tests, Routine ; Humans ; Spectroscopy, Near-Infrared
    Sprache Englisch
    Erscheinungsdatum 2004-11
    Erscheinungsland United States
    Dokumenttyp Comment ; Letter
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/01.STR.0000144656.77330.18
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  5. Artikel: An ultra-spatially resolved method to quali-quantitative monitor particulate matter in urban environment

    Baldacchini, Chiara / Sgrigna, Gregorio / Clarke, Woody / Tallis, Matthew / Calfapietra, Carlo

    Environmental science and pollution research international. 2019 June, v. 26, no. 18

    2019  

    Abstract: ... of tree leaves by scanning electron microscopy combined with X-ray spectroscopy (SEM/EDX). We have tested ...

    Abstract Monitoring the amount and composition of airborne particulate matter (PM) in the urban environment is a crucial aspect to guarantee citizen health. To focus the action of stakeholders in limiting air pollution, fast and highly spatially resolved methods for monitoring PM are required. Recently, the trees’ capability in capturing PM inspired the development of several methods intended to use trees as biomonitors; this results in the potential of having an ultra-spatially resolved network of low-cost PM monitoring stations throughout cities, without the needing of on-site stations. Within this context, we propose a fast and reliable method to qualitatively and quantitatively characterize the PM present in urban air based on the analysis of tree leaves by scanning electron microscopy combined with X-ray spectroscopy (SEM/EDX). We have tested our method in the Real Bosco di Capodimonte urban park (Naples, Italy), by collecting leaves from Quercus ilex trees along transects parallel to the main wind directions. The coarse (PM10–2.5) and fine (PM2.5) amounts obtained per unit leaf area have been validated by weighting the PM washed from leaves belonging to the same sample sets. PM size distribution and elemental composition match appropriately with the known pollution sources in the sample sites (i.e., traffic and marine aerosol). The proposed methodology will then allow the use of the urban forest as an ultra-spatially resolved PM monitoring network, also supporting the work of urban green planners and stakeholders.
    Schlagwörter Quercus ilex ; X-radiation ; aerosols ; air ; air pollution ; cities ; elemental composition ; energy-dispersive X-ray analysis ; indicator species ; leaf area ; leaves ; monitoring ; particulates ; scanning electron microscopy ; spectroscopy ; stakeholders ; traffic ; trees ; urban areas ; urban forests ; urban parks ; wind direction ; Italy
    Sprache Englisch
    Erscheinungsverlauf 2019-06
    Umfang p. 18719-18729.
    Erscheinungsort Springer Berlin Heidelberg
    Dokumenttyp Artikel
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-019-05160-8
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  6. Artikel: 1-trimethylsilylphosphirane as a ligand and as a stable masked reagent for phosphirane.

    Tallis, Huw A / Newman, Paul D / Edwards, Peter G / Ooi, Liling / Stasch, Andreas

    Dalton transactions (Cambridge, England : 2003)

    2008  , Heft 1, Seite(n) 47–53

    Abstract: ... the X-ray crystal structures of fac-Cr(CO)3(C2H4PSiMe3)3 and fac-Mo(CO)3(C2H4PH)3 have also been determined. ...

    Abstract 1-Trimethylsilylphosphirane, C2H4PSiMe3, has been prepared on a multi gram scale from P(SiMe3)3 via CICH2CH2P(SiMe3)2. C2H4PSiMe3 is readily susceptible to protonolysis forming the thermally unstable parent phosphirane, C2H4PH, in good yields. Reaction of C2H4PSiMe3 with fac-M(CO)3(CH3CN)3 (M = Cr, Mo) or [Fe(eta5-C5H5)(eta6-C6H6)](PF6) give rise tofac-M(CO)3(C2H4PSiMe3)3 and [Fe(eta5-C5H5)(C2H4PSiMe3)3](PF6) respectively. Protonolysis of the free or coordinated 1-trimethylsilylphosphirane readily causes P-Si cleavage to give rise to the parent C2H4PH or the respective complexes,fac-M(CO)3(C2H4PH)3 andfac-[Fe(eta5-C5H5)(C2H4PH)3](PF6) in situ. All new complexes are characterised by analytical and spectroscopic methods and the X-ray crystal structures of fac-Cr(CO)3(C2H4PSiMe3)3 and fac-Mo(CO)3(C2H4PH)3 have also been determined.
    Sprache Englisch
    Erscheinungsdatum 2008-03-11
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1472887-4
    ISSN 1364-5447 ; 1477-9234 ; 1477-9226 ; 0300-9246
    ISSN (online) 1364-5447 ; 1477-9234
    ISSN 1477-9226 ; 0300-9246
    DOI 10.1039/b715327a
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  7. Artikel: Can integrating wildlife and livestock enhance ecosystem services in central Kenya?

