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Artikel ; Online: Rate of pathological complete response in early HER2 breast cancer.

Bodet, Marie-Lucile / Rouzier, Roman / Héquet, Delphine

2022 Band 109, Heft 6, Seite(n) 722–723

Mesh-Begriff(e)	Antineoplastic Combined Chemotherapy Protocols ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Humans ; Neoadjuvant Therapy ; Receptor, ErbB-2 ; Trastuzumab/therapeutic use ; Treatment Outcome
Chemische Substanzen	Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Sprache	Englisch
Erscheinungsdatum	2022-05-11
Erscheinungsland	France
Dokumenttyp	Letter
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2022.02.016
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France.

Eliès, Antoine / Bonneau, Claire / Houzard, Sophie / Rouzier, Roman / Héquet, Delphine

PloS one

2022 Band 17, Heft 3, Seite(n) e0264821

Abstract: Objective: To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study.: Methods: We conducted a retrospective real-life cohort study on data collected prospectively by ... ...

Abstract	Objective: To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. Methods: We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97th sample of the French population. We extracted data about all women born between 1983 and 1991, corresponding to the catch-up population (vaccination after 14 years old) at the time of implementation of HPV vaccination. The primary outcome was the occurrence of conization (all types of procedures) compared between vaccinated and non-vaccinated women. Results: The cohort consisted of 42,452 women. Vaccination coverage (at least one dose) was low (9.8%, n = 4,129), but increased with time from vaccine implementation, from 0% in the 1983 cohort to 31% in the 1991 cohort. The conization rate was 1% for the overall population. The risk of conization for women between the ages of 19 and 30 years was reduced in the vaccinated group with a Hazard Ratio (HR) of 0.59 (95% CI[0.39-0.90]; p = 0.043). Conclusions: With a 10-year follow-up, catch-up HPV vaccination is associated with risk reduction of conization between the ages of 19 and 30.
Mesh-Begriff(e)	Adolescent ; Adult ; Alphapapillomavirus ; Cohort Studies ; Conization ; Female ; Humans ; Male ; Papillomavirus Infections ; Papillomavirus Vaccines ; Retrospective Studies ; Uterine Cervical Neoplasms ; Vaccination ; Young Adult
Chemische Substanzen	Papillomavirus Vaccines
Sprache	Englisch
Erscheinungsdatum	2022-03-11
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0264821
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France

Antoine Eliès / Claire Bonneau / Sophie Houzard / Roman Rouzier / Delphine Héquet

PLoS ONE, Vol 17, Iss

2022 Band 3

Abstract: Objective To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. Methods We conducted a retrospective real-life cohort study on data collected prospectively by French ... ...

Abstract	Objective To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. Methods We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97th sample of the French population. We extracted data about all women born between 1983 and 1991, corresponding to the catch-up population (vaccination after 14 years old) at the time of implementation of HPV vaccination. The primary outcome was the occurrence of conization (all types of procedures) compared between vaccinated and non-vaccinated women. Results The cohort consisted of 42,452 women. Vaccination coverage (at least one dose) was low (9.8%, n = 4,129), but increased with time from vaccine implementation, from 0% in the 1983 cohort to 31% in the 1991 cohort. The conization rate was 1% for the overall population. The risk of conization for women between the ages of 19 and 30 years was reduced in the vaccinated group with a Hazard Ratio (HR) of 0.59 (95% CI[0.39–0.90]; p = 0.043). Conclusions With a 10-year follow-up, catch-up HPV vaccination is associated with risk reduction of conization between the ages of 19 and 30.
Schlagwörter	Medicine ; R ; Science ; Q
Sprache	Englisch
Erscheinungsdatum	2022-01-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France.

Antoine Eliès / Claire Bonneau / Sophie Houzard / Roman Rouzier / Delphine Héquet

PLoS ONE, Vol 17, Iss 3, p e

2022 Band 0264821

Abstract	Objective To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. Methods We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97th sample of the French population. We extracted data about all women born between 1983 and 1991, corresponding to the catch-up population (vaccination after 14 years old) at the time of implementation of HPV vaccination. The primary outcome was the occurrence of conization (all types of procedures) compared between vaccinated and non-vaccinated women. Results The cohort consisted of 42,452 women. Vaccination coverage (at least one dose) was low (9.8%, n = 4,129), but increased with time from vaccine implementation, from 0% in the 1983 cohort to 31% in the 1991 cohort. The conization rate was 1% for the overall population. The risk of conization for women between the ages of 19 and 30 years was reduced in the vaccinated group with a Hazard Ratio (HR) of 0.59 (95% CI[0.39-0.90]; p = 0.043). Conclusions With a 10-year follow-up, catch-up HPV vaccination is associated with risk reduction of conization between the ages of 19 and 30.
Schlagwörter	Medicine ; R ; Science ; Q
Sprache	Englisch
Erscheinungsdatum	2022-01-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Regional spread of an atypical ESBL-producing

