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  1. Artikel ; Online: Mapping the subcortical connectome using in vivo diffusion MRI: Feasibility and reliability.

    Kai, Jason / Khan, Ali R / Haast, Roy Am / Lau, Jonathan C

    NeuroImage

    2022  Band 262, Seite(n) 119553

    Abstract: Tractography combined with regions of interest (ROIs) has been used to non-invasively study the structural connectivity of the cortex as well as to assess the reliability of these connections. However, the subcortical connectome (subcortex to subcortex) ... ...

    Abstract Tractography combined with regions of interest (ROIs) has been used to non-invasively study the structural connectivity of the cortex as well as to assess the reliability of these connections. However, the subcortical connectome (subcortex to subcortex) has not been comprehensively examined, in part due to the difficulty of performing tractography in this complex and compact region. In this study, we performed an in vivo investigation using tractography to assess the feasibility and reliability of mapping known connections between structures of the subcortex using the test-retest dataset from the Human Connectome Project (HCP). We further validated our observations using a separate unrelated subjects dataset from the HCP. Quantitative assessment was performed by computing tract densities and spatial overlap of identified connections between subcortical ROIs. Further, known connections between structures of the basal ganglia and thalamus were identified and visually inspected, comparing tractography reconstructed trajectories with descriptions from tract-tracing studies. Our observations demonstrate both the feasibility and reliability of using a data-driven tractography-based approach to map the subcortical connectome in vivo.
    Mesh-Begriff(e) Cerebral Cortex ; Connectome ; Diffusion Magnetic Resonance Imaging ; Feasibility Studies ; Humans ; Reproducibility of Results
    Sprache Englisch
    Erscheinungsdatum 2022-08-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2022.119553
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Adoption and Utilization of Social Media Among Adult and Pediatric Infectious Diseases Divisions and Fellowship Programs in the United States.

    Ryder, Jonathan H / Mowrer, Clayton / Van Roy, Zachary / Lyden, Elizabeth / Cawcutt, Kelly A / Marcelin, Jasmine R

    Open forum infectious diseases

    2023  Band 10, Heft 3, Seite(n) ofad065

    Abstract: Background: Social media (SoMe) is ubiquitous, but its adoption and utilization by infectious diseases (ID) divisions are poorly characterized in the United States.: Methods: A systematic search of US ID fellowship/division Twitter, Facebook, and ... ...

    Abstract Background: Social media (SoMe) is ubiquitous, but its adoption and utilization by infectious diseases (ID) divisions are poorly characterized in the United States.
    Methods: A systematic search of US ID fellowship/division Twitter, Facebook, and Instagram accounts occurred in November-December 2021. Social media account and program characteristics, post frequency and content, and other measures of SoMe adoption and utilization were recorded and compared between adult and pediatric programs. Posts were thematically categorized as social, promotional, educational, recruitment, or other.
    Results: Of 222 ID programs identified, 158 (71.2%) were adult and 64 (28.8%) pediatric. Seventy (31.5%) Twitter, 14 (6.3%) Facebook, and 14 (6.3%) Instagram accounts were identified from US programs. Twitter accounts were associated with larger programs and higher match rates. More adult than pediatric programs had Twitter accounts (37.3% vs 17.2%,
    Conclusions: Social media remains underutilized across ID divisions, but COVID-19 and virtual recruiting may have influenced recent account creation. Twitter was the most frequently used ID program SoMe platform. Social media may benefit ID programs in recruitment and amplification of their trainees, faculty, and specialty.
    Sprache Englisch
    Erscheinungsdatum 2023-02-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad065
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Adjuvanted nanoliposomes displaying six hemagglutinins and neuraminidases as an influenza virus vaccine.

    Sia, Zachary R / Roy, Jayishnu / Huang, Wei-Chiao / Song, Yiting / Zhou, Shiqi / Luo, Yuan / Li, Qinzhe / Arpin, Dominic / Kutscher, Hilliard L / Ortega, Joaquin / Davidson, Bruce A / Lovell, Jonathan F

    Cell reports. Medicine

    2024  Band 5, Heft 3, Seite(n) 101433

    Abstract: Inclusion of defined quantities of the two major surface proteins of influenza virus, hemagglutinin (HA) and neuraminidase (NA), could benefit seasonal influenza vaccines. Recombinant HA and NA multimeric proteins derived from three influenza serotypes, ... ...