    Allan, Brian F / Heather Tallis / Rebecca Chaplin‐Kramer / Steven Huckett / Virginia A Kowal / Jessica Musengezi / Sharon Okanga / Richard S Ostfeld / Jennifer Schieltz / Charles M Warui / Spencer A Wood / Felicia Keesing

    Frontiers in ecology and the environment. 2017 Aug., v. 15, no. 6

    2017  

    Abstract: ... livestock ranching typically have been portrayed as conflicting uses of African savannas. Here, we offer ...

    Abstract Because wildlife and livestock compete for grazing resources, biodiversity conservation and livestock ranching typically have been portrayed as conflicting uses of African savannas. Here, we offer an alternative perspective by describing a savanna ecosystem in central Kenya where wildlife and livestock exhibit a suite of potential positive interactions. For example, treating livestock with an acaricide offers the unintended benefit of removing ticks from the landscape, a result that has now been shown to occur at both large and small scales. When humans derive financial benefits both from wildlife (through tourism) and from livestock (through food production), they may achieve greater economic stability than when income is derived solely from one source. The integrated management of wildlife and livestock can simultaneously improve human health and wildlife conservation. Optimization of human and wildlife benefits will require the management of ecological and socioeconomic trade‐offs when conflicts occur between stakeholders.
    Schlagwörter acaricides ; biodiversity conservation ; ecosystem services ; ecosystems ; food production ; grazing ; human health ; humans ; income ; landscapes ; livestock ; ranching ; savannas ; stakeholders ; ticks ; tourism ; wildlife ; wildlife management ; Kenya
    Sprache Englisch
    Erscheinungsverlauf 2017-08
    Umfang p. 328-335.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 2110853-5
    ISSN 1540-9309 ; 1540-9295
    ISSN (online) 1540-9309
    ISSN 1540-9295
    DOI 10.1002/fee.1501
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  8. Artikel ; Online: Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.

    Sharifi, Reza / Morra, Rosa / Appel, C Denise / Tallis, Michael / Chioza, Barry / Jankevicius, Gytis / Simpson, Michael A / Matic, Ivan / Ozkan, Ege / Golia, Barbara / Schellenberg, Matthew J / Weston, Ria / Williams, Jason G / Rossi, Marianna N / Galehdari, Hamid / Krahn, Juno / Wan, Alexander / Trembath, Richard C / Crosby, Andrew H /
    Ahel, Dragana / Hay, Ron / Ladurner, Andreas G / Timinszky, Gyula / Williams, R Scott / Ahel, Ivan

    The EMBO journal

    2013  Band 32, Heft 9, Seite(n) 1225–1237

    Abstract: ... residues in PARP-modified proteins. X-ray structures and biochemical analysis of C6orf130 suggest ...

    Abstract Adenosine diphosphate (ADP)-ribosylation is a post-translational protein modification implicated in the regulation of a range of cellular processes. A family of proteins that catalyse ADP-ribosylation reactions are the poly(ADP-ribose) (PAR) polymerases (PARPs). PARPs covalently attach an ADP-ribose nucleotide to target proteins and some PARP family members can subsequently add additional ADP-ribose units to generate a PAR chain. The hydrolysis of PAR chains is catalysed by PAR glycohydrolase (PARG). PARG is unable to cleave the mono(ADP-ribose) unit directly linked to the protein and although the enzymatic activity that catalyses this reaction has been detected in mammalian cell extracts, the protein(s) responsible remain unknown. Here, we report the homozygous mutation of the c6orf130 gene in patients with severe neurodegeneration, and identify C6orf130 as a PARP-interacting protein that removes mono(ADP-ribosyl)ation on glutamate amino acid residues in PARP-modified proteins. X-ray structures and biochemical analysis of C6orf130 suggest a mechanism of catalytic reversal involving a transient C6orf130 lysyl-(ADP-ribose) intermediate. Furthermore, depletion of C6orf130 protein in cells leads to proliferation and DNA repair defects. Collectively, our data suggest that C6orf130 enzymatic activity has a role in the turnover and recycling of protein ADP-ribosylation, and we have implicated the importance of this protein in supporting normal cellular function in humans.
    Mesh-Begriff(e) Amino Acid Sequence ; Base Sequence ; Cells, Cultured ; Child ; Child, Preschool ; Family ; Female ; Glycoside Hydrolases/genetics ; Glycoside Hydrolases/physiology ; HEK293 Cells ; HeLa Cells ; Humans ; Male ; Models, Molecular ; Molecular Sequence Data ; Neurodegenerative Diseases/enzymology ; Neurodegenerative Diseases/genetics ; Pedigree ; Poly Adenosine Diphosphate Ribose/genetics ; Poly Adenosine Diphosphate Ribose/physiology ; Protein Processing, Post-Translational/genetics ; Sequence Homology, Amino Acid ; Thiolester Hydrolases/genetics ; Thiolester Hydrolases/physiology
    Chemische Substanzen Poly Adenosine Diphosphate Ribose (26656-46-2) ; OARD1 protein, human (EC 3.1.2.-) ; Thiolester Hydrolases (EC 3.1.2.-) ; Glycoside Hydrolases (EC 3.2.1.-)
    Sprache Englisch
    Erscheinungsdatum 2013-03-12
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.1038/emboj.2013.51
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: The cortical topography of human swallowing musculature in health and disease.

