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Artikel ; Online: Letter to the Editor.

Treleaven, Julia / Thomas, Lucy / Jull, Gwendolen / Liang, Zhiqi

2023 Band 37, Heft 12, Seite(n) 1717–1718

Sprache	Englisch
Erscheinungsdatum	2023-06-05
Erscheinungsland	England
Dokumenttyp	Letter ; Comment
ZDB-ID	639276-3
ISSN	1477-0873 ; 0269-2155
ISSN (online)	1477-0873
ISSN	0269-2155
DOI	10.1177/02692155231180718
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: How to Treat

Belani, Neel / Liang, Katherine / Fradley, Michael / Judd, Julia / Borghaei, Hossein

JACC. CardioOncology

2023 Band 5, Heft 4, Seite(n) 542–545

Abstract: Mutations in ... ...

Abstract	•Mutations in the
Sprache	Englisch
Erscheinungsdatum	2023-06-27
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ISSN	2666-0873
ISSN (online)	2666-0873
DOI	10.1016/j.jaccao.2023.04.005
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update.

Hillebrand, Laura / Liang, Xiaojun Julia / Serafim, Ricardo A M / Gehringer, Matthias

Journal of medicinal chemistry

2024

Abstract: Covalent inhibitors and other types of covalent modalities have seen a revival in the past two decades, with a variety of new targeted covalent drugs having been approved in recent years. A key feature of such molecules is an intrinsically reactive group, ...

Abstract	Covalent inhibitors and other types of covalent modalities have seen a revival in the past two decades, with a variety of new targeted covalent drugs having been approved in recent years. A key feature of such molecules is an intrinsically reactive group, typically a weak electrophile, which enables the irreversible or reversible formation of a covalent bond with a specific amino acid of the target protein. This reactive group, often called the "warhead", is a critical determinant of the ligand's activity, selectivity, and general biological properties. In 2019, we summarized emerging and re-emerging warhead chemistries to target cysteine and other amino acids (Gehringer, M.; Laufer, S. A.
Sprache	Englisch
Erscheinungsdatum	2024-05-06
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c01825
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Subgrouping individuals with migraine associated neck pain for targeted management.

Liang, Zhiqi / Thomas, Lucy / Jull, Gwendolen / Treleaven, Julia

Musculoskeletal science & practice

2023 Band 66, Seite(n) 102801

Abstract: Introduction: Neck pain is one of the most common and burdensome symptoms associated with migraine. Many individuals with migraine and neck pain seek neck treatment, but evidence for such treatment is limited. Most studies have treated this population ... ...

Abstract	Introduction: Neck pain is one of the most common and burdensome symptoms associated with migraine. Many individuals with migraine and neck pain seek neck treatment, but evidence for such treatment is limited. Most studies have treated this population as a homogenous group, providing uniform cervical interventions that have yet to show clinically important effects. However, different neurophysiological and musculoskeletal mechanisms can underlie neck pain in migraine. Targeting treatment to specific underlying mechanisms may therefore be the key to improving treatment outcomes. Our research characterised neck pain mechanisms and identified subgroups based on cervical musculoskeletal function and cervical hypersensitivity. This suggests that specific management aimed towards addressing mechanisms relevant to each subgroup might be beneficial. Purpose: This paper explains our research approach and findings to date. Potential management strategies for the identified subgroups and future research directions are discussed. Implications: Clinicians should perform skilled physical examination with the aim of identifying if patterns of cervical musculoskeletal dysfunction and or hypersensitivity are present in the individual patient. There is currently no research into treatments differentiated for subgroups to address specific underlying mechanisms. It is possible that neck treatments addressing musculoskeletal impairments may be most beneficial for those subgroups where neck pain is primarily due to musculoskeletal dysfunction. Future research should define treatment aims and select specific subgroups for targeted management to determine which treatments are most effective for each subgroup. Trial registration: Not applicable.
Mesh-Begriff(e)	Humans ; Neck Pain ; Migraine Disorders/therapy ; Neck ; Physical Examination ; Treatment Outcome
Sprache	Englisch
Erscheinungsdatum	2023-06-14
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	2888772-4
ISSN	2468-7812
ISSN (online)	2468-7812
DOI	10.1016/j.msksp.2023.102801
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Validation of Brief Condom Use Attitudes Scales for Spanish-Speaking People Who Use Crack Cocaine in El Salvador.

Beachy, Sara / Lechuga, Julia / Dickson-Gomez, Julia / Liang, Christopher T H

Archives of sexual behavior

2022 Band 51, Heft 5, Seite(n) 2679–2688

Abstract: People who use crack cocaine (PWUCC) are a population severely impacted by a concentrated epidemic of HIV. Behavioral interventions to prevent and treat HIV among PWUCC have been implemented around the world including in low- and middle-income countries ... ...