Martischang, Romain / Seth-Smith, Helena / Verschuuren, Tess D / Héquet, Delphine / Gaïa, Nadia / François, Patrice / Fluit, Ad C / Kluytmans, Jan A J W / Seiffert, Salome N / Tacconelli, Evelina / Cherkaoui, Abdessalam / Harbarth, Stephan / Egli, Adrian / Kohler, Philipp

Antimicrobial agents and chemotherapy

2024 Band 68, Heft 2, Seite(n) e0092523

Abstract: We describe the inter-regional spread of a novel ESBL- ... ...

Abstract	We describe the inter-regional spread of a novel ESBL-producing
Mesh-Begriff(e)	Humans ; Escherichia coli Infections/epidemiology ; Switzerland ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Anti-Bacterial Agents ; beta-Lactamases ; Molecular Epidemiology
Chemische Substanzen	Escherichia coli Proteins ; Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
Sprache	Englisch
Erscheinungsdatum	2024-01-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00925-23
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Bouffées de chaleur et cancer du sein avec récepteurs hormonaux positifs : mécanismes et prise en charge.

Cavadias, Iphigénie / Rouzier, Roman / Lerebours, Florence / Héquet, Delphine

Bulletin du cancer

2020 Band 107, Heft 11, Seite(n) 1171–1185

Abstract: Breast cancer is the most frequently diagnosed cancer in women and the first cause of cancer death in France. Among the different subtypes of breast cancer, the predominant form is characterized by positive hormone receptors (more than 70% of breast ... ...

Titelübersetzung	Hot flushes and breast cancer with positive hormone receptors: Mechanisms and management.
Abstract	Breast cancer is the most frequently diagnosed cancer in women and the first cause of cancer death in France. Among the different subtypes of breast cancer, the predominant form is characterized by positive hormone receptors (more than 70% of breast cancers). Hormone therapy thus plays a key role in the strategy of management of these cancers both in adjuvant and metastatic situations. The two types of adjuvant hormone therapy used are selective estrogen receptor modulators and aromatase inhibitors. Fulvestrant, an anti-estrogen, is used alone or in combination with other molecules in metastatic situations. Hot flashes are one of the symptoms most frequently reported by patients under hormone therapy. Hormone replacement therapy, which is currently the most effective treatment for hot flashes, is contraindicated in patients with a personal history of breast cancer. Various therapeutic classes of drugs have been tested in this indication but without real efficacy in the various studies carried out to date, and moreover associated with non-negligible side effects. The recent discovery of the implication of the kisspeptin system located at the hypothalamic level in the mechanism of genesis of hot flashes opens the way to possible new symptomatic treatments for hot flashes. Neurokinin 3 receptor antagonists have shown encouraging preliminary results in postmenopausal cancer-free patients and could be considered in patients in hormonal therapy for breast cancer. Broader additional studies are needed to confirm these initial results.
Mesh-Begriff(e)	Antineoplastic Agents, Hormonal/therapeutic use ; Aromatase Inhibitors/therapeutic use ; Breast Neoplasms/chemistry ; Breast Neoplasms/drug therapy ; Contraindications, Drug ; Estrogen Replacement Therapy/adverse effects ; Female ; Fulvestrant/therapeutic use ; Hot Flashes/etiology ; Humans ; Kisspeptins/physiology ; Ovary/drug effects ; Ovary/surgery ; Receptors, Neurokinin-3/antagonists & inhibitors ; Selective Estrogen Receptor Modulators/administration & dosage ; Selective Estrogen Receptor Modulators/therapeutic use ; Tamoxifen/administration & dosage ; Tamoxifen/therapeutic use
Chemische Substanzen	Antineoplastic Agents, Hormonal ; Aromatase Inhibitors ; KISS1 protein, human ; Kisspeptins ; Receptors, Neurokinin-3 ; Selective Estrogen Receptor Modulators ; Tamoxifen (094ZI81Y45) ; Fulvestrant (22X328QOC4)
Sprache	Französisch
Erscheinungsdatum	2020-09-25
Erscheinungsland	France
Dokumenttyp	Journal Article ; Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2020.07.005
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Financement à l’épisode de soins : évaluation du coût d’une chirurgie première pour cancer du sein précoce.