    Abstract Inclusion of defined quantities of the two major surface proteins of influenza virus, hemagglutinin (HA) and neuraminidase (NA), could benefit seasonal influenza vaccines. Recombinant HA and NA multimeric proteins derived from three influenza serotypes, H1N1, H3N2, and type B, are surface displayed on nanoliposomes co-loaded with immunostimulatory adjuvants, generating "hexaplex" particles that are used to immunize mice. Protective immune responses to hexaplex liposomes involve functional antibody elicitation against each included antigen, comparable to vaccination with monovalent antigen particles. When compared to contemporary recombinant or adjuvanted influenza virus vaccines, hexaplex liposomes perform favorably in many areas, including antibody production, T cell activation, protection from lethal virus challenge, and protection following passive sera transfer. Based on these results, hexaplex liposomes warrant further investigation as an adjuvanted recombinant influenza vaccine formulation.
    Mesh-Begriff(e) Mice ; Animals ; Humans ; Influenza Vaccines ; Hemagglutinins ; Neuraminidase/genetics ; Orthomyxoviridae Infections ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Liposomes ; Influenza, Human ; Adjuvants, Immunologic ; Vaccines, Synthetic
    Chemische Substanzen Influenza Vaccines ; Hemagglutinins ; Neuraminidase (EC 3.2.1.18) ; Liposomes ; Adjuvants, Immunologic ; Vaccines, Synthetic
    Sprache Englisch
    Erscheinungsdatum 2024-02-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2024.101433
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Intracardiac vs Transesophageal Echocardiography for Left Atrial Appendage Occlusion With Watchman FLX in the U.S.

    Ferro, Enrico G / Alkhouli, Mohamad / Nair, Devi G / Kapadia, Samir R / Hsu, Jonathan C / Gibson, Douglas N / Freeman, James V / Price, Matthew J / Roy, Kristine / Allocco, Dominic J / Yeh, Robert W / Piccini, Jonathan P

    JACC. Clinical electrophysiology

    2023  Band 9, Heft 12, Seite(n) 2587–2599

    Abstract: Background: Intraprocedural imaging is critical for device delivery in transcatheter left atrial appendage occlusion (LAAO). Although pivotal trials of LAAO devices were conducted using transesophageal echocardiography (TEE), intracardiac ... ...

    Abstract Background: Intraprocedural imaging is critical for device delivery in transcatheter left atrial appendage occlusion (LAAO). Although pivotal trials of LAAO devices were conducted using transesophageal echocardiography (TEE), intracardiac echocardiography (ICE) is an emerging imaging modality.
    Objectives: This study compared outcomes after ICE- and TEE-guided Watchman FLX implantation in the SURPASS (SURveillance Post Approval AnalySiS Plan) nationwide LAAO registry.
    Methods: Baseline characteristics were compared using chi-square and t-tests. Outcomes were reported in unadjusted and adjusted comparisons via propensity weighting.
    Results: Between August 2020 and September 2021, LAAO was attempted in 39,759 patients at 698 sites, including 2,272 cases (5.7%) with ICE and 31,835 (80.0%) with TEE. ICE and TEE patients had similar baseline characteristics and mean procedural times (ICE 82 minutes vs TEE 78 minutes). ICE patients were less likely to receive general anesthesia (54% vs 98%, P < 0.01). Successful device implantation (98.3% vs 97.6%) and complete seal rates at 45 days were similar (n = 25,280; 83% vs 82%). Most adverse event rates were similar; unadjusted mortality rates at 45 days were 1.1% for ICE vs 0.8% for TEE (P = 0.14), and 1.0% vs 0.7% (P = 0.27) in adjusted analyses. Even after adjustment, pericardial effusion rates requiring intervention were significantly higher with ICE at 45 days (1.0% vs 0.5%; P = 0.02). This rate decreased as operators performed more ICE-guided procedures, although 82% of operators had performed <10 ICE-guided procedures overall.
    Conclusions: In the largest comparison to date, ICE use was infrequent. ICE and TEE both achieved high rates of complete LAAO. ICE was associated with significantly higher rates of pericardial effusion requiring intervention.
    Mesh-Begriff(e) Humans ; Echocardiography, Transesophageal ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Pericardial Effusion/etiology ; Atrial Fibrillation/complications ; Atrial Fibrillation/surgery ; Cardiac Catheterization/methods
    Sprache Englisch
    Erscheinungsdatum 2023-10-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.08.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The relationship between sleep, perfectionistic strivings, perfectionistic concerns, and academic and sports performance in young athletes.

    Roy, Jonathan / Godin, Roxanne / Gaudreault, Pascale / Forest, Geneviève

    Chronobiology international

    2023  Band 40, Heft 11, Seite(n) 1500–1514

    Abstract: Perfectionism is associated with sleep as well as with academic and sports performance. Given the importance of sleep for performance and the sleep changes that occur during adolescence, the present study aimed to explore the relationship between sleep, ... ...