Abstract	People who use crack cocaine (PWUCC) are a population severely impacted by a concentrated epidemic of HIV. Behavioral interventions to prevent and treat HIV among PWUCC have been implemented around the world including in low- and middle-income countries which have been disproportionately affected by HIV. However, few studies have validated and assessed psychometric properties of measures on PWUCC, especially in transnational populations. Our sample was comprised of 1324 PWUCC, Spanish mono-lingual speakers, residing in the metropolitan area of San Salvador, El Salvador. Exploratory factor analysis and subsequent confirmatory factor analysis using statistical softwares SPSS and Amos were conducted on three abbreviated and translated condom use attitude measures (i.e., Condom Use Attitudes Scale-Spanish Short Form, Condom Use Social Norm-Spanish Short Form [CUSN-SSF], Condom Use Self-Efficacy-Spanish Short Form). Convergent validity was examined by computing bivariate correlations between the scales and condom use and sexually transmitted disease diagnosis. Results indicated that a two-factor, 8-item correlated model for the CUAS-SSF scale had an excellent fit and adequate reliability (α = .76). The confirmatory factor analysis for the 5-item CUSN-SSF scale indicated a satisfactory fit with 3 of 6 fit indices indicating adequate fit. Analysis of the two-factor 5-item CUSE-SSF scale indicated satisfactory fit and adequate reliability (α = .84). There were significant correlations between all measures and with self-reported condom use. Results indicate that these brief measures are reliable and valid and can be utilized to assess the effectiveness of HIV risk reduction interventions among Spanish-speaking PWUCC.
Mesh-Begriff(e)	Condoms ; Crack Cocaine ; El Salvador ; HIV Infections/prevention & control ; Humans ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires
Chemische Substanzen	Crack Cocaine
Sprache	Englisch
Erscheinungsdatum	2022-05-04
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	184221-3
ISSN	1573-2800 ; 0004-0002
ISSN (online)	1573-2800
ISSN	0004-0002
DOI	10.1007/s10508-021-02193-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Exploring Sociodemographic Factors in Allergic Fungal Rhinosinusitis in a Northern California Patient Population.

Debbaneh, Peter / Singh, Priyanka / Swisher, Austin R / Wei, Julia C / Liang, Jonathan

The Permanente journal

2024 , Seite(n) 1–8

Abstract: Background: Allergic fungal rhinosinusitis (AFRS) is a subtype of chronic rhinosinusitis (CRS) that has previously been associated with younger age and Black patients. However, the role of demographic and socioeconomic factors in AFRS severity remains ... ...

Abstract	Background: Allergic fungal rhinosinusitis (AFRS) is a subtype of chronic rhinosinusitis (CRS) that has previously been associated with younger age and Black patients. However, the role of demographic and socioeconomic factors in AFRS severity remains to be fully elucidated. Objective: The objective of this study was to determine whether demographic and socioeconomic factors are associated with incidence of AFRS, as well as with disease severity in Northern California. Methods: A retrospective cohort study was conducted of adult patients with AFRS and CRS from 2010 to 2019. AFRS was determined by the Bent and Kuhn criteria, and severity was assessed by radiographic evidence of cranioorbital invasion and other clinical parameters. Chi-square and t-test were used to assess demographic and socioeconomic differences between AFRS and CRS cohorts, and multivariable logistic regression was used to assess risk factors for severe AFRS. Results: Black patients represented 26.2% (55/210 patients) of the AFRS group and 4.9% (842/17,300 patients) of the CRS group, with pairwise comparison of race/ethnicity categories showing that the AFRS group had significantly higher proportions of Black race/ethnicity compared with other race/ethnicities (p < 0.01). AFRS and CRS groups differed significantly by age, with mean ages of 48.7 and 51.0 years, respectively (p = 0.04). There were no significant differences in gender, Medicaid status, comorbidities, and socioeconomic status measures. Multivariate logistic regression showed that Black patients had higher odds of having severe AFRS (adjusted odds ratio = 2.29; 95% confidence interval: 1.18-4.45). Conclusion: AFRS has a unique predilection for Black patients, and severe disease is also more likely in this population.
Sprache	Englisch
Erscheinungsdatum	2024-05-15
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2062823-7
ISSN	1552-5775 ; 1552-5775
ISSN (online)	1552-5775
ISSN	1552-5775
DOI	10.7812/TPP/23.165
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Providing Evidence for Dogma: Risk of Epistaxis After COVID-19 Nasal-Screening Swab.