Majou, Doriane / Mekarnia, Yanis / Martin, Barbara / Rouzier, Roman / Héquet, Delphine

Bulletin du cancer

2021 Band 108, Heft 12, Seite(n) 1091–1100

Abstract: Introduction: Episode-based bundled payment model is actually opposing to fee-for-service model, intending to incentivize coordinated care. The aims of these study were to determine episode-based costs for surgery in early breast cancer patients and to ... ...

Titelübersetzung	Episode-based bundled payment model: evaluation of medical costs for early operable breast cancer.
Abstract	Introduction: Episode-based bundled payment model is actually opposing to fee-for-service model, intending to incentivize coordinated care. The aims of these study were to determine episode-based costs for surgery in early breast cancer patients and to propose a payment model. Methods: OPTISOINS01 was a multicenter prospective study including early breast cancer patients from diagnosis to one-year follow up. Direct medical costs, quality and patient reported outcomes were collected. Results: Data from 604 patients were analyzed. Episode-based costs for surgery were higher in case of: planned radical surgery (OR=9,47 ; IC95 % [3,49-28,01]; P<0,001), hospitalization during more than one night (OR=6,73; IC95% [2,59-17,46]; P<0,001), home hospitalization (OR=11,07 ; IC95 % [3,01-173][3,01-54][3,01-543][3,01-54,33]; P<0,001) and re-hospitalization (OR=25,71 ; IC95 % [9,24-89,17; P<0,001). The average cost was 5 268 € [2 947-18 461] when a lumpectomy was planned and 7408 € [4 222-22 565] in case of radical mastectomy. Bootstrap method was applied for internal validation of the cost model showing the reliability of the model with an area under the curve of 0,83 (95 % CI [0,80-0,86]). Care quality and patient reported outcomes were not related to the costs. Discussion: This is the first report of episode-based costs for breast cancer surgery. An external validation will be necessary to validate our payment model.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Breast Neoplasms/economics ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Direct Service Costs ; Fee-for-Service Plans/economics ; Female ; Home Care Services/economics ; Hospitalization/economics ; Humans ; Mastectomy, Radical/economics ; Mastectomy, Segmental/economics ; Middle Aged ; Patient Readmission/economics ; Patient Reported Outcome Measures ; Prospective Studies ; Quality of Health Care ; Reimbursement Mechanisms/economics ; Reproducibility of Results
Sprache	Französisch
Erscheinungsdatum	2021-10-14
Erscheinungsland	France
Dokumenttyp	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2021.07.006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: COVID-19 burden and influencing factors in Swiss long-term-care facilities: a cross-sectional analysis of a multicentre observational cohort.

Scanferla, Giulia / Héquet, Delphine / Graf, Nicole / Münzer, Thomas / Kessler, Simone / Kohler, Philipp / Nussbaumer, Andres / Petignat, Christiane / Schlegel, Matthias / Flury, Domenica

Swiss medical weekly

2023 Band 153, Seite(n) 40052

Abstract: Objectives: To describe the burden of COVID-19 in Swiss long-term care facilities in 2020, to identify its influencing factors, and to assess vaccination rates among residents and healthcare workers at the end of the vaccine campaign in Switzerland in ... ...

Abstract	Objectives: To describe the burden of COVID-19 in Swiss long-term care facilities in 2020, to identify its influencing factors, and to assess vaccination rates among residents and healthcare workers at the end of the vaccine campaign in Switzerland in May 2021. Design: Cross-sectional survey. Setting and participants: Long-term care facilities from two Swiss cantons (St. Gallen / Eastern Switzerland and Vaud / Western Switzerland). Methods: We collected numbers of COVID-19 cases and related deaths and all-cause mortality for 2020, potential risk factors at the institutional level (e.g. size, infection prevention and control measures, and resident characteristics), and vaccination rates among residents and healthcare workers. Univariate and multivariate analyses were used to identify factors associated with resident mortality in 2020. Results: We enrolled 59 long-term care facilities with a median of 46 (interquartile range [IQR]: 33-69) occupied beds. In 2020, the median COVID-19 incidence was 40.2 (IQR: 0-108.6) per 100 occupied beds, with higher rates in VD (49.9%) than in SG (32.5%; p = 0.037). Overall, 22.7% of COVID-19 cases died, of which 24.8% were COVID-19-related deaths. In the univariate analysis, higher resident mortality was associated with COVID-19 rates among residents (p < 0.001) and healthcare workers (p = 0.002) and age (p = 0.013). Lower resident mortality was associated with the proportion of single rooms (p = 0.012), isolation of residents with COVID-19 in single rooms (p = 0.003), symptom screening of healthcare workers (p = 0.031), limiting the number of visits per day (p = 0.004), and pre-scheduling visits (p = 0.037). In the multivariate analysis, higher resident mortality was only associated with age (p = 0.03) and the COVID-19 rate among residents (p = 0.013). Among 2936 residents, 2042 (69.9%) received ≥1 dose of the COVID-19 vaccine before 31 May 2021. Vaccine uptake among healthcare workers was 33.8%. Conclusion and implications: COVID-19 burden was high but also highly variable in Swiss long-term care facilities. severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among healthcare workers was a modifiable factor associated with increased resident mortality. Symptom screening of healthcare workers appeared to be an effective preventive strategy and should be included in routine infection prevention and control measures. Promoting COVID-19 vaccine uptake among healthcare workers should be a priority in Swiss long-term care facilities.
Mesh-Begriff(e)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cross-Sectional Studies ; SARS-CoV-2 ; COVID-19 Vaccines ; Switzerland/epidemiology
Chemische Substanzen	COVID-19 Vaccines
Sprache	Englisch
Erscheinungsdatum	2023-03-31
Erscheinungsland	Switzerland
Dokumenttyp	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.57187/smw.2023.40052
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Utilisation des réseaux sociaux en oncologie.