    Hamdy, S / Aziz, Q / Rothwell, J C / Singh, K D / Barlow, J / Hughes, D G / Tallis, R C / Thompson, D G

    Nature medicine

    1996  Band 2, Heft 11, Seite(n) 1217–1224

    Abstract: Because no detailed information exists regarding the topographic representation of swallowing musculature on the human cerebral cortex in health or disease, we used transcranial magnetic stimulation to study the cortical topography of human oral, ... ...

    Abstract Because no detailed information exists regarding the topographic representation of swallowing musculature on the human cerebral cortex in health or disease, we used transcranial magnetic stimulation to study the cortical topography of human oral, pharyngeal and esophageal musculature in 20 healthy individuals and the topography of pharyngeal musculature in two stroke patients, one with and one without dysphagia. Our results demonstrate that swallowing musculature is discretely and somatotopically represented on the motor and premotor cortex of both hemispheres but displays interhemispheric asymmetry, independent of handedness. Following stroke, dysphagia appeared to be associated with smaller pharyngeal representation on the intact hemisphere, which increases in size with recovery of swallowing.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Brain Mapping ; Cerebrovascular Disorders/physiopathology ; Deglutition/physiology ; Electromyography ; Esophagus/physiopathology ; Female ; Hemiplegia/physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Cortex/physiopathology ; Muscle, Smooth/physiopathology ; Pharynx/physiopathology ; Prefrontal Cortex/physiopathology ; Reproducibility of Results ; Signal Transduction ; Tomography Scanners, X-Ray Computed ; Twins, Monozygotic
    Sprache Englisch
    Erscheinungsdatum 1996-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm1196-1217
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  10. Artikel: Spinal cord stimulation in the United Kingdom.

    Illis, L S / Read, D J / Sedgwick, E M / Tallis, R C

    Journal of neurology, neurosurgery, and psychiatry

    1983  Band 46, Heft 4, Seite(n) 299–304

    Abstract: ... large centres as x-ray screening, urodynamic and neurophysiological assessment facilities are required ...

    Abstract All the medical, surgical and engineering personnel in the UK who have used spinal cord stimulation (SCS) in patients, attended a workshop to discuss their results. The major use of SCS has been for multiple sclerosis and intractable pain. It was concluded that the technique benefited up to two thirds of patients with bladder dysfunction, and that pain and possibly spasticity also responded to SCS, but other manifestations of multiple sclerosis did not. Further information on long term benefit is needed and the use of SCS in other conditions, such as spinal injury and peripheral vascular disease, is not yet established. SCS cannot be recommended for use outside large centres as x-ray screening, urodynamic and neurophysiological assessment facilities are required as well as biological engineering assistance.
    Mesh-Begriff(e) Electric Stimulation Therapy/adverse effects ; Electrodes ; Humans ; Motor Skills/physiology ; Multiple Sclerosis/complications ; Multiple Sclerosis/therapy ; Pain, Intractable/therapy ; Spinal Cord ; Spinal Injuries/therapy ; United Kingdom ; Urinary Bladder Diseases/etiology ; Urinary Bladder Diseases/therapy ; Vascular Diseases/therapy
    Sprache Englisch
    Erscheinungsdatum 1983-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp.46.4.299
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