Block-Wheeler, Nikolas R / Wei, Julia / Weintraub, Miranda R / Liang, Jonathan

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2023 Band 169, Heft 1, Seite(n) 47–54

Abstract: Objective: There is anecdotal evidence SARS-CoV-2 (COVID) RT-PCR screening nasal swabs confer an elevated epistaxis risk. We aimed to assess the association between epistaxis and exposure to a COVID nasal swab.: Study design: A matched pairs design ... ...

Abstract	Objective: There is anecdotal evidence SARS-CoV-2 (COVID) RT-PCR screening nasal swabs confer an elevated epistaxis risk. We aimed to assess the association between epistaxis and exposure to a COVID nasal swab. Study design: A matched pairs design was used. Setting: The study was performed in a single, integrated health care system. Methods: All patients who received a single COVID nasal swab at our institution between April 2020 and March 2021 were included. McNemar's test was used to compare rates of epistaxis between the 7 days following the index COVID swab (hazard period), and the 7 days preceding the index COVID swab (control period). Conditional logistic regression was used to evaluate sociodemographic and clinical risk factors for epistaxis. Results: A total of 827,987 participants were included, with 1047 epistaxis encounters. The prevalence of epistaxis during the hazard and control periods were 0.08% and 0.04%, respectively. Swab exposure was associated with 1.92-fold odds of epistaxis during the hazard period (95% confidence interval [1.73, 2.12]). Older age, Asian/Pacific Islander (PI) (compared to white), male sex, hypertension, prior facial trauma, and warfarin or direct-acting oral anticoagulant use were also associated with significantly increased odds of epistaxis (p ≦ 0.01). Conclusion: COVID nasal swabs are associated with increased odds of epistaxis. Physicians should counsel patients, particularly those at the highest risk, including a history of prior facial trauma, anticoagulants/antiplatelets, or hypertension.
Mesh-Begriff(e)	Humans ; Male ; COVID-19/complications ; COVID-19/epidemiology ; SARS-CoV-2 ; Epistaxis/diagnosis ; Epistaxis/epidemiology ; Epistaxis/etiology ; Specimen Handling ; Hypertension
Sprache	Englisch
Erscheinungsdatum	2023-01-29
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1002/ohn.253
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Individual perceptions on the relationship between migraine and neck pain.

Schulz, Michael / Xu, Wenrui / Treleaven, Julia / Thomas, Lucy / Liang, Zhiqi

Musculoskeletal science & practice

2023 Band 66, Seite(n) 102812

Abstract: Background: Despite neck pain being a common complaint for people with migraine, little is known about how individuals perceive the relationship between their migraine and neck pain. Exploring their beliefs and perceptions could provide valuable ... ...

Abstract	Background: Despite neck pain being a common complaint for people with migraine, little is known about how individuals perceive the relationship between their migraine and neck pain. Exploring their beliefs and perceptions could provide valuable understanding to improve overall management and reduce the burden of migraine and neck pain. Objectives: To investigate individual perspectives on how migraine and neck pain relate. Methods: A retrospective qualitative study was performed. Seventy participants (mean age 39.2, 60 female) were recruited via community and social media advertisements, and interviewed by an experienced physiotherapist using a semi-structured interview framework. An Inductive thematic analysis was used to analyse the responses. Results: Five themes were identified from the interviews: (i) the timing of neck pain and migraine, (ii) causality beliefs, (iii) burden of neck pain and migraine, (iv) experiences with treatment and (v) mismatched perspectives. Diverse views emerged, revealing links between the first two themes of timing and causality, showing increased burden in those suffering from both neck pain and migraine, and providing insights into apparently ineffective or even aggravating treatments. Conclusions: Valuable insights for clinicians emerged. Due to the complex relationship, clinicians should discuss the aetiology of neck pain in migraine with patients. For some individuals, neck treatment may not produce long-term relief and may even aggravate migraine, but the value of short-term relief in a chronic condition must be considered individually. Clinicians are ideally placed to have discussions with patients individually to tailor individual decisions about management.
Mesh-Begriff(e)	Humans ; Female ; Neck Pain ; Retrospective Studies ; Migraine Disorders/therapy ; Chronic Disease ; Qualitative Research
Sprache	Englisch
Erscheinungsdatum	2023-06-25
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	2888772-4
ISSN	2468-7812
ISSN (online)	2468-7812
DOI	10.1016/j.msksp.2023.102812
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A repository of COVID-19 related molecular dynamics simulations and utilisation in the context of nsp10-nsp16 antivirals.