    Abstract Perfectionism is associated with sleep as well as with academic and sports performance. Given the importance of sleep for performance and the sleep changes that occur during adolescence, the present study aimed to explore the relationship between sleep, two dimensions of perfectionism (perfectionistic strivings and perfectionistic concerns), with academic and sports performance in young athletes. The occurrence of perfectionistic strivings was identified as a tendency to set high personal standards for oneself, while the occurrence of perfectionistic concerns was identified as a tendency to feel pressure to be perfect and have concerns about imperfections. A total of 32 athletes aged 13 to 16 years old participated in this study. Perfectionism, sleep, and course grades were measured at the end of the school year. Sleep was measured by actigraphy, and sports performance improvement was obtained by comparing individual performance at the beginning and the end of the school year. The moderating effect of both dimensions of perfectionism on the relationships between sleep and academic and sports performance improvement was measured. First, results showed no significant relationship between sleep and academic/sports performance. Further analyses revealed that perfectionistic strivings moderated the relationship between certain aspects of sleep with academic and sports performance improvement. Delayed and suboptimal sleep habits were associated with lower academic and sports performance improvement when low levels of perfectionistic strivings were present. Results with perfectionistic concerns showed that this dimension did not moderate the relationship between sleep and academic and sports performance improvement. This study supports the notion that high levels of perfectionistic strivings in young athletes may mitigate the adverse effects of poor sleep habits in young athletes.
    Mesh-Begriff(e) Adolescent ; Humans ; Perfectionism ; Circadian Rhythm ; Athletes ; Athletic Performance ; Sleep
    Sprache Englisch
    Erscheinungsdatum 2023-11-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 998996-1
    ISSN 1525-6073 ; 0742-0528
    ISSN (online) 1525-6073
    ISSN 0742-0528
    DOI 10.1080/07420528.2023.2273828
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2068: Hefte anzeigen Standort:
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  6. Artikel ; Online: An Introduction to the Native and Non-Native Plant-Insect Interactions and Potential Pollinators of Puerto Williams and Yendegaia, Cabo de Hornos, Chile.

    Burkett, Carmen A / Corwin, Ri / Lautenbach, Jonathan / Serrani Gallego, Issabella / Joseph, Sara A / Burkett, Francesca / Hendrickson, Benton J / Jackson, Desiree A / McCool, Morghan / Molina, Clarissa M / Armijo Morales, Felipe / Todd, Erin R / Mackenzie, Roy / Sanchez Jardon, Laura / Thompson, Michael / Rozzi, Ricardo / Gregory, Andrew J

    microPublication biology

    2024  Band 2024

    Abstract: The Magellanic sub-Antarctic ecoregion of southern Chile represents one of the last remaining pristine areas on Earth, but there are knowledge gaps concerning the biodiversity and interactions of the regions' flora and fauna. Non-native insect species ... ...

    Abstract The Magellanic sub-Antarctic ecoregion of southern Chile represents one of the last remaining pristine areas on Earth, but there are knowledge gaps concerning the biodiversity and interactions of the regions' flora and fauna. Non-native insect species like
    Sprache Englisch
    Erscheinungsdatum 2024-04-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.001158
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  7. Artikel: Nanoscopic and Functional Characterization of Keratinocyte-Originating Exosomes in the Wound Fluid of Non-Diabetic and Diabetic Chronic Wound Patients.

    Guda, Poornachander R / Sharma, Anu / Anthony, Adam J / ElMasry, Mohamed S / Couse, Andrew D / Ghatak, Piya Das / Das, Amitava / Timsina, Lava / Trinidad, Jonathan C / Roy, Sashwati / Clemmer, David E / Sen, Chandan K / Ghatak, Subhadip

    Nano today

    2023  Band 52

    Abstract: Exosomes, a class of extracellular vesicles of endocytic origin, play a critical role in paracrine signaling for successful cell-cell ... ...

    Abstract Exosomes, a class of extracellular vesicles of endocytic origin, play a critical role in paracrine signaling for successful cell-cell crosstalk
    Sprache Englisch
    Erscheinungsdatum 2023-08-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2224882-1
    ISSN 1878-044X ; 1748-0132
    ISSN (online) 1878-044X
    ISSN 1748-0132
    DOI 10.1016/j.nantod.2023.101954
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  8. Artikel ; Online: Draft Whole-Genome Sequences of 10

    Gray, Katie / Green, Luke R / Chaudhuri, Roy R / Shaw, Jonathan G

    Microbiology resource announcements

    2019  Band 8, Heft 30

    Abstract: ... ...

    Abstract Aeromonas
    Sprache Englisch
    Erscheinungsdatum 2019-07-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00170-19
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  9. Artikel ; Online: Metal and Organic Templates Together Control the Size of Covalent Macrocycles and Cages.

    Lavendomme, Roy / Ronson, Tanya K / Nitschke, Jonathan R

    Journal of the American Chemical Society

    2019  Band 141, Heft 30, Seite(n) 12147–12158

    Abstract: Covalent macrocycles and three-dimensional cages were prepared by the self-assembly of di- or tritopic anilines and 2,6-diformylpyridine subcomponents around palladium(II) templates. The resulting 2,6-bis(imino)pyridyl- ... ...

    Abstract Covalent macrocycles and three-dimensional cages were prepared by the self-assembly of di- or tritopic anilines and 2,6-diformylpyridine subcomponents around palladium(II) templates. The resulting 2,6-bis(imino)pyridyl-Pd
    Sprache Englisch
    Erscheinungsdatum 2019-07-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.9b06182
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    Verfügbar in ZB MED Bonn

    Z 4' 55/32: Hefte anzeigen
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  10. Artikel ; Online: A Zn

    Lu, Zhenpin / Lavendomme, Roy / Burghaus, Olaf / Nitschke, Jonathan R

    Angewandte Chemie (International ed. in English)

    2019  Band 58, Heft 27, Seite(n) 9073–9077

    Abstract: A redox-switchable self-assembled ... ...

    Abstract A redox-switchable self-assembled Zn
    Sprache Englisch
    Erscheinungsdatum 2019-05-24
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201903286
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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