Mottais-Cosnefroy, Victoria / Allouche, Dan / Zerbib, Elie / Hequet, Delphine / Bonneau, Claire / Rouzier, Roman

Bulletin du cancer

2022 Band 109, Heft 3, Seite(n) 382–383

Titelübersetzung	Use of social networks in oncology.
Mesh-Begriff(e)	Humans ; Medical Oncology ; Social Networking
Sprache	Französisch
Erscheinungsdatum	2022-02-11
Erscheinungsland	France
Dokumenttyp	Letter
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2021.12.015
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Determinants of geographic inequalities in HPV vaccination in the most populated region of France.

Héquet, Delphine / Rouzier, Roman

PloS one

2017 Band 12, Heft 3, Seite(n) e0172906

Abstract: Background: In France, there are recommendations and reimbursements for human papillomavirus (HPV) vaccination but no HPV vaccination programs. Therefore, vaccination is largely determined by parents' initiative, which can lead to inequalities. The ... ...

Abstract	Background: In France, there are recommendations and reimbursements for human papillomavirus (HPV) vaccination but no HPV vaccination programs. Therefore, vaccination is largely determined by parents' initiative, which can lead to inequalities. The objective of this study was to determine the factors associated with poorer vaccination coverage rates in the most populated region of France. Methods: The data of this study were obtained from the National Health Insurance between 2011 and 2013. Correlations between vaccination initiation rate (at least 1 dose reimbursed) and socio-demographic/cultural factors were assessed using Pearson's product-moment correlation coefficient. Multivariate analyses were performed using logistic regression. Results: In total, 121,636 girls received at least one HPV vaccine dose. The vaccination rate for girls born from 1996 to 1999 was 18.7%. Disparities in vaccination coverage rates were observed between the 8 departments of the region, ranging from 12.9% to 22.6%. At the department level, unemployment, proportion of immigrants and foreigners, and coverage by CMU health insurance ("Couverture Maladie Universelle", a health insurance plan for those who are not otherwise covered through business or employment and who have a low income) were significantly inversely correlated with vaccination rates, whereas urban residence, medical density, income and use of medical services were not related to coverage. In the multivariate model, only the percentage of foreigners remained independently associated with lower vaccination coverage. At the individual level, the use of medical services was a strong driver of HPV vaccination initiation. Conclusion: We observed geographic disparities in HPV vaccination initiation coverage. Even if no clear factor was identified as a vaccination determinant, we observed a failure of vaccination only based on parents' initiative. Therefore, an organized policy on HPV vaccination, such as school-based programs, can help improve coverage rates.
Mesh-Begriff(e)	Adolescent ; Emigrants and Immigrants/statistics & numerical data ; Female ; France ; Geography ; Humans ; Insurance, Health/statistics & numerical data ; Multivariate Analysis ; Papillomavirus Infections/economics ; Papillomavirus Infections/immunology ; Papillomavirus Infections/prevention & control ; Papillomavirus Infections/virology ; Papillomavirus Vaccines/administration & dosage ; Papillomavirus Vaccines/economics ; Socioeconomic Factors ; Vaccination/economics ; Vaccination/statistics & numerical data
Chemische Substanzen	Papillomavirus Vaccines
Sprache	Englisch
Erscheinungsdatum	2017-03-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0172906
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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