Liang, Julia J / Pitsillou, Eleni / Hung, Andrew / Karagiannis, Tom C

Journal of molecular graphics & modelling

2023 Band 126, Seite(n) 108666

Abstract: The coronavirus disease 2019 (COVID-19) pandemic highlighted the importance of establishing systems and infrastructure to develop vaccines, antiviral drugs, and therapeutic antibodies against emerging pathogens. Typical drug discovery processes involve ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic highlighted the importance of establishing systems and infrastructure to develop vaccines, antiviral drugs, and therapeutic antibodies against emerging pathogens. Typical drug discovery processes involve targeting suitable proteins to effect pathogen replication or to attenuate host responses, by examining either large chemical databases or protein-protein interactions. Following initial screens, molecular dynamics (MD) simulations are critical for gaining further insight into molecular interactions. During the COVID-19 pandemic, many research groups made their simulations widely available, as highlighted by the comprehensive D.E. Shaw Research trajectory database. To investigate protein target sites and evaluate potential lead compounds, we performed over 300 MD simulations relating to COVID-19. We organised our simulations into a repository, which is publicly available at https://epimedlab.org/trajectories/. The trajectories cover a large part of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteome, and the majority of our MD simulations focused on the identification of potential antivirals. For example, we focused on the S-adenosyl-l-methionine binding site of the nsp10-nsp16 complex, a critical component of viral replication, revealing verbascoside as a potential lead. Moreover, we utilised MD trajectories to explore the interface between the spike protein receptor binding domain and human angiotensin-converting enzyme 2 receptor, with the ultimate aim being investigation of new variants in real-time. Overall, MD simulations are a critical component of the in silico drug discovery process and as highlighted throughout the pandemic, data sharing enables accelerated progress. We have organised our extensive collection of COVID-19 related MD trajectories into an easily accessible repository.
Mesh-Begriff(e)	Humans ; COVID-19 ; Molecular Dynamics Simulation ; SARS-CoV-2 ; Pandemics ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Antiviral Agents/chemistry
Chemische Substanzen	Antiviral Agents
Sprache	Englisch
Erscheinungsdatum	2023-11-10
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1396450-1
ISSN	1873-4243 ; 1093-3263
ISSN (online)	1873-4243
ISSN	1093-3263
DOI	10.1016/j.jmgm.2023.108666
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The temporal behaviour of migraine related neck pain does not inform on the origin of neck pain: An observational study.

Liang, Zhiqi / Thomas, Lucy / Jull, Gwendolen / Treleaven, Julia

Musculoskeletal science & practice

2022 Band 58, Seite(n) 102522

Abstract: Background: Clinicians seek to identify associations between pain behaviours to understand if symptoms are related or separate conditions. This study determined whether the temporal behaviour of migraine related neck pain related to i) the presence of ... ...

Abstract	Background: Clinicians seek to identify associations between pain behaviours to understand if symptoms are related or separate conditions. This study determined whether the temporal behaviour of migraine related neck pain related to i) the presence of cervical musculoskeletal function or ii) migraine hypersensitivity. Methods: Cross-sectional study of migraineurs with neck pain (n = 110). Participants reported daily for one month via an online survey, on migraine and other headaches, neck symptoms, location of onset and self-identified triggers. Allodynia Symptom Checklist (ASC12), Pressure pain thresholds (PPTs), and presence or absence of cervical musculoskeletal dysfunction were also assessed. Results: The temporal behaviours of neck pain in 92 participants (46 migraine only, 46 migraine plus another headache) were categorised as: i) ictal only (n = 42), ii) ictal and infrequent interictal (n = 26), iii) ictal and frequent interictal (n = 17), and iv) undecipherable (n = 7). Cervical musculoskeletal dysfunction was present in 43%. Temporal behaviours of neck pain were not associated with cervical musculoskeletal dysfunction (p = 1.00 and 0.21), nor related to ASC12, PPTs, headache triggers, neck pain, nor region of symptom onset, whether migraine only or migraine and another headache was reported (p = 0.29 to 0.97). Conclusion: Individuals with migraine present with varied behaviours of neck pain in relation to the headache. As temporal behaviour is not informative, a physical examination is needed to negate or confirm a cervical source of neck pain in migraine.
Mesh-Begriff(e)	Cross-Sectional Studies ; Headache ; Humans ; Migraine Disorders/diagnosis ; Neck Muscles ; Neck Pain
Sprache	Englisch
Erscheinungsdatum	2022-01-31
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Observational Study
ZDB-ID	2888772-4
ISSN	2468-7812
ISSN (online)	2468-7812
DOI	10.1016/j.msksp.2022.102522